Search Results - "Ubanako, Philemon"

LPS induces inflammatory chemokines via TLR-4 signalling and enhances the Warburg Effect in THP-1 cells by Ubanako, Philemon, Xelwa, Ntombikayise, Ntwasa, Monde

“…The Warburg Effect has emerged as a potential drug target because, in some cancer cell lines, it is sufficient to subvert it in order to kill cancer cells. It…”
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Recent Advances in Microneedle Platforms for Transdermal Drug Delivery Technologies by Mdanda, Sipho, Ubanako, Philemon, Kondiah, Pierre P. D., Kumar, Pradeep, Choonara, Yahya E.

“…In many clinical applications, the transdermal route is used as an alternative approach to avoid the significant limitations associated with oral drug…”
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A 3D-Printed Biomaterial Scaffold Reinforced with Inorganic Fillers for Bone Tissue Engineering: In Vitro Assessment and In Vivo Animal Studies by Sithole, Mduduzi N, Kumar, Pradeep, Du Toit, Lisa C, Erlwanger, Kennedy H, Ubanako, Philemon N, Choonara, Yahya E

“…This research aimed to substantiate the potential practicality of utilizing a matrix-like platform, a novel 3D-printed biomaterial scaffold, to enhance and…”
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Exosome-mediated delivery of siRNA molecules in cancer therapy: triumphs and challenges by Ubanako, Philemon, Mirza, Sheefa, Ruff, Paul, Penny, Clement

“…The discovery of novel and innovative therapeutic strategies for cancer treatment and management remains a major global challenge. Exosomes are endogenous…”
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Synthesis and Cytotoxic Activity of 1,2,4-Triazolo-Linked Bis-Indolyl Conjugates as Dual Inhibitors of Tankyrase and PI3K by Yakkala, Prasanna A., Panda, Samir R., Shafi, Syed, Naidu, V. G. M., Yar, M. Shahar, Ubanako, Philemon N., Adeyemi, Samson A., Kumar, Pradeep, Choonara, Yahya E., Radchenko, Eugene V., Palyulin, Vladimir A., Kamal, Ahmed

“…A series of new 1,2,4-triazolo-linked bis-indolyl conjugates (15a–r) were prepared by multistep synthesis and evaluated for their cytotoxic activity against…”
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In Vivo Evaluation of Praziquantel-Loaded Solid Lipid Nanoparticles against S. mansoni Infection in Preclinical Murine Models by Adekiya, Tayo A., Kumar, Pradeep, Kondiah, Pierre P. D., Ubanako, Philemon, Choonara, Yahya E.

“…This study aimed to develop and assess the long-term stability of drug-loaded solid lipid nanoparticles (SLNs). The SLNs were designed to extend the release…”
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Genipin-Crosslinked, Proteosaccharide Scaffolds for Potential Neural Tissue Engineering Applications by Cassimjee, Henna, Kumar, Pradeep, Ubanako, Philemon, Choonara, Yahya E

“…Traumatic brain injuries (TBIs) are still a challenge for the field of modern medicine. Many treatment options such as autologous grafts and stem cells show…”
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Advances in Nano-Enabled Platforms for the Treatment of Depression by Mutingwende, Fadzai P, Kondiah, Pierre P D, Ubanako, Philemon, Marimuthu, Thashree, Choonara, Yahya E

“…Nanotechnology has aided in the advancement of drug delivery for the treatment of several neurological disorders including depression. Depression is a…”
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Dual Rifampicin and Isoniazid Mannose-Decorated Lipopolysaccharide Nanospheres for Macrophage- Targeted Lung Delivery by Sumaila, Mumuni, Kumar, Pradeep, Ubanako, Philemon, Adeyemi, Samson A, Choonara, Yahya E

“…Currently, the treatment protocols for tuberculosis (TB) have several challenges, such as inconsistent oral bioavailability, dose-related adverse effects, and…”
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Capparis sepiaria -Loaded Sodium Alginate Single- and Double-Layer Membrane Composites for Wound Healing by Ndlovu, Sindi P, Motaung, Keolebogile S C M, Razwinani, Mapula, Alven, Sibusiso, Adeyemi, Samson A, Ubanako, Philemon N, Ngema, Lindokuhle M, Fonkui, Thierry Y, Ndinteh, Derek T, Kumar, Pradeep, Choonara, Yahya E, Aderibigbe, Blessing A

“…: Effective wound dressing is the key solution to combating the increased death rate and prolonged hospital stay common to patients with wounds. : Sodium…”
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Surface Immobilization of Anti-VEGF Peptide on SPIONs for Antiangiogenic and Targeted Delivery of Paclitaxel in Non-Small-Cell Lung Carcinoma by Ngema, Lindokuhle M., Adeyemi, Samson A., Marimuthu, Thashree, Ubanako, Philemon N., Ngwa, Wilfred, Choonara, Yahya E.

