Search Results - "URIARTE, Iker"

Fibroblast growth factor 15/19 (FGF15/19) protects from diet-induced hepatic steatosis: development of an FGF19-based chimeric molecule to promote fatty liver regeneration by Alvarez-Sola, Gloria, Uriarte, Iker, Latasa, M Ujue, Fernandez-Barrena, Maite G, Urtasun, Raquel, Elizalde, Maria, Barcena-Varela, Marina, Jiménez, Maddalen, Chang, Haisul C, Barbero, Roberto, Catalán, Victoria, Rodríguez, Amaia, Frühbeck, Gema, Gallego-Escuredo, José M, Gavaldà-Navarro, Aleix, Villarroya, Francesc, Rodriguez-Ortigosa, Carlos M, Corrales, Fernando J, Prieto, Jesus, Berraondo, Pedro, Berasain, Carmen, Avila, Matias A

“…Fibroblast growth factor 15/19 (FGF15/19), an enterokine that regulates synthesis of hepatic bile acids (BA), has been proposed to influence fat metabolism…”
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Dual Targeting of Histone Methyltransferase G9a and DNA‐Methyltransferase 1 for the Treatment of Experimental Hepatocellular Carcinoma by Bárcena‐Varela, Marina, Caruso, Stefano, Llerena, Susana, Álvarez‐Sola, Gloria, Uriarte, Iker, Latasa, M. Ujue, Urtasun, Raquel, Rebouissou, Sandra, Alvarez, Laura, Jimenez, Maddalen, Santamaría, Eva, Rodriguez‐Ortigosa, Carlos, Mazza, Giuseppe, Rombouts, Krista, San José‐Eneriz, Edurne, Rabal, Obdulia, Agirre, Xabier, Iraburu, Maria, Santos‐Laso, Alvaro, Banales, Jesus M., Zucman‐Rossi, Jessica, Prósper, Felipe, Oyarzabal, Julen, Berasain, Carmen, Ávila, Matías A., Fernández‐Barrena, Maite G.

“…Epigenetic modifications such as DNA and histone methylation functionally cooperate in fostering tumor growth, including that of hepatocellular carcinoma…”
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Characterization of cannibalism in early paralarvae of Patagonian red octopus, Enteroctopus megalocyathus (Gould, 1852), grown in a controlled environment by Viviana Espinoza, Ana Farías, Iker Uriarte

“…Abstract In the experimental mariculture of Patagonian red octopus, Enteroctopus megalocyathus, paralarvae rearing showed the highest mortalities. Part of this…”
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Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice by Uriarte, Iker, Fernandez-Barrena, Maite G, Monte, Maria J, Latasa, Maria U, Chang, Haisul C Y, Carotti, Simone, Vespasiani-Gentilucci, Umberto, Morini, Sergio, Vicente, Eva, Concepcion, Axel R, Medina, Juan F, Marin, José Juan G, Berasain, Carmen, Prieto, Jesus, Avila, Matías A

“…Cholestasis is associated with increased liver injury and morbidity after partial hepatectomy (PH), yet bile acids (BAs) are emerging as important mediators of…”
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Dual Targeting of G9a and DNA Methyltransferase‐1 for the Treatment of Experimental Cholangiocarcinoma by Colyn, Leticia, Bárcena‐Varela, Marina, Álvarez‐Sola, Gloria, Latasa, M. Ujue, Uriarte, Iker, Santamaría, Eva, Herranz, Jose M., Santos‐Laso, Alvaro, Arechederra, Maria, Ruiz de Gauna, Mikel, Aspichueta, Patricia, Canale, Matteo, Casadei‐Gardini, Andrea, Francesconi, Maria, Carotti, Simone, Morini, Sergio, Nelson, Leonard J., Iraburu, Maria J., Chen, Chaobo, Sangro, Bruno, Marin, Jose J.G., Martinez‐Chantar, Maria L., Banales, Jesus M., Arnes‐Benito, Robert, Huch, Meritxell, Patino, John M., Dar, Altaf A., Nosrati, Mehdi, Oyarzábal, Julen, Prósper, Felipe, Urman, Jesus, Cubero, Francisco Javier, Trautwein, Christian, Berasain, Carmen, Fernandez‐Barrena, Maite G., Avila, Matias A.

“…Background and Aims Cholangiocarcinoma (CCA) is a devastating disease often detected at advanced stages when surgery cannot be performed. Conventional and…”
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Ileal FGF15 contributes to fibrosis‐associated hepatocellular carcinoma development by Uriarte, Iker, Latasa, M. Ujue, Carotti, Simone, Fernandez‐Barrena, Maite G., Garcia‐Irigoyen, Oihane, Elizalde, Maria, Urtasun, Raquel, Vespasiani‐Gentilucci, Umberto, Morini, Sergio, Mingo, Alvaro, Mari, Montserrat, Corrales, Fernando J., Prieto, Jesus, Berasain, Carmen, Avila, Matias A.

