Search Results - "UHLEN, Mathias"

A pathology atlas of the human cancer transcriptome by Uhlen, Mathias, Zhang, Cheng, Lee, Sunjae, Sjöstedt, Evelina, Fagerberg, Linn, Bidkhori, Gholamreza, Benfeitas, Rui, Arif, Muhammad, Liu, Zhengtao, Edfors, Fredrik, Sanli, Kemal, von Feilitzen, Kalle, Oksvold, Per, Lundberg, Emma, Hober, Sophia, Nilsson, Peter, Mattsson, Johanna, Schwenk, Jochen M., Brunnström, Hans, Glimelius, Bengt, Sjöblom, Tobias, Edqvist, Per-Henrik, Djureinovic, Dijana, Micke, Patrick, Lindskog, Cecilia, Mardinoglu, Adil, Ponten, Fredrik

“…Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and…”
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Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays by Chen, Ao, Liao, Sha, Cheng, Mengnan, Ma, Kailong, Wu, Liang, Lai, Yiwei, Qiu, Xiaojie, Yang, Jin, Xu, Jiangshan, Hao, Shijie, Wang, Xin, Lu, Huifang, Chen, Xi, Liu, Xing, Huang, Xin, Li, Zhao, Hong, Yan, Jiang, Yujia, Peng, Jian, Liu, Shuai, Shen, Mengzhe, Liu, Chuanyu, Li, Quanshui, Yuan, Yue, Wei, Xiaoyu, Zheng, Huiwen, Feng, Weimin, Wang, Zhifeng, Liu, Yang, Wang, Zhaohui, Yang, Yunzhi, Xiang, Haitao, Han, Lei, Qin, Baoming, Guo, Pengcheng, Lai, Guangyao, Muñoz-Cánoves, Pura, Maxwell, Patrick H., Thiery, Jean Paul, Wu, Qing-Feng, Zhao, Fuxiang, Chen, Bichao, Li, Mei, Dai, Xi, Wang, Shuai, Kuang, Haoyan, Hui, Junhou, Wang, Liqun, Fei, Ji-Feng, Wang, Ou, Wei, Xiaofeng, Lu, Haorong, Wang, Bo, Liu, Shiping, Gu, Ying, Ni, Ming, Zhang, Wenwei, Mu, Feng, Yin, Ye, Yang, Huanming, Lisby, Michael, Cornall, Richard J., Mulder, Jan, Uhlén, Mathias, Esteban, Miguel A., Li, Yuxiang, Liu, Longqi, Xu, Xun, Wang, Jian

“…Spatially resolved transcriptomic technologies are promising tools to study complex biological processes such as mammalian embryogenesis. However, the…”
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A genome-wide transcriptomic analysis of protein-coding genes in human blood cells by Uhlen, Mathias, Karlsson, Max J, Zhong, Wen, Tebani, Abdellah, Pou, Christian, Mikes, Jaromir, Lakshmikanth, Tadepally, Forsström, Björn, Edfors, Fredrik, Odeberg, Jacob, Mardinoglu, Adil, Zhang, Cheng, von Feilitzen, Kalle, Mulder, Jan, Sjöstedt, Evelina, Hober, Andreas, Oksvold, Per, Zwahlen, Martin, Ponten, Fredrik, Lindskog, Cecilia, Sivertsson, Åsa, Fagerberg, Linn, Brodin, Petter

“…Blood is the predominant source for molecular analyses in humans, both in clinical and research settings. It is the target for many therapeutic strategies,…”
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Identification of anticancer drugs for hepatocellular carcinoma through personalized genome‐scale metabolic modeling by Agren, Rasmus, Mardinoglu, Adil, Asplund, Anna, Kampf, Caroline, Uhlen, Mathias, Nielsen, Jens

“…Genome‐scale metabolic models (GEMs) have proven useful as scaffolds for the integration of omics data for understanding the genotype–phenotype relationship in…”
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Addressing the Protease Bias in Quantitative Proteomics by Woessmann, Jakob, Kotol, David, Hober, Andreas, Uhlén, Mathias, Edfors, Fredrik

“…Protein quantification strategies using multiple proteases have been shown to deliver poor interprotease accuracy in label-free mass spectrometry experiments…”
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An atlas of the protein-coding genes in the human, pig, and mouse brain by Sjöstedt, Evelina, Zhong, Wen, Fagerberg, Linn, Karlsson, Max, Mitsios, Nicholas, Adori, Csaba, Oksvold, Per, Edfors, Fredrik, Limiszewska, Agnieszka, Hikmet, Feria, Huang, Jinrong, Du, Yutao, Lin, Lin, Dong, Zhanying, Yang, Ling, Liu, Xin, Jiang, Hui, Xu, Xun, Wang, Jian, Yang, Huanming, Bolund, Lars, Mardinoglu, Adil, Zhang, Cheng, von Feilitzen, Kalle, Lindskog, Cecilia, Pontén, Fredrik, Luo, Yonglun, Hökfelt, Tomas, Uhlén, Mathias, Mulder, Jan