“…A design has been established for the surface decoration of superparamagnetic iron oxide nanoparticles (SPIONs) with anti-vascular endothelial growth factor…”
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Synthesis of Novel Conjugated Linoleic Acid (CLA)-Coated Superparamagnetic Iron Oxide Nanoparticles (SPIONs) for the Delivery of Paclitaxel with Enhanced In Vitro Anti-Proliferative Activity on A549 Lung Cancer Cells by Ngema, Lindokuhle M, Adeyemi, Samson A, Marimuthu, Thashree, Ubanako, Philemon, Wamwangi, Daniel, Choonara, Yahya E

“…The application of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as a nanomedicine for Non-Small Cell Lung Carcinoma (NSCLC) can provide effective…”
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Fabrication and Characterisation of a Photo-Responsive, Injectable Nanosystem for Sustained Delivery of Macromolecules by Mahlumba, Pakama, Kumar, Pradeep, du Toit, Lisa C, Poka, Madan S, Ubanako, Philemon, Choonara, Yahya E

“…The demand for biodegradable sustained release carriers with minimally invasive and less frequent administration properties for therapeutic proteins and…”
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A Topical Alginate-Based Wound Gel Fixated with Metal-Based Nanoparticles and Tranexamic Acid as a Hemostatic Wound Healing System by Nqoro, Xhamla, Adeyemi, Samson A., Ubanako, Philemon, Ndinteh, Derek T., Kumar, Pradeep, Choonara, Yahya E., Aderibigbe, Blessing A.

“…Wounds are usually accompanied by complications such as excessive bleeding and bacteria invasion. The design of wound dressings that rapidly stop excessive…”
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Short Antiangiogenic MMP‑2 Peptide-Decorated Conjugated Linoleic Acid-Coated SPIONs for Targeted Paclitaxel Delivery in an A549 Cell Xenograft Mouse Tumor Model by Ngema, Lindokuhle M., Adeyemi, Samson A., Marimuthu, Thashree, Ubanako, Philemon N., Ngwa, Wilfred, Choonara, Yahya E.

“…The design of targeted antiangiogenic nanovectors for the delivery of anticancer drugs presents a viable approach for effective management of nonsmall-cell…”
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Microporous proteosaccharide platforms for potential neural tissue engineering applications by Cassimjee, Henna, Kumar, Pradeep, Ubanako, Philemon, Choonara, Yahya E.

“…•Chitosan and Puramatrix effectively form a proteosaccharide complex.•Chitosan complexation of Puramatrix increased its thermal stability.•The platform…”
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Synthesis and in vitro assessment of gold nanoparticles conjugated with extracts, sterols and pure compounds derived from marine sponges from the Indian and Pacific Oceans by Ramanjooloo, Avin, Bekah, Devesh, Adeyemi, Samson A., Ubanako, Philemon, Ngema, Lindokuhle, Choonara, Yahya E., Williams, David E., Polishchuk, Elena A., Andersen, Raymond J., Bhaw-Luximon, Archana

“…Gold nanoparticles (AuNPs) exhibit different physical properties compared to small molecules, bulk materials and other nanoparticles. Their synthesis using…”
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Synthesis of a novel monofilament bioabsorbable suture for biomedical applications by Harpe, Kara M., Marimuthu, Thashree, Kondiah, Pierre P. D., Kumar, Pradeep, Ubanako, Philemon, Choonara, Yahya E.

“…In this research, a novel bioabsorbable suture that is, monofilament and capable of localized drug delivery, was developed from a combination of natural…”
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Novel ferrocenylbisphosphonate hybrid compounds: Synthesis, characterization and potent activity against cancer cell lines by Anusionwu, Chioma G., Aderibigbe, Blessing A., Adeyemi, Samson A., Ubanako, Philemon, Oselusi, Samson O., Choonara, Yahya E., Yangkou Mbianda, Xavier

“…[Display omitted] The toxicity of existing anticancer agents on healthy cells and the emergence of multidrug-resistance cancer cells have led to the search for…”
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Sodium alginate-based nanofibers loaded with Capparis Sepiaria plant extract for wound healing by Ndlovu, Sindi P., Motaung, Keolebogile S. C. M, Adeyemi, Samson A., Ubanako, Philemon, Ngema, Lindokuhle, Fonkui, Thierry Y., Ndinteh, Derek T., Kumar, Pradeep, Choonara, Yahya E., Aderibigbe, Blessing A.

“…Burn wounds are associated with infections, drug resistance, allergic reactions, odour, bleeding, excess exudates, and scars, requiring prolonged hospital…”
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