Search Results - "Uddin, Fathema"

CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future by Uddin, Fathema, Rudin, Charles M, Sen, Triparna

“…A series of recent discoveries harnessing the adaptive immune system of prokaryotes to perform targeted genome editing is having a transformative influence…”
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Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer by Chan, Joseph M., Quintanal-Villalonga, Álvaro, Gao, Vianne Ran, Xie, Yubin, Allaj, Viola, Chaudhary, Ojasvi, Masilionis, Ignas, Egger, Jacklynn, Chow, Andrew, Walle, Thomas, Mattar, Marissa, Yarlagadda, Dig V.K., Wang, James L., Uddin, Fathema, Offin, Michael, Ciampricotti, Metamia, Qeriqi, Besnik, Bahr, Amber, de Stanchina, Elisa, Bhanot, Umesh K., Lai, W. Victoria, Bott, Matthew J., Jones, David R., Ruiz, Arvin, Baine, Marina K., Li, Yanyun, Rekhtman, Natasha, Poirier, John T., Nawy, Tal, Sen, Triparna, Mazutis, Linas, Hollmann, Travis J., Pe'er, Dana, Rudin, Charles M.

“…Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A, -N,…”
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Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer by Wohlhieter, Corrin A., Richards, Allison L., Uddin, Fathema, Hulton, Christopher H., Quintanal-Villalonga, Àlvaro, Martin, Axel, de Stanchina, Elisa, Bhanot, Umeshkumar, Asher, Marina, Shah, Nisargbhai S., Hayatt, Omar, Buonocore, Darren J., Rekhtman, Natasha, Shen, Ronglai, Arbour, Kathryn C., Donoghue, Mark, Poirier, John T., Sen, Triparna, Rudin, Charles M.

“…Concurrent loss-of-function mutations in STK11 and KEAP1 in lung adenocarcinoma (LUAD) are associated with aggressive tumor growth, resistance to available…”
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The ectonucleotidase CD39 identifies tumor-reactive CD8+ T cells predictive of immune checkpoint blockade efficacy in human lung cancer by Chow, Andrew, Uddin, Fathema Z., Liu, Michael, Dobrin, Anton, Nabet, Barzin Y., Mangarin, Levi, Lavin, Yonit, Rizvi, Hira, Tischfield, Sam E., Quintanal-Villalonga, Alvaro, Chan, Joseph M., Shah, Nisargbhai, Allaj, Viola, Manoj, Parvathy, Mattar, Marissa, Meneses, Maximiliano, Landau, Rebecca, Ward, Mariana, Kulick, Amanda, Kwong, Charlene, Wierzbicki, Matthew, Yavner, Jessica, Egger, Jacklynn, Chavan, Shweta S., Farillas, Abigail, Holland, Aliya, Sridhar, Harsha, Ciampricotti, Metamia, Hirschhorn, Daniel, Guan, Xiangnan, Richards, Allison L., Heller, Glenn, Mansilla-Soto, Jorge, Sadelain, Michel, Klebanoff, Christopher A., Hellmann, Matthew D., Sen, Triparna, de Stanchina, Elisa, Wolchok, Jedd D., Merghoub, Taha, Rudin, Charles M.

“…Improved identification of anti-tumor T cells is needed to advance cancer immunotherapies. CD39 expression is a promising surrogate of tumor-reactive CD8+…”
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Multiomic Analysis of Lung Tumors Defines Pathways Activated in Neuroendocrine Transformation by Quintanal-Villalonga, Alvaro, Taniguchi, Hirokazu, Zhan, Yingqian A, Hasan, Maysun M, Chavan, Shweta S, Meng, Fanli, Uddin, Fathema, Manoj, Parvathy, Donoghue, Mark T A, Won, Helen H, Chan, Joseph M, Ciampricotti, Metamia, Chow, Andrew, Offin, Michael, Chang, Jason C, Ray-Kirton, Jordana, Tischfield, Sam E, Egger, Jacklynn, Bhanot, Umesh K, Linkov, Irina, Asher, Marina, Sinha, Sonali, Silber, Joachim, Iacobuzio-Donahue, Christine A, Roehrl, Michael H, Hollmann, Travis J, Yu, Helena A, Qiu, Juan, de Stanchina, Elisa, Baine, Marina K, Rekhtman, Natasha, Poirier, John T, Loomis, Brian, Koche, Richard P, Rudin, Charles M, Sen, Triparna

