Search Results - "URFER, Roman"
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Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor
Published in Synapse (New York, N.Y.) (01-07-2012)“…The sigma‐1 receptor (Sig‐1R) is a novel endoplasmic reticulum (ER) molecular chaperone that regulates protein folding and degradation. The Sig‐1R activation…”
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Phase II Trial of the Sigma-1 Receptor Agonist Cutamesine (SA4503) for Recovery Enhancement After Acute Ischemic Stroke
Published in Stroke (1970) (01-11-2014)“…The σ-1 receptor (Sig-1R) agonist cutamesine (SA4503) enhanced functional recovery after experimental stroke with a treatment initiation window of 48 hours and…”
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3
The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke
Published in Brain (London, England : 1878) (01-03-2011)“…Stroke leads to brain damage with subsequent slow and incomplete recovery of lost brain functions. Enriched housing of stroke-injured rats provides multi-modal…”
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4
Death-associated Protein Kinase Is Activated by Dephosphorylation in Response to Cerebral Ischemia
Published in The Journal of biological chemistry (23-12-2005)“…Death-associated protein kinase (DAPK) is a calcium calmodulin-regulated serine/threonine protein kinase involved in ischemic neuronal death. In situ…”
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5
GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion
Published in Oncogene (03-03-2005)“…GPR56 (also known as TM7XN1) is a newly discovered orphan G-protein-coupled receptor (GPCR) of the secretin family that has a role in the development of neural…”
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6
Regulation of NMDA receptor trafficking and function by striatal-enriched tyrosine phosphatase (STEP)
Published in The European journal of neuroscience (01-06-2006)“…Regulation of N‐methyl‐d‐aspartate (NMDA) receptors is critical for the normal functioning of the central nervous system. There must be precise mechanisms to…”
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A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke
Published in PloS one (18-07-2013)“…With the availability and ease of small molecule production and design continuing to improve, robust, high-throughput methods for screening are increasingly…”
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8
Npas4, a novel helix-loop-helix PAS domain protein, is regulated in response to cerebral ischemia
Published in The European journal of neuroscience (01-11-2006)“…Basic helix–loop–helix PAS domain proteins form a growing family of transcription factors. These proteins are involved in the process of adaptation to cellular…”
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9
Serum Amyloid A (apoSAA) Expression Is Up-Regulated in Rheumatoid Arthritis and Induces Transcription of Matrix Metalloproteinases
Published in The Journal of immunology (1950) (15-02-2001)“…The acute-phase reactant rabbit serum amyloid A 3 (SAA3) was identified as the major difference product in Ag-induced arthritis in the rabbit, a model…”
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10
Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia
Published in The European journal of neuroscience (01-05-2008)“…Striatal enriched protein tyrosine phosphatase (STEP) acts in the central nervous system to dephosphorylate a number of important proteins involved in synaptic…”
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11
The Viral CC Chemokine-binding Protein vCCI Inhibits Monocyte Chemoattractant Protein-1 Activity by Masking Its CCR2B-binding Site
Published in The Journal of biological chemistry (16-11-2001)“…Monocyte chemoattractant protein-1 (MCP-1) is a chemotactic cytokine mainly acting on monocytes and T cells that elicits its biological effects by interacting…”
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12
A high-throughput turbidometric assay for screening inhibitors of protein disulfide isomerase activity
Published in Journal of biomolecular screening (01-10-2004)“…Protein disulfide isomerase (PDI) plays a key role in protein folding by catalyzing rearrangements of disulfide bonds in substrate proteins following their…”
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13
High Resolution Mapping of the Binding Site of TrkA for Nerve Growth Factor and TrkC for Neurotrophin-3 on the Second Immunoglobulin-like Domain of the Trk Receptors
Published in The Journal of biological chemistry (06-03-1998)“…Neurotrophic factors are important for survival and maintenance of neurons during developmental and adult stages of the vertebrate nervous system. The…”
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14
Identification of a Nuclear Respiratory Factor 1 Recognition Motif in the Apolipoprotein E Variant APOE4 linked to Alzheimer’s Disease
Published in Scientific reports (17-01-2017)“…Alzheimer’s disease affects tens of millions of people worldwide and its prevalence continues to rise. It is caused by a combination of a subject’s heredity,…”
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15
Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2
Published in Journal of neuro-oncology (01-02-2006)“…Invasion of glioma cells involves the attachment of invading tumor cells to extracellular matrix (ECM), disruption of ECM components, and subsequent cell…”
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Identification of Cathepsin B as a Mediator of Neuronal Death Induced by Aβ-activated Microglial Cells Using a Functional Genomics Approach
Published in The Journal of biological chemistry (13-02-2004)“…Alzheimer's disease is a progressive neurodegenerative disease characterized by senile plaques, neurofibrillary tangles, dystrophic neurites, and reactive…”
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Targeting of the receptor protein tyrosine phosphatase β with a monoclonal antibody delays tumor growth in a glioblastoma model
Published in Cancer research (Chicago, Ill.) (15-02-2006)“…The receptor protein tyrosine phosphatase beta (RPTPbeta) is a functional biomarker for several solid tumor types. RPTPbeta expression is largely restricted to…”
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18
FAS associated phosphatase (FAP-1) blocks apoptosis of astrocytomas through dephosphorylation of FAS
Published in Journal of neuro-oncology (01-09-2005)“…Astrocytomas are the most common primary tumor of the adult human central nervous system. Despite efforts to develop more effective clinical treatment…”
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19
The importance of surface loops for stabilizing an eightfold βα barrel protein
Published in Protein science (01-01-1992)“…An important step in understanding how a protein folds is to determine those regions of the sequence that are critical to both its stability and its folding…”
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A Pharmacological Screening Approach for Discovery of Neuroprotective Compounds in Ischemic Stroke. e69233
Published in PloS one (01-07-2013)“…With the availability and ease of small molecule production and design continuing to improve, robust, high-throughput methods for screening are increasingly…”
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