“…Fibroblast growth factor 15 (FGF15), FGF19 in humans, is a gut‐derived hormone and a key regulator of bile acids and carbohydrate metabolism. FGF15 also…”
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A new FGF15 /19‐mediated gut‐to‐heart axis controls cardiac hypertrophy by Morón‐Ros, Samantha, Blasco‐Roset, Albert, Navarro‐Gascon, Artur, Rupérez, Celia, Zamora, Monica, Crispi, Fatima, Uriarte, Iker, Fernández‐Barrena, Maite G, Avila, Matias, Ferrer‐Curriu, Gemma, Lupón, Josep, Bayés‐Genis, Antoni, Villarroya, Francesc, Gavaldà‐Navarro, Aleix, Planavila, Anna

“…Abstract FGF15 and its human orthologue, FGF19, are members of the endocrine FGF family and are secreted by ileal enterocytes in response to bile acids…”
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New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming by Colyn, Leticia, Alvarez-Sola, Gloria, Latasa, M Ujue, Uriarte, Iker, Herranz, Jose M, Arechederra, Maria, Vlachogiannis, George, Rae, Colin, Pineda-Lucena, Antonio, Casadei-Gardini, Andrea, Pedica, Federica, Aldrighetti, Luca, López-López, Angeles, López-Gonzálvez, Angeles, Barbas, Coral, Ciordia, Sergio, Van Liempd, Sebastiaan M, Falcón-Pérez, Juan M, Urman, Jesus, Sangro, Bruno, Vicent, Silve, Iraburu, Maria J, Prosper, Felipe, Nelson, Leonard J, Banales, Jesus M, Martinez-Chantar, Maria Luz, Marin, Jose J G, Braconi, Chiara, Trautwein, Christian, Corrales, Fernando J, Cubero, F Javier, Berasain, Carmen, Fernandez-Barrena, Maite G, Avila, Matias A

“…Cholangiocarcinoma (CCA) is still a deadly tumour. Histological and molecular aspects of thioacetamide (TAA)-induced intrahepatic CCA (iCCA) in rats mimic…”
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Comprehensive analysis of epigenetic and epitranscriptomic genes’ expression in human NAFLD by Herranz, Jose M., López-Pascual, Amaya, Clavería-Cabello, Alex, Uriarte, Iker, Latasa, M. Ujúe, Irigaray-Miramon, Ainara, Adán-Villaescusa, Elena, Castelló-Uribe, Borja, Sangro, Bruno, Arechederra, María, Berasain, Carmen, Avila, Matías A., Fernández-Barrena, Maite G

“…Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition with a complex etiology. Its incidence is increasing globally in parallel with the…”
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FGF15/19 is required for adipose tissue plasticity in response to thermogenic adaptations by Morón-Ros, Samantha, Uriarte, Iker, Berasain, Carmen, Avila, Matías A., Sabater-Masdeu, Mònica, Moreno-Navarrete, José María, Fernández-Real, José Manuel, Giralt, Marta, Villarroya, Francesc, Gavaldà-Navarro, Aleix

“…To determine the role of enterokine FGF15/19 in adipose tissue thermogenic adaptations. Circulating FGF19 and gene expression (qRT-PCR) levels were assessed in…”
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Pilot Multi-Omic Analysis of Human Bile from Benign and Malignant Biliary Strictures: A Machine-Learning Approach by Urman, Jesús M., Herranz, José M., Uriarte, Iker, Rullán, María, Oyón, Daniel, González, Belén, Fernandez-Urién, Ignacio, Carrascosa, Juan, Bolado, Federico, Zabalza, Lucía, Arechederra, María, Alvarez-Sola, Gloria, Colyn, Leticia, Latasa, María U., Puchades-Carrasco, Leonor, Pineda-Lucena, Antonio, Iraburu, María J., Iruarrizaga-Lejarreta, Marta, Alonso, Cristina, Sangro, Bruno, Purroy, Ana, Gil, Isabel, Carmona, Lorena, Cubero, Francisco Javier, Martínez-Chantar, María L., Banales, Jesús M., Romero, Marta R., Macias, Rocio I.R., Monte, Maria J., Marín, Jose J. G., Vila, Juan J., Corrales, Fernando J., Berasain, Carmen, Fernández-Barrena, Maite G., Avila, Matías A.

