Search Results - "Uberti, Michelle A."

Discovery and structure–activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators by Zhou, Hao, Topiol, Sidney W., Grenon, Michel, Jimenez, Hermogenes N., Uberti, Michelle A., Smith, Daniel G., Brodbeck, Robbin M., Chandrasena, Gamini, Pedersen, Henrik, Madsen, Jens Christian, Doller, Darío, Li, Guiying

“…The design, syntheses and structure–activity relationships (SAR) of novel 1,3-cyclohexyl amide derivatives as mGluR5 negative allosteric modulators are…”
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Synergy between l-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: Implications for Parkinson's disease treatment and dyskinesia by Bennouar, Khaled-Ezaheir, Uberti, Michelle A., Melon, Christophe, Bacolod, Maria D., Jimenez, Hermogenes N., Cajina, Manuel, Kerkerian-Le Goff, Lydia, Doller, Darío, Gubellini, Paolo

“…Group III metabotropic glutamate (mGlu) receptors are localized in presynaptic terminals within basal ganglia (BG) circuitry that become hyperactive due to…”
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Anxiolytic- but not antidepressant-like activity of Lu AF21934, a novel, selective positive allosteric modulator of the mGlu4 receptor by Sławińska, Anna, Wierońska, Joanna M., Stachowicz, Katarzyna, Pałucha-Poniewiera, Agnieszka, Uberti, Michelle A., Bacolod, Maria A., Doller, Dario, Pilc, Andrzej

“…Previous studies demonstrated that the Group III mGlu receptor-selective orthosteric agonist, LSP1-2111 produced anxiolytic- but not antidepressant-like…”
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Tricyclic Thiazolopyrazole Derivatives as Metabotropic Glutamate Receptor 4 Positive Allosteric Modulators by Hong, Sang-Phyo, Liu, Kevin G, Ma, Gil, Sabio, Michael, Uberti, Michelle A, Bacolod, Maria D, Peterson, John, Zou, Zack Z, Robichaud, Albert J, Doller, Darío

“…There is an increasing amount of evidence to support that activation of the metabotropic glutamate receptor 4 (mGlu4 receptor), either with an orthosteric…”
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Olfactory receptor surface expression is driven by association with the β2-adrenergic receptor by Hague, Chris, Uberti, Michelle A., Chen, Zhongjian, Bush, Cristina F., Jones, Seth V., Ressler, Kerry J., Hall, Randy A., Minneman, Kenneth P.

“…Olfactory receptors (ORs) comprise more than half of the large class I G protein-coupled receptor (GPCR) superfamily. Although cloned over a decade ago, little…”
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4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators by Jimenez, Hermogenes N., Liu, Kevin G., Hong, Sang-Phyo, Reitman, Michael S., Uberti, Michelle A., Bacolod, Maria D., Cajina, Manuel, Nattini, Megan, Sabio, Michael, Doller, Darío

“…4-(1-Phenyl-1H-pyrazol-4-yl)quinoline (1) was identified by screening the Lundbeck compound collection, and characterized as having mGlu4 receptor positive…”
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Structure-Activity Relationships for Negative Allosteric mGluR5 Modulators by Kaae, Birgitte H., Harpsøe, Kasper, Kvist, Trine, Mathiesen, Jesper M., Mølck, Christina, Gloriam, David, Jimenez, Hermogenes N., Uberti, Michelle A., Nielsen, Søren M., Nielsen, Birgitte, Bräuner-Osborne, Hans, Sauerberg, Per, Clausen, Rasmus P., Madsen, Ulf

“…A series of compounds based on the mGluR5‐selective ligand 2‐methyl‐6‐(phenylethynyl)pyridine (MPEP) were designed and synthesized. The compounds were found to…”
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6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators by Weiss, Jesse M., Jimenez, Hermogenes N., Li, Guiying, April, Myriam, Uberti, Michelle A., Bacolod, Maria D., Brodbeck, Robb M., Doller, Darío

“…A series of 6-aryl-3-pyrrolidinylpyridine analogs was explored as structurally novel negative allosteric modulators of the mGlu5 receptor lacking an alkyne or…”
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N-terminal truncation of human α1D-adrenoceptors increases expression of binding sites but not protein by PUPO, Andre S, UBERTI, Michelle A, MINNEMAN, Kenneth P

