Search Results - "Uchimura, Tomoya"

An essential role for IGF2 in cartilage development and glucose metabolism during postnatal long bone growth by Uchimura, Tomoya, Hollander, Judith M, Nakamura, Daisy S, Liu, Zhiyi, Rosen, Clifford J, Georgakoudi, Irene, Zeng, Li

“…Postnatal bone growth involves a dramatic increase in length and girth. Intriguingly, this period of growth is independent of growth hormone and the underlying…”
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A human iPS cell myogenic differentiation system permitting high-throughput drug screening by Uchimura, Tomoya, Otomo, Jun, Sato, Masae, Sakurai, Hidetoshi

“…Muscular dystrophy is a disease characterized by progressive muscle weakness and degeneration. There are currently no available treatments for most muscular…”
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Heat shock factor 1 protects germ cell proliferation during early ovarian differentiation in medaka by Furukawa, Fumiya, Hamasaki, Shin, Hara, Seiji, Uchimura, Tomoya, Shiraishi, Eri, Osafune, Natsumi, Takagi, Hisanori, Yazawa, Takashi, Kamei, Yasuhiro, Kitano, Takeshi

“…The heat shock response is important for the viability of all living organisms. It involves the induction of heat shock proteins whose expression is mainly…”
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Orai1–STIM1 Regulates Increased Ca2+ Mobilization, Leading to Contractile Duchenne Muscular Dystrophy Phenotypes in Patient-Derived Induced Pluripotent Stem Cells by Uchimura, Tomoya, Sakurai, Hidetoshi

“…Ca2+ overload is one of the factors leading to Duchenne muscular dystrophy (DMD) pathogenesis. However, the molecular targets of dystrophin…”
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Involvement of Heat Shock Proteins on the Transcriptional Regulation of Corticotropin-Releasing Hormone in Medaka by Uchimura, Tomoya, Hara, Seiji, Yazawa, Takashi, Kamei, Yasuhiro, Kitano, Takeshi

“…Medaka ( ) are teleost fish with a XX/XY sex determination system. Recently, it was reported that high temperature (HT) induced the masculinization of XX…”
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Erythromycin acts through the ghrelin receptor to attenuate inflammatory responses in chondrocytes and maintain joint integrity by Uchimura, Tomoya, Nakamura, Daisy S., Link, Eric M., Noguchi, Yoshihiko, Ōmura, Satoshi, Sunazuka, Toshiaki, Greenblatt, David J., Zeng, Li

“…[Display omitted] Osteoarthritis (OA) is a prevalent disease characterized by chronic joint degeneration and low-grade localized inflammation. There is no…”
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A muscle fatigue-like contractile decline was recapitulated using skeletal myotubes from Duchenne muscular dystrophy patient-derived iPSCs by Uchimura, Tomoya, Asano, Toshifumi, Nakata, Takao, Hotta, Akitsu, Sakurai, Hidetoshi

“…Duchenne muscular dystrophy (DMD) is a muscle degenerating disease caused by dystrophin deficiency, for which therapeutic options are limited. To facilitate…”
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The Chondroprotective Role of Erythromycin in a Murine Joint Destruction Model by Uchimura, Tomoya, Foote, Andrea T., Markel, David C., Ren, Weiping, Zeng, Li

“…Objective Inflammation is a major player in the joint destruction process. Macrolide antibiotics have recently been found to have a novel anti-inflammatory…”
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Cyclic true stress true strain relation in the large strain region of common steel for welded structures by Matsuda, Kazuki, Shimoka, Tsukasa, Murakami, Koji, Uchimura, Tomoya, Gotoh, Koji

“…Cyclic true stress - true strain curves were obtained using general-purpose shipbuilding steel in the large strain region. Test methods are incremental step…”
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Insulin-Like Growth Factor II (IGF-II) Inhibits IL-1β-Induced Cartilage Matrix Loss and Promotes Cartilage Integrity in Experimental Osteoarthritis by Uchimura, Tomoya, Foote, Andrea T., Smith, Eric L., Matzkin, Elizabeth G., Zeng, Li

