Search Results - "UPPAL, Hirdesh"

Enzalutamide for the Treatment of Androgen Receptor-Expressing Triple-Negative Breast Cancer by Traina, Tiffany A, Miller, Kathy, Yardley, Denise A, Eakle, Janice, Schwartzberg, Lee S, O'Shaughnessy, Joyce, Gradishar, William, Schmid, Peter, Winer, Eric, Kelly, Catherine, Nanda, Rita, Gucalp, Ayca, Awada, Ahmad, Garcia-Estevez, Laura, Trudeau, Maureen E, Steinberg, Joyce, Uppal, Hirdesh, Tudor, Iulia Cristina, Peterson, Amy, Cortes, Javier

“…Purpose Studies suggest that a subset of patients with triple-negative breast cancer (TNBC) have tumors that express the androgen receptor (AR) and may benefit…”
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Direct reprogramming of human fibroblasts to hepatocyte-like cells by synthetic modified mRNAs by Simeonov, Kamen P, Uppal, Hirdesh

“…Direct reprogramming by overexpression of defined transcription factors is a promising new method of deriving useful but rare cell types from readily available…”
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Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer by Lin, WeiYu, Xu, Daqi, Austin, Cary D, Caplazi, Patrick, Senger, Kate, Sun, Yonglian, Jeet, Surinder, Young, Judy, Delarosa, Donnie, Suto, Eric, Huang, Zhiyu, Zhang, Juan, Yan, Donghong, Corzo, Cesar, Barck, Kai, Rajan, Sharmila, Looney, Carrie, Gandham, Vineela, Lesch, Justin, Liang, Wei-Ching, Mai, Elaine, Ngu, Hai, Ratti, Navneet, Chen, Yongmei, Misner, Dinah, Lin, Tori, Danilenko, Dimitry, Katavolos, Paula, Doudemont, Estelle, Uppal, Hirdesh, Eastham, Jeffrey, Mak, Judy, de Almeida, Patricia E, Bao, Katherine, Hadadianpour, Azadeh, Keir, Mary, Carano, Richard A D, Diehl, Lauri, Xu, Min, Wu, Yan, Weimer, Robby M, DeVoss, Jason, Lee, Wyne P, Balazs, Mercedesz, Walsh, Kevin, Alatsis, Kathila R, Martin, Flavius, Zarrin, Ali A

“…Colony-stimulating factor 1 (CSF1) and interleukin 34 (IL34) signal the CSF1 receptor to regulate macrophage differentiation. Studies in IL34- or…”
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A Novel Pregnane X Receptor-mediated and Sterol Regulatory Element-binding Protein-independent Lipogenic Pathway by Zhou, Jie, Zhai, Yonggong, Mu, Ying, Gong, Haibiao, Uppal, Hirdesh, Toma, David, Ren, Songrong, Evans, Ronald M., Xie, Wen

“…The pregnane X receptor (PXR) was isolated as a xenosensor regulating xenobiotic responses. In this study, we show that PXR plays an endobiotic role by…”
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736 A phase 1/2 open-label, dose-escalation study of ST-067, a decoy-resistant IL-18 cytokine, given as a monotherapy and with pembrolizumab in advanced solid tumor malignancies by Moser, Justin C, Sullivan, Ryan, Taylor, Matthew H, Puzanov, Igor, Falchook, Gerald S, Sznol, Mario, Paton, Virginia E, Chonzi, David, Garofalo, Brage, Sonnemann, Mark, Uppal, Hirdesh, Barton, Jeremy, McQueen, Beatrice Y, Ring, Aaron M, Kluger, Harriet

“…BackgroundIL-18 is an inflammatory cytokine with immuno-stimulatory activities on both the innate and adaptive immune systems. However, tumors generate an…”
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Estrogen Deprivation and Inhibition of Breast Cancer Growth in Vivo through Activation of the Orphan Nuclear Receptor Liver X Receptor by Gong, Haibiao, Guo, Ping, Zhai, Yonggong, Zhou, Jie, Uppal, Hirdesh, Jarzynka, Michael J, Song, Wen-Chao, Cheng, Shi-Yuan, Xie, Wen

“…Estrogen plays an important role in normal physiology. It is also a risk factor for breast cancer, and antiestrogen therapies have been shown to be effective…”
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Activation of LXRs prevents bile acid toxicity and cholestasis in female mice by Uppal, Hirdesh, Saini, Simrat P.S., Moschetta, Antonio, Mu, Ying, Zhou, Jie, Gong, Haibiao, Zhai, Yonggong, Ren, Songrong, Michalopoulos, George K., Mangelsdorf, David J., Xie, Wen

“…Liver X receptors (LXRs) have been identified as sterol sensors that regulate cholesterol and lipid homeostasis and macrophage functions. In this study, we…”
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Activation of liver X receptor sensitizes mice to gallbladder cholesterol crystallization by Uppal, Hirdesh, Zhai, Yonggong, Gangopadhyay, Archana, Khadem, Shaheen, Ren, Songrong, Moser, James A., Xie, Wen

“…Gallstone disease is a hepatobiliary disorder due to biochemical imbalances in the gallbladder bile. In this report, we show that activation of nuclear…”
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A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification by Saini, Simrat P S, Sonoda, Junichiro, Xu, Li, Toma, David, Uppal, Hirdesh, Mu, Ying, Ren, Songrong, Moore, David D, Evans, Ronald M, Xie, Wen

