Search Results - "UPRICHARD, J."

Ongoing risk of thrombosis with factor XI concentrate: 5 years experience in two centres by Batty, P., Honke, A., Bowles, L., Hart, D. P., Pasi, K. J., Uprichard, J., Austin, S. K.

“…Introduction Factor XI (FXI) deficiency is the commonest of the rare bleeding disorders, affecting 2079 individuals in the United Kingdom. Treatment options…”
Get full text

Emergency preparedness, resilience and response guidance for UK hospital transfusion teams by Doughty, Heidi, Chowdhury, Fateha, Ameh, V, Batrick, N, Baxter, L, Bolton–Maggs, P, Cowdrey, T, Glasgow, S, Jackson, A, Robinson, S, Smith, M, Staves, J, Sorour, Y, Pendry, K, Uprichard, J, Weaver, A, Wilkes, C, Allard, S, Murphy, M, Kendrick, C., Doughty, H, Earley, J, Frith, L

“…Objectives To present Emergency Preparedness, Resilience and Response (EPRR) guidance for Hospital Transfusion Teams on behalf of the National Blood…”
Get full text

The impact of providing blood to the scene of an accident on transfusion laboratory practice by Wolf, S., Morris, J., Kennedy, K., Lawn, M., Mcloughlin, T., Feane, K., Uprichard, J., Weaver, A., Allard, S., Green, L.

“…SUMMARY Background Haemorrhage is the leading cause of mortality during trauma. In 2012, London's Air Ambulance introduced Blood on Board (BOB), transfusing…”
Get full text

Factor IX replacement to cover total knee replacement surgery in haemophilia B: a single-centre experience, 2000-2010 by UPRICHARD, J., ADAMIDOU, D., GODDARD, N. J., MANN, H. A., YEE, T. T.

“…Total knee replacement (TKR) is a well recognized treatment for haemophilic arthropathy. Successful haemostasis can be achieved by bolus doses or continuous…”
Get full text

Use of thromboelastography to assess the combined role of pregnancy and obesity on coagulation: a prospective study by Sharma, S, Uprichard, J, Moretti, A, Boyce, H, Szydlo, R, Stocks, G

“…Abstract Background Thromboelastography (TEG®) is a point of care monitor of whole blood coagulation and has previously demonstrated hypercoagulability in both…”
Get full text

Lower Uterine Segment Placental Thickness in Women With Abnormally Invasive Placenta by Bhide, A, Laoreti, A, Agten, A.K, Papageorghiou, A, Khalil, A, Uprichard, J, Thilaganathan, B, Chandraharan, E

“…(Acta Obstet Gynecol Scand. 2019;98:95–100)Although uncommon, abnormally invasive placentation (AIP) is associated with adverse maternal outcomes, including…”
Get full text

Haemopoietic stem cell transplantation induces tolerance to donor antigens but not to foreign FVIII peptides by UPRICHARD, J., DAZZI, F., APPERLEY, J. F., LAFFAN, M. A.

“…A 22‐year‐old male with severe haemophilia A and high responding factor VIII (FVIII) inhibitor underwent sibling haematopoietic stem cell transplantation in an…”
Get full text

British Society of Haematology, Slide Session presented at the Annual Scientific Meeting, Brighton 2009 by McLORNAN, D. P., BURTHEM, J., DUNCOMBE, A., HATTON, C., HUTCHINSON, C. V., MARSDEN, K., MACARTNEY, C. M., SMITH-STRANEY, T., UPRICHARD, J., WALLIS, J., WEBB, S., WILKINS, B. S., McMULLIN, M. F.

“…Summary Seven cases were discussed by an expert panel at the 2009 Annual Scientific Meeting of the British Society of Haematology. These cases are presented in…”
Get full text

The Lipgene Food-Exchange Model: a tool to enable investigation of four diets distinct in fatty acid composition by Shaw, DI, Tierney, AC, McCarthy, S, Uprichard, J, Vermunt, S, Roche, HM, Lovegrove, JA

Get full text

Factor X Leicester: Ile411Phe associated with a low antigen level and a disproportionately low functional activity of factor X by Deam, S., Uprichard, J., Eaton, J. T., Perkins, S. J., Dolan, G.

Get full text

Investigating microcytic anaemia by Uprichard, W Owen, Uprichard, James

“…This article explores how to assess the common causes of microcytic anaemia…”
Get full text

Phase I Trial of PT-100 (PT-100), A Cytokine-Inducing Small Molecule, Following Chemotherapy for Solid Tumor Malignancy by Nemunaitis, John, Vukelja, Svetislava J., Richards, Donald, Cunningham, Casey, Senzer, Neil, Nugent, John, Duncan, Houston, Jones, Barry, Haltom, Eric, Uprichard, Margaret J.

“…PT-100 upregulates cytokine expression competitively inhibiting the dipeptidyl peptidase activity of fibroblast activation protein (FAP) and dipeptidyl…”
Get full text

Factor X deficiency by Uprichard, James, Perry, David J.

“…Factor X is one of the vitamin K-dependent serine proteases. It plays a crucial role in the coagulation cascade, as the first enzyme in the common pathway of…”
Get full text

Gene mutations and three‐dimensional structural analysis in 13 families with severe factor X deficiency by Peyvandi, Flora, Menegatti, Marzia, Santagostino, Elena, Akhavan, Sepideh, Uprichard, James, Perry, David J., Perkins, Stephen J., Mannucci, Pier M.

“…Factor X (FX) deficiency is a rare autosomal recessive disorder. The phenotype and genotype of 15 Iranian patients with FX deficiency from 13 unrelated…”
Get full text

Clarification of possible anemia by Uprichard, J, Bain, B J

Get more information

Investigating suspected anaemia by Uprichard, James, Bain, Barbara J

“…Often a blood count only is not sufficient for prompt diagnosis of suspected anaemia. This article details the additional tests that should be performed…”
Get full text

Two new factor X mutations (Pro382Leu and Phe356Cys) associated with low activity and low antigen levels by Deam, Susan, Uprichard, James, Eaton, Julian T, Perkins, Stephen J, Dasani, Hasmukh, Hanley, John, Dolan, Gerard

Get more information

Hepatitis C virus cures after direct acting antiviral-related drug-induced liver injury: Case report by Hasin, Yaakov, Shteingart, Shimon, Dahari, Harel, Gafanovich, Inna, Floru, Sharon, Braun, Marius, Shlomai, Amir, Verstandig, Anthony, Dery, Ilana, Uprichard, Susan L, Cotler, Scott J, Lurie, Yoav

“…The United States Food and Drug Administration recently warned that the direct acting antiviral(DAA) combination hepatitis C virus(HCV) treatment of…”
Get full text

Phase 1 Rising Multiple-Dose Study of Talabostat (PT-100) in Healthy Subjects by Uprichard, Margaret J., Jones, Barry

“…Background: Talabostat (PT-100) is an orally available small molecule that competitively inhibits dipeptidyl peptidases such as DPP-IV/CD26 and fibroblast…”
Get full text

Phase 2 study of talabostat/gemcitabine in Stage IV pancreatic cancer by Nugent, F. W., Cunningham, C., Barve, M. A., Fisher, W., Patel, H., Meiri, E., Oza, Y. V., Yang, Z., Jurkowski, E. C., Uprichard, M. J.

“…Abstract only 4616 Background: Talabostat is an oral small molecule inhibitor of fibroblast activation protein (FAP), a stromal enzyme with collagenase and…”
Get full text