“…Lineage plasticity is implicated in treatment resistance in multiple cancers. In lung adenocarcinomas (LUAD) amenable to targeted therapy, transformation to…”
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Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade by Pai, Joy A., Hellmann, Matthew D., Sauter, Jennifer L., Mattar, Marissa, Rizvi, Hira, Woo, Hyung Jun, Shah, Nisargbhai, Nguyen, Evelyn M., Uddin, Fathema Z., Quintanal-Villalonga, Alvaro, Chan, Joseph M., Manoj, Parvathy, Allaj, Viola, Baine, Marina K., Bhanot, Umesh K., Jain, Mala, Linkov, Irina, Meng, Fanli, Brown, David, Chaft, Jamie E., Plodkowski, Andrew J., Gigoux, Mathieu, Won, Helen H., Sen, Triparna, Wells, Daniel K., Donoghue, Mark T.A., de Stanchina, Elisa, Wolchok, Jedd D., Loomis, Brian, Merghoub, Taha, Rudin, Charles M., Chow, Andrew, Satpathy, Ansuman T.

“…Paired single-cell RNA and T cell receptor sequencing (scRNA/TCR-seq) has allowed for enhanced resolution of clonal T cell dynamics in cancer. Here, we report…”
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WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC by Taniguchi, Hirokazu, Caeser, Rebecca, Chavan, Shweta S., Zhan, Yingqian A., Chow, Andrew, Manoj, Parvathy, Uddin, Fathema, Kitai, Hidenori, Qu, Rui, Hayatt, Omar, Shah, Nisargbhai S., Quintanal Villalonga, Álvaro, Allaj, Viola, Nguyen, Evelyn M., Chan, Joseph, Michel, Adam O., Mukae, Hiroshi, de Stanchina, Elisa, Rudin, Charles M., Sen, Triparna

“…Small cell lung cancers (SCLCs) have high mutational burden but are relatively unresponsive to immune checkpoint blockade (ICB). Using SCLC models, we…”
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Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation by Quintanal-Villalonga, Alvaro, Taniguchi, Hirokazu, Zhan, Yingqian A, Hasan, Maysun M, Chavan, Shweta S, Meng, Fanli, Uddin, Fathema, Allaj, Viola, Manoj, Parvathy, Shah, Nisargbhai S, Chan, Joseph M, Ciampricotti, Metamia, Chow, Andrew, Offin, Michael, Ray-Kirton, Jordana, Egger, Jacklynn D, Bhanot, Umesh K, Linkov, Irina, Asher, Marina, Roehrl, Michael H, Ventura, Katia, Qiu, Juan, de Stanchina, Elisa, Chang, Jason C, Rekhtman, Natasha, Houck-Loomis, Brian, Koche, Richard P, Yu, Helena A, Sen, Triparna, Rudin, Charles M

“…Lineage plasticity, the ability to transdifferentiate among distinct phenotypic identities, facilitates therapeutic resistance in cancer. In lung…”
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CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation by Quintanal-Villalonga, Alvaro, Kawasaki, Kenta, Redin, Esther, Uddin, Fathema, Rakhade, Swanand, Durani, Vidushi, Sabet, Amin, Shafer, Moniquetta, Karthaus, Wouter R., Zaidi, Samir, Zhan, Yingqian A., Manoj, Parvathy, Sridhar, Harsha, Kinyua, Dennis, Zhong, Hong, Mello, Barbara P., Ciampricotti, Metamia, Bhanot, Umesh K., Linkov, Irina, Qiu, Juan, Patel, Radhika A., Morrissey, Colm, Mehta, Sanjoy, Barnes, Jesse, Haffner, Michael C., Socci, Nicholas D., Koche, Richard P., de Stanchina, Elisa, Molina-Pinelo, Sonia, Salehi, Sohrab, Yu, Helena A., Chan, Joseph M., Rudin, Charles M.