“…ABSTRACT Osteoarthritis (OA) is a widespread chronic joint disease characterized by articular cartilage destruction and accompanied by pain and disability. In…”
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Insulin-Like Growth Factor II (IGF-II) Inhibits IL-1[beta]-Induced Cartilage Matrix Loss and Promotes Cartilage Integrity in Experimental Osteoarthritis by Uchimura, Tomoya, Foote, Andrea T, Smith, Eric L, Matzkin, Elizabeth G, Zeng, Li

“…Osteoarthritis (OA) is a widespread chronic joint disease characterized by articular cartilage destruction and accompanied by pain and disability. In this…”
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Wnt7a Inhibits IL-1β Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis by Gibson, Averi L., Hui Mingalone, Carrie K., Foote, Andrea T., Uchimura, Tomoya, Zhang, Ming, Zeng, Li

“…Wnt7a is a protein that plays a critical role in skeletal development. However, its effect on cartilage homeostasis under pathological conditions is not known…”
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Pigment Epithelium-Derived Factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions by Nakamura, Daisy S, Hollander, Judith M, Uchimura, Tomoya, Nielsen, Heber C, Zeng, Li

“…Inflammation is a major cause of cartilage destruction and leads to the imbalance of metabolic activities in the arthritic joint. Pigment epithelium-derived…”
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Somitic disruption of GNAS in chick embryos mimics progressive osseous heteroplasia by Cairns, Dana M, Pignolo, Robert J, Uchimura, Tomoya, Brennan, Tracy A, Lindborg, Carter M, Xu, Meiqi, Kaplan, Frederick S, Shore, Eileen M, Zeng, Li

“…Progressive osseous heteroplasia (POH) is a rare developmental disorder of heterotopic ossification (HO) caused by heterozygous inactivating germline mutations…”
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A Role for IGF-II in Cartilage Development and Disease by Uchimura, Tomoya

“…Proper cartilage development is critical for normal postnatal long bone growth, however, precise mechanisms how early postnatal long bone growth is regulated…”
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The role of muscle cells in regulating cartilage matrix production by Cairns, Dana M., Lee, Philip G., Uchimura, Tomoya, Seufert, Christopher R., Kwon, Heenam, Zeng, Li

“…Muscle is one of the tissues located in close proximity to cartilage tissue. Although it has been suggested that muscle could influence skeletal development…”
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Somitic disruption of GNAS in chick embryos mimics progressive osseous heteroplasia by Cairns, Dana M., Pignolo, Robert J., Uchimura, Tomoya, Brennan, Tracy A., Lindborg, Carter M., Xu, Meiqi, Kaplan, Frederick S., Shore, Eileen M., Zeng, Li

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Muscle cells enhance resistance to pro-inflammatory cytokine-induced cartilage destruction by Cairns, Dana M., Uchimura, Tomoya, Kwon, Heenam, Lee, Philip G., Seufert, Christopher R., Matzkin, Elizabeth, Zeng, Li

“…Pro-inflammatory cytokines IL-1β and TNFα play important roles in the manifestation of arthritis by disrupting the anabolic and catabolic activities of the…”
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Wnt7a Inhibits IL-1[beta] Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis by Gibson, Averi L, Hui Mingalone, Carrie K, Foote, Andrea T, Uchimura, Tomoya, Zhang, Ming, Zeng, Li

“…Wnt7a is a protein that plays a critical role in skeletal development. However, its effect on cartilage homeostasis under pathological conditions is not known…”
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The role of muscle cells in regulating cartilage matrix production: MUSCLE CELL-MEDIATED CARTILAGE REGULATION by Cairns, Dana M., Lee, Philip G., Uchimura, Tomoya, Seufert, Christopher R., Kwon, Heenam, Zeng, Li

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