Search Results - "URLEB, Uros"

Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement by Chopra, Ian, Prof, Schofield, Christopher, Prof, Everett, Martin, PhD, O'Neill, Alex, PhD, Miller, Keith, PhD, Wilcox, Mark, Prof, Frère, Jean-Marie, Prof, Dawson, Mike, PhD, Czaplewski, Lloyd, PhD, Urleb, Uros, PhD, Courvalin, Patrice, Prof

“…Summary This consensus statement presents the conclusions of a group of academic and industrial experts who met in London in September, 2006, to consider the…”
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Recent advances in serine protease inhibitors as anticoagulant agents by Prezelj, Andrej, Anderluh, Petra Stefanic, Peternel, Luka, Urleb, Uros

“…The drawbacks and limitations of existing anticoagulant therapy which may result in serious adverse effects and a high mortality rate, have given rise to many…”
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Structure of a Synthetic Fragment of the Lipopolysaccharide (LPS) Binding Protein When Bound to LPS and Design of a Peptidic LPS Inhibitor by Pristovšek, Primož, Simčič, Saša, Wraber, Branka, Urleb, Uroš

“…Peptidic lipopolysaccharide (LPS) antagonists are the subject of intensive research. We report an NMR and modeling study of LBP-14 (RVQGRWKVRASFFK), a…”
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Histamine release, an undesired effect of thrombin inhibitors with basic character, is mediated through direct activation of Gi proteins by STEMPELJ, Mateja, ZORKO, Matjaz, PETEMEL, Luka, URLEB, Uros, FERJAN, Ilonka

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Stereoselective synthesis of fluorine-containing analogues of anti-bacterial sanfetrinem and LK-157 by Mohar, Barbara, Stephan, Michel, Urleb, Uroš

“…The synthesis of (1′ S,3 R,4 R)-4-acetoxy-3-(1′-trimethylsilyloxy-2′,2′,2′-trifluoroethyl)-2-azetidinone ( 10) precursor of modified carbapenems is described…”
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Forced degradation of tacrolimus and the development of a UHPLC method for impurities determination by Peterka, Tanja Rozman, Lušin, Tina Trdan, Bergles, Jure, Ham, Zoran, Grahek, Rok, Urleb, Uroš

“…An ultra-high performance liquid chromatography method for simultaneous determination of tacrolimus impurities in pharmaceutical dosage forms has been…”
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Evaluation of the light scattering and the turbidity microtiter plate-based methods for the detection of the excipient-mediated drug precipitation inhibition by Petruševska, Marija, Urleb, Uroš, Peternel, Luka

“…The excipient-mediated precipitation inhibition is classically determined by the quantification of the dissolved compound in the solution. In this study, two…”
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Solid state compatibility study and characterization of a novel degradation product of tacrolimus in formulation by Rozman Peterka, Tanja, Grahek, Rok, Hren, Jure, Bastarda, Andrej, Bergles, Jure, Urleb, Uroš

“…•Solid state compatibility study.•Isolation and characterization of new tacrolimus degradation impurity.•Structural elucidation using NMR and MS.•Degradation…”
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Optimization of UPLC Method for Simultaneous Determination of Rosuvastatin and Rosuvastatin Degradation Products by Zakrajšek, Jure, Bevc-Černilec, Katarina, Bohanec, Simona, Urleb, Uroš

“…An ultra-performance liquid chromatographic method for simultaneous determination of rosuvastatin and rosuvastatin degradation products was developed and…”
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A novel 2-oxoindolinylidene inhibitor of bacterial MurD ligase: Enzyme kinetics, protein-inhibitor binding by NMR and a molecular dynamics study by Simčič, Mihael, Pureber, Kaja, Kristan, Katja, Urleb, Uroš, Kocjan, Darko, Grdadolnik, Simona Golič

“…N-(5-(5-nitro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)4-oxo-2-thioxo-1,3-thiazolidin-3-yl)nicotinamide, a 2-oxoindolinylidene derivative with novel structure…”
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Novel Naphthalene-N-sulfonyl-d-glutamic Acid Derivatives as Inhibitors of MurD, a Key Peptidoglycan Biosynthesis Enzyme by Humljan, Jan, Kotnik, Miha, Contreras-Martel, Carlos, Blanot, Didier, Urleb, Uroš, Dessen, Andréa, Šolmajer, Tom, Gobec, Stanislav