“…Neuroendocrine (NE) transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor prognosis. Up to date,…”
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An optimized NGS sample preparation protocol for in vitro CRISPR screens by Wohlhieter, Corrin A., Uddin, Fathema, Quintanal-Villalonga, Àlvaro, Poirier, John T., Sen, Triparna, Rudin, Charles M.

“…This standardized protocol describes the preparation of PCR amplified and purified samples from human cell lines passaged and collected from CRISPR screening…”
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524 Tim-4+ resident macrophages impair anti-tumor immunity in the serous body cavities By sequestering viable and cytotoxic CD8+ T cells expressing high levels of phosphatidylserine by Chow, Andrew, Schad, Sara, Green, Michael, Hellmann, Matthew, Ceglia, Nicholas, Allaj, Viola, Zago, Giulia, Shah, Nisarg, Sharma, Sai, Mattar, Marissa, Chan, Joseph, Rizvi, Hira, Zhong, Hong, Liu, Cailian, Bykov, Yonina, Zamarin, Dmitriy, Shi, Hongyu, Budhu, Sadna, Wohlhieter, Corrin, Uddin, Fathema, Gupta, Aditi, Khodos, Inna, Waninger, Jessica, Qin, Angel, Balachandran, Vinod, Zou, Weiping, Shah, Sohrab, McPherson, Andrew, Panageas, Katherine, Lewis, Jason, Perry, Justin, Stanchina, Elisa de, Sen, Triparna, Poirier, John, Wolchok, Jedd, Rudin, Charles, Merghoub, Taha

“…BackgroundMalignant pleural effusions and peritoneal carcinomatosis are associated with poor outcomes in patients with cancer.1–3 Macrophages in these serous…”
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Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity by Chow, Andrew, Schad, Sara, Green, Michael D., Hellmann, Matthew D., Allaj, Viola, Ceglia, Nicholas, Zago, Giulia, Shah, Nisargbhai S., Sharma, Sai Kiran, Mattar, Marissa, Chan, Joseph, Rizvi, Hira, Zhong, Hong, Liu, Cailian, Bykov, Yonina, Zamarin, Dmitriy, Shi, Hongyu, Budhu, Sadna, Wohlhieter, Corrin, Uddin, Fathema, Gupta, Aditi, Khodos, Inna, Waninger, Jessica J., Qin, Angel, Markowitz, Geoffrey J., Mittal, Vivek, Balachandran, Vinod, Durham, Jennifer N., Le, Dung T., Zou, Weiping, Shah, Sohrab P., McPherson, Andrew, Panageas, Katherine, Lewis, Jason S., Perry, Justin S.A., de Stanchina, Elisa, Sen, Triparna, Poirier, John T., Wolchok, Jedd D., Rudin, Charles M., Merghoub, Taha

“…Immune checkpoint blockade (ICB) has been a remarkable clinical advance for cancer; however, the majority of patients do not respond to ICB therapy. We show…”
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Targeting Lysine-Specific Demethylase 1 Rescues Major Histocompatibility Complex Class I Antigen Presentation and Overcomes Programmed Death-Ligand 1 Blockade Resistance in SCLC by Nguyen, Evelyn M, Taniguchi, Hirokazu, Chan, Joseph M, Zhan, Yingqian A, Chen, Xiaoping, Qiu, Juan, de Stanchina, Elisa, Allaj, Viola, Shah, Nisargbhai S, Uddin, Fathema, Manoj, Parvathy, Liu, Michael, Cai, Sheng F, Levine, Ross, Quintanal-Villalonga, Álvaro, Sen, Triparna, Chow, Andrew, Rudin, Charles M

“…SCLC is a highly aggressive neuroendocrine tumor that is characterized by early acquired therapeutic resistance and modest benefit from immune checkpoint…”
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A heterometallic ruthenium–gold complex displays antiproliferative, antimigratory, and antiangiogenic properties and inhibits metastasis and angiogenesis-associated proteases in renal cancer by Elie, Benelita T., Pechenyy, Yuriy, Uddin, Fathema, Contel, María

