Search Results - "Udhane, Sameer"

Variability in human drug metabolizing cytochrome P450 CYP2C9, CYP2C19 and CYP3A5 activities caused by genetic variations in cytochrome P450 oxidoreductase by Velazquez, Maria Natalia Rojas, Parween, Shaheena, Udhane, Sameer S., Pandey, Amit V.

“…A broad spectrum of human diseases are caused by mutations in the NADPH cytochrome P450 oxidoreductase (POR). Cytochrome P450 proteins perform several…”
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CYP17A1 inhibitor abiraterone, an anti-prostate cancer drug, also inhibits the 21-hydroxylase activity of CYP21A2 by Malikova, Jana, Brixius-Anderko, Simone, Udhane, Sameer S., Parween, Shaheena, Dick, Bernhard, Bernhardt, Rita, Pandey, Amit V.

“…•Abiraterone, a CYP17A1 inhibitor also targets CYP21A2.•Effect of abiraterone on steroid metabolism was studied in cultured cells.•Abiraterone inhibited…”
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P450 Oxidoreductase deficiency: Analysis of mutations and polymorphisms by Burkhard, Fabian Z., Parween, Shaheena, Udhane, Sameer S., Flück, Christa E., Pandey, Amit V.

“…•Mutations in POR cause a rare form of congenital adrenal hyperplasia called PORD.•PORD has symptoms of multiple defects in steroid metabolizing enzymes.•POR…”
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Specificity of anti-prostate cancer CYP17A1 inhibitors on androgen biosynthesis by Udhane, Sameer S., Dick, Bernhard, Hu, Qingzhong, Hartmann, Rolf W., Pandey, Amit V.

“…The orteronel, abiraterone and galeterone, which were developed to treat castration resistant prostate cancer, inhibit 17,20 lyase activity but little is known…”
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Regulation of human (adrenal) androgen biosynthesis—New insights from novel throughput technology studies by Udhane, Sameer S., Flück, Christa E.

“…[Display omitted] Androgens are precursors for sex steroids and are predominantly produced in the human gonads and the adrenal cortex. They are important for…”
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Combined transcriptome and metabolome analyses of metformin effects reveal novel links between metabolic networks in steroidogenic systems by Udhane, Sameer S., Legeza, Balazs, Marti, Nesa, Hertig, Damian, Diserens, Gaëlle, Nuoffer, Jean-Marc, Vermathen, Peter, Flück, Christa E.

“…Metformin is an antidiabetic drug, which inhibits mitochondrial respiratory-chain-complex I and thereby seems to affect the cellular metabolism in many ways…”
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Variability in Loss of Multiple Enzyme Activities Due to the Human Genetic Variation P284T Located in the Flexible Hinge Region of NADPH Cytochrome P450 Oxidoreductase by Parween, Shaheena, Rojas Velazquez, Maria Natalia, Udhane, Sameer S., Kagawa, Norio, Pandey, Amit V.

“…Cytochromes P450 located in the endoplasmic reticulum require NADPH cytochrome P450 oxidoreductase (POR) for their catalytic activities. Mutations in POR cause…”
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Altered CYP19A1 and CYP3A4 Activities Due to Mutations A115V, T142A, Q153R and P284L in the Human P450 Oxidoreductase by Udhane, Sameer S, Parween, Shaheena, Kagawa, Norio, Pandey, Amit V

“…All cytochromes P450s in the endoplasmic reticulum rely on P450 oxidoreductase (POR) for their catalytic activities. Mutations in POR cause metabolic disorders…”
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Molecular Basis of CYP19A1 Deficiency in a 46,XX Patient With R550W Mutation in POR: Expanding the PORD Phenotype by Parween, Shaheena, Fernández-Cancio, Mónica, Benito-Sanz, Sara, Camats, Núria, Rojas Velazquez, Maria Natalia, López-Siguero, Juan-Pedro, Udhane, Sameer S, Kagawa, Norio, Flück, Christa E, Audí, Laura, Pandey, Amit V

“…Mutations in cytochrome P450 oxidoreductase (POR) cause a form of congenital adrenal hyperplasia (CAH). We report a novel R550W mutation in POR identified in a…”
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Retinoic acid receptor beta and angiopoietin-like protein 1 are involved in the regulation of human androgen biosynthesis by Udhane, Sameer S., Pandey, Amit V., Hofer, Gaby, Mullis, Primus E., Flück, Christa E.

“…Androgens are essential for sexual development and reproduction. However, androgen regulation in health and disease is poorly understood. We showed that human…”
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Human 3β-hydroxysteroid dehydrogenase deficiency seems to affect fertility but may not harbor a tumor risk: lesson from an experiment of nature by Burckhardt, Marie-Anne, Udhane, Sameer S, Marti, Nesa, Schnyder, Isabelle, Tapia, Coya, Nielsen, John E, Mullis, Primus E, Rajpert-De Meyts, Ewa, Flück, Christa E

