Search Results - "UNGER, Christine"

Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer by Unterleuthner, Daniela, Neuhold, Patrick, Schwarz, Katharina, Janker, Lukas, Neuditschko, Benjamin, Nivarthi, Harini, Crncec, Ilija, Kramer, Nina, Unger, Christine, Hengstschläger, Markus, Eferl, Robert, Moriggl, Richard, Sommergruber, Wolfgang, Gerner, Christopher, Dolznig, Helmut

“…WNT2 acts as a pro-angiogenic factor in placental vascularization and increases angiogenesis in liver sinusoidal endothelial cells (ECs) and other ECs…”
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Modeling human carcinomas: Physiologically relevant 3D models to improve anti-cancer drug development by Unger, Christine, Kramer, Nina, Walzl, Angelika, Scherzer, Martin, Hengstschläger, Markus, Dolznig, Helmut

“…Anti-cancer drug development is inefficient, mostly due to lack of efficacy in human patients. The high fail rate is partly due to the lack of predictive…”
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Biomimetic Sensors to Detect Bioanalytes in Real-Life Samples Using Molecularly Imprinted Polymers: A Review by Bräuer, Birgit, Unger, Christine, Werner, Martin, Lieberzeit, Peter A.

“…Molecularly imprinted polymers (MIPs) come with the promise to be highly versatile, useful artificial receptors for sensing a wide variety of analytes. Despite…”
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STAT3 regulated ARF expression suppresses prostate cancer metastasis by Pencik, Jan, Schlederer, Michaela, Gruber, Wolfgang, Unger, Christine, Walker, Steven M., Chalaris, Athena, Marié, Isabelle J., Hassler, Melanie R., Javaheri, Tahereh, Aksoy, Osman, Blayney, Jaine K., Prutsch, Nicole, Skucha, Anna, Herac, Merima, Krämer, Oliver H., Mazal, Peter, Grebien, Florian, Egger, Gerda, Poli, Valeria, Mikulits, Wolfgang, Eferl, Robert, Esterbauer, Harald, Kennedy, Richard, Fend, Falko, Scharpf, Marcus, Braun, Martin, Perner, Sven, Levy, David E., Malcolm, Tim, Turner, Suzanne D., Haitel, Andrea, Susani, Martin, Moazzami, Ali, Rose-John, Stefan, Aberger, Fritz, Merkel, Olaf, Moriggl, Richard, Culig, Zoran, Dolznig, Helmut, Kenner, Lukas

“…Prostate cancer (PCa) is the most prevalent cancer in men. Hyperactive STAT3 is thought to be oncogenic in PCa. However, targeting of the IL-6/STAT3 axis in…”
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Exclusion from spheroid formation identifies loss of essential cell-cell adhesion molecules in colon cancer cells by Stadler, Mira, Scherzer, Martin, Walter, Stefanie, Holzner, Silvio, Pudelko, Karoline, Riedl, Angelika, Unger, Christine, Kramer, Nina, Weil, Beatrix, Neesen, Jürgen, Hengstschläger, Markus, Dolznig, Helmut

“…Many cell lines derived from solid cancers can form spheroids, which recapitulate tumor cell clusters and are more representative of the in vivo situation than…”
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CD155/PVR plays a key role in cell motility during tumor cell invasion and migration by Sloan, Kevin E, Eustace, Brenda K, Stewart, Jean K, Zehetmeier, Carol, Torella, Claudia, Simeone, Marina, Roy, Jennifer E, Unger, Christine, Louis, David N, Ilag, Leodevico L, Jay, Daniel G

“…Invasion is an important early step of cancer metastasis that is not well understood. Developing therapeutics to limit metastasis requires the identification…”
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Comparison of cancer cells cultured in 2D vs 3D reveals differences in AKT/mTOR/S6-kinase signaling and drug response by Riedl, Angelika, Schlederer, Michaela, Pudelko, Karoline, Stadler, Mira, Walter, Stefanie, Unterleuthner, Daniela, Unger, Christine, Kramer, Nina, Hengstschläger, Markus, Kenner, Lukas, Pfeiffer, Dagmar, Krupitza, Georg, Dolznig, Helmut

“…3D cancer models are used as preclinical systems to mimic physiologic drug response. We provide evidence for robust changes of proliferation and metabolic…”
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An in vitro ES cell imprinting model shows that imprinted expression of the Igf2r gene arises from an allele-specific expression bias by Latos, Paulina A, Stricker, Stefan H, Steenpass, Laura, Pauler, Florian M, Huang, Ru, Senergin, Basak H, Regha, Kakkad, Koerner, Martha V, Warczok, Katarzyna E, Unger, Christine, Barlow, Denise P

“…Genomic imprinting is an epigenetic process that results in parental-specific gene expression. Advances in understanding the mechanism that regulates imprinted…”
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Molecularly imprinted thin film surfaces in sensing: Chances and challenges by Unger, Christine, Lieberzeit, Peter A.

