Search Results - "UKAWA, Masami"

A Novel Strategy to Increase the Yield of Exosomes (Extracellular Vesicles) for an Expansion of Basic Research by Emam, Sherif E., Ando, Hidenori, Lila, Amr Selim Abu, Shimizu, Taro, Ukawa, Masami, Okuhira, Keiichiro, Ishima, Yu, Mahdy, Mahmoud A., Ghazy, Fakhr-eldin S., Ishida, Tatsuhiro

“…Exosomes are tiny extracellular vesicles that are usually harvested in small quantities. Such small yield has been an obstacle for the expansion of the basic…”
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Performance of Cell-Penetrating Peptides Anchored to Polysaccharide Platforms Applied via Various Mucosal Routes as an Absorption Enhancer by Yagi, Haruya, Tomono, Takumi, Handa, Yuma, Saito, Natsuki, Ukawa, Masami, Miyata, Kohei, Shigeno, Koichi, Sakuma, Shinji

“…We have been investigating the potential of cell-penetrating peptides anchored to polymeric platforms as a novel absorption enhancer which delivers biologics…”
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The Improved Antigen Uptake and Presentation of Dendritic Cells Using Cell-Penetrating D-octaarginine-Linked PNVA-co-AA as a Novel Dendritic Cell-Based Vaccine by Fujioka, Yuri, Ueki, Hideto, A, Ruhan, Sasajima, Akari, Tomono, Takumi, Ukawa, Masami, Yagi, Haruya, Sakuma, Shinji, Kitagawa, Koichi, Shirakawa, Toshiro

“…Cancer immunotherapy using antigen-pulsed dendritic cells can induce strong cellular immune responses by priming cytotoxic T lymphocytes. In this study, we…”
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Evaluation of a D-Octaarginine-linked polymer as a transfection tool for transient and stable transgene expression in human and murine cell lines by SAKUMA, Saki, OKAMOTO, Mariko, MATSUSHITA, Nao, UKAWA, Masami, TOMONO, Takumi, KAWAMOTO, Keiko, IKEDA, Teruo, SAKUMA, Shinji

“…Poly(N-vinylacetamide-co-acrylic acid) coupled with d-octaarginine (VP-R8) promotes the cellular uptake of peptides/proteins in vitro; however, details of the…”
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Hepatic Tumor Metastases Cause Enhanced PEGylated Liposome Uptake by Kupffer Cells by Ukawa, Masami, Fujiwara, Yukako, Ando, Hidenori, Shimizu, Taro, Ishida, Tatsuhiro

“…Kupffer cells in livers bearing tumor metastases were found to have promoted tumor invasion and exacerbated the metastasis. This implies that the function of…”
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Modulation of antitumor immunity contributes to the enhanced therapeutic efficacy of liposomal oxaliplatin in mouse model by Shimizu, Taro, Abu Lila, Amr S., Nishio, Miho, Doi, Yusuke, Ando, Hidenori, Ukawa, Masami, Ishima, Yu, Ishida, Tatsuhiro

“…Immune modulation of the tumor microenvironment has been reported to participate in the therapeutic efficacy of many chemotherapeutic agents. Recently, we…”
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Effects of the Chemical Structures of Oligoarginines Conjugated to Biocompatible Polymers as a Mucosal Adjuvant on Antibody Induction in Nasal Cavities by Mohri, Kohta, Miyata, Kohei, Egawa, Tomomi, Tanishita, Sohei, Endo, Rikito, Yagi, Haruya, Ukawa, Masami, Ochiai, Kyohei, Hiwatari, Ken-ichiro, Tsubaki, Kazufumi, Shigeno, Koichi, Tobita, Etsuo, Uto, Tomofumi, Baba, Masanori, Sakuma, Shinji

“…We have been investigating the potential of oligoarginine-linked polymers as an adjuvant for mucosal vaccination that induces immunoglobulin G (IgG) in…”
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Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach by Ikeda, Mayumi, Ishima, Yu, Shibata, Akitomo, Chuang, Victor T.G., Sawa, Tomohiro, Ihara, Hideshi, Watanabe, Hiroshi, Xian, Ming, Ouchi, Yuya, Shimizu, Taro, Ando, Hidenori, Ukawa, Masami, Ishida, Tatsuhiro, Akaike, Takaaki, Otagiri, Masaki, Maruyama, Toru

“…Hydrogen sulfide (H2S) signaling involves polysulfide (RSSnSR′) formation on various proteins. However, the current lack of sensitive polysulfide detection…”
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Advanced therapeutic approach for the treatment of malignant pleural mesothelioma via the intrapleural administration of liposomal pemetrexed by Ando, Hidenori, Kobayashi, Sakiko, Abu Lila, Amr S., Eldin, Noha Essam, Kato, Chihiro, Shimizu, Taro, Ukawa, Masami, Kawazoe, Kazuyoshi, Ishida, Tatsuhiro

“…Malignant pleural mesothelioma (MPM) is an aggressive cancer that proliferates in the pleural cavity. Pemetrexed (PMX) in combination with cisplatin is…”
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Hydrodynamic Tail Vein Injection as a Simple Tool for Yielding Extended Transgene Expression in Solid Tumors by Takayama, Takuma, Ukawa, Masami, Kanazawa, Yuki, Ando, Hidenori, Shimizu, Taro, Ishida, Tatsuhiro