“…Context3β-hydroxysteroid dehydrogenase deficiency (3βHSD) is a rare disorder of sexual development and steroidogenesis. There are two isozymes of 3βHSD, HSD3B1…”
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Loss of Nuclear Localized Parathyroid Hormone-Related Protein in Primary Breast Cancer Predicts Poor Clinical Outcome and Correlates with Suppressed Stat5 Signaling by Tran, Thai H, Utama, Fransiscus E, Sato, Takahiro, Peck, Amy R, Langenheim, John F, Udhane, Sameer S, Sun, Yunguang, Liu, Chengbao, Girondo, Melanie A, Kovatich, Albert J, Hooke, Jeffrey A, Shriver, Craig D, Hu, Hai, Palazzo, Juan P, Bibbo, Marluce, Auer, Paul W, Flister, Michael J, Hyslop, Terry, Mitchell, Edith P, Chervoneva, Inna, Rui, Hallgeir

“…Parathyroid hormone-related protein (PTHrP) is required for normal mammary gland development and biology. A gene polymorphism is associated with breast cancer…”
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Diffuse interstitial pneumonia-like/macrophage activation syndrome-like changes in patients with COVID-19 correlate with length of illness by Felix, Juan C., Sheinin, Yuri M., Suster, David, Ronen, Natali, Ratiani, Mariam, Vanden Heuvel, Tana, Winge, Emilie, Patton, Mollie D., Rau, Mary J., Ge, Linna, Sun, Yunguang, Udhane, Sameer S., Langenheim, John F., Rui, Hallgeir

“…Assess the pathologic changes in the lungs of COVID-19 decedents and correlate these changes with demographic data, clinical course, therapies, and duration of…”
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Differential regulation of human 3β-hydroxysteroid dehydrogenase type 2 for steroid hormone biosynthesis by starvation and cyclic AMP stimulation: studies in the human adrenal NCI-H295R cell model by Udhane, Sameer, Kempna, Petra, Hofer, Gaby, Mullis, Primus E, Flück, Christa E

“…Human steroid biosynthesis depends on a specifically regulated cascade of enzymes including 3β-hydroxysteroid dehydrogenases (HSD3Bs). Type 2 HSD3B catalyzes…”
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Sensitive and Specific Immunohistochemistry Protocol for Nucleocapsid Protein from All Common SARS-CoV-2 Virus Strains in Formalin-Fixed, Paraffin Embedded Tissues by Sun, Yunguang, Ge, Linna, Udhane, Sameer S., Langenheim, John F., Rau, Mary J., Patton, Mollie D., Gallan, Alexander J., Felix, Juan C., Rui, Hallgeir

“…Human coronavirus disease 2019 (COVID-19) is a life-threatening and highly contagious disease caused by coronavirus SARS-CoV-2. Sensitive and specific…”
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High PD-L2 Predicts Early Recurrence of ER-Positive Breast Cancer by Chervoneva, Inna, Peck, Amy R, Sun, Yunguang, Yi, Misung, Udhane, Sameer S, Langenheim, John F, Girondo, Melanie A, Jorns, Julie M, Chaudhary, Lubna N, Kamaraju, Sailaja, Bergom, Carmen, Flister, Michael J, Hooke, Jeffrey A, Kovatich, Albert J, Shriver, Craig D, Hu, Hai, Palazzo, Juan P, Bibbo, Marluce, Hyslop, Terry, Nevalainen, Marja T, Pestell, Richard G, Fuchs, Serge Y, Mitchell, Edith P, Rui, Hallgeir

“…T-cell-mediated cytotoxicity is suppressed when programmed cell death-1 (PD-1) is bound by PD-1 ligand-1 (PD-L1) or PD-L2. Although PD-1 inhibitors have been…”
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NSG-Pro mouse model for uncovering resistance mechanisms and unique vulnerabilities in human luminal breast cancers by Sun, Yunguang, Yang, Ning, Utama, Fransiscus E, Udhane, Sameer S, Zhang, Junling, Peck, Amy R, Yanac, Alicia, Duffey, Katherine, Langenheim, John F, Udhane, Vindhya, Xia, Guanjun, Peterson, Jess F, Jorns, Julie M, Nevalainen, Marja T, Rouet, Romain, Schofield, Peter, Christ, Daniel, Ormandy, Christopher J, Rosenberg, Anne L, Chervoneva, Inna, Tsaih, Shirng-Wern, Flister, Michael J, Fuchs, Serge Y, Wagner, Kay-Uwe, Rui, Hallgeir

“…Most breast cancer deaths are caused by estrogen receptor-α–positive (ER ) disease. Preclinical progress is hampered by a shortage of therapy-naïve ER tumor…”
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Non-Virilizing Congenital Adrenal Hyperplasia in a Female Patient with a Novel HSD3B2 Mutation by Probst-Scheidegger, Ursina, Udhane, Sameer S, l'Allemand, Dagmar, Flück, Christa E, Camats, Núria

“…Classic 3β-hydroxysteroid dehydrogenase type 2 (3β-HSD II) deficiency causes congenital adrenal hyperplasia with glucocorticoid, mineralocorticoid, and sex…”
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Changes in Drug Metabolizing Enzyme Cytochrome P450 CYP3A4 Activities Due to Polymorphisms in Human Cytochrome P450 Oxidoreductase by Parween, Shaheena, Udhane, Sameer S, Pandey, Amit V

“…Background Cytochromes P450 proteins are responsible for the metabolism of drugs and xenobiotics. All cytochromes P450s in the endoplasmic reticulum rely on…”
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Effect of CYP17A1 17,20 Lyase Inhibitors on Regulation of Adrenal Androgen Biosynthesis by Pandey, Amit V, Udhane, Sameer S

“…Abstract only…”
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