“…The brain, with its diverse physiology and intricate cellular organization, is the most complex organ of the mammalian body. To expand our basic understanding…”
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Tissue-based map of the human proteome by Uhlén, Mathias, Fagerberg, Linn, Hallström, Björn M., Lindskog, Cecilia, Oksvold, Per, Mardinoglu, Adil, Sivertsson, Åsa, Kampf, Caroline, Sjöstedt, Evelina, Asplund, Anna, Olsson, IngMarie, Edlund, Karolina, Lundberg, Emma, Navani, Sanjay, Szigyarto, Cristina Al-Khalili, Odeberg, Jacob, Djureinovic, Dijana, Takanen, Jenny Ottosson, Hober, Sophia, Alm, Tove, Edqvist, Per-Henrik, Berling, Holger, Tegel, Hanna, Mulder, Jan, Rockberg, Johan, Nilsson, Peter, Schwenk, Jochen M., Hamsten, Marica, von Feilitzen, Kalle, Forsberg, Mattias, Persson, Lukas, Johansson, Fredric, Zwahlen, Martin, von Heijne, Gunnar, Nielsen, Jens, Pontén, Fredrik

“…Protein expression across human tissues Sequencing the human genome gave new insights into human biology and disease. However, the ultimate goal is to…”
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A subcellular map of the human proteome by Thul, Peter J., Åkesson, Lovisa, Wiking, Mikaela, Mahdessian, Diana, Geladaki, Aikaterini, Blal, Hammou Ait, Alm, Tove, Asplund, Anna, Björk, Lars, Breckels, Lisa M., Bäckström, Anna, Danielsson, Frida, Fagerberg, Linn, Fall, Jenny, Gatto, Laurent, Gnann, Christian, Hober, Sophia, Hjelmare, Martin, Johansson, Fredric, Lee, Sunjae, Lindskog, Cecilia, Mulder, Jan, Mulvey, Claire M., Nilsson, Peter, Oksvold, Per, Rockberg, Johan, Schutten, Rutger, Schwenk, Jochen M., Sivertsson, Åsa, Sjöstedt, Evelina, Skogs, Marie, Stadler, Charlotte, Sullivan, Devin P., Tegel, Hanna, Winsnes, Casper, Zhang, Cheng, Zwahlen, Martin, Mardinoglu, Adil, Pontén, Fredrik, von Feilitzen, Kalle, Lilley, Kathryn S., Uhlén, Mathias, Lundberg, Emma

“…Resolving the spatial distribution of the human proteome at a subcellular level can greatly increase our understanding of human biology and disease. Here we…”
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Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease by Mardinoglu, Adil, Agren, Rasmus, Kampf, Caroline, Asplund, Anna, Uhlen, Mathias, Nielsen, Jens

“…Several liver disorders result from perturbations in the metabolism of hepatocytes, and their underlying mechanisms can be outlined through the use of…”
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An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans by Mardinoglu, Adil, Wu, Hao, Bjornson, Elias, Zhang, Cheng, Hakkarainen, Antti, Räsänen, Sari M., Lee, Sunjae, Mancina, Rosellina M., Bergentall, Mattias, Pietiläinen, Kirsi H., Söderlund, Sanni, Matikainen, Niina, Ståhlman, Marcus, Bergh, Per-Olof, Adiels, Martin, Piening, Brian D., Granér, Marit, Lundbom, Nina, Williams, Kevin J., Romeo, Stefano, Nielsen, Jens, Snyder, Michael, Uhlén, Mathias, Bergström, Göran, Perkins, Rosie, Marschall, Hanns-Ulrich, Bäckhed, Fredrik, Taskinen, Marja-Riitta, Borén, Jan

“…A carbohydrate-restricted diet is a widely recommended intervention for non-alcoholic fatty liver disease (NAFLD), but a systematic perspective on the multiple…”
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Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics by Fagerberg, Linn, Hallström, Björn M., Oksvold, Per, Kampf, Caroline, Djureinovic, Dijana, Odeberg, Jacob, Habuka, Masato, Tahmasebpoor, Simin, Danielsson, Angelika, Edlund, Karolina, Asplund, Anna, Sjöstedt, Evelina, Lundberg, Emma, Szigyarto, Cristina Al-Khalili, Skogs, Marie, Takanen, Jenny Ottosson, Berling, Holger, Tegel, Hanna, Mulder, Jan, Nilsson, Peter, Schwenk, Jochen M., Lindskog, Cecilia, Danielsson, Frida, Mardinoglu, Adil, Sivertsson, Åsa, von Feilitzen, Kalle, Forsberg, Mattias, Zwahlen, Martin, Olsson, IngMarie, Navani, Sanjay, Huss, Mikael, Nielsen, Jens, Ponten, Fredrik, Uhlén, Mathias

