Search Results - "Uchiyama, Susumu"

Effects of syringe material and silicone oil lubrication on the stability of pharmaceutical proteins by Krayukhina, Elena, Tsumoto, Kouhei, Uchiyama, Susumu, Fukui, Kiichi

“…Currently, polymer-based prefillable syringes are being promoted to the pharmaceutical market because they provide an increased break resistance relative to…”
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Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9 by Ohto, Umeharu, Shibata, Takuma, Tanji, Hiromi, Ishida, Hanako, Krayukhina, Elena, Uchiyama, Susumu, Miyake, Kensuke, Shimizu, Toshiyuki

“…Crystal structures of three forms of Toll-like receptor (TLR) 9 — unliganded or bound either to immune stimulatory CpG-containing DNA or inhibitory DNA —…”
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Assessment of the Injection Performance of a Tapered Needle for Use in Prefilled Biopharmaceutical Products by Krayukhina, Elena, Fukuhara, Ayano, Uchiyama, Susumu

“…The design of injection devices, including prefilled syringes (PFSs) and autoinjectors, requires an understanding of the optimization of injection conditions…”
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Synergistic Effect of Cavitation and Agitation on Protein Aggregation by Torisu, Tetsuo, Maruno, Takahiro, Hamaji, Yoshinori, Ohkubo, Tadayasu, Uchiyama, Susumu

“…It was recently reported that dropping induces protein aggregation due to the occurrence of cavitation. Agitation also causes protein aggregation. In this…”
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Structure of IZUMO1–JUNO reveals sperm–oocyte recognition during mammalian fertilization by Ohto, Umeharu, Ishida, Hanako, Krayukhina, Elena, Uchiyama, Susumu, Inoue, Naokazu, Shimizu, Toshiyuki

“…The structure of the IZUMO1–JUNO complex, crucial for sperm–oocyte interaction during fertilization, is reported, providing a first step towards understanding…”
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Automatic Identification of the Stress Sources of Protein Aggregates Using Flow Imaging Microscopy Images by Gambe-Gilbuena, Arni, Shibano, Yuriko, Krayukhina, Elena, Torisu, Tetsuo, Uchiyama, Susumu

“…A novel approach to identify 5 types of simulated stresses that induce protein aggregation in prefilled syringe-type biopharmaceuticals was developed…”
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Stirring rate affects thermodynamics and unfolding kinetics in isothermal titration calorimetry by Maruno, Takahiro, Ohkubo, Tadayasu, Uchiyama, Susumu

“…Abstract Isothermal titration calorimetry (ITC) directly provides thermodynamic parameters depicting the energetics of intermolecular interactions in solution…”
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Estimation of the Viscosity of an Antibody Solution from the Diffusion Interaction Parameter by Shimomura, Takuya, Sekiguchi, Mitsuhiro, Honda, Reisa, Yamazaki, Miki, Yokoyama, Masami, Uchiyama, Susumu

“…Understanding a monoclonal antibody’s (MAb) physicochemical properties early in drug discovery is important for determining developability. Viscosity is…”
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Ionic liquids and protein folding—old tricks for new solvents by Wakayama, Ryota, Uchiyama, Susumu, Hall, Damien

“…One important aspect of the green chemistry revolution has been the use of ionic liquids as the solvent in liquid-phase enzymatic catalysis. An essential…”
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Effect of UVC Irradiation on the Oxidation of Histidine in Monoclonal Antibodies by Miyahara, Yuya, Shintani, Koya, Hayashihara-Kakuhou, Kayoko, Zukawa, Takehiro, Morita, Yukihiro, Nakazawa, Takashi, Yoshida, Takuya, Ohkubo, Tadayasu, Uchiyama, Susumu

“…We oxidized histidine residues in monoclonal antibody drugs of immunoglobulin gamma 1 (IgG1) using ultraviolet C irradiation (UVC: 200–280 nm), which is known…”
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Behavior of Monoclonal Antibodies: Relation Between the Second Virial Coefficient (B2) at Low Concentrations and Aggregation Propensity and Viscosity at High Concentrations by Saito, Shuntaro, Hasegawa, Jun, Kobayashi, Naoki, Kishi, Naoyuki, Uchiyama, Susumu, Fukui, Kiichi

