Search Results - "UTKIN, Yuri N"

Three-finger toxins, a deadly weapon of elapid venom – Milestones of discovery by Utkin, Yuri N.

“…Three-finger toxins (TFTs) are the main venom components of snakes from Elapidae family. Amino acid sequences of more than five hundreds TFTs are determined;…”
Get full text

Molecular Mechanisms of Animal Toxins, Venoms and Antivenoms by Kini, R. Manjunatha, Utkin, Yuri N.

“…In many animals belonging to different taxa, venoms evolved as a means of defense and/or a means of attack/hunting [...]…”
Get full text

Specific Amino Acid Residues in the Three Loops of Snake Cytotoxins Determine Their Membrane Activity and Provide a Rationale for a New Classification of These Toxins by Dubovskii, Peter V, Utkin, Yuri N

“…Cytotoxins (CTs) are three-finger membrane-active toxins present mainly in cobra venom. Our analysis of the available CT amino acid sequences, literature data…”
Get full text

Current Insights in the Mechanisms of Cobra Venom Cytotoxins and Their Complexes in Inducing Toxicity: Implications in Antivenom Therapy by Kalita, Bhargab, Utkin, Yuri N, Mukherjee, Ashis K

“…Cytotoxins (CTXs), an essential class of the non-enzymatic three-finger toxin family, are ubiquitously present in cobra venoms. These low-molecular-mass…”
Get full text

Effects of Cobra Cardiotoxins on Intracellular Calcium and the Contracture of Rat Cardiomyocytes Depend on Their Structural Types by Averin, Alexey S, Berezhnov, Alexey V, Pimenov, Oleg Y, Galimova, Miliausha H, Starkov, Vladislav G, Tsetlin, Victor I, Utkin, Yuri N

“…Cardiotoxins (CaTx) of the three-finger toxin family are one of the main components of cobra venoms. Depending on the structure of the N-terminal or the…”
Get full text

Membrane-Disrupting Activity of Cobra Cytotoxins Is Determined by Configuration of the N-Terminal Loop by Dubovskii, Peter V, Ignatova, Anastasia A, Alekseeva, Anna S, Starkov, Vladislav G, Boldyrev, Ivan A, Feofanov, Alexey V, Utkin, Yuri N

“…In aqueous solutions, cobra cytotoxins (CTX), three-finger folded proteins, exhibit conformational equilibrium between conformers with either cis or trans…”
Get full text

Effects of Cardiotoxins from Naja oxiana Cobra Venom on Rat Heart Muscle and Aorta: A Comparative Study of Toxin-Induced Contraction Mechanisms by Averin, Alexey S, Nenov, Miroslav N, Starkov, Vladislav G, Tsetlin, Victor I, Utkin, Yuri N

“…Cardiotoxins (CaTxs) are a group of snake toxins that affect the cardiovascular system (CVS). Two types (S and P) of CaTxs are known, but the exact differences…”
Get full text

Variability in the Spatial Structure of the Central Loop in Cobra Cytotoxins Revealed by X-ray Analysis and Molecular Modeling by Dubovskii, Peter V, Dubova, Kira M, Bourenkov, Gleb, Starkov, Vladislav G, Konshina, Anastasia G, Efremov, Roman G, Utkin, Yuri N, Samygina, Valeriya R

“…Cobra cytotoxins (CTs) belong to the three-fingered protein family and possess membrane activity. Here, we studied cytotoxin 13 from cobra venom (CT13Nn). For…”
Get full text

Pancreatic and snake venom presynaptically active phospholipases A2 inhibit nicotinic acetylcholine receptors by Vulfius, Catherine A, Kasheverov, Igor E, Kryukova, Elena V, Spirova, Ekaterina N, Shelukhina, Irina V, Starkov, Vladislav G, Andreeva, Tatyana V, Faure, Grazyna, Zouridakis, Marios, Tsetlin, Victor I, Utkin, Yuri N

“…Phospholipases A2 (PLA2s) are enzymes found throughout the animal kingdom. They hydrolyze phospholipids in the sn-2 position producing lysophospholipids and…”
Get full text

α-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors by Osipov, Alexey V, Terpinskaya, Tatiana I, Yanchanka, Tatsiana, Balashevich, Tatjana, Zhmak, Maxim N, Tsetlin, Victor I, Utkin, Yuri N

“…Several biochemical mechanisms, including the arachidonic acid cascade and activation of nicotinic acetylcholine receptors (nAChRs), are involved in increased…”
Get full text

Antiproliferative activity of cobra venom cytotoxins by Dubovskii, Peter V, Utkin, Yuri N

“…Cytotoxins (or cardiotoxins, CTs) are small rigid membrane-active proteins of the three-finger toxin (TFT) family. They comprise about 60 amino acid residues,…”
Get more information

