Search Results - "URWYLER, Heinrich"

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria by Charman, Susan A., Arbe-Barnes, Sarah, Bathurst, Ian C., Brun, Reto, Campbell, Michael, Charman, William N., Chiu, Francis C. K., Chollet, Jacques, Craft, J. Carl, Creek, Darren J., Dong, Yuxiang, Matile, Hugues, Maurer, Melanie, Morizzi, Julia, Nguyen, Tien, Papastogiannidis, Petros, Scheurer, Christian, Shackleford, David M., Sriraghavan, Kamaraj, Stingelin, Lukas, Tang, Yuanqing, Urwyler, Heinrich, Wang, Xiaofang, White, Karen L., Wittlin, Sergio, Zhou, Lin, Vennerstrom, Jonathan L., Wellems, Thomas E.

“…Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans. OZ439 has successfully completed Phase…”
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Structure–Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439) by Dong, Yuxiang, Wang, Xiaofang, Kamaraj, Sriraghavan, Bulbule, Vivek J, Chiu, Francis C. K, Chollet, Jacques, Dhanasekaran, Manickam, Hein, Christopher D, Papastogiannidis, Petros, Morizzi, Julia, Shackleford, David M, Barker, Helena, Ryan, Eileen, Scheurer, Christian, Tang, Yuanqing, Zhao, Qingjie, Zhou, Lin, White, Karen L, Urwyler, Heinrich, Charman, William N, Matile, Hugues, Wittlin, Sergio, Charman, Susan A, Vennerstrom, Jonathan L

“…Building on insights gained from the discovery of the antimalarial ozonide arterolane (OZ277), we now describe the structure–activity relationship (SAR) of the…”
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In Vitro and In Vivo Properties of Dihydrophthalazine Antifolates, a Novel Family of Antibacterial Drugs by CASPERS, Patrick, BURY, Luc, GAUCHER, Bérangère, HEIM, Jutta, SHAPIRO, Stuart, SIEGRIST, Sibylle, SCHMITT-HOFFMANN, Anne, THENOZ, Laure, URWYLER, Heinrich

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Identification of an antimalarial synthetic trioxolane drug development candidate by Vennerstrom, Jonathan L, Arbe-Barnes, Sarah, Brun, Reto, Charman, Susan A, Chiu, Francis C. K, Chollet, Jacques, Dong, Yuxiang, Dorn, Arnulf, Hunziker, Daniel, Matile, Hugues, McIntosh, Kylie, Padmanilayam, Maniyan, Santo Tomas, Josefina, Scheurer, Christian, Scorneaux, Bernard, Tang, Yuanqing, Urwyler, Heinrich, Wittlin, Sergio, Charman, William N

“…The discovery of artemisinin more than 30 years ago provided a completely new antimalarial structural prototype; that is, a molecule with a pharmacophoric…”
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The Structure−Activity Relationship of the Antimalarial Ozonide Arterolane (OZ277) by Dong, Yuxiang, Wittlin, Sergio, Sriraghavan, Kamaraj, Chollet, Jacques, Charman, Susan A, Charman, William N, Scheurer, Christian, Urwyler, Heinrich, Santo Tomas, Josefina, Snyder, Christopher, Creek, Darren J, Morizzi, Julia, Koltun, Maria, Matile, Hugues, Wang, Xiaofang, Padmanilayam, Maniyan, Tang, Yuanqing, Dorn, Arnulf, Brun, Reto, Vennerstrom, Jonathan L

“…The structure and stereochemistry of the cyclohexane substituents of analogues of arterolane (OZ277) had little effect on potency against Plasmodium falciparum…”
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Spiro and Dispiro-1,2,4-trioxolanes as Antimalarial Peroxides:  Charting a Workable Structure−Activity Relationship Using Simple Prototypes by Dong, Yuxiang, Chollet, Jacques, Matile, Hugues, Charman, Susan A, Chiu, Francis C. K, Charman, William N, Scorneaux, Bernard, Urwyler, Heinrich, Santo Tomas, Josefina, Scheurer, Christian, Snyder, Christopher, Dorn, Arnulf, Wang, Xiaofang, Karle, Jean M, Tang, Yuanqing, Wittlin, Sergio, Brun, Reto, Vennerstrom, Jonathan L

“…This paper describes the discovery of synthetic 1,2,4-trioxolane antimalarials and how we established a workable structure−activity relationship in the context…”
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Weak base dispiro-1,2,4-trioxolanes: Potent antimalarial ozonides by Tang, Yuanqing, Dong, Yuxiang, Wittlin, Sergio, Charman, Susan A., Chollet, Jacques, Chiu, Francis C.K., Charman, William N., Matile, Hugues, Urwyler, Heinrich, Dorn, Arnulf, Bajpai, Saroj, Wang, Xiaofang, Padmanilayam, Maniyan, Karle, Jean M., Brun, Reto, Vennerstrom, Jonathan L.

“…Thirty weak base 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. Amino amide trioxolanes had the best combination of antimalarial and…”
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Fluoroquinolone antibacterials enhance UVA-induced skin tumors by Klecak, Georg, Urbach, Frederick, Urwyler, Heinrich

“…Fluoroquinolone antibacterials are known to be phototoxic, both in vivo and in vitro. The action spectrum for the phototoxicity of the quinolones lies mainly…”
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The comparative antimalarial properties of weak base and neutral synthetic ozonides by Tang, Yuanqing, Wittlin, Sergio, Charman, Susan A., Chollet, Jacques, Chiu, Francis C.K., Morizzi, Julia, Johnson, Lisa M., Tomas, Josefina Santo, Scheurer, Christian, Snyder, Chistopher, Zhou, Lin, Dong, Yuxiang, Charman, William N., Matile, Hugues, Urwyler, Heinrich, Dorn, Arnulf, Vennerstrom, Jonathan L.

“…Thirty-three N-acyl 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. For these ozonides, weak base functional groups were not required for high…”
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4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum by RIDLEY, R. G, HOFHEINZ, W, URWYLER, H, HUBER, W, THAIGHONG, S, PETERS, W, MATILE, H, JAQUET, C, DORN, A, MASCIADRI, R, JOLIDON, S, RICHTER, W. F, GUENZI, A, GIROMETTA, M.-A

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Improved risk assessment by screening sperm parameters by Plassmann, Stephanie, Urwyler, Heinrich

“…The question of whether a 4 or 9 week premating treatment period is more suitable in studies for effects on fertility and early embryonic development, and the…”
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