“…Mur ligases have essential roles in the biosynthesis of peptidoglycan, and they represent attractive targets for the design of novel antibacterials. MurD…”
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Stereoselective synthesis of (1′ S,3 R,4 R)-4-acetoxy-3-(2′-fluoro-1′-trimethylsilyloxyethyl)-2-azetidinone by Plantan, Ivan, Stephan, Michel, Urleb, Uroš, Mohar, Barbara

“…A stereoselective synthesis of (1′ S,3 R,4 R)-4-acetoxy-3-(2′-fluoro-1′-trimethylsilyloxyethyl)-2-azetidinone as a new fluorine-containing intermediate towards…”
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In Vitro Activity of LK-157, a Novel Tricyclic Carbapenem As Broad-Spectrum β-Lactamase Inhibitor by PAUKNER, Susanne, HESSE, Lars, PREGELJ, Andrej, SOLMAJER, Tomaz, URLEB, Uros

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Quality by design based optimization of a high performance liquid chromatography method for assay determination of low concentration preservatives in complex nasal formulations by Zakrajšek, Jure, Stojić, Vladimir, Bohanec, Simona, Urleb, Uroš

“…The effects of seven different chromatographic parameters and five sample preparation parameters in a high performance liquid chromatography (HPLC) method for…”
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Antithrombotic potential of new direct thrombin inhibitors built on the azaphenylalanine scaffold in two rat venous thrombosis models by Peternel, Luka, Stegnar, Mojca, Drevensek, Gorazd, Budihna, Metka V, Bozic, Mojca, Zega, Anamarija, Stalc, Anton, Cerne, Manica, Urleb, Uros

“…The antithrombotic potential of new direct thrombin inhibitors built on the azaphenylalanine scaffold (LK-732, LK-639 and LK-731) and their amidoxime prodrugs…”
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Revealing fosfomycin primary effect on Staphylococcus aureus transcriptome: modulation of cell envelope biosynthesis and phosphoenolpyruvate induced starvation by Petek, Marko, Baebler, Spela, Kuzman, Drago, Rotter, Ana, Podlesek, Zdravko, Gruden, Kristina, Ravnikar, Maja, Urleb, Uros

“…Staphylococcus aureus is a highly adaptable human pathogen and there is a constant search for effective antibiotics. Fosfomycin is a potent irreversible…”
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Evaluation of a high-throughput screening method for the detection of the excipient-mediated precipitation inhibition of poorly soluble drugs by Petruševska, Marija, Urleb, Uroš, Peternel, Luka

“…The objective of the present study was to develop and evaluate a high-throughput (HT) precipitation inhibitor screening method that can be used for the…”
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Structural and Functional Characterization of Enantiomeric Glutamic Acid Derivatives as Potential Transition State Analogue Inhibitors of MurD Ligase by Kotnik, Miha, Humljan, Jan, Contreras-Martel, Carlos, Oblak, Marko, Kristan, Katja, Hervé, Mireille, Blanot, Didier, Urleb, Uroš, Gobec, Stanislav, Dessen, Andréa, Solmajer, Tom

“…Mur ligases play an essential role in the intracellular biosynthesis of bacterial peptidoglycan, the main component of the bacterial cell wall, and represent…”
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Hydroxypropyl Methylcellulose Mediated Precipitation Inhibition of Sirolimus: From a Screening Campaign to a Proof-of-Concept Human Study by Petruševska, Marija, Homar, Miha, Petek, Boštjan, Resman, Aleksander, Kocjan, Darko, Urleb, Uroš, Peternel, Luka

“…The aim of this study was to develop a sirolimus (BCS class II drug substance) solid oral dosage form containing a precipitation inhibitor, which would result…”
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A new approach towards peptidosulfonamides: synthesis of potential inhibitors of bacterial peptidoglycan biosynthesis enzymes MurD and MurE by Humljan, Jan, Kotnik, Miha, Boniface, Audrey, Šolmajer, Tomaž, Urleb, Uroš, Blanot, Didier, Gobec, Stanislav

“…Peptidosulfonamides are an emerging group of peptidomimetics with a variety of applications in medicinal chemistry. We present a novel approach to the…”
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