“…Molecularly imprinted polymers (MIP) claim the potential of replacing biological recognition species, such as antibodies, in sensing. This perspective gives a…”
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In vitro cell migration and invasion assays by Kramer, Nina, Walzl, Angelika, Unger, Christine, Rosner, Margit, Krupitza, Georg, Hengstschläger, Markus, Dolznig, Helmut

“…Determining the migratory and invasive capacity of tumor and stromal cells and clarifying the underlying mechanisms is most relevant for novel strategies in…”
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Identification of a clinically relevant immunodominant region of collagen IV in Goodpasture disease by HELLMARK, T, SEGELMARK, M, UNGER, C, BURKHARDT, H, SAUS, J, WIESLANDER, J

“…The characteristic feature of Goodpasture disease is the occurrence of an autoantibody response to the noncollagenous domain of the alpha3 chain of type IV…”
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Functional proteomic screen identifies a modulating role for CD44 in death receptor-mediated apoptosis by HAUPTSCHEIN, Robert S, SLOAN, Kevin E, TORELLA, Claudia, MOEZZIFARD, Roya, GIEL-MOLONEY, Maryann, ZEHETMEIER, Carol, UNGER, Christine, ILAG, Leodevico L, JAY, Daniel G

“…Apoptotic evasion is a hallmark of cancer and its resistance to chemotherapeutic drugs. Identification of cellular proteins that mediate apoptotic programs is…”
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Insights into microbial diversity of traditional Austrian sourdough by Fraberger, Vera, Unger, Christine, Kummer, Christian, Domig, Konrad J.

“…In sourdough processing, lactic acid bacteria (LAB) and yeasts are responsible for the bread's unique characteristics. To evaluate the microbial ecology of…”
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Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT-mTOR-S6K signaling and drug responses by Riedl, Angelika, Schlederer, Michaela, Pudelko, Karoline, Stadler, Mira, Walter, Stefanie, Unterleuthner, Daniela, Unger, Christine, Kramer, Nina, Hengstschläger, Markus, Kenner, Lukas, Pfeiffer, Dagmar, Krupitza, Georg, Dolznig, Helmut

“…Three-dimensional (3D) cancer models are used as preclinical systems to mimic physiologic drug responses. We provide evidence for strong changes of…”
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Arthritis-related B Cell Epitopes in Collagen II Are Conformation-dependent and Sterically Privileged in Accessible Sites of Cartilage Collagen Fibrils by Schulte, Stefan, Unger, Christine, Mo, John A., Wendler, Olaf, Bauer, Eva, Frischholz, Svenja, von der Mark, Klaus, Kalden, Joachim R., Holmdahl, Rikard, Burkhardt, Harald

“…In collagen-induced arthritis, a murine autoimmune model for rheumatoid arthritis, immunization with native but not heat-denatured cartilage-specific collagen…”
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Identification of conformation-dependent epitopes and V gene selection in the B cell response to type II collagen in the DA rat by Wernhoff, Patrik, Unger, Christine, Bajtner, Estelle, Burkhardt, Harald, Holmdahl, Rikard

“…Collagen-induced arthritis (CIA) is a widely used model for rheumatoid arthritis. Induction of CIA in rats using rat type II collagen (CII) results in a…”
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Increased complexity in carcinomas: Analyzing and modeling the interaction of human cancer cells with their microenvironment by Stadler, Mira, Walter, Stefanie, Walzl, Angelika, Kramer, Nina, Unger, Christine, Scherzer, Martin, Unterleuthner, Daniela, Hengstschläger, Markus, Krupitza, Georg, Dolznig, Helmut

“…Abstract Solid cancers are not simple accumulations of malignant tumor cells but rather represent complex organ-like structures. Despite a more chaotic general…”
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The Resazurin Reduction Assay Can Distinguish Cytotoxic from Cytostatic Compounds in Spheroid Screening Assays by Walzl, Angelika, Unger, Christine, Kramer, Nina, Unterleuthner, Daniela, Scherzer, Martin, Hengstschläger, Markus, Schwanzer-Pfeiffer, Dagmar, Dolznig, Helmut

“…Spheroid-based cellular screening approaches represent a highly physiologic experimental setup to identify novel anticancer drugs and an innovative preclinical…”
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Three-dimensional and co-culture models for preclinical evaluation of metal-based anticancer drugs by Schreiber-Brynzak, Ekaterina, Klapproth, Erik, Unger, Christine, Lichtscheidl-Schultz, Irene, Göschl, Simone, Schweighofer, Sarah, Trondl, Robert, Dolznig, Helmut, Jakupec, Michael A., Keppler, Bernhard K.

“…Summary Background Hypoxic and necrotic regions that accrue within solid tumors in vivo are known to be associated with metastasis formation, radio- and…”
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Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasiveness by Jay, Daniel G, Eustace, Brenda K, Sakurai, Takashi, Stewart, Jean K, Yimlamai, Dean, Unger, Christine, Zehetmeier, Carol, Lain, Blanca, Torella, Claudia, Henning, Stefan W, Beste, Gerald, Scroggins, Bradley T, Neckers, Len, Ilag, Leodevico L

“…Tumour cell invasiveness is crucial for cancer metastasis and is not yet understood. Here we describe two functional screens for proteins required for the…”
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