Is methylenetetrahydrofolate reductase (MTHFR) gene A1298C polymorphism related with varicocele risk?

Is methylenetetrahydrofolate reductase (MTHFR) gene A1298C polymorphism related with varicocele risk?

Summary Varicocele is one of the main reasons for male infertility the exact aetiology of which remains unclear. Methylenetetrahydrofolate reductase (MTHFR) is important for DNA synthesis and methylation, which has a key role during spermatogenesis. Numerous literature suggests that the MTHFR polymo...

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Bibliographic Details
Published in:Andrologia Vol. 47; no. 1; pp. 42 - 46
Main Authors: Ucar, V. B., Nami, B., Acar, H., Kılınç, M.
Format: Journal Article
Language:English
Published: Germany Blackwell Publishing Ltd 01-02-2015
Wiley Subscription Services, Inc
Subjects:
Adolescent
Adult
Case-Control Studies
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
MTHFR-1298
MTHFR-677
polymorphism
Polymorphism, Single Nucleotide
varicocele
Varicocele - genetics
Young Adult
MTHFR-1298
MTHFR-677
polymorphism
varicocele
Online Access:Get full text
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Summary:Summary Varicocele is one of the main reasons for male infertility the exact aetiology of which remains unclear. Methylenetetrahydrofolate reductase (MTHFR) is important for DNA synthesis and methylation, which has a key role during spermatogenesis. Numerous literature suggests that the MTHFR polymorphism may be genetic risk factors for male infertility. In this study, we evaluated C677T and A1298C MTHFR gene polymorphism frequency in patients with varicocele and normal men. A total of 107 varicocele patients and 109 fertile healthy individuals were included. Genotyping of the MTHFR gene in C677T and A1298C base pairs carried out by using real‐time PCR technique and afterwards, the statistical analysis accomplished. There is a statistical difference for the frequency of 1298AA genotype in patients with varicocele compared with normal controls (P = 0.0051, OR = 2.2750). Instead, subsequently, 1298/A allel frequency in patient group was significantly higher in comparison with control group (P = 0.0174). According to our results, 1298AA genotype in MTHFR gene raises the risk of varicocele approximately 2.3 times more compared with men carrying other genotypes. The results show that genetic factors have an important role in the molecular basis of varicocele.
Bibliography:ark:/67375/WNG-XRLFJ81H-K
ArticleID:AND12229
istex:9D47089D2494480034B6F938C81A84A75D683F3F
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0303-4569
1439-0272
DOI:10.1111/and.12229