Search Results - "URBAN, G. J"

ISSLS PRIZE in Clinical Science 2023: comparison of degenerative MRI features of the intervertebral disc between those with and without chronic low back pain. An exploratory study of two large female populations using automated annotation by Jamaludin, A., Kadir, T., Zisserman, A., McCall, I., Williams, F. M. K., Lang, H., Buchanan, E., Urban, J. P. G., Fairbank, J. C. T.

“…Objectives The relationship of degeneration to symptoms has been questioned. MRI detects apparently similar disc degeneration and degenerative changes in…”
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Analysis of cell viability in intervertebral disc: Effect of endplate permeability on cell population by Shirazi-Adl, A, Taheri, M, Urban, J.P.G

“…Abstract Responsible for making and maintaining the extracellular matrix, the cells of intervertebral discs are supplied with essential nutrients by diffusion…”
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Effect of nutrient deprivation on the viability of intervertebral disc cells by Bibby, S R S, Urban, J P G

“…There is evidence that a fall in nutrient supply leads to disc degeneration but little understanding of the effects of nutrient deprivation on the physiology…”
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Disc size markedly influences concentration profiles of intravenously administered solutes in the intervertebral disc: a computational study on glucosamine as a model solute by Motaghinasab, S., Shirazi-Adl, A., Parnianpour, M., Urban, J. P. G.

“…Purpose Tests on animals of different species with large differences in intervertebral disc size are commonly used to investigate the therapeutic efficacy of…”
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Computational pharmacokinetics of solute penetration into human intervertebral discs—Effects of endplate permeability, solute molecular weight and disc size by Motaghinasab, S, Shirazi-Adl, A, Urban, J.P.G, Parnianpour, M

“…Abstract A finite element model is developed to predict the penetration time-history of three different solutes into the human lumbar disc following…”
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Investigation of solute concentrations in a 3D model of intervertebral disc by Mokhbi Soukane, D., Shirazi-Adl, A., Urban, J. P. G.

“…As the disc is the largest avascular structure in the body, disc cells depend for their normal function on an adequate supply of nutrients (oxygen and glucose)…”
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Divalproex in the Long-term Treatment of Chronic Daily Headache by Freitag, Frederick G., Diamond, Seymour, Diamond, Merle L., Urban, George J.

“…Objective.—The purpose of this study was to assess the safety and efficacy of divalproex sodium in the long‐term treatment of chronic daily headache…”
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Serotonin syndrome induced by transitioning from phenelzine to venlafaxine : Four patient reports by DIAMOND, S, PEPPER, B. J, DIAMOND, M. L, FREITAG, F. G, URBAN, G. J, ERDEMOGLU, A. K

“…With the use of the newer antidepressants beyond the traditional tricyclics and monoamine oxidase inhibitors, newer options in headache prophylaxis are…”
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Delivering Focused Ultrasound to Intervertebral Discs Using Time-Reversal by Qiao, S., Elbes, D., Boubriak, O., Urban, J.P.G, Coussios, C-C., Cleveland, R.O.

“…Chronic low back pain causes more disability worldwide than any other condition and is thought to arise in part through loss of biomechanical function of…”
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Injectable hydrogels with high fixed charge density and swelling pressure for nucleus pulposus repair: Biomimetic glycosaminoglycan analogues by Sivan, S.S., Roberts, S., Urban, J.P.G., Menage, J., Bramhill, J., Campbell, D., Franklin, V.J., Lydon, F., Merkher, Y., Maroudas, A., Tighe, B.J.

“…The load-bearing biomechanical role of the intervertebral disc is governed by the composition and organization of its major macromolecular components, collagen…”
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The role of the physicochemical environment in determining disc cell behaviour by Urban, J P G

“…The cells of the intervertebral disc exist in an unusual environment. They are embedded in a dense matrix containing a high concentration of aggrecan whose…”
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Regulation of matrix synthesis rates by the ionic and osmotic environment of articular chondrocytes by Urban, J P, Hall, A C, Gehl, K A

“…Chondrocytes in cartilage are embedded in a matrix containing a high concentration of proteoglycans and hence of fixed negative charges. Their extracellular…”
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Influence of extracellular osmolarity and mechanical stimulation on gene expression of intervertebral disc cells by Wuertz, K., Urban, J.P.G., Klasen, J., Ignatius, A., Wilke, H.-J., Claes, L., Neidlinger-Wilke, C.

“…Intervertebral discs (IVD) have a higher extracellular osmolarity than most other tissues; moreover their osmolarity changes by around 25% during each diurnal…”
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Computation of coupled diffusion of oxygen, glucose and lactic acid in an intervertebral disc by Mokhbi Soukane, D, Shirazi-Adl, A, Urban, J.P.G

“…Abstract The present numerical study aims to investigate the disc nutrition and factors affecting it by evaluating the concentrations of oxygen, glucose and…”
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The effects of hydrostatic pressure on matrix synthesis in articular cartilage by Hall, A C, Urban, J P, Gehl, K A

“…The direct effects of hydrostatic pressure on matrix synthesis in articular cartilage can be studied independently of the other factors that change during…”
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Osmolarity effects on bovine articular chondrocytes during three-dimensional culture in alginate beads by Xu, X, Urban, J.P.G, Tirlapur, U.K, Cui, Z

“…Summary Objective With the development of engineered cartilage, the determination of the appropriate culture conditions is vital in order to maximize…”
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The effect of hip resurfacing on oxygen concentration in the femoral head by STEFFEN, R. T, SMITH, S. R, URBAN, J. P. G, MCLARDY-SMITH, P, BEARD, D. J, GILL, H. S, MURRAY, D. W

“…We inserted an electrode up the femoral neck into the femoral head of ten patients undergoing a metal-on-metal hip resurfacing arthroplasty through a posterior…”
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In vivo measurement of tissue metabolism in tendons of the rotator cuff : Implications for surgical management by MATTHEWS, T. J. W, SMITH, S. R, PEACH, C. A, REES, J. L, URBAN, J. P. G, CARR, A. J

“…We have undertaken an in vivo assessment of the tissue metabolism and cellular activity in torn tendons of the rotator cuff. Cellular oxygen consumption was…”
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Application of multiple parallel perfused microbioreactors and three-dimensional stem cell culture for toxicity testing by Cui, Z.F., Xu, X., Trainor, N., Triffitt, J.T., Urban, J.P.G., Tirlapur, U.K.

“…In this study, a multiple parallel perfused microbioreactor platform, TissueFlex ®, was developed which can be used to perform cell and tissue culture under…”
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Analysis of nonlinear coupled diffusion of oxygen and lactic acid in intervertebral discs by Soukane, D Mokhbi, Shirazi-Adl, A, Urban, J P G

“…The transport of oxygen and lactate (i.e., lactic acid) in the human intervertebral disc was investigated accounting for the measured coupling between species…”
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