Search Results - "Udayan, Sreeram"
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Macrophage cytokine responses to commensal Gram-positive Lactobacillus salivarius strains are TLR2-independent and Myd88-dependent
Published in Scientific reports (15-03-2021)“…The mechanisms through which cells of the host innate immune system distinguish commensal bacteria from pathogens are currently unclear. Toll-like receptors…”
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2
A Fyn biosensor reveals pulsatile, spatially localized kinase activity and signaling crosstalk in live mammalian cells
Published in eLife (04-02-2020)“…Cell behavior is controlled through spatio-temporally localized protein activity. Despite unique and often contradictory roles played by Src-family-kinases…”
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Bifidobacterium breve Exopolysaccharide Blocks Dendritic Cell Maturation and Activation of CD4+ T Cells
Published in Frontiers in microbiology (16-06-2021)“…Exopolysaccharide (EPS) is a bacterial extracellular carbohydrate moiety which has been associated with immunomodulatory activity and host protective effects…”
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Vancomycin-induced gut microbial dysbiosis alters enteric neuron-macrophage interactions during a critical period of postnatal development
Published in Frontiers in immunology (12-10-2023)“…Vancomycin is a broad-spectrum antibiotic widely used in cases of suspected sepsis in premature neonates. While appropriate and potentially lifesaving in this…”
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Identification of Gut Bacteria such as Lactobacillus johnsonii that Disseminate to Systemic Tissues of Wild Type and MyD88-/- Mice
Published in Gut microbes (01-01-2022)“…In healthy hosts the gut microbiota is restricted to gut tissues by several barriers some of which require MyD88-dependent innate immune sensor pathways…”
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MHCII Expression by Intestinal Goblet Cells in Immune Homeostasis
Published in The Journal of immunology (1950) (01-05-2023)“…Abstract As the primary barrier in the gut, intestinal epithelial cells (IECs) are positioned to promote tolerance and immunity against pathogens. MHCII is…”
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Goblet cells regulate expansion of colonic iNKT cells in CD1d-dependent manner
Published in The Journal of immunology (1950) (01-05-2022)“…Abstract Invariant natural killer T (iNKT) cells are innate-like T cells that secrete a wide array of cytokines and immune mediators. These cells recognize…”
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Protective colonic iNKT cells are expanded by Goblet cell-associated antigen passages in CD1d-dependent manner in adults
Published in The Journal of immunology (1950) (01-05-2023)“…Abstract Invariant natural killer T (iNKT) cells are unique innate immune cell which secrete cytokines and immune mediators. These cells recognize self or…”
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9
Neonatal Antibiotic Exposure Alters Intestinal Macrophage Frequency and Polarization
Published in The Journal of immunology (1950) (01-05-2022)“…Abstract More than 75% of premature infants are given antibiotics in the first week of life. This is lifesaving for neonates with serious bacterial infections…”
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10
Intergenerational protective anti-gut commensal immunoglobulin G originates in early life
Published in Proceedings of the National Academy of Sciences - PNAS (26-03-2024)“…Maternal immunoglobulins of the class G (IgGs) protect offspring from enteric infection, but when, where, and how these antibodies are physiologically…”
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11
Identification of Gut Bacteria such as Lactobacillus johnsonii that Disseminate to Systemic Tissues of Wild Type and MyD88-/- Mice
Published in Gut Microbes (31-12-2022)“…In healthy hosts the gut microbiota is restricted to gut tissues by several barriers some of which require MyD88-dependent innate immune sensor pathways…”
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