Search Results - "UMEZAWA, Y."

Long-term clinical safety and efficacy of brodalumab in the treatment of Japanese patients with moderate-to-severe plaque psoriasis by Umezawa, Y., Nakagawa, H., Niiro, H., Ootaki, K.

“…Background Brodalumab (KHK4827) is a human anti‐interleukin‐17‐receptor A monoclonal antibody. In Japanese patients with moderate‐to‐severe plaque psoriasis,…”
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Noninvasive Imaging of Protein-Protein Interactions in Living Subjects by Using Reporter Protein Complementation and Reconstitution Strategies by Paulmurugan, R., Umezawa, Y., Gambhir, S.S.

“…In this study we have developed bioluminescence-imaging strategies to noninvasively and quantitatively image protein-protein interactions in living mice by…”
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Seasonal shifts in the contributions of the Changjiang River and the Kuroshio Current to nitrate dynamics in the continental shelf of the northern East China Sea based on a nitrate dual isotopic composition approach by Umezawa, Y, Yamaguchi, A, Ishizaka, J, Hasegawa, T, Yoshimizu, C, Tayasu, I, Yoshimura, H, Morii, Y, Aoshima, T, Yamawaki, N

“…The northern East China Sea (ECS) serves as a spawning and nursery ground for many species of fish and squid. To clarify the basis of the food web in the…”
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Long‐term efficacy and safety results from an open‐label phase III study (UNCOVER‐J) in Japanese plaque psoriasis patients: impact of treatment withdrawal and retreatment of ixekizumab by Umezawa, Y., Torisu‐Itakura, H., Morisaki, Y., ElMaraghy, H., Nakajo, K., Akashi, N., Saeki, H., Akasaka, Toshihide, Asano, Yoshihide, Etoh, Takafumi, Fujita, Yasuyuki, Hashimoto, Takashi, Higashiyama, Mari, Igarashi, Atsuyuki, Ihn, Hironobu, Iwatsuki, Keiji, Kabashima, Kenji, Kawada, Akira, Kawashima, Makoto, Nakamura, Koichiro, Okubo, Yukari, Okuyama, Ryuhei, Ozawa, Akira, Sayama, Koji, Seishima, Mariko, Shiohara, Tetsuo, Takahara, Masakazu, Takahashi, Hidetoshi, Takehara, Kazuhiko, Tanese, Keiji, Tani, Mamori, Watanabe, Hideaki, Yamanaka, Keiichi

“…Background Long‐term management of moderate‐to‐severe psoriasis is usually discussed in terms of continuous administration; however, there are many situations…”
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Successful treatment of ustekinumab in a severe psoriasis patient with human immunodeficiency virus infection by Saeki, H., Ito, T., Hayashi, M., Fukuchi, O., Umezawa, Y., Nobeyama, Y., Teruya, K., Nakagawa, H.

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Inhibition of osteosarcoma cell growth by geraniin in vivo by Tatsuda, D, Momose, I, Ohba, S.I, Umezawa, Y, Kawada, M, Shibasaki, M

“…Background: p53 is a regulated transcription factor that induces cell cycle arrest or apoptosis in response to damage by UV and IR radiation, and chemical…”
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Thymine-methyl/π interaction implicated in the sequence-dependent deformability of DNA by Umezawa, Yoji, Nishio, Motohiro

“…The crystal structures of deoxy-oligonucleotides were retrieved from the Nucleic Acid Database and analyzed with the use of our program CHPI. The structure of…”
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Split Luciferase as an Optical Probe for Detecting Protein−Protein Interactions in Mammalian Cells Based on Protein Splicing by Ozawa, Takeaki, Kaihara, Asami, Sato, Moritoshi, Tachihara, Kazunari, Umezawa, Yoshio

“…We describe a new method for detecting protein−protein interactions in intact mammalian cells; the approach is based on protein splicing-induced…”
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Clinical features and risk factors for developing varicella zoster virus dissemination following hematopoietic stem cell transplantation by Umezawa, Y., Kakihana, K., Oshikawa, G., Kobayashi, T., Doki, N., Sakamaki, H., Ohashi, K.