“…Global classification of the human proteins with regards to spatial expression patterns across organs and tissues is important for studies of human biology and…”
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A high-stringency blueprint of the human proteome by Adhikari, Subash, Nice, Edouard C., Deutsch, Eric W., Lane, Lydie, Omenn, Gilbert S., Pennington, Stephen R., Paik, Young-Ki, Overall, Christopher M., Corrales, Fernando J., Cristea, Ileana M., Van Eyk, Jennifer E., Uhlén, Mathias, Lindskog, Cecilia, Chan, Daniel W., Bairoch, Amos, Waddington, James C., Justice, Joshua L., LaBaer, Joshua, Rodriguez, Henry, He, Fuchu, Kostrzewa, Markus, Ping, Peipei, Gundry, Rebekah L., Stewart, Peter, Srivastava, Sanjeeva, Srivastava, Sudhir, Nogueira, Fabio C. S., Domont, Gilberto B., Vandenbrouck, Yves, Lam, Maggie P. Y., Wennersten, Sara, Vizcaino, Juan Antonio, Wilkins, Marc, Schwenk, Jochen M., Lundberg, Emma, Bandeira, Nuno, Marko-Varga, Gyorgy, Weintraub, Susan T., Pineau, Charles, Kusebauch, Ulrike, Moritz, Robert L., Ahn, Seong Beom, Palmblad, Magnus, Snyder, Michael P., Aebersold, Ruedi, Baker, Mark S.

“…The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data…”
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Sequential sequencing by synthesis and the next-generation sequencing revolution by Uhlen, Mathias, Quake, Stephen R.

“…The impact of next-generation sequencing (NGS) cannot be overestimated. The technology has transformed the field of life science, contributing to a dramatic…”
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Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes by Romanov, Roman A, Zeisel, Amit, Bakker, Joanne, Girach, Fatima, Hellysaz, Arash, Tomer, Raju, Alpár, Alán, Mulder, Jan, Clotman, Frédéric, Keimpema, Erik, Hsueh, Brian, Crow, Ailey K, Martens, Henrik, Schwindling, Christian, Calvigioni, Daniela, Bains, Jaideep S, Máté, Zoltán, Szabó, Gábor, Yanagawa, Yuchio, Zhang, Ming-Dong, Rendeiro, Andre, Farlik, Matthias, Uhlén, Mathias, Wulff, Peer, Bock, Christoph, Broberger, Christian, Deisseroth, Karl, Hökfelt, Tomas, Linnarsson, Sten, Horvath, Tamas L, Harkany, Tibor

“…The hypothalamus is a brain region rich in functionally segregated neurons. Here Romanov and colleagues use single-cell RNA sequencing to distinguish 62…”
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The Role of SATB2 as a Diagnostic Marker for Tumors of Colorectal Origin by Dragomir, Anca, de Wit, Meike, Johansson, Christine, Uhlen, Mathias, Pontén, Fredrik

“…Objectives: Immunohistochemistry is an important extension to clinical information and morphology, and prevails as an invaluable tool for establishing a…”
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A single-cell type transcriptomics map of human tissues by Karlsson, Max, Zhang, Cheng, Méar, Loren, Zhong, Wen, Digre, Andreas, Katona, Borbala, Sjöstedt, Evelina, Butler, Lynn, Odeberg, Jacob, Dusart, Philip, Edfors, Fredrik, Oksvold, Per, von Feilitzen, Kalle, Zwahlen, Martin, Arif, Muhammad, Altay, Ozlem, Li, Xiangyu, Ozcan, Mehmet, Mardinoglu, Adil, Fagerberg, Linn, Mulder, Jan, Luo, Yonglun, Ponten, Fredrik, Uhlén, Mathias, Lindskog, Cecilia

“…Advances in molecular profiling have opened up the possibility to map the expression of genes in cells, tissues, and organs in the human body. Here, we…”
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Towards a knowledge-based Human Protein Atlas by Uhlen, Mathias, Oksvold, Per, Fagerberg, Linn, Lundberg, Emma, Jonasson, Kalle, Forsberg, Mattias, Zwahlen, Martin, Kampf, Caroline, Wester, Kenneth, Hober, Sophia, Wernerus, Henrik, Björling, Lisa, Ponten, Fredrik

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A Protein Epitope Signature Tag (PrEST) Library Allows SILAC-based Absolute Quantification and Multiplexed Determination of Protein Copy Numbers in Cell Lines by Zeiler, Marlis, Straube, Werner L., Lundberg, Emma, Uhlen, Mathias, Mann, Matthias

“…Mass spectrometry-based proteomics increasingly relies on relative or absolute quantification. In relative quantification, stable isotope based methods often…”
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Longitudinal Exposomics in a Multiomic Wellness Cohort Reveals Distinctive and Dynamic Environmental Chemical Mixtures in Blood by Sdougkou, Kalliroi, Papazian, Stefano, Bonnefille, Bénilde, Xie, Hongyu, Edfors, Fredrik, Fagerberg, Linn, Uhlén, Mathias, Bergström, Göran, Martin, Leah J., Martin, Jonathan W.

“…Chemical exposomes can now be comprehensively measured in human blood, but knowledge of their variability and longitudinal stability is required for robust…”
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Systems biology in hepatology: approaches and applications by Mardinoglu, Adil, Boren, Jan, Smith, Ulf, Uhlen, Mathias, Nielsen, Jens

“…Detailed insights into the biological functions of the liver and an understanding of its crosstalk with other human tissues and the gut microbiota can be used…”
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