Search Results - "UHRBOM, L"

Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma by Lindberg, N, Kastemar, M, Olofsson, T, Smits, A, Uhrbom, L

“…Gliomas are primary brain tumors mainly affecting adults. The cellular origin is unknown. The recent identification of tumor-initiating cells in glioma, which…”
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Snail depletes the tumorigenic potential of glioblastoma by Savary, K, Caglayan, D, Caja, L, Tzavlaki, K, Bin Nayeem, S, Bergström, T, Jiang, Y, Uhrbom, L, Forsberg-Nilsson, K, Westermark, B, Heldin, C-H, Ferletta, M, Moustakas, A

“…Glioblastoma multiforme (GBM) is an aggressive brain malignancy characterized by high heterogeneity and invasiveness. It is increasingly accepted that the…”
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Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma by TCHOUGOUNOVA, E, KASTEMAR, M, BRASÄTER, D, HOLLAND, E. C, WESTERMARK, B, UHRBOM, L

“…In a subset of gliomas, the platelet-derived growth factor (PDGF) signaling pathway is perturbed. This is usually an early event occurring in low-grade tumors…”
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Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence by Tchougounova, E, Jiang, Y, Bråsäter, D, Lindberg, N, Kastemar, M, Asplund, A, Westermark, B, Uhrbom, L

“…SOX5 is a member of the high-mobility group superfamily of architectural non-histone proteins involved in gene regulation and maintenance of chromatin…”
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Case-specific potentiation of glioblastoma drugs by pterostilbene by Schmidt, Linnéa, Baskaran, Sathishkumar, Johansson, Patrik, Padhan, Narendra, Matuszewski, Damian, Green, Lydia C, Elfineh, Ludmila, Wee, Shimei, Häggblad, Maria, Martens, Ulf, Westermark, Bengt, Forsberg-Nilsson, Karin, Uhrbom, Lene, Claesson-Welsh, Lena, Andäng, Michael, Sintorn, Ida-Maria, Lundgren, Bo, Lönnstedt, Ingrid, Krona, Cecilia, Nelander, Sven

“…Glioblastoma multiforme (GBM, astrocytoma grade IV) is the most common malignant primary brain tumor in adults. Addressing the shortage of effective treatment…”
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Modeling gliomagenesis with somatic cell gene transfer using retroviral vectors by Uhrbom, L, Holland, E C

“…Modeling brain tumor formation in experimental animals with somatic cell gene transfer has a long history. In the early experiments naturally occurring…”
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Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing by Xie, Yuan, He, Liqun, Lugano, Roberta, Zhang, Yanyu, Cao, Haiyan, He, Qiyuan, Chao, Min, Liu, Boxuan, Cao, Qingze, Wang, Jianhao, Jiao, Yang, Hu, Yaqin, Han, Liying, Zhang, Yong, Huang, Hua, Uhrbom, Lene, Betsholtz, Christer, Wang, Liang, Dimberg, Anna, Zhang, Lei

“…Passage of systemically delivered pharmacological agents into the brain is largely blocked by the blood-brain-barrier (BBB), an organotypic specialization of…”
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Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival by Lu, Xi, Maturi, Naga Prathyusha, Jarvius, Malin, Yildirim, Irem, Dang, Yonglong, Zhao, Linxuan, Xie, Yuan, Tan, E-Jean, Xing, Pengwei, Larsson, Rolf, Fryknäs, Mårten, Uhrbom, Lene, Chen, Xingqi

“…There is ample support for developmental regulation of glioblastoma stem cells. To examine how cell lineage controls glioblastoma stem cell function, we…”
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A molecularly distinct subset of glioblastoma requires serum‐containing media to establish sustainable bona fide glioblastoma stem cell cultures by Maturi, Naga Prathyusha, Tan, E‐Jean, Xie, Yuan, Sundström, Anders, Bergström, Tobias, Jiang, Yiwen, Uhrbom, Lene

“…Glioblastoma (GBM) is the most frequent and deadly primary malignant brain tumor. Hallmarks are extensive intra‐tumor and inter‐tumor heterogeneity and highly…”
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Glioblastoma stem cells express non‐canonical proteins and exclusive mesenchymal‐like or non‐mesenchymal‐like protein signatures by Babačić, Haris, Galardi, Silvia, Umer, Husen M., Hellström, Mats, Uhrbom, Lene, Maturi, Nagaprathyusha, Cardinali, Deborah, Pellegatta, Serena, Michienzi, Alessandro, Trevisi, Gianluca, Mangiola, Annunziato, Lehtiö, Janne, Ciafrè, Silvia Anna, Pernemalm, Maria

“…Glioblastoma (GBM) cancer stem cells (GSCs) contribute to GBM's origin, recurrence, and resistance to treatment. However, the understanding of how mRNA…”
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Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells by Zhang, Lei, Laaniste, Liisi, Jiang, Yiwen, Alafuzoff, Irina, Uhrbom, Lene, Dimberg, Anna

“…Pleiotrophin (PTN) augments tumor growth by increasing proliferation of tumor cells and promoting vascular abnormalization, but its role in early gliomagenesis…”
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LGR5 promotes tumorigenicity and invasion of glioblastoma stem‐like cells and is a potential therapeutic target for a subset of glioblastoma patients by Xie, Yuan, Sundström, Anders, Maturi, Naga P, Tan, E‐Jean, Marinescu, Voichita D, Jarvius, Malin, Tirfing, Malin, Jin, Chuan, Chen, Lei, Essand, Magnus, Swartling, Fredrik J, Nelander, Sven, Jiang, Yiwen, Uhrbom, Lene

“…Glioblastoma (GBM) is the most common and lethal primary malignant brain tumor which lacks efficient treatment and predictive biomarkers. Expression of the…”
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Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin by Jiang, Yiwen, Marinescu, Voichita Dana, Xie, Yuan, Jarvius, Malin, Maturi, Naga Prathyusha, Haglund, Caroline, Olofsson, Sara, Lindberg, Nanna, Olofsson, Tommie, Leijonmarck, Caroline, Hesselager, Göran, Alafuzoff, Irina, Fryknäs, Mårten, Larsson, Rolf, Nelander, Sven, Uhrbom, Lene

“…The identity of the glioblastoma (GBM) cell of origin and its contributions to disease progression and treatment response remain largely unknown. We have…”
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PDGF-B Can Sustain Self-renewal and Tumorigenicity of Experimental Glioma-Derived Cancer-Initiating Cells by Preventing Oligodendrocyte Differentiation by Jiang, Yiwen, Boije, Maria, Westermark, Bengt, Uhrbom, Lene

“…Abstract According to the cancer stem cell (CSC)/cancer-initiating cell hypothesis, glioma development is driven by a subpopulation of cells with unique…”
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Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model by Holland, Eric C, Uhrbom, Lene, Nerio, Edward

“…Bioluminescence imaging has previously been used to monitor the formation of grafted tumors in vivo and measure cell number during tumor progression and…”
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Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses by Niklasson, Mia, Maddalo, Gianluca, Sramkova, Zuzana, Mutlu, Ercan, Wee, Shimei, Sekyrova, Petra, Schmidt, Linnéa, Fritz, Nicolas, Dehnisch, Ivar, Kyriatzis, Gregorios, Krafcikova, Michaela, Carson, Brittany B, Feenstra, Jennifer M, Marinescu, Voichita D, Segerman, Anna, Haraldsson, Martin, Gustavsson, Anna-Lena, Hammarström, Lars G J, Jenmalm Jensen, Annika, Uhrbom, Lene, Altelaar, A F Maarten, Linnarsson, Sten, Uhlén, Per, Trantirek, Lukas, Vincent, C Theresa, Nelander, Sven, Enger, Per Øyvind, Andäng, Michael

“…Glioma-initiating cells (GIC) are considered the underlying cause of recurrences of aggressive glioblastomas, replenishing the tumor population and undermining…”
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PAIRED GLIOBLASTOMA CELL CULTURES OF THE FLUORESCENT BULK TUMOR AND NON-FLUORESCENT TUMOR MARGIN DISPLAY DIFFERENTIAL PHENOTYPES AND CELL STATES ACROSS PATIENTS by Neves, I, Maturi, N, Dang, YL, Lu, X, Latini, F, Yildirim, I, Sundstrom, A, Jokinen, V, Bergstrom, T, Xing, PW, Jarvius, M, Larsson, R, Fryknas, M, Ryttlefors, M, Chen, XQ, Swartling, F, Uhrbom, L

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Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt by UHRBOM, Lene, CHENGKAI DAI, CELESTINO, Joseph C, ROSENBLUM, Marc K, FULLER, Gregory N, HOLLAND, Eric C

“…Deletion of the INK4a-ARF locus is found in the majority of human malignant gliomas. However, the role of INK4a-ARF loss in gliomagenesis is unclear. Animal…”
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MODELING AND UNDERSTANDING GLIOBLASTOMA EDGE CELLS by Maturi, NP, Neves, I, Dang, YL, Yildirim, I, Latini, F, Bergstrom, T, Sundstrom, A, Xing, PW, Jarvius, M, Larsson, R, Fryknas, M, Ryttlefors, M, Chen, XQ, Swartling, F, Uhrbom, L

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miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma by Põlajeva, Jelena, Swartling, Fredrik J, Jiang, Yiwen, Singh, Umashankar, Pietras, Kristian, Uhrbom, Lene, Westermark, Bengt, Roswall, Pernilla

“…MicroRNAs (miRNAs) and their role during tumor development have been studied in great detail during the last decade, albeit their expression pattern and…”
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