“…Cholangiocarcinoma (CCA) and pancreatic adenocarcinoma (PDAC) may lead to the development of extrahepatic obstructive cholestasis. However, biliary stenoses…”
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DAIR (Debridement, Antibiotics and Implant Retention) less effective in hematogenous total knee arthroplasty infections by Iza, Kattalin, Foruria, Xabier, Moreta, Jesús, Uriarte, Iker, Loroño, Ane, Aguirre, Urko, de Los Mozos, José Luis Martínez

“…Debridement and irrigation with prosthetic retention followed by antibiotic therapy (DAIR) is one of the treatments of choice in acute infections after a total…”
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Fibroblast Growth Factor 15/19 in Hepatocarcinogenesis by Alvarez-Sola, Gloria, Uriarte, Iker, Latasa, M Ujue, Urtasun, Raquel, Bárcena-Varela, Marina, Elizalde, Maria, Jiménez, Maddalen, Rodriguez-Ortigosa, Carlos M, Corrales, Fernando J, Fernández-Barrena, Maite G, Berasain, Carmen, Avila, Matías A

“…Advanced hepatocellular carcinoma (HCC) is a neoplastic disease with a very bad prognosis and increasing worldwide incidence. HCCs are resistant to…”
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Regulation of amphiregulin gene expression by β-catenin signaling in human hepatocellular carcinoma cells: a novel crosstalk between FGF19 and the EGFR system by Latasa, Maria U, Salis, Fabiana, Urtasun, Raquel, Garcia-Irigoyen, Oihane, Elizalde, Maria, Uriarte, Iker, Santamaria, Monica, Feo, Francesco, Pascale, Rosa M, Prieto, Jesús, Berasain, Carmen, Avila, Matías A

“…Hepatocellular carcinoma (HCC) is the most prevalent liver tumor and a deadly disease with limited therapeutic options. Dysregulation of cell signaling…”
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A GAPDH-Mediated Trans-Nitrosylation Pathway Is Required for Feedback Inhibition of Bile Salt Synthesis in Rat Liver by Rodríguez-Ortigosa, Carlos M, Celay, Jon, Olivas, Israel, Juanarena, Nerea, Arcelus, Sara, Uriarte, Iker, Marín, José Juan G, Avila, Matias A, Medina, Juan F, Prieto, Jesus

“…Background & Aims Bile salts inhibit their own production by inducing the nuclear receptor small heterodimer partner (SHP) (encoded by NR0B2 ), which…”
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Matrix metalloproteinase-10 expression is induced during hepatic injury and plays a fundamental role in liver tissue repair by Garcia-Irigoyen, Oihane, Carotti, Simone, Latasa, Maria U., Uriarte, Iker, Fernández-Barrena, Maite G., Elizalde, Maria, Urtasun, Raquel, Vespasiani-Gentilucci, Umberto, Morini, Sergio, Banales, Jesús M., Parks, William C., Rodriguez, Jose A., Orbe, Josune, Prieto, Jesús, Páramo, Jose A., Berasain, Carmen, Ávila, Matías A.

“…Background & Aims Upon tissue injury, the liver mounts a potent reparative and regenerative response. A role for proteases, including serine and matrix…”
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Gene supplementation of CYP27A1 in the liver restores bile acid metabolism in a mouse model of cerebrotendinous xanthomatosis by Lumbreras, Sara, Ricobaraza, Ana, Baila-Rueda, Lucia, Gonzalez-Aparicio, Manuela, Mora-Jimenez, Lucia, Uriarte, Iker, Bunuales, Maria, Avila, Matias A., Monte, Maria J., Marin, Jose J.G., Cenarro, Ana, Gonzalez-Aseguinolaza, Gloria, Hernandez-Alcoceba, Ruben

“…Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive disease caused by mutations in the CYP27A1 gene, encoding the sterol 27-hydroxylase. Disruption…”
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Lack of Abcc3 expression impairs bile-acid induced liver growth and delays hepatic regeneration after partial hepatectomy in mice by Fernández-Barrena, Maite G, Monte, Maria J, Latasa, Maria U, Uriarte, Iker, Vicente, Eva, Chang, Haisul C.Y, Rodriguez-Ortigosa, Carlos M, Elferink, Ronald Oude, Berasain, Carmen, Marin, Jose J.G, Prieto, Jesus, Ávila, Matias A

“…Background & Aims Bile acids (BA) are increasingly recognized as important modulators of liver regeneration. Increased enterohepatic BA flux has been proposed…”
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Revision hip arthroplasty with a rectangular tapered cementless stem: a retrospective study of the SLR-Plus stem at a mean follow-up of 4.1 years by Uriarte, Iker, Moreta, Jesús, Cortés, Laura, Bernuy, Lucía, Aguirre, Urko, Martínez de los Mozos, José Luis

“…Purpose Demand for revision total hip arthroplasty (THA) is growing, and this type of surgery remains challenging for orthopedic surgeons. Our objectives were…”
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Medium-term outcomes of the S-ROM modular femoral stem in revision hip replacement by Moreta, Jesús, Uriarte, Iker, Foruria, Xabier, Loroño, Ane, Agirre, Urko, Jáuregui, Iñaki, Martínez-de los Mozos, José Luis

“…Introduction The objective of this study was to analyse results achieved with the S-ROM modular stem in revision surgery. Materials and methods A retrospective…”
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