“…ABSTRACT Purpose To investigate relationship between second virial coefficient B 2 and viscosity and aggregation propensity of highly concentrated monoclonal…”
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Critical analysis of techniques and materials used in devices, syringes, and needles used for intravitreal injections by Melo, Gustavo Barreto, Cruz, Natasha Ferreira Santos da, Emerson, Geoffrey Guy, Rezende, Flávio Atanázio, Meyer, Carsten H., Uchiyama, Susumu, Carpenter, John, Shiroma, Hélio Francisco, Farah, Michel Eid, Maia, Maurício, Rodrigues, Eduardo Büchele

“…Intravitreal injections have become the most commonly performed intraocular treatments worldwide. Because intravitreal injections may induce severe adverse…”
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Native mass spectrometry for understanding dynamic protein complex by Ishii, Kentaro, Zhou, Min, Uchiyama, Susumu

“…Biomolecules have evolved to perform specific and sophisticated activities in a highly coordinated manner organizing into multi-component complexes consisting…”
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Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance by Kabe, Yasuaki, Nakane, Takanori, Koike, Ikko, Yamamoto, Tatsuya, Sugiura, Yuki, Harada, Erisa, Sugase, Kenji, Shimamura, Tatsuro, Ohmura, Mitsuyo, Muraoka, Kazumi, Yamamoto, Ayumi, Uchida, Takeshi, Iwata, So, Yamaguchi, Yuki, Krayukhina, Elena, Noda, Masanori, Handa, Hiroshi, Ishimori, Koichiro, Uchiyama, Susumu, Kobayashi, Takuya, Suematsu, Makoto

“…Progesterone-receptor membrane component 1 (PGRMC1/Sigma-2 receptor) is a haem-containing protein that interacts with epidermal growth factor receptor (EGFR)…”
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Protein encapsulation within synthetic molecular hosts by Fujita, Daishi, Suzuki, Kosuke, Sato, Sota, Yagi-Utsumi, Maho, Yamaguchi, Yoshiki, Mizuno, Nobuhiro, Kumasaka, Takashi, Takata, Masaki, Noda, Masanori, Uchiyama, Susumu, Kato, Koichi, Fujita, Makoto

“…Protein encapsulation has long attracted many chemists and biologists because of its potential to control the structure and functions of proteins, but has been…”
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Interdependency and phosphorylation of KIF4 and condensin I are essential for organization of chromosome scaffold by Poonperm, Rawin, Takata, Hideaki, Uchiyama, Susumu, Fukui, Kiichi

“…Kinesin family member 4 (KIF4) and condensins I and II are essential chromosomal proteins for chromosome organization by locating primarily to the chromosome…”
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Molecular mechanism underlying the increased risk of colorectal cancer metastasis caused by single nucleotide polymorphisms in LI-cadherin gene by Yui, Anna, Kuroda, Daisuke, Maruno, Takahiro, Nakakido, Makoto, Nagatoishi, Satoru, Uchiyama, Susumu, Tsumoto, Kouhei

“…LI-cadherin is a member of the cadherin superfamily. LI-cadherin mediates Ca 2+ -dependent cell–cell adhesion through homodimerization. A previous study…”
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Structural Dynamics of the PET-Degrading Cutinase-like Enzyme from Saccharomonospora viridis AHK190 in Substrate-Bound States Elucidates the Ca2+-Driven Catalytic Cycle by Numoto, Nobutaka, Kamiya, Narutoshi, Bekker, Gert-Jan, Yamagami, Yuri, Inaba, Satomi, Ishii, Kentaro, Uchiyama, Susumu, Kawai, Fusako, Ito, Nobutoshi, Oda, Masayuki

“…A cutinase-type polyesterase from Saccharomonospora viridis AHK190 (Cut190) has been shown to degrade the inner block of polyethylene terephthalate. A unique…”
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Friability Testing as a New Stress-Stability Assay for Biopharmaceuticals by Torisu, Tetsuo, Maruno, Takahiro, Yoneda, Saki, Hamaji, Yoshinori, Honda, Shinya, Ohkubo, Tadayasu, Uchiyama, Susumu

“…A cycle of dropping and shaking a vial containing antibody solution was reported to induce aggregation. In this study, antibody solutions in glass prefillable…”
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Temperature-controlled repeatable scrambling and induced-sorting of building blocks between cubic assemblies by Zhan, Yi-Yang, Kojima, Tatsuo, Ishii, Kentaro, Takahashi, Satoshi, Haketa, Yohei, Maeda, Hiromitsu, Uchiyama, Susumu, Hiraoka, Shuichi

“…Separation of a homogeneous mixture of different components to reach an ordered out-of-equilibrium state in solution has attracted continuous attention. While…”
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