Search Results - "UNDEM, B. J"

Basic mechanisms of itch by Potenzieri, C., Undem, B. J.

“…Summary Chronic itch represents a burdensome clinical problem that can originate from a variety of aetiologies. Pruriceptive itch originates following the…”
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Mechanisms of pruritogen‐induced activation of itch nerves in isolated mouse skin by Ru, F., Sun, H., Jurcakova, D., Herbstsomer, R. A., Meixong, J., Dong, X., Undem, B. J.

“…Key points Chloroquine (CQ) stimulates itch nerves and causes intense scratching in mice by activating the G‐protein coupled receptor (GPCR) MrgprA3; it is not…”
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Different role of TTX‐sensitive voltage‐gated sodium channel (NaV1) subtypes in action potential initiation and conduction in vagal airway nociceptors by Kollarik, M., Sun, H., Herbstsomer, R. A., Ru, F., Kocmalova, M., Meeker, S. N., Undem, B. J.

“…Key points The action potential initiation in the nerve terminals and its subsequent conduction along the axons of afferent nerves are not necessarily…”
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Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal by Taylor‐Clark, T. E., McAlexander, M. A., Nassenstein, C., Sheardown, S. A., Wilson, S., Thornton, J., Carr, M. J., Undem, B. J.

“…Transient receptor potential (TRP) A1 channels are cation channels found preferentially on nociceptive sensory neurones, including capsaicin-sensitive…”
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Subtypes of vagal afferent C-fibres in guinea-pig lungs by Undem, B. J., Chuaychoo, B., Lee, M.‐G., Weinreich, D., Myers, A. C., Kollarik, M.

“…An ex vivo , vagally innervated, lung preparation was used to address the hypothesis that vagal C-fibres comprise at least two distinct phenotypes…”
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Activation of bronchopulmonary vagal afferent nerves with bradykinin, acid and vanilloid receptor agonists in wild‐type and TRPV1–/– mice by Kollarik, M., Undem, B. J.

“…The vanilloid receptor TRPV1 (formerly VR1) has been implicated in the activation of nociceptive sensory nerves by capsaicin, noxious heat, protons,…”
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Cough sensors. V. Pharmacological modulation of cough sensors by Mazzone, S B, Undem, B J

“…Several airway afferent nerve subtypes have been implicated in coughing. These include bronchopulmonary C-fibers, rapidly adapting airway mechanoreceptors and…”
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The voltage-gated sodium channel NaV1.8 blocker A-803467 inhibits cough in the guinea pig by Brozmanova, M., Svajdova, S., Pavelkova, N., Muroi, Y., Undem, B.J., Kollarik, M.

“…•In respiratory diseases inflammation stimulates airway C-fibers to trigger cough.•Inflammatory mediators act on multiple receptors expressed in airway…”
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Nerve growth factor-induced phenotypic switch in guinea pig airway sensory neurons by HUNTER, D. D, MYERS, A. C, UNDEM, B. J

“…Immunohistochemistry was combined with retrograde tracing techniques to characterize the effect of nerve growth factor (NGF) on substance P (SP) producing…”
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Identification and substance P content of vagal afferent neurons innervating the epithelium of the guinea pig trachea by HUNTER, D. D, UNDEM, B. J

“…Both the nodose and jugular vagal ganglia provide sensory innervation to the airways. The purpose of this study was to localize and characterize the substance…”
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Capsaicin-sensitive and -insensitive vagal bronchopulmonary C-fibres in the mouse by Kollarik, Marian, Dinh, Q Thai, Fischer, Axel, Undem, Bradley J

“…We developed an isolated tracheally perfused (35–37 °C) nerve-lung preparation for the study of bronchopulmonary afferent nerve activity in the mouse…”
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Neurobiology of the upper and lower airways by Undem, B. J., McAlexander, M., Hunter, Dawn D.

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Interganglionic segregation of distinct vagal afferent fibre phenotypes in guinea-pig airways by Ricco, M M, Kummer, W, Biglari, B, Myers, A C, Undem, B J

“…1. The present study addressed the hypothesis that jugular and nodose vagal ganglia contain the somata of functionally and anatomically distinct airway…”
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Immunological Aspects of Allergic Asthma by Bochner, B S, Undem, B J, Lichtenstein, L M

“…Asthma is a chronic obstructive disease of the lower airways. It is characterized by episodic exacerbations of at least partially reversible airflow…”
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Electrophysiological effects of tachykinins and capsaicin on guinea-pig bronchial parasympathetic ganglion neurones by Myers, A C, Undem, B J

“…1. We evaluated the effects of neurokinins, tachykinin analogues, or capsaicin on passive membrane properties of guinea-pig bronchial parasympathetic neurones…”
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Identification, characterization and functional role of phosphodiesterase isozymes in human airway smooth muscle by Torphy, T J, Undem, B J, Cieslinski, L B, Luttmann, M A, Reeves, M L, Hay, D W

“…In the present study phosphodiesterase (PDE) isozymes in human airway smooth muscle were isolated, identified and characterized, and the functional roles of…”
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Sphingosine‐1‐phosphate selectively activates vagal afferent C‐fiber subtype in guinea pig esophagus by Yu, X., Patil, M. J., Yu, M., Liu, Y., Wang, J., Undem, B. J., Yu, S.

“…Background Activation and sensitization of visceral afferent nerves by inflammatory mediators play important roles in visceral nociception…”
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Leukotriene D 4 increases the excitability of capsaicin‐sensitive nasal sensory nerves to electrical and chemical stimuli by Taylor‐Clark, T E, Nassenstein, C, Undem, B J

“…Background and purpose: Clinical studies have demonstrated significant reductions in allergen‐induced nasal symptoms of atopic rhinitis subjects by CysLT 1…”
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Tachykinin-independent effects of capsaicin on smooth muscle in human isolated bronchi by Ellis, J L, Sham, J S, Undem, B J

“…Contractile and relaxant responses to capsaicin and resiniferatoxin were examined in human isolated bronchus (5-12 mm o.d.). Bronchi isolated from 10 of 16…”
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Immunomodulation of afferent neurons in guinea-pig isolated airway by Riccio, M M, Myers, A C, Undem, B J

“…1. The trachea, larynx and main bronchi with the right vagus nerve and nodose ganglion were isolated from guinea-pigs passively immunized 24 h previously with…”
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