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Development of an aequorin luminescence calcium assay for high-throughput screening using a plate reader, the LumiLux by Menon, Veena, Ranganathn, Arun, Jorgensen, Vincent H, Sabio, Michael, Christoffersen, Claus T, Uberti, Michelle A, Jones, Kenneth A, Babu, Poda Suresh

“…A luminescence assay using a new plate reader, the LumiLux (PerkinElmer, Waltham, MA), has been validated for high-throughput screening (HTS). In this study,…”
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Subtype-specific dimerization of alpha 1-adrenoceptors: effects on receptor expression and pharmacological properties by Uberti, Michelle A, Hall, Randy A, Minneman, Kenneth P

“…The potential role of dimerization in controlling the expression and pharmacological properties of alpha1-adrenoceptor subtypes was examined using…”
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Molecular characterization of a rabbit long-chain fatty acyl CoA synthetase that is highly expressed in the vascular endothelium by Uberti, Michelle A, Pierce, James, Weis, Margaret T

“…The formation of coenzyme A thioesters from long-chain fatty acids represents a metabolic branch point. We have isolated, cloned and sequenced a long-chain…”
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Heterodimerization with beta2-adrenergic receptors promotes surface expression and functional activity of alpha1D-adrenergic receptors by Uberti, Michelle A, Hague, Chris, Oller, Heide, Minneman, Kenneth P, Hall, Randy A

“…The alpha1D-adrenergic receptor (alpha1D-AR) is a G protein-coupled receptor (GPCR) that is poorly trafficked to the cell surface and largely nonfunctional…”
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N-terminal truncation of human alpha1D-adrenoceptors increases expression of binding sites but not protein by Pupo, Andre S, Uberti, Michelle A, Minneman, Kenneth P

“…The role of the N-terminus of human alpha(1D)-adrenoceptors was examined by deleting the first 79 amino acids (Delta(1-79)) and epitope-tagging to facilitate…”
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N-terminal truncation of human α 1D-adrenoceptors increases expression of binding sites but not protein by Pupo, Andre S, Uberti, Michelle A, Minneman, Kenneth P

“…The role of the N-terminus of human α 1D-adrenoceptors was examined by deleting the first 79 amino acids (Δ 1–79) and epitope-tagging to facilitate…”
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Cell Surface Expression of α1D-Adrenergic Receptors Is Controlled by Heterodimerization with α1B-Adrenergic Receptors by Hague, Chris, Uberti, Michelle A., Chen, Zhongjian, Hall, Randy A., Minneman, Kenneth P.

“…α1-Adrenergic receptors (ARs) belong to the large Class I G protein-coupled receptor superfamily and comprise three subtypes (α1A, α1B, and α1D). Previous work…”
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Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors by Hague, Chris, Uberti, Michelle A, Chen, Zhongjian, Hall, Randy A, Minneman, Kenneth P

“…alpha(1)-Adrenergic receptors (ARs) belong to the large Class I G protein-coupled receptor superfamily and comprise three subtypes (alpha(1A), alpha(1B), and…”
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Cell Surface Expression of α1D-Adrenergic Receptors Is Controlled by Heterodimerization with α1B-Adrenergic Receptors by Chris Hague, Michelle A. Uberti, Zhongjian Chen, Randy A. Hall, Kenneth P. Minneman

“…α 1 -Adrenergic receptors (ARs) belong to the large Class I G protein-coupled receptor superfamily and comprise three subtypes (α 1A , α 1B , and α 1D )…”
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Olfactory Receptor Surface Expression Is Driven by Association with the β 2-Adrenergic Receptor by Hague, Chris, Uberti, Michelle A., Chen, Zhongjian, Bush, Cristina F., Jones, Seth V., Ressler, Kerry J., Hall, Randy A., Minneman, Kenneth P., Lefkowitz, Robert J.

“…Olfactory receptors (ORs) comprise more than half of the large class I G protein-coupled receptor (GPCR) superfamily. Although cloned over a decade ago, little…”
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Olfactory receptor surface expression is driven by association with the beta sub(2)-adrenergic receptor by Hague, Chris, Uberti, Michelle A, Chen, Zhongjian, Bush, Cristina F, Jones, Seth V, Ressler, Kerry J, Hall, Randy A, Minneman, Kenneth P

“…Olfactory receptors (ORs) comprise more than half of the large class I G protein-coupled receptor (GPCR) superfamily. Although cloned over a decade ago, little…”
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