Search Results - "UNWIN, R. J."

Alterations of sucrose preference after Roux-en-Y gastric bypass by Bueter, M, Miras, A.D, Chichger, H, Fenske, W, Ghatei, M.A, Bloom, S.R, Unwin, R.J, Lutz, T.A, Spector, A.C, le Roux, C.W

“…Abstract Roux-en-Y gastric bypass (gastric bypass) patients reportedly have changes in perception and consumption of sweet-tasting foods. This study aimed to…”
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Urinary acidification assessed by simultaneous furosemide and fludrocortisone treatment: an alternative to ammonium chloride by Walsh, S.-B., Shirley, D.-G., Wrong, O.-M., Unwin, R.-J.

“…Distal renal tubular acidosis (RTA) can lead to rickets in children or osteomalacia in adults if undetected. This disorder is normally diagnosed by means of an…”
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Tropical distal renal tubular acidosis: clinical and epidemiological studies in 78 patients by KHOSITSETH, S, BRUCE, L. J, KINGWATANAKUL, P, SUMBOONNANONDA, A, VASUVATTAKUL, S, YENCHITSOMANUS, P, WRONG, O, WALSH, S. B, BAWAZIR, W. M, OGLE, G. D, UNWIN, R. J, THONG, M.-K, SINHA, R, CHOO, K. E, CHARTAPISAK, W

“…Distal renal tubular acidosis (dRTA) caused by mutations of the SLC4A1 gene encoding the erythroid and kidney isoforms of anion exchanger 1 (AE1 or band 3) has…”
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Drug-induced renal Fanconi syndrome by Hall, A M, Bass, P, Unwin, R J

“…A number of therapeutic drugs are toxic to the kidney proximal tubule (PT) and can cause the renal Fanconi syndrome (FS). The most frequently implicated drugs…”
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Human Hypertension Caused by Mutations in WNK Kinases by Wilson, Frederick H., Disse-Nicodème, Sandra, Choate, Keith A., Ishikawa, Kazuhiko, Nelson-Williams, Carol, Desitter, Isabelle, Gunel, Murat, Milford, David V., Lipkin, Graham W., Achard, Jean-Michel, Feely, Morgan P., Dussol, Bertrand, Berland, Yvon, Unwin, Robert J., Mayan, Haim, Simon, David B., Farfel, Zvi, Jeunemaitre, Xavier, Lifton, Richard P.

“…Hypertension is a major public health problem of largely unknown cause. Here, we identify two genes causing pseudohypoaldosteronism type II, a Mendelian trait…”
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An intact kidney slice model to investigate vasa recta properties and function in situ by Crawford, C, Kennedy-Lydon, T, Sprott, C, Desai, T, Sawbridge, L, Munday, J, Unwin, R J, Wildman, S S P, Peppiatt-Wildman, C M

“…Medullary blood flow is via vasa recta capillaries, which possess contractile pericytes. In vitro studies using isolated descending vasa recta show that…”
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In vivo stimulation of apical P2 receptors in collecting ducts: evidence for inhibition of sodium reabsorption by Shirley, D G, Bailey, M A, Unwin, R J

“…In vitro evidence suggests that intraluminal nucleotides, acting on apical P2 receptors, may influence amiloride-sensitive sodium reabsorption in collecting…”
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Extracellular nucleotides affect pericyte-mediated regulation of rat in situ vasa recta diameter by Crawford, C., Kennedy-Lydon, T. M., Callaghan, H., Sprott, C., Simmons, R. L., Sawbridge, L., Syme, H. M., Unwin, R. J., Wildman, S. S. P., Peppiatt-Wildman, C. M.