“…Hydrodynamic tail vein injection was considered an in vivo transfection method that yields a higher level of gene expression mainly in the liver. This method…”
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2-Methacryloyloxyethyl phosphorylcholine polymer (MPC)-coating improves the transfection activity of GALA-modified lipid nanoparticles by assisting the cellular uptake and intracellular dissociation of plasmid DNA in primary hepatocytes by Ukawa, Masami, Akita, Hidetaka, Masuda, Tomoya, Hayashi, Yasuhiro, Konno, Tomohiro, Ishihara, Kazuhiko, Harashima, Hideyoshi

“…Abstract We previously reported that modification of GALA peptide on the surface of liposomes enhanced fusion with endosomal membrane, and cytoplasmic release…”
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Tumor recognition of peanut agglutinin-immobilized fluorescent nanospheres in biopsied human tissues by Kumagai, Hironori, Yamada, Kosuke, Nakai, Kanako, Kitamura, Tokio, Mohri, Kohta, Ukawa, Masami, Tomono, Takumi, Eguchi, Takaaki, Yoshizaki, Testuya, Fukuchi, Takumi, Yoshino, Takuya, Matsuura, Minoru, Tobita, Etsuo, Pham, Wellington, Nakase, Hiroshi, Sakuma, Shinji

“…[Display omitted] We are investigating an imaging agent for early detection of colorectal cancer. The agent, named the nanobeacon, is coumarin 6-encapsulated…”
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Neutralized Nanoparticle Composed of SS-Cleavable and pH-Activated Lipid-Like Material as a Long-Lasting and Liver-Specific Gene Delivery System by Ukawa, Masami, Akita, Hidetaka, Hayashi, Yasuhiro, Ishiba, Ryohei, Tange, Kota, Arai, Masaya, Kubo, Kazuhiro, Higuchi, Yuriko, Shimizu, Kazunori, Konishi, Satoshi, Hashida, Mitsuru, Harashima, Hideyoshi

“…Charge‐neutralized lipid envelope‐type nanoparticles formed with SS‐cleavable and pH‐activated lipid‐like materials (ssPalm) accumulate rapidly in the liver…”
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Envelope-type lipid nanoparticles incorporating a short PEG-lipid conjugate for improved control of intracellular trafficking and transgene transcription by Masuda, Tomoya, Akita, Hidetaka, Niikura, Kenichi, Nishio, Takashi, Ukawa, Masami, Enoto, Kaoru, Danev, Radostin, Nagayama, Kuniaki, Ijiro, Kuniharu, Harashima, Hideyoshi

“…Abstract Lipid envelope-type nanoparticles are promising carriers for gene delivery. The modification of liposomes with polyethyleneglycol (PEG) can often be…”
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SPECIFIC MOLECULAR RECOGNITION AS A STRATEGY TO DELINEATE TUMOR MARGIN USING TOPICALLY APPLIED FLUORESCENCE EMBEDDED NANOPARTICLES by Barton, Shawn, Li, Bo, Siuta, Michael, Vaibhav, Janve, Song, Jessica, Holt, Clinton M, Tomono, Takumi, Ukawa, Masami, Kumagai, Hironori, Tobita, Etsuo, Wilson, Kevin, Sakuma, Shinji, Pham, Wellington

“…The Thomsen-Friedenreich (TF) antigen is a tumor-associated antigen consistently expressed on the apical surface of epithelial-based cancer cells, including…”
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Acquisition of absorption-enhancing abilities of cationic oligopeptides with short chain arginine residues through conjugation to hyaluronic acid by Tomono, Takumi, Yagi, Haruya, Kanemoto, Saki, Ukawa, Masami, Miyata, Kohei, Shigeno, Koichi, Sakuma, Shinji

“…[Display omitted] Cell-penetrating peptides such as oligoarginines are one of promising tools that improve mucosal absorption of poorly membrane-permeable…”
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Mucosal absorption of antibody drugs enhanced by cell-penetrating peptides anchored to a platform of polysaccharides by Tomono, Takumi, Yagi, Haruya, Igi, Ryoji, Tabaru, Akihiro, Fujimoto, Koichi, Enomoto, Kaho, Ukawa, Masami, Miyata, Kohei, Shigeno, Koichi, Sakuma, Shinji

“…Our previous studies demonstrated that L-octaarginine grafted onto hyaluronic acid via a tetraglycine spacer significantly enhanced intranasal absorption of…”
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Ganglioside inserted into PEGylated liposome attenuates anti-PEG immunity by Mima, Yu, Abu Lila, Amr S., Shimizu, Taro, Ukawa, Masami, Ando, Hidenori, Kurata, Yasuko, Ishida, Tatsuhiro

“…Despite the clinical introduction of a vast number of polyethylene glycol (PEG)-conjugated therapeutics, conjugated PEG is also known for an unfortunate…”
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Anti-PEG IgM and complement system are required for the association of second doses of PEGylated liposomes with splenic marginal zone B cells by Shimizu, Taro, Mima, Yu, Hashimoto, Yosuke, Ukawa, Masami, Ando, Hidenori, Kiwada, Hiroshi, Ishida, Tatsuhiro

“…Abstract The accelerated blood clearance (ABC) phenomenon makes it crucial to use PEGylated liposomes and micelles to deliver drugs. The ABC phenomenon is an…”
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Deciphering the Roots of Pharmacists’ Critical Thinking About Pseudoscientific Claims: Insights from a Cross-Sectional Survey by Watanabe, Tomofumi, Matsumoto, Mari, Ukawa, Masami, Ohira, Makoto, Tsunoda, Masaru

“…The global trend toward self-medication has increased public reliance on over-the-counter treatments and health-related information, contributing to the spread…”
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