Radiological features of thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: case series and systematic review

Radiological features of thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: case series and systematic review

Purpose To comprehensively summarize the clinical data and CT/MRI characteristics of thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA). Methods Twenty-seven lesions from 25 study articles identified through a systematic review and three lesions from our institution associate...

Full description

Saved in:
Bibliographic Details
Published in:Neuroradiology Vol. 66; no. 2; pp. 249 - 259
Main Authors: Baba, Akira, Matsushima, Satoshi, Kessoku, Hisashi, Omura, Kazuhiro, Kurokawa, Ryo, Fukasawa, Nei, Takeshita, Yuhei, Yamauchi, Hideomi, Ogino, Nobuhiro, Kayama, Reina, Uchihara, Kimiyuki, Yoshimatsu, Lynn, Ojiri, Hiroya
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-02-2024
Springer Nature B.V
Subjects:
Adenocarcinoma
Cancer
Computed tomography
Diagnosis
Head-Neck-ENT Radiology
Imaging
Lesions
Medical imaging
Medicine
Medicine & Public Health
Metastases
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Radiology
Sclerosis
Skull
Systematic review
Thyroid
Thyroid gland
Systematic review
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma
Computed tomography
Magnetic resonance imaging
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose To comprehensively summarize the clinical data and CT/MRI characteristics of thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA). Methods Twenty-seven lesions from 25 study articles identified through a systematic review and three lesions from our institution associated with TL-LGNPPA were evaluated. Results The mean age of the patients at diagnosis was 35.7 years, and the male-to-female ratio was nearly half. The chief complaint was nasal obstruction, followed by epistaxis. All patients underwent excision. None of the patients had neck nodes or distant metastases. All patients survived with no locoregional/distant recurrence during 3–93 months of follow-up. All lesions were located at the posterior edge of the nasal septum, attached to the nasopharyngeal parietal wall, and showed no laterality. The mean lesion diameter was 1.7 cm. The margins of lesions were well-defined and lobulated, followed by well-defined smooth margins. None of lesions were associated with parapharyngeal space or skull base destruction. All lesions were iso- and low-density on non-contrast CT. Adjacent skull base sclerosis was detected in 63.6% of lesions. High signal intensity on T2-weighted imaging and mostly iso-signal intensity on T1-weighted imaging compared to muscle tissue. Most lesions were heterogeneous and exhibited moderate contrast enhancement. Relatively large lesions (≥1.4 cm) tended to be more lobulated than smooth margins compared to relatively small lesions (<1.4 cm) ( p = 0.016). Conclusion We summarized the clinical and radiological features of TL-LGNPPA to facilitate accurate diagnosis and appropriate management.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
ISSN:0028-3940
1432-1920
DOI:10.1007/s00234-023-03254-2