Search Results - "UPTON, P. B"

Quantification of DNA and hemoglobin adducts of 3,4-epoxy-1,2-butanediol in rodents exposed to 3-butene-1,2-diol by Powley, M.W., Li, Y., Upton, P.B., Walker, V.E., Swenberg, J.A.

“…1,3-Butadiene (BD) is a confirmed rodent carcinogen and a suspect human carcinogen that forms mutagenic epoxide metabolites during biotransformation. Species…”
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Highly sensitive apurinic/apyrimidinic site assay can detect spontaneous and chemically induced depurination under physiological conditions by NAKAMURA, J, WALKER, V. E, UPTON, P. B, CHIANG, S.-Y, KOW, Y. W, SWENBERG, J. A

“…One of the most prevalent lesions in DNA is the apurinic/apyrimidinic (AP) site, which is derived from the cleavage of the N-glycosyl bond by DNA glycosylase…”
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Identification and quantitation of DNA adducts from calf thymus DNA exposed to 3,4-epoxy-1-butene by TRETYAKOVA, N, LIN, Y.-P, SANGAIAH, R, UPTON, P. B, SWENBERG, J. A

“…3,4-Epoxy-1-butene (EB) is the major mutagenic metabolite of butadiene (BD), an important industrial chemical classified as a probable human carcinogen…”
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Formation of Quinonoid-Derived Protein Adducts in the Liver and Brain of Sprague-Dawley Rats Treated with 2,2‘,5,5‘-Tetrachlorobiphenyl by Lin, Po-Hsiung, Sangaiah, Ramiah, Ranasinghe, Asoka, Upton, Patricia B, La, David K, Gold, Avram, Swenberg, James A

“…A possible role for metabolic activation of 2,2‘,5,5‘-tetrachlorobiphenyl (TCB) to quinonoid metabolites was investigated in vitro in rat liver microsomes and…”
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DNA adducts: effects of low exposure to ethylene oxide, vinyl chloride and butadiene by Swenberg, James A, Ham, Amy, Koc, Hasan, Morinello, Eric, Ranasinghe, Asoka, Tretyakova, Natalia, Upton, Patricia B, Wu, Kuen-Yuh

“…Dose–response relationships of genotoxic agents differ greatly depending on the agent and the endpoint being evaluated. Simple conclusions that genotoxic…”
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Molecular dosimetry of endogenous and ethylene oxide-induced N7-(2-hydroxyethyl) guanine formation in tissues of rodents by Wu, Kuen-Yuh, Ranasinghe, Asoka, Upton, Patricia B., Walker, Vernon E., Swenberg, James A.

“…The formation of N7-(2-hydroxyethyl)guanine (7-HEG) in DNA was investigated previously in target and non-target tissues of F-344 rats and B6C3F1 mice exposed…”
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Molecular dosimetry of ethylene oxide : formation and persistence of 7-(2-hydroxyethyl)guanine in DNA following repeated exposures of rats and mice by WALKER, V. E, FENNELL, T. R, UPTON, P. B, SKOPEK, T. R, RPEVOST, V, SHUKER, D. E. G, SWENBERG, J. A

“…The formation of 7-(2-hydroxyethyl)guanine (7-HEG) in DNA of target and nontarget tissues was investigated in male B6C3F1 mice (20/group) and F344 rats…”
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Formation and repair of DNA adducts in vinyl chloride- and vinyl fluoride-induced carcinogenesis by Swenberg, J A, Bogdanffy, M S, Ham, A, Holt, S, Kim, A, Morinello, E J, Ranasinghe, A, Scheller, N, Upton, P B

“…Vinyl chloride is a known human and animal carcinogen that induces angiosarcomas of the liver. We review here studies on the formation and repair of DNA…”
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Molecular Dosimetry of DNA and Hemoglobin Adducts in Mice and Rats Exposed to Ethylene Oxide by Walker, Vernon E., Fennell, Timothy R., Upton, Patricia B., MacNeela, John P., Swenberg, James A.

“…Experiments involving ethylene oxide (ETO) have been used to support the concept of using adducts in hemoglobin as a surrogate for DNA adducts in target…”
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Evaluation of Effects from Repeated Inhalation Exposure of F344 Rats to High Concentrations of Propylene by Pottenger, Lynn H., Malley, Linda A., Bogdanffy, Matthew S., Donner, E. Maria, Upton, Patricia B., Li, Yutai, Walker, Vernon E., Harkema, Jack R., Banton, Marcy I., Swenberg, James A.