“…Background We retrospectively analyzed 80 instances of varicella zoster virus (VZV) disease in 72 patients who underwent allogeneic hematopoietic stem cell…”
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219 Inhibition of p53–Mdm2 Interaction by Ellagitannins by Tatsuda, D, Umezawa, Y, Iijima, M, Momose, I, Nomoto, A

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A novel MYD88 mutation, L265RPP, in Waldenström macroglobulinemia activates the NF-κB pathway to upregulate Bcl-xL expression and enhances cell survival by Nagao, T, Oshikawa, G, Ishida, S, Akiyama, H, Umezawa, Y, Nogami, A, Kurosu, T, Miura, O

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Extragenital subcutaneous cellular angiofibroma of the elbow by Omori, Y., Saeki, H., Ito, K., Umezawa, Y., Ishiji, T., Ota, A., Fukunaga, M., Nakagawa, H.

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Therapeutic guidelines for the treatment of generalized pustular psoriasis (GPP) based on a proposed classification of disease severity by Umezawa, Y, Ozawa, A, Kawasima, T, Shimizu, H, Terui, T, Tagami, H, Ikeda, S, Ogawa, H, Kawada, A, Tezuka, T, Igarashi, A, Harada, S

“…Generalized pustular psoriasis (GPP) is a rare but notoriously recalcitrant cutaneous diseases. Therefore, there have been few reports of more than ten…”
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Fluorescent Indicators for Cyclic GMP Based on Cyclic GMP-Dependent Protein Kinase Iα and Green Fluorescent Proteins by Sato, Moritoshi, Hida, Naoki, Ozawa, Takeaki, Umezawa, Yoshio

“…We describe herein fluorescent indicators for cyclic GMP (cGMP) in single living cells. cGMP-dependent protein kinase Iα (PKG Iα), a receptor for cGMP, was…”
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Significance of groundwater nitrogen discharge into coral reefs at Ishigaki island, southwest of Japan by UMEZAWA, Y, MIYAJIMA, T, KAYANNE, H, KOIKE, I

“…Groundwater discharge from adjacent terrestrial areas can be a potentially important nutrient source to coastal coral reefs, since adjacent lands are often…”
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A Fluorescent Indicator for Detecting Protein−Protein Interactions in Vivo Based on Protein Splicing by Ozawa, Takeaki, Nogami, Satoru, Sato, Moritoshi, Ohya, Yoshikazu, Umezawa, Yoshio

“…We describe a new method with general applicability for monitoring any protein−protein interaction in vivo. The principle is based on a protein splicing…”
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Electrochemical Detection of a One-Base Mismatch in an Oligonucleotide Using Ion-Channel Sensors with Self-Assembled PNA Monolayers by Aoki, Hiroshi, Bühlmann, Philippe, Umezawa, Yoshio

“…Mixed monolayers of peptide nucleic acid (PNA) and 6‐mercapto‐1‐hexanol on gold disk electrodes were used to detect complementary oligonucleotides at a…”
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P-300 Azacitidine for the treatment of myelodysplastic syndrome or acute myeloid leukaemia in different clinical settings; retrospective analysis in a single institution by Oshikawa, G, Yasunaga, M, Umezawa, Y, Kobayashi, T, Doki, N, Kakihana, K, Ohashi, K, Sakamaki, H

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Microbiological nitrogen transformation in carbonate sediments of a coral-reef lagoon and associated seagrass beds by Miyajima, Toshihiro, Suzumura, Masahiro, Umezawa, Yu, Koike, Isao

“…Nitrogen fixation (NF), denitrification (DN), microalgal uptake (MU) of dissolved inorganic nitrogen (DIN) and the net diffusive DIN flux (FL) between the…”
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Scanning Tunneling Microscopy with Chemically Modified Tips:  Discrimination of Porphyrin Centers Based on Metal Coordination and Hydrogen Bond Interactions by Ohshiro, Takahito, Ito, Takashi, Bühlmann, Philippe, Umezawa, Yoshio

“…STM gold tips chemically modified with 4-mercaptopyridine (4MP) were found capable of discriminating zinc(II) 5,15-bis(4-octadecyloxyphenyl)porphyrin (Por-Zn)…”
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