Search Results - "UHL, Martin"

Health-related quality of life and neurocognitive functioning with lomustine–temozolomide versus temozolomide in patients with newly diagnosed, MGMT-methylated glioblastoma (CeTeG/NOA-09): a randomised, multicentre, open-label, phase 3 trial by Weller, Johannes, MD, Tzaridis, Theophilos, MD, Mack, Frederic, MD, Steinbach, Joachim Peter, Prof, Schlegel, Uwe, Prof, Hau, Peter, Prof, Krex, Dietmar, MD, Grauer, Oliver, MD, Goldbrunner, Roland, Prof, Bähr, Oliver, MD, Uhl, Martin, MD, Seidel, Clemens, MD, Tabatabai, Ghazaleh, Prof, Brehmer, Stefanie, MD, Bullinger, Lars, Prof, Galldiks, Norbert, MD, Schaub, Christina, MD, Kebir, Sied, MD, Stummer, Walter, Prof, Simon, Matthias, MD, Fimmers, Rolf, PhD, Coch, Christoph, MD, Glas, Martin, MD, Herrlinger, Ulrich, Prof, Schäfer, Niklas, MD

“…SummaryBackgroundThe CeTeG/NOA-09 trial showed significantly longer overall survival with combined lomustine–temozolomide therapy compared with standard…”
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Fatal Liver and Bone Marrow Toxicity by Combination Treatment of Dichloroacetate and Artesunate in a Glioblastoma Multiforme Patient: Case Report and Review of the Literature by Uhl, Martin, Schwab, Stefan, Efferth, Thomas

“…A 52-year-old male patient was treated with standard radiochemotherapy with temozolomide for glioblastoma multiforme (GBM). After worsening of his clinical…”
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Case report: Cerebrospinal fluid neutrophilic pleocytosis upon intrathecal triamcinolone injection by Tsaktanis, Thanos, Stritzelberger, Jenny, To, Vi Tuong Daniel, Uhl, Martin, Schwab, Stefan, Heuss, Dieter, Rothhammer, Veit

“…Intrathecal corticosteroids, initially employed in the 1950s, faced declining use due to complications like arachnoiditis and aseptic meningitis…”
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Metabolic Heterogeneity of Brain Tumor Cells of Proneural and Mesenchymal Origin by Seliger, Corinna, Meyer, Anne-Louise, Leidgens, Verena, Rauer, Lisa, Moeckel, Sylvia, Jachnik, Birgit, Proske, Judith, Dettmer, Katja, Rothhammer-Hampl, Tanja, Kaulen, Leon D., Riemenschneider, Markus J., Oefner, Peter J., Kreutz, Marina, Schmidt, Nils-Ole, Merrill, Marsha, Uhl, Martin, Renner, Kathrin, Vollmann-Zwerenz, Arabel, Proescholdt, Martin, Hau, Peter

“…Brain-tumor-initiating cells (BTICs) of proneural and mesenchymal origin contribute to the highly malignant phenotype of glioblastoma (GB) and resistance to…”
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Cetuximab-Induced Aseptic Meningitis in a Patient with Colorectal Cancer: A Case Report and Review of Literature by Jäger, Jakob, Sprügel, Maximilian, Brunner, Tamara, Uhl, Martin, Schwab, Stefan, Vitali, Francesco, Wein, Axel, Volbers, Bastian

“…Cetuximab is a chimeric IgG1 monoclonal antibody against epidermal growth factor receptor. It is approved by the European medical agency for the treatment of…”
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NOA-03 trial of high-dose methotrexate in primary central nervous system lymphoma: Final report by Herrlinger, Ulrich, Küker, Wilhelm, Uhl, Martin, Blaicher, Hans-Peter, Karnath, Hans-Otto, Kanz, Lothar, Bamberg, Michael, Weller, Michael

“…The NOA‐03 trial explored high‐dose methotrexate alone in 37 patients with primary central nervous system lymphoma. The overall median survival was 25 months…”
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A Case Report of Severe Delirium after Amantadine Withdrawal by Marxreiter, Franz, Winkler, Jürgen, Uhl, Martin, Madžar, Dominik

“…Amantadine is frequently used in addition to dopaminergic substances like dopamine agonists or L-Dopa in advanced Parkinson disease (PD). However, adverse…”
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High-Grade Glioma: Refined Diagnostics Steering Stratified Therapy by Uhl, Martin, Hau, Peter