α-Conotoxins and α-Cobratoxin Promote, while Lipoxygenase and Cyclooxygenase Inhibitors Suppress the Proliferation of Glioma C6 Cells by Terpinskaya, Tatiana I, Osipov, Alexey V, Kryukova, Elena V, Kudryavtsev, Denis S, Kopylova, Nina V, Yanchanka, Tatsiana L, Palukoshka, Alena F, Gondarenko, Elena A, Zhmak, Maxim N, Tsetlin, Victor I, Utkin, Yuri N

“…Among the brain tumors, glioma is the most common. In general, different biochemical mechanisms, involving nicotinic acetylcholine receptors (nAChRs) and the…”
Get full text

Activation of α7 Nicotinic Acetylcholine Receptor Upregulates HLA-DR and Macrophage Receptors: Potential Role in Adaptive Immunity and in Preventing Immunosuppression by Siniavin, Andrei E, Streltsova, Maria A, Kudryavtsev, Denis S, Shelukhina, Irina V, Utkin, Yuri N, Tsetlin, Victor I

“…Immune response during sepsis is characterized by hyper-inflammation followed by immunosuppression. The crucial role of macrophages is well-known for both…”
Get full text

Editorial: Venoms, Animal and Microbial Toxins by Cao, Zhijian, Wang, Jing-Lin, McNutt, Patrick Michael, Utkin, Yuri N., Shahbazzadeh, Delavar, Wulff, Heike, Kovacic, Hervé, Sabatier, Jean-Marc

Get full text

Snake cytotoxins bind to membranes via interactions with phosphatidylserine head groups of lipids by Konshina, Anastasia G, Boldyrev, Ivan A, Utkin, Yuri N, Omel'kov, Anton V, Efremov, Roman G

“…The major representatives of Elapidae snake venom, cytotoxins (CTs), share similar three-fingered fold and exert diverse range of biological activities against…”
Get full text

From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs by Kryukova, Elena V, Egorova, Natalia S, Kudryavtsev, Denis S, Lebedev, Dmitry S, Spirova, Ekaterina N, Zhmak, Maxim N, Garifulina, Aleksandra I, Kasheverov, Igor E, Utkin, Yuri N, Tsetlin, Victor I

“…The proteins of the Ly6 family have a three-finger folding as snake venom α-neurotoxins, targeting nicotinic acetylcholine receptors (nAChRs), and some of…”
Get full text

S- and P-type cobra venom cardiotoxins differ in their action on isolated rat heart by Averin, Alexey S, Goltyaev, Mikhail V, Andreeva, Tatyana V, Starkov, Vladislav G, Tsetlin, Victor I, Utkin, Yuri N

“…The cardiovascular system is one of the first systems to be affected by snake toxins; but not many toxins exert a direct effect on the heart. Cobra venom…”
Get full text

Inhibition of nicotinic acetylcholine receptors, a novel facet in the pleiotropic activities of snake venom phospholipases A2 by Vulfius, Catherine A, Kasheverov, Igor E, Starkov, Vladislav G, Osipov, Alexey V, Andreeva, Tatyana V, Filkin, Sergey Yu, Gorbacheva, Elena V, Astashev, Maxim E, Tsetlin, Victor I, Utkin, Yuri N

“…Phospholipases A2 represent the most abundant family of snake venom proteins. They manifest an array of biological activities, which is constantly expanding…”
Get full text

Screening Snake Venoms for Toxicity to Tetrahymena Pyriformis Revealed Anti-Protozoan Activity of Cobra Cytotoxins by Kuleshina, Olga N, Kruykova, Elena V, Cheremnykh, Elena G, Kozlov, Leonid V, Andreeva, Tatyana V, Starkov, Vladislav G, Osipov, Alexey V, Ziganshin, Rustam H, Tsetlin, Victor I, Utkin, Yuri N

“…Snake venoms possess lethal activities against different organisms, ranging from bacteria to higher vertebrates. Several venoms were shown to be active against…”
Get full text

Azemiopsin, a Selective Peptide Antagonist of Muscle Nicotinic Acetylcholine Receptor: Preclinical Evaluation as a Local Muscle Relaxant by Shelukhina, Irina V, Zhmak, Maxim N, Lobanov, Alexander V, Ivanov, Igor A, Garifulina, Alexandra I, Kravchenko, Irina N, Rasskazova, Ekaterina A, Salmova, Margarita A, Tukhovskaya, Elena A, Rykov, Vladimir A, Slashcheva, Gulsara A, Egorova, Natalya S, Muzyka, Inessa S, Tsetlin, Victor I, Utkin, Yuri N

“…Azemiopsin (Az), a linear peptide from the viper venom, contains no disulfide bonds, is a high-affinity and selective inhibitor of nicotinic acetylcholine…”
Get full text