Search Results - "Udine, Evan"

Advances in sequencing technologies for amyotrophic lateral sclerosis research by Udine, Evan, Jain, Angita, van Blitterswijk, Marka

“…Amyotrophic lateral sclerosis (ALS) is caused by upper and lower motor neuron loss and has a fairly rapid disease progression, leading to fatality in an…”
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Distinct non-inflammatory signature of microglia in post-mortem brain tissue of patients with major depressive disorder by Snijders, Gijsje J. L. J., Sneeboer, Marjolein A. M., Fernández-Andreu, Alba, Udine, Evan, Boks, Marco P., Ormel, Paul R., van Berlekom, Amber Berdenis, van Mierlo, Hans C., Bӧttcher, Chotima, Priller, Josef, Raj, Towfique, Hol, Elly M., Kahn, René S., de Witte, Lot D.

“…Findings from epidemiological studies, biomarker measurements and animal experiments suggest a role for aberrant immune processes in the pathogenesis of major…”
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Genome-wide association study and functional validation implicates JADE1 in tauopathy by Farrell, Kurt, Kim, SoongHo, Han, Natalia, Iida, Megan A., Gonzalez, Elias M., Otero-Garcia, Marcos, Walker, Jamie M., Richardson, Timothy E., Renton, Alan E., Andrews, Shea J., Fulton-Howard, Brian, Humphrey, Jack, Vialle, Ricardo A., Bowles, Kathryn R., de Paiva Lopes, Katia, Whitney, Kristen, Dangoor, Diana K., Walsh, Hadley, Marcora, Edoardo, Hefti, Marco M., Casella, Alicia, Sissoko, Cheick T., Kapoor, Manav, Novikova, Gloriia, Udine, Evan, Wong, Garrett, Tang, Weijing, Bhangale, Tushar, Hunkapiller, Julie, Ayalon, Gai, Graham, Robert R., Cherry, Jonathan D., Cortes, Etty P., Borukov, Valeriy Y., McKee, Ann C., Stein, Thor D., Vonsattel, Jean-Paul, Teich, Andy F., Gearing, Marla, Glass, Jonathan, Troncoso, Juan C., Frosch, Matthew P., Hyman, Bradley T., Dickson, Dennis W., Murray, Melissa E., Attems, Johannes, Flanagan, Margaret E., Mao, Qinwen, Mesulam, M.-Marsel, Weintraub, Sandra, Woltjer, Randy L., Pham, Thao, Kofler, Julia, Schneider, Julie A., Yu, Lei, Purohit, Dushyant P., Haroutunian, Vahram, Hof, Patrick R., Gandy, Sam, Sano, Mary, Beach, Thomas G., Poon, Wayne, Kawas, Claudia H., Corrada, María M., Rissman, Robert A., Metcalf, Jeff, Shuldberg, Sara, Salehi, Bahar, Nelson, Peter T., Trojanowski, John Q., Lee, Edward B., Wolk, David A., McMillan, Corey T., Keene, C. Dirk, Latimer, Caitlin S., Montine, Thomas J., Kovacs, Gabor G., Lutz, Mirjam I., Fischer, Peter, Perrin, Richard J., Cairns, Nigel J., Franklin, Erin E., Cohen, Herbert T., Raj, Towfique, Cobos, Inma, Frost, Bess, Goate, Alison, White III, Charles L., Crary, John F.

“…Primary age-related tauopathy (PART) is a neurodegenerative pathology with features distinct from but also overlapping with Alzheimer disease (AD). While both…”
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Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLs by Ramdhani, Satesh, Navarro, Elisa, Udine, Evan, Efthymiou, Anastasia G, Schilder, Brian M, Parks, Madison, Goate, Alison, Raj, Towfique

“…Recent human genetic studies suggest that cells of the innate immune system have a primary role in the pathogenesis of neurodegenerative diseases. However, the…”
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Transcriptome deregulation of peripheral monocytes and whole blood in GBA-related Parkinson's disease by Riboldi, Giulietta Maria, Vialle, Ricardo A, Navarro, Elisa, Udine, Evan, de Paiva Lopes, Katia, Humphrey, Jack, Allan, Amanda, Parks, Madison, Henderson, Brooklyn, Astudillo, Kelly, Argyrou, Charalambos, Zhuang, Maojuan, Sikder, Tamjeed, Oriol Narcis, J, Kumar, Shilpa Dilip, Janssen, William, Sowa, Allison, Comi, Giacomo P, Di Fonzo, Alessio, Crary, John F, Frucht, Steven J, Raj, Towfique

“…Genetic mutations in beta-glucocerebrosidase (GBA) represent the major genetic risk factor for Parkinson's disease (PD). GBA participates in both the…”
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Exploring shared features in neurodegenerative diseases by Jain, Angita, Udine, Evan, van Blitterswijk, Marka

“…This scientific commentary refers to ‘Genetic risk factor clustering within and across neurodegenerative diseases’ by Koretsky et al…”
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A characterization of the molecular phenotype and inflammatory response of schizophrenia patient-derived microglia-like cells by Ormel, Paul R., Böttcher, Chotima, Gigase, Frederieke A.J., Missall, Roy D., van Zuiden, Welmoed, Fernández Zapata, M. Camila, Ilhan, Dilara, de Goeij, Michelle, Udine, Evan, Sommer, Iris E.C., Priller, Josef, Raj, Towfique, Kahn, René S., Hol, Elly M., de Witte, Lot D.