“…Aim:  We hypothesized that extracellular nucleotides, established as being released from renal tubular epithelial cells, act at pericytes to regulate vasa…”
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Regulation of renal function by the gastrointestinal tract: potential role of gut-derived peptides and hormones by Michell, A R, Debnam, E S, Unwin, R J

“…The concept of a regulatory link between the gastrointestinal tract and kidneys is not new. The idea that dietary intake and composition can affect renal…”
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Heavy metal contents of livestock feeds and animal manures in England and Wales by Nicholson, F.A, Chambers, B.J, Williams, J.R, Unwin, R.J

“…In this study, 183 livestock feeds and 85 animal manure samples were collected from commercial farms in England and Wales and analysed to determine their heavy…”
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Mutations in the Chloride-Bicarbonate Exchanger Gene AE1 Cause Autosomal Dominant but not Autosomal Recessive Distal Renal Tubular Acidosis by Karet, F. E., Gainza, F. J., Gyory, A. Z., Unwin, R. J., Wrong, O., Tanner, M. J. A., Nayir, A., Alpay, H., Santos, F., Hulton, S. A., Bakkaloglu, A., Ozen, S., Cunningham, M. J., Di Pietro, A., Walker, W. G., Lifton, R. P.

“…Primary distal renal tubular acidosis (dRTA) is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis,…”
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Renal function and mitochondrial cytopathy (MC): more questions than answers? by Hall, A.M., Unwin, R.J., Hanna, M.G., Duchen, M.R.

“…Our knowledge of mitochondrial biology has advanced significantly in the last 10 years. The effects of mitochondrial dysfunction or cytopathy (MC) on the heart…”
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Renal P2 receptors and hypertension by Menzies, R. I., Unwin, R. J., Bailey, M. A.

“…The regulation of extracellular fluid volume is a key component of blood pressure homeostasis. Long‐term blood pressure is stabilized by the acute pressure…”
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Localization of P2X1 purinoceptors by autoradiography and immunohistochemistry in rat kidneys by Chan, C M, Unwin, R J, Bardini, M, Oglesby, I B, Ford, A P, Townsend-Nicholson, A, Burnstock, G

“…P2 receptors have been identified in rat kidney by autoradiography, using the radioligand [3H] alpha, beta-methylene ATP, and by immunohistochemistry, using a…”
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The pattern of distribution of selected ATP-sensitive P2 receptor subtypes in normal rat kidney: an immunohistological study by Turner, C M, Vonend, O, Chan, C, Burnstock, G, Unwin, R J

“…Using immunohistological techniques and available polyclonal antibodies, we have identified several ATP-sensitive P2 receptor subtypes in specific structures…”
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Band 3 mutations, renal tubular acidosis and South-East Asian ovalocytosis in Malaysia and Papua New Guinea: loss of up to 95% band 3 transport in red cells by Bruce, L J, Wrong, O, Toye, A M, Young, M T, Ogle, G, Ismail, Z, Sinha, A K, McMaster, P, Hwaihwanje, I, Nash, G B, Hart, S, Lavu, E, Palmer, R, Othman, A, Unwin, R J, Tanner, M J

“…We describe three mutations of the red-cell anion exchangerband 3 (AE1, SLC4A1) gene associated with distalrenal tubular acidosis (dRTA) in families from…”
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Albumin uptake in OK cells exposed to rotenone: a model for studying the effects of mitochondrial dysfunction on endocytosis in the proximal tubule? by Hall, A M, Campanella, M, Loesch, A, Duchen, M R, Unwin, R J

“…The renal proximal tubule (PT) is clinically vulnerable to mitochondrial dysfunction; sub-lethal injury can lead to the Fanconi syndrome, with elevated urinary…”
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Controlling Soil Water Erosion and Phosphorus Losses from Arable Land in England and Wales by Chambers, B. J., Garwood, T. W. D., Unwin, R. J.

“…Soil water erosion and P losses were monitored annually in 13 erosion susceptible arable catchments (ca. 80 fields) in England and Wales between 1989 and 1994…”
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Detection of glucagon receptor mRNA in the rat proximal tubule: potential role for glucagon in the control of renal glucose transport by Marks, J, Debnam, E S, Dashwood, M R, Srai, S K, Unwin, R J

“…Glucagon is known to affect glomerular filtration rate and renal tubular solute and fluid transport, although it is only thought to act directly on the thick…”
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P2Y receptors present in the native and isolated rat glomerulus by Bailey, M A, Turner, C M, Hus-Citharel, A, Marchetti, J, Imbert-Teboul, M, Milner, P, Burnstock, G, Unwin, R J

“…Extracellular ATP can mobilize intracellular calcium in rat glomeruli by interacting with P2Y receptors. However, the identity of the receptor subtypes…”
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