“…Chronic exposure to propylene does not result in any increased incidence of tumors, yet does increase N7-hydroxypropylguanine (N7-HPGua) adducts in tissue DNA…”
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Effects of ethylene oxide and ethylene inhalation on DNA adducts, apurinic/apyrimidinic sites and expression of base excision DNA repair genes in rat brain, spleen, and liver by Rusyn, Ivan, Asakura, Shoji, Li, Yutai, Kosyk, Oksana, Koc, Hasan, Nakamura, Jun, Upton, Patricia B., Swenberg, James A.

“…Ethylene oxide (EO) is an important industrial chemical that is classified as a known human carcinogen (IARC, Group 1). It is also a metabolite of ethylene…”
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Analysis of DNA adducts in rats exposed to pentachlorophenol by Lin, Po-Hsiung, La, David K., Upton, Patricia B., Swenberg, James A.

“…Pentachlorophenol (PCP) is a widely used biocide that has been reported to be hepatocarcinogenic in mice. Its effects in rats are equivocal, but the liver…”
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Endogenous versus exogenous DNA adducts: their role in carcinogenesis, epidemiology, and risk assessment by Swenberg, James A, Lu, Kun, Moeller, Benjamin C, Gao, Lina, Upton, Patricia B, Nakamura, Jun, Starr, Thomas B

“…There is a strong need for science-based risk assessment that utilizes known data from diverse sources to arrive at accurate assessments of human health risk…”
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Oxidative damage and direct adducts in calf thymus DNA induced by the pentachlorophenol metabolites, tetrachlorohydroquinone and tetrachloro-1,4-benzoquinone by Lin, Po-Hsiung, Nakamura, Jun, Yamaguchi, Shuji, Upton, Patricia B., La, David K., Swenberg, James A.

“…DNA damage induced by quinoid metabolites of pentachlorophenol (PCP), i.e. tetrachloro-1,4-benzoquinone (Cl4BQ) and tetrachlorohydroquinone (Cl4HQ), was…”
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Using DNA and hemoglobin adducts to improve the risk assessment of butadiene by Swenberg, James A, Koc, Hasan, Upton, Patricia B, Georguieva, Nadia, Ranasinghe, Asoka, Walker, Vernon E, Henderson, Rogene

“…The purpose of this paper is to review what we know about various biomarkers of butadiene in animal, human and in vitro studies, and to draw inferences from…”
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Biomarkers of exposure and effect as indicators of potential carcinogenic risk arising from in vivo metabolism of ethylene to ethylene oxide by Walker, Vernon E., Wu, Kuen-Yuh, Upton, Patricia B., Ranasinghe, Asoka, Scheller, Nova, Cho, Myung-Haeng, Vergnes, Jane S., Skopek, Thomas R., Swenberg, James A.

“…The purposes of the present study were: (i) to investigate the potential use of several biomarkers as quantitative indicators of the in vivo conversion of…”
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Expression of base excision repair enzymes in rat and mouse liver is induced by peroxisome proliferators and is dependent upon carcinogenic potency by Rusyn, Ivan, Denissenko, Mikhail F., Wong, Victoria A., Butterworth, Byron E., Cunningham, Michael L., Upton, Patricia B., Thurman, Ronald G., Swenberg, James A.

“…Elevated and sustained cell replication, together with a decrease in apoptosis, is considered to be the main mechanism of hepatic tumor promotion due to…”
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Deficiency of N-methylpurine-DNA-glycosylase expression in nonparenchymal cells, the target cell for vinyl chloride and vinyl fluoride by Holt, S, Roy, G, Mitra, S, Upton, P.B, Bogdanffy, M.S, Swenberg, J.A

“…The ability to repair promutagenic damage resulting from exposure to carcinogens is a critical factor in determining quantitative relationships in…”
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1,3-butadiene: cancer, mutations, and adducts. Part V: Hemoglobin adducts as biomarkers of 1,3-butadiene exposure and metabolism by Swenberg, J A, Christova-Gueorguieva, N I, Upton, P B, Ranasinghe, A, Scheller, N, Wu, K Y, Yen, T Y, Hayes, R

“…1,3-Butadiene (BD) is an important chemical used largely in the manufacture of synthetic rubber and thermoplastic resins. In addition, it has been identified…”
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Macromolecular adducts of butadiene by Tretyakova, Natalia Yu, Lin, Yu-pang, Upton, Patricia B., Sangaiah, Ramiah, Swenberg, James A.

“…Butadiene (BD) is an important industrial chemical classified as a probable human carcinogen. Marked species differences in susceptibility to the carcinogenic…”
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