“…Cytosolic sulfotransferase (SULT)-mediated sulfation plays an essential role in the detoxification of bile acids and is necessary to avoid pathological…”
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Identification of a kinase profile that predicts chromosome damage induced by small molecule kinase inhibitors by Olaharski, Andrew J, Gonzaludo, Nina, Bitter, Hans, Goldstein, David, Kirchner, Stephan, Uppal, Hirdesh, Kolaja, Kyle

“…Kinases are heavily pursued pharmaceutical targets because of their mechanistic role in many diseases. Small molecule kinase inhibitors (SMKIs) are a compound…”
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Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice by Saini, Simrat P.S., Zhang, Bin, Niu, Yongdong, Jiang, Mengxi, Gao, Jie, Zhai, Yonggong, Hoon Lee, Jung, Uppal, Hirdesh, Tian, Hui, Tortorici, Michael A., Poloyac, Samuel M., Qin, Wenxin, Venkataramanan, Raman, Xie, Wen

“…Overdose of acetaminophen (APAP), the active ingredient of Tylenol, is the leading cause of drug‐induced acute liver failure in the United States. As such, it…”
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Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice by UPPAL, Hirdesh, TOMA, David, SAINI, Simrat P. S, SONGRONG REN, JONES, Thomas J, WEN XIE

“…Efficient detoxification of bile acids is necessary to avoid pathological conditions such as cholestatic liver damage and colon cancer. The orphan nuclear…”
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Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism by Xie, Wen, Uppal, Hirdesh, Saini, Simrat P.S, Mu, Ying, Little, Joanna M, Radominska-Pandya, Anna, Zemaitis, Michael A

“…The regulation of drug-metabolizing enzymes and transporters has an important role in drug metabolism and many human diseases. The genes that encode these…”
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Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice by SAINI, Simrat P. S, YING MU, HAIBIAO GONG, TOMA, David, UPPAL, Hirdesh, SONGRONG REN, SONG LI, POLOYAC, Samuel M, WEN XIE

“…The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are implicated in xenobiotic and endobiotic detoxification, including the…”
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Mechanism of subendocardial cell proliferation in the rat and relevance for understanding drug-induced valvular heart disease in humans by Fielden, Mark R., Hassani, Mary, Uppal, Hirdesh, Day-Lollini, Patricia, Button, Donald, Martin, Renee S., Garrido, Rosario, Liu, Xingrong, Kolaja, Kyle L.

“…A number of drugs and drug candidates, including fenfluramine and ergot derivatives, are associated with valvulopathy in humans; however, these responses are…”
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Harnessing Stem Cells for Predictive Toxicology: Meeting the Challenges of Drug Discovery Today by Uppal, Hirdesh, Roquemore, Liz

“…Abstract only The core techniques used in toxicology studies have remained largely unchanged for over 40 years. It is acknowledged in the pharmaceutical…”
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Abstract 4073: Decoy-resistant IL-18 enhances checkpoint inhibitor combinations beyond anti-PD-1 in vitro and in vivo by Lindquist, Jeffrey N., Qin, Kai, Ring, Aaron M., Uppal, Hirdesh

“…Background: Interleukin-18 (IL18) is a proinflammatory cytokine that modulates both innate and adaptive immune responses. Historically, wild-type recombinant…”
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Potential mechanisms for thrombocytopenia development with trastuzumab emtansine (T-DM1) by Uppal, Hirdesh, Doudement, Estelle, Mahapatra, Kaushiki, Darbonne, Walter C, Bumbaca, Daniela, Shen, Ben-Quan, Du, Xiaoyan, Saad, Ola, Bowles, Kristin, Olsen, Steve, Lewis Phillips, Gail D, Hartley, Dylan, Sliwkowski, Mark X, Girish, Sandhya, Dambach, Donna, Ramakrishnan, Vanitha

“…Trastuzumab-emtansine (T-DM1) is an antibody-drug conjugate (ADC) comprising the cytotoxic agent DM1 conjugated to trastuzumab with a stable linker…”
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Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase by Zabka, Tanja S, Singh, Jatinder, Dhawan, Preeti, Liederer, Bianca M, Oeh, Jason, Kauss, Mara A, Xiao, Yang, Zak, Mark, Lin, Tori, McCray, Bobbi, La, Nghi, Nguyen, Trung, Beyer, Joseph, Farman, Cynthia, Uppal, Hirdesh, Dragovich, Peter S, O'Brien, Thomas, Sampath, Deepak, Misner, Dinah L

“…Nicotinamide phosphoribosyltransferase (NAMPT) is a pleiotropic protein with intra- and extra-cellular functions as an enzyme, cytokine, growth factor, and…”
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Chronic Activation of Liver X Receptor Sensitizes Mice to High Cholesterol Diet-Induced Gut Toxicity by Garbacz, Wojciech G, Uppal, Hirdesh, Yan, Jiong, Xu, Meishu, Ren, Songrong, Stolz, Donna B, Huang, Min, Xie, Wen

“…Cholesterol is essential for numerous biologic functions and processes, but an excess of intracellular cholesterol can be toxic. Intestinal cholesterol…”
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