“…Heterobimetallic compounds are designed to harness chemotherapeutic traits of distinct metal species into a single molecule. The ruthenium–gold (Ru–Au) family…”
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Inhibition of XPO1 Sensitizes Small Cell Lung Cancer to First- and Second-Line Chemotherapy by Quintanal-Villalonga, Alvaro, Taniguchi, Hirokazu, Hao, Yuan, Chow, Andrew, Zhan, Yingqian A, Chavan, Shweta S, Uddin, Fathema, Allaj, Viola, Manoj, Parvathy, Shah, Nisargbhai S, Chan, Joseph M, Offin, Michael, Ciampricotti, Metamia, Ray-Kirton, Jordana, Egger, Jacklynn, Bhanot, Umesh, Linkov, Irina, Asher, Marina, Roehrl, Michael H, Qiu, Juan, de Stanchina, Elisa, Hollmann, Travis J, Koche, Richard P, Sen, Triparna, Poirier, John T, Rudin, Charles M

“…Small cell lung cancer (SCLC) is an aggressive malignancy characterized by early metastasis and extreme lethality. The backbone of SCLC treatment over the past…”
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Abstract 1800A: STK11 and KEAP1 co-mutation cooperatively promotes rapid tumor growth in lung adenocarcinoma by Wohlhieter, Corrin A., Richards, Allison L., Poirier, John T., Uddin, Fathema, Hulton, Christopher, De Stanchina, Elisa, Papagiannakopoulos, Thales, Sen, Triparna, Rudin, Charles M.

“…Abstract Background: Genomic profiling and targeted therapies have significantly improved outcomes for oncogene-addicted subgroups of lung adenocarcinoma…”
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Abstract 2004: CDC7 inhibition prevents neuroendocrine transformation in the lung and prostate through MYC degradation by Quintanal-Villalonga, Alvaro, Uddin, Fathema, Kawasaki, Kenta, Redin, Esther, Durani, Vidushi, Sabet, Amin, Karthaus, Wouter, Zhan, Yingqian A., Zaidi, Samir, Shaffer, Moniquetta, Sridhar, Harsha, Qiu, Juan, Manoj, Parvathy, De Stanchina, Elisa, Haffner, Michael C., Sawyers, Charles L., Rudin, Charles M.

“…Abstract Neuroendocrine (NE) transformation occurs as a mechanism of resistance to targeted therapy in up to 14% and 30% of EGFR-mutant lung and AR-dependent…”
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Abstract 3594: Exportin 1 inhibition as a therapeutic strategy for small cell lung cancer by Quintanal-Villalonga, Alvaro, Taniguchi, Hirokazu, Hao, Yuan, Chow, Andrew, Zhan, Yingqian A., Uddin, Fathema, Allaj, Viola, Manoj, Parvathy, Shah, Nisargbhai S., Bhanot, Umesh K., Qiu, Juan, de Stanchina, Elisa, Koche, Richard P., Sen, Triparna, Poirier, John T., Rudin, Charles M.

“…Abstract Small cell lung cancer (SCLC) is an aggressive disease characterized by early metastasis and exceptional lethality, comprising 13% of all lung cancer…”
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Abstract 658: AKT pathway as a therapeutic target to constrain lineage plasticity leading to histological transdifferentiation by Quintanal-Villalonga, Alvaro, Taniguchi, Hirokazu, Zhan, Yingqian A., Uddin, Fathema, Allaj, Viola, Manoj, Parvathy, Shah, Nisargbhai S., Bhanot, Umesh K., Egger, Jacklynn, Qiu, Juan, de Stanchina, Elisa, Rekhtman, Natasha, Houck-Loomis, Brian, Koche, Richard P., Yu, Helena A., Sen, Triparna, Rudin, Charles M.

“…Abstract Lineage plasticity contributes to therapeutic resistance in cancer. In lung adenocarcinomas (LUADs), this phenomenon drives neuroendocrine (NE) and…”
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