“…An adequately sampled tumor histology that is evaluated by an experienced neuropathologist is the current international standard for the diagnosis of…”
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Migratory neural stem cells for improved thymidine kinase-based gene therapy of malignant gliomas by Uhl, Martin, Weiler, Markus, Wick, Wolfgang, Jacobs, Andreas H., Weller, Michael, Herrlinger, Ulrich

“…Gene therapy of glioma based on viral delivery of herpes simplex virus type I thymidine kinase (HSV-TK) has failed in the clinic because of low transduction…”
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Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA–09): a randomised, open-label, phase 3 trial by Herrlinger, Ulrich, Tzaridis, Theophilos, Mack, Frederic, Steinbach, Joachim Peter, Schlegel, Uwe, Sabel, Michael, Hau, Peter, Kortmann, Rolf-Dieter, Krex, Dietmar, Grauer, Oliver, Goldbrunner, Roland, Schnell, Oliver, Bähr, Oliver, Uhl, Martin, Seidel, Clemens, Tabatabai, Ghazaleh, Kowalski, Thomas, Ringel, Florian, Schmidt-Graf, Friederike, Suchorska, Bogdana, Brehmer, Stefanie, Weyerbrock, Astrid, Renovanz, Miriam, Bullinger, Lars, Galldiks, Norbert, Vajkoczy, Peter, Misch, Martin, Vatter, Hartmut, Stuplich, Moritz, Schäfer, Niklas, Kebir, Sied, Weller, Johannes, Schaub, Christina, Stummer, Walter, Tonn, Jörg-Christian, Simon, Matthias, Keil, Vera C, Nelles, Michael, Urbach, Horst, Coenen, Martin, Wick, Wolfgang, Weller, Michael, Fimmers, Rolf, Schmid, Matthias, Hattingen, Elke, Pietsch, Torsten, Coch, Christoph, Glas, Martin

“…There is an urgent need for more effective therapies for glioblastoma. Data from a previous unrandomised phase 2 trial suggested that lomustine-temozolomide…”
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Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β-dependent adaptive immunity against tumors by Ullrich, Evelyn, Uhl, Martin, Tschopp, Jürg, McLaughlin, Nicole M, Lidereau, Rosette, Aymeric, Laetitia, Kanellopoulos, Jean, Génin, Pierre, Haynes, Nicole M, Civas, Ahmet, Schlemmer, Frédéric, Apetoh, Lionel, Kroemer, Guido, Ryffel, Bernhard, Perfettini, Jean-Luc, Ghiringhelli, François, Ortiz, Carla, Mignot, Grégoire, Tesniere, Antoine, Ma, Yuting, Smyth, Mark J, Panaretakis, Theocharis, Zitvogel, Laurence, André, Fabrice, Vermaelen, Karim, Tasdemir, Ezgi

“…Dying tumor cells release ATP, which activates the NLRP3 inflammasome in dendritic cells, enabling the secretion of interleukin-1β and the subsequent priming…”
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Bevacizumab Plus Irinotecan Versus Temozolomide in Newly Diagnosed O 6 -Methylguanine–DNA Methyltransferase Nonmethylated Glioblastoma: The Randomized GLARIUS Trial by Herrlinger, Ulrich, Schäfer, Niklas, Steinbach, Joachim P., Weyerbrock, Astrid, Hau, Peter, Goldbrunner, Roland, Friedrich, Franziska, Rohde, Veit, Ringel, Florian, Schlegel, Uwe, Sabel, Michael, Ronellenfitsch, Michael W., Uhl, Martin, Maciaczyk, Jaroslaw, Grau, Stefan, Schnell, Oliver, Hänel, Mathias, Krex, Dietmar, Vajkoczy, Peter, Gerlach, Rüdiger, Kortmann, Rolf-Dieter, Mehdorn, Maximilian, Tüttenberg, Jochen, Mayer-Steinacker, Regine, Fietkau, Rainer, Brehmer, Stefanie, Mack, Frederic, Stuplich, Moritz, Kebir, Sied, Kohnen, Ralf, Dunkl, Elmar, Leutgeb, Barbara, Proescholdt, Martin, Pietsch, Torsten, Urbach, Horst, Belka, Claus, Stummer, Walter, Glas, Martin

“…Purpose In patients with newly diagnosed glioblastