Search Results - "Uchida, Yoshikazu"

Ceramides in Skin Health and Disease: An Update by Uchida, Yoshikazu, Park, Kyungho

“…Ceramides are a class of sphingolipid that is the backbone structure for all sphingolipids, such as glycosphingolipids and phosphosphingolipids. While being a…”
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Diesel Particulate Extract Accelerates Premature Skin Aging in Human Fibroblasts via Ceramide-1-Phosphate-Mediated Signaling Pathway by Shin, Kyong-Oh, Uchida, Yoshikazu, Park, Kyungho

“…Both intrinsic (i.e., an individual's body clock) and extrinsic factors (i.e., air pollutants and ultraviolet irradiation) accelerate premature aging…”
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The role of fatty acid elongation in epidermal structure and function by Uchida, Yoshikazu

“…Heterogeneous molecular species of epidermal ceramide (Cer) play critical roles in forming a competent permeability barrier of lamellar membrane structures in…”
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Epidermal sphingolipids: Metabolism, function, and roles in skin disorders by Holleran, Walter M., Takagi, Yutaka, Uchida, Yoshikazu

“…Mammalian epidermis produces and delivers large quantities of glucosylceramide and sphingomyelin precursors to stratum corneum extracellular domains, where…”
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Formation and functions of the corneocyte lipid envelope (CLE) by Elias, Peter M., Gruber, Robert, Crumrine, Debra, Menon, Gopinathan, Williams, Mary L., Wakefield, Joan S., Holleran, Walter M., Uchida, Yoshikazu

“…Corneocytes in mammalian stratum corneum are surrounded by a monolayer of covalently bound ω-OH-ceramides that form the corneocyte (-bound) lipid envelope…”
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Regulation of Cathelicidin Antimicrobial Peptide Expression by an Endoplasmic Reticulum (ER) Stress Signaling, Vitamin D Receptor-independent Pathway by Park, Kyungho, Elias, Peter M., Oda, Yuko, Mackenzie, Donald, Mauro, Theodora, Holleran, Walter M., Uchida, Yoshikazu

“…Vitamin D receptor (VDR)-dependent mechanisms regulate human cathelicidin antimicrobial peptide (CAMP)/LL-37 in various cell types, but CAMP expression also…”
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N-Palmitoyl Serinol Stimulates Ceramide Production through a CB1-Dependent Mechanism in In Vitro Model of Skin Inflammation by Shin, Kyong-Oh, Kim, Sungeun, Park, Byeong Deog, Uchida, Yoshikazu, Park, Kyungho

“…Ceramides, a class of sphingolipids containing a backbone of sphingoid base, are the most important and effective structural component for the formation of the…”
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Omega- O -acylceramide, a lipid essential for mammalian survival by Uchida, Yoshikazu, Holleran, Walter M

“…Summary The prevention of water loss through the skin is critical for terrestrial mammalian species. This function is served by the epidermal permeability…”
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ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex by Park, Kyungho, Ikushiro, Hiroko, Seo, Ho Seong, Shin, Kyong-Oh, Kim, Young il, Kim, Jong Youl, Lee, Yong-Moon, Yano, Takato, Holleran, Walter M., Elias, Peter, Uchida, Yoshikazu

“…We recently identified a previously unidentified sphingosine-1-phosphate (S1P) signaling mechanism that stimulates production of a key innate immune element,…”
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Activation of TLR3 in Keratinocytes Increases Expression of Genes Involved in Formation of the Epidermis, Lipid Accumulation, and Epidermal Organelles by Borkowski, Andrew W., Park, Kyungho, Uchida, Yoshikazu, Gallo, Richard L.

“…Injury to the skin, and the subsequent release of noncoding double-stranded RNA (dsRNA) from necrotic keratinocytes, has been identified as an endogenous…”
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Mutations in Recessive Congenital Ichthyoses Illuminate the Origin and Functions of the Corneocyte Lipid Envelope by Crumrine, Debra, Khnykin, Denis, Krieg, Peter, Man, Mao-Qiang, Celli, Anna, Mauro, Theodora M., Wakefield, Joan S., Menon, Gopinathan, Mauldin, Elizabeth, Miner, Jeffrey H., Lin, Meei-Hua, Brash, Alan R., Sprecher, Eli, Radner, Franz P.W., Choate, Keith, Roop, Dennis, Uchida, Yoshikazu, Gruber, Robert, Schmuth, Matthias, Elias, Peter M.

“…The corneocyte lipid envelope (CLE), a monolayer of ω-hydroxyceramides whose function(s) remain(s) uncertain, is absent in patients with autosomal recessive…”
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Ginsenoside Rb1 Enhances Keratinocyte Migration by a Sphingosine-1-Phosphate-Dependent Mechanism by Shin, Kyong-Oh, Choe, Sung Jay, Uchida, Yoshikazu, Kim, Inyong, Jeong, Yoonhwa, Park, Kyungho

“…The cutaneous wound healing process is tightly regulated by a range of cellular responses, including migration. Sphingosine-1-phosphate (S1P) is a signaling…”
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Phenotypic overlap between atopic dermatitis and autism by Shin, Kyong-Oh, Crumrine, Debra A, Kim, Sungeun, Lee, Yerin, Kim, Bogyeong, Abuabara, Katrina, Park, Chaehyeong, Uchida, Yoshikazu, Wakefield, Joan S, Meyer, Jason M, Jeong, Sekyoo, Park, Byeong Deog, Park, Kyungho, Elias, Peter M

“…Autism, a childhood behavioral disorder, belongs to a large suite of diseases, collectively referred to as autism spectrum disorders (ASD). Though…”
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Hair follicles modulate skin barrier function by Ford, Noah C., Benedeck, Rachel E., Mattoon, Matthew T., Peterson, Jamie K., Mesler, Arlee L., Veniaminova, Natalia A., Gardon, Danielle J., Tsai, Shih-Ying, Uchida, Yoshikazu, Wong, Sunny Y.

“…Our skin provides a protective barrier that shields us from our environment. Barrier function is typically associated with the interfollicular epidermis;…”
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Vitamin D Receptor and Coactivators SRC2 and 3 Regulate Epidermis-Specific Sphingolipid Production and Permeability Barrier Formation by Oda, Yuko, Uchida, Yoshikazu, Moradian, Sam, Crumrine, Debra, Elias, Peter M., Bikle, Daniel D.

“…The vitamin D receptor (VDR) is a nuclear hormone receptor that controls transcription of target genes. It exerts its biological effects through…”
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Increased glucocorticoid activation during mouse skin wound healing by Tiganescu, Ana, Hupe, Melanie, Uchida, Yoshikazu, Mauro, Theodora, Elias, Peter M, Holleran, Walter M

“…Glucocorticoid (GC) excess inhibits wound healing causing increased patient discomfort and infection risk. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)…”
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Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing by Bonnart, Chrystelle, Deraison, Céline, Lacroix, Matthieu, Uchida, Yoshikazu, Besson, Céline, Robin, Aurélie, Briot, Anaïs, Gonthier, Marie, Lamant, Laurence, Dubus, Pierre, Monsarrat, Bernard, Hovnanian, Alain

“…The human epidermis serves 2 crucial barrier functions: it protects against water loss and prevents penetration of infectious agents and allergens. The…”
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Cellular and Metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin)–Deficient Canines by Mauldin, Elizabeth A., Crumrine, Debra, Casal, Margret L., Jeong, Sekyoo, Opálka, Lukáš, Vavrova, Katerina, Uchida, Yoshikazu, Park, Kyungho, Craiglow, Brittany, Choate, Keith A., Shin, Kyong-Oh, Lee, Yong-Moon, Grove, Gary L., Wakefield, Joan S., Khnykin, Denis, Elias, Peter M.

“…Mutations in several lipid synthetic enzymes that block fatty acid and ceramide production produce autosomal recessive congenital ichthyoses (ARCIs) and…”
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Exogenous Ceramide Serves as a Precursor to Endogenous Ceramide Synthesis and as a Modulator of Keratinocyte Differentiation by Shin, Kyong-Oh, Mihara, Hisashi, Ishida, Kenya, Uchida, Yoshikazu, Park, Kyungho

“…Since ceramide is a key epidermal barrier constituent and its deficiency causes barrier-compromised skin, several molecular types of ceramides are formulated…”
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Altered sphingoid base profiles predict compromised membrane structure and permeability in atopic dermatitis by Loiseau, Nicolas, Obata, Yasuko, Moradian, Sam, Sano, Hiromu, Yoshino, Saeko, Aburai, Kenichi, Takayama, Kozo, Sakamoto, Kazutami, Holleran, Walter M, Elias, Peter M, Uchida, Yoshikazu

“…Abstract Background Ceramide hydrolysis by ceramidase in the stratum corneum (SC) yields both sphingoid bases and free fatty acids (FFA). While FFA are key…”
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