“…•Monocytes were cultured towards a microglia-like phenotype in vitro.•The phenotype of these induced microglia (iMG) resembles cultured primary microglia.•iMG…”
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PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons by Milioto, Carmelo, Carcolé, Mireia, Giblin, Ashling, Coneys, Rachel, Attrebi, Olivia, Ahmed, Mhoriam, Harris, Samuel S., Lee, Byung Il, Yang, Mengke, Ellingford, Robert A., Nirujogi, Raja S., Biggs, Daniel, Salomonsson, Sally, Zanovello, Matteo, de Oliveira, Paula, Katona, Eszter, Glaria, Idoia, Mikheenko, Alla, Geary, Bethany, Udine, Evan, Vaizoglu, Deniz, Anoar, Sharifah, Jotangiya, Khrisha, Crowley, Gerard, Smeeth, Demelza M., Adams, Mirjam L., Niccoli, Teresa, Rademakers, Rosa, van Blitterswijk, Marka, Devoy, Anny, Hong, Soyon, Partridge, Linda, Coyne, Alyssa N., Fratta, Pietro, Alessi, Dario R., Davies, Ben, Busche, Marc Aurel, Greensmith, Linda, Fisher, Elizabeth M. C., Isaacs, Adrian M.

“…Dipeptide repeat proteins are a major pathogenic feature of C9orf72 amyotrophic lateral sclerosis (C9ALS)/frontotemporal dementia (FTD) pathology, but their…”
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Abundant transcriptomic alterations in the human cerebellum of patients with a C9orf72 repeat expansion by Udine, Evan, DeJesus-Hernandez, Mariely, Tian, Shulan, das Neves, Sofia Pereira, Crook, Richard, Finch, NiCole A., Baker, Matthew C., Pottier, Cyril, Graff-Radford, Neill R., Boeve, Bradley F., Petersen, Ronald C., Knopman, David S., Josephs, Keith A., Oskarsson, Björn, Da Mesquita, Sandro, Petrucelli, Leonard, Gendron, Tania F., Dickson, Dennis W., Rademakers, Rosa, van Blitterswijk, Marka

“…The most prominent genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) is a repeat expansion in the gene…”
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Cell type‐specific gene expression changes in Alzheimer’s patients with varying levels of cerebral amyloid angiopathy by Patel, Tulsi, Udine, Evan, Wang, Xue, Allen, Mariet, Is, Ozkan, Tutor‐New, Frederick Q, Carnwath, Troy, Deniz, Kaancan, Lincoln, Sarah J., Nguyen, Thuy, Malphrus, Kimberly G., Quicksall, Zachary, Lewis‐Tuffin, Laura, Reddy, Joseph S., Carrasquillo, Minerva M., Crook, Julia E., Kanekiyo, Takahisa, Murray, Melissa E, Bu, Guojun, Dickson, Dennis W, Ertekin‐Taner, Nilufer

“…Background Tau neurofibrillary tangles and senile plaques comprised of insoluble amyloid beta are the major histopathological hallmarks of Alzheimer’s disease…”
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Dysregulation of mitochondrial and proteolysosomal genes in Parkinson's disease myeloid cells by Navarro, Elisa, Udine, Evan, de Paiva Lopes, Katia, Parks, Madison, Riboldi, Giulietta, Schilder, Brian M, Humphrey, Jack, Snijders, Gijsje J L, Vialle, Ricardo A, Zhuang, Maojuan, Sikder, Tamjeed, Argyrou, Charalambos, Allan, Amanda, Chao, Michael J, Farrell, Kurt, Henderson, Brooklyn, Simon, Sarah, Raymond, Deborah, Elango, Sonya, Ortega, Roberto A, Shanker, Vicki, Swan, Matthew, Zhu, Carolyn W, Ramdhani, Ritesh, Walker, Ruth H, Tse, Winona, Sano, Mary, Pereira, Ana C, Ahfeldt, Tim, Goate, Alison M, Bressman, Susan, Crary, John F, de Witte, Lotje, Frucht, Steven, Saunders-Pullman, Rachel, Raj, Towfique

“…An increasing number of identified Parkinson's disease (PD) risk loci contain genes highly expressed in innate immune cells, yet their role in pathology is not…”
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