Search Results - "UHLMANN, Frank"

Biochemical reconstitution of topological DNA binding by the cohesin ring by Murayama, Yasuto, Uhlmann, Frank

“…Cohesion between sister chromatids, mediated by the chromosomal cohesin complex, is a prerequisite for faithful chromosome segregation in mitosis. Cohesin also…”
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A matter of choice: the establishment of sister chromatid cohesion by Uhlmann, Frank

“…Sister chromatid cohesion is the basis for the recognition of chromosomal DNA replication products for their bipolar segregation in mitosis. Fundamental to…”
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Establishment of DNA-DNA Interactions by the Cohesin Ring by Murayama, Yasuto, Samora, Catarina P., Kurokawa, Yumiko, Iwasaki, Hiroshi, Uhlmann, Frank

“…The ring-shaped structural maintenance of chromosome (SMC) complexes are multi-subunit ATPases that topologically encircle DNA. SMC rings make vital…”
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Cdk-counteracting phosphatases unlock mitotic exit by Queralt, Ethel, Uhlmann, Frank

“…Entry into mitosis of the eukaryotic cell cycle is driven by rising cyclin-dependent kinase (Cdk) activity. During exit from mitosis, Cdk activity must again…”
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Condensin, Chromatin Crossbarring and Chromosome Condensation by Thadani, Rahul, Uhlmann, Frank, Heeger, Sebastian

“…The processes underlying the large-scale reorganisation of chromatin in mitosis that form compact mitotic chromosomes and ensure the fidelity of chromosome…”
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The Scc2–Scc4 complex acts in sister chromatid cohesion and transcriptional regulation by maintaining nucleosome-free regions by Lopez-Serra, Lidia, Kelly, Gavin, Patel, Harshil, Stewart, Aengus, Uhlmann, Frank

“…Frank Uhlmann and colleagues show that the yeast Scc2–Scc4 cohesin loader complex is recruited to nucleosome-free regions in the promoters of highly expressed…”
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Division of Labor between PCNA Loaders in DNA Replication and Sister Chromatid Cohesion Establishment by Liu, Hon Wing, Bouchoux, Céline, Panarotto, Mélanie, Kakui, Yasutaka, Patel, Harshil, Uhlmann, Frank

“…Concomitant with DNA replication, the chromosomal cohesin complex establishes cohesion between newly replicated sister chromatids. Several…”
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A Brownian ratchet model for DNA loop extrusion by the cohesin complex by Higashi, Torahiko L, Pobegalov, Georgii, Tang, Minzhe, Molodtsov, Maxim I, Uhlmann, Frank

“…The cohesin complex topologically encircles DNA to promote sister chromatid cohesion. Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin…”
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Rapid movement and transcriptional re-localization of human cohesin on DNA by Davidson, Iain F, Goetz, Daniela, Zaczek, Maciej P, Molodtsov, Maxim I, Huis in 't Veld, Pim J, Weissmann, Florian, Litos, Gabriele, Cisneros, David A, Ocampo-Hafalla, Maria, Ladurner, Rene, Uhlmann, Frank, Vaziri, Alipasha, Peters, Jan-Michael

“…The spatial organization, correct expression, repair, and segregation of eukaryotic genomes depend on cohesin, ring‐shaped protein complexes that are thought…”
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Protocol for studying topological DNA interactions by purified fission yeast condensin by Tang, Minzhe, Uhlmann, Frank

“…To understand the transition from interphase chromatin into well-shaped chromosomes during cell divisions, we need to understand the biochemical activities of…”
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Functional crosstalk between the cohesin loader and chromatin remodelers by Muñoz, Sofía, Jones, Andrew, Bouchoux, Céline, Gilmore, Tegan, Patel, Harshil, Uhlmann, Frank

“…The cohesin complex participates in many structural and functional aspects of genome organization. Cohesin recruitment onto chromosomes requires…”
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Open questions: Chromosome condensation - why does a chromosome look like a chromosome? by Uhlmann, Frank

“…Doc number: 9…”
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Eco1-Dependent Cohesin Acetylation During Establishment of Sister Chromatid Cohesion by Ben-Shahar, Tom Rolef, Heeger, Sebastian, Lehane, Chris, East, Philip, Flynn, Helen, Skehel, Mark, Uhlmann, Frank

“…Replicated chromosomes are held together by the chromosomal cohesin complex from the time of their synthesis in S phase onward. This requires the replication…”
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Comparison of loop extrusion and diffusion capture as mitotic chromosome formation pathways in fission yeast by Gerguri, Tereza, Fu, Xiao, Kakui, Yasutaka, Khatri, Bhavin S, Barrington, Christopher, Bates, Paul A, Uhlmann, Frank

“…Underlying higher order chromatin organization are Structural Maintenance of Chromosomes (SMC) complexes, large protein rings that entrap DNA. The molecular…”
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Budding Yeast Wapl Controls Sister Chromatid Cohesion Maintenance and Chromosome Condensation by Lopez-Serra, Lidia, Lengronne, Armelle, Borges, Vanessa, Kelly, Gavin, Uhlmann, Frank

“…The establishment of stable sister chromatid cohesion during DNA replication requires acetylation of the chromosomal cohesin complex by the replication…”
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Chromosome arm length, and a species-specific determinant, define chromosome arm width by Kakui, Yasutaka, Barrington, Christopher, Kusano, Yoshiharu, Thadani, Rahul, Fallesen, Todd, Hirota, Toru, Uhlmann, Frank

“…Mitotic chromosomes in different organisms adopt various dimensions. What defines these dimensions is scarcely understood. Here, we compare mitotic chromosomes…”
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Cdc14 and PP2A Phosphatases Cooperate to Shape Phosphoproteome Dynamics during Mitotic Exit by Touati, Sandra A., Hofbauer, Lorena, Jones, Andrew W., Snijders, Ambrosius P., Kelly, Gavin, Uhlmann, Frank

“…Temporal control over protein phosphorylation and dephosphorylation is crucial for accurate chromosome segregation and for completion of the cell division…”
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Bridging-induced phase separation induced by cohesin SMC protein complexes by Ryu, Je-Kyung, Bouchoux, Céline, Liu, Hon Wing, Kim, Eugene, Minamino, Masashi, de Groot, Ralph, Katan, Allard J, Bonato, Andrea, Marenduzzo, Davide, Michieletto, Davide, Uhlmann, Frank, Dekker, Cees

“…Structural maintenance of chromosome (SMC) protein complexes are able to extrude DNA loops. While loop extrusion constitutes a fundamental building block of…”
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A quantitative model for cyclin-dependent kinase control of the cell cycle: revisited by Uhlmann, Frank, Bouchoux, Céline, López-Avilés, Sandra

“…The eukaryotic cell division cycle encompasses an ordered series of events. Chromosomal DNA is replicated during S phase of the cell cycle before being…”
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Fission yeast condensin contributes to interphase chromatin organization and prevents transcription-coupled DNA damage by Kakui, Yasutaka, Barrington, Christopher, Barry, David J, Gerguri, Tereza, Fu, Xiao, Bates, Paul A, Khatri, Bhavin S, Uhlmann, Frank

“…Structural maintenance of chromosomes (SMC) complexes are central organizers of chromatin architecture throughout the cell cycle. The SMC family member…”
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