Search Results - "Uchiyama, Keiji"

Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells by Hara, Hideyuki, Chida, Junji, Uchiyama, Keiji, Pasiana, Agriani Dini, Takahashi, Etsuhisa, Kido, Hiroshi, Sakaguchi, Suehiro

“…Misfolding of the cellular prion protein, PrP C , into the amyloidogenic isoform, PrP Sc , which forms infectious protein aggregates, the so-called prions, is…”
Get full text

Analysis of intracellular IgG secretion in Chinese hamster ovary cells to improve IgG production by Kaneyoshi, Kohei, Uchiyama, Keiji, Onitsuka, Masayoshi, Yamano, Noriko, Koga, Yuichi, Omasa, Takeshi

“…The production of biopharmaceutical immunoglobulin G (IgG) using cultured mammalian cells, especially Chinese hamster ovary (CHO) cells is well established and…”
Get full text

The N-Terminal Polybasic Region of Prion Protein Is Crucial in Prion Pathogenesis Independently of the Octapeptide Repeat Region by Das, Nandita Rani, Miyata, Hironori, Hara, Hideyuki, Chida, Junji, Uchiyama, Keiji, Masujin, Kentaro, Watanabe, Hitomi, Kondoh, Gen, Sakaguchi, Suehiro

“…Conformational conversion of the cellular isoform of prion protein, designated PrP C , into the abnormally folded, amyloidogenic isoform, PrP Sc , is an…”
Get full text

Ethanolamine Is a New Anti-Prion Compound by Uchiyama, Keiji, Hara, Hideyuki, Chida, Junji, Pasiana, Agriani Dini, Imamura, Morikazu, Mori, Tsuyoshi, Takatsuki, Hanae, Atarashi, Ryuichiro, Sakaguchi, Suehiro

“…Prion diseases are a group of fatal neurodegenerative disorders caused by accumulation of proteinaceous infectious particles, or prions, which mainly consist…”
Get full text

Prions disturb post-Golgi trafficking of membrane proteins by Uchiyama, Keiji, Muramatsu, Naomi, Yano, Masashi, Usui, Takeshi, Miyata, Hironori, Sakaguchi, Suehiro

“…Conformational conversion of normal cellular prion protein PrP C into pathogenic PrP Sc is central to the pathogenesis of prion diseases. However, the…”
Get full text

Prion protein protects mice from lethal infection with influenza A viruses by Chida, Junji, Hara, Hideyuki, Yano, Masashi, Uchiyama, Keiji, Das, Nandita Rani, Takahashi, Etsuhisa, Miyata, Hironori, Tomioka, Yukiko, Ito, Toshihiro, Kido, Hiroshi, Sakaguchi, Suehiro

“…The cellular prion protein, designated PrPC, is a membrane glycoprotein expressed abundantly in brains and to a lesser extent in other tissues. Conformational…”
Get full text

Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice by Chida, Junji, Hara, Hideyuki, Uchiyama, Keiji, Takahashi, Etsuhisa, Miyata, Hironori, Kosako, Hidetaka, Tomioka, Yukiko, Ito, Toshihiro, Horiuchi, Hiroyuki, Matsuda, Haruo, Kido, Hiroshi, Sakaguchi, Suehiro

“…The cellular prion protein, PrP.sup.C, is a glycosylphosphatidylinositol anchored-membrane glycoprotein expressed most abundantly in neuronal and to a lesser…”
Get full text

Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein by Linsenmeier, Luise, Mohammadi, Behnam, Wetzel, Sebastian, Puig, Berta, Jackson, Walker S, Hartmann, Alexander, Uchiyama, Keiji, Sakaguchi, Suehiro, Endres, Kristina, Tatzelt, Jörg, Saftig, Paul, Glatzel, Markus, Altmeppen, Hermann C

“…Keywords: ADAM10, Antibody, Exosomes, Glycosylation, Membrane anchor, Neurodegeneration, Prion protein, Proteolytic cleavage, Shedding…”
Get full text

Secretion analysis of intracellular “difficult-to-express” immunoglobulin G (IgG) in Chinese hamster ovary (CHO) cells by Kaneyoshi, Kohei, Kuroda, Kouki, Uchiyama, Keiji, Onitsuka, Masayoshi, Yamano-Adachi, Noriko, Koga, Yuichi, Omasa, Takeshi

“…The Chinese hamster ovary (CHO) cell line is the most widely used host cell for therapeutic antibody production. Although its productivity has been improved by…”
Get full text

Prions amplify through degradation of the VPS10P sorting receptor sortilin by Uchiyama, Keiji, Tomita, Mitsuru, Yano, Masashi, Chida, Junji, Hara, Hideyuki, Das, Nandita Rani, Nykjaer, Anders, Sakaguchi, Suehiro

“…Prion diseases are a group of fatal neurodegenerative disorders caused by prions, which consist mainly of the abnormally folded isoform of prion protein,…”
Get full text

Vaporized Hydrogen Peroxide and Ozone Gas Synergistically Reduce Prion Infectivity on Stainless Steel Wire by Hara, Hideyuki, Chida, Junji, Pasiana, Agriani Dini, Uchiyama, Keiji, Kikuchi, Yutaka, Naito, Tomoko, Takahashi, Yuichi, Yamamura, Junji, Kuromatsu, Hisashi, Sakaguchi, Suehiro

“…Prions are infectious agents causing prion diseases, which include Creutzfeldt-Jakob disease (CJD) in humans. Several cases have been reported to be…”
Get full text

Strain-Dependent Prion Infection in Mice Expressing Prion Protein with Deletion of Central Residues 91-106 by Uchiyama, Keiji, Miyata, Hironori, Yamaguchi, Yoshitaka, Imamura, Morikazu, Okazaki, Mariya, Pasiana, Agriani Dini, Chida, Junji, Hara, Hideyuki, Atarashi, Ryuichiro, Watanabe, Hitomi, Kondoh, Gen, Sakaguchi, Suehiro

“…Conformational conversion of the cellular prion protein, PrP , into the abnormally folded isoform, PrP , is a key pathogenic event in prion diseases. However,…”
Get full text

Analysis of the immunoglobulin G (IgG) secretion efficiency in recombinant Chinese hamster ovary (CHO) cells by using Citrine-fusion IgG by Kaneyoshi, Kohei, Yamano-Adachi, Noriko, Koga, Yuichi, Uchiyama, Keiji, Omasa, Takeshi

“…Biopharmaceuticals represented by immunoglobulin G (IgG) are produced by the cultivation of recombinant animal cells, especially Chinese hamster ovary (CHO)…”
Get full text

Effects of prion protein devoid of the N-terminal residues 25-50 on prion pathogenesis in mice by Das, Nandita Rani, Miyata, Hironori, Hara, Hideyuki, Uchiyama, Keiji, Chida, Junji, Yano, Masashi, Watanabe, Hitomi, Kondoh, Gen, Sakaguchi, Suehiro

“…The N-terminal polybasic region of the normal prion protein, PrP C , which encompasses residues 23-31, is important for prion pathogenesis by affecting…”
Get full text

p37 Is a p97 Adaptor Required for Golgi and ER Biogenesis in Interphase and at the End of Mitosis by Uchiyama, Keiji, Totsukawa, Go, Puhka, Maija, Kaneko, Yayoi, Jokitalo, Eija, Dreveny, Ingrid, Beuron, Fabienne, Zhang, Xiaodong, Freemont, Paul, Kondo, Hisao

“…We previously reported that p97/p47-assisted membrane fusion is important for the reassembly of organelles at the end of mitosis, but not for their maintenance…”
Get full text

Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47 by Dreveny, Ingrid, Kondo, Hisao, Uchiyama, Keiji, Shaw, Anthony, Zhang, Xiaodong, Freemont, Paul S

“…The AAA ATPase p97/VCP is involved in many cellular events including ubiquitin‐dependent processes and membrane fusion. In the latter, the p97 adaptor protein…”
Get full text

p97/p47-Mediated Biogenesis of Golgi and ER by Uchiyama, Keiji, Kondo, Hisao

“…In mammalian cells, the Golgi apparatus and endoplasmic reticulum have typical structures during interphase: stacked cisternae located adjacent to the nucleus…”
Get full text

Mouse-hamster chimeric prion protein (PrP) devoid of N-terminal residues 23-88 restores susceptibility to 22L prions, but not to RML prions in PrP-knockout mice by Uchiyama, Keiji, Miyata, Hironori, Yano, Masashi, Yamaguchi, Yoshitaka, Imamura, Morikazu, Muramatsu, Naomi, Das, Nandita Rani, Chida, Junji, Hara, Hideyuki, Sakaguchi, Suehiro

“…Prion infection induces conformational conversion of the normal prion protein PrPC, into the pathogenic isoform PrPSc, in prion diseases. It has been shown…”
Get full text

VCIP135, a Novel Essential Factor for p97/p47-Mediated Membrane Fusion, Is Required for Golgi and ER Assembly in vivo by Uchiyama, Keiji, Jokitalo, Eija, Kano, Fumi, Murata, Masayuki, Zhang, Xiaodong, Canas, Benito, Newman, Richard, Rabouille, Catherine, Pappin, Darryl, Freemont, Paul, Kondo, Hisao

“…NSF and p97 are ATPases required for the heterotypic fusion of transport vesicles with their target membranes and the homotypic fusion of organelles. NSF uses…”
Get full text

Biological and biochemical characterization of mice expressing prion protein devoid of the octapeptide repeat region after infection with prions by Yamaguchi, Yoshitaka, Miyata, Hironori, Uchiyama, Keiji, Ootsuyama, Akira, Inubushi, Sachiko, Mori, Tsuyoshi, Muramatsu, Naomi, Katamine, Shigeru, Sakaguchi, Suehiro

“…Accumulating lines of evidence indicate that the N-terminal domain of prion protein (PrP) is involved in prion susceptibility in mice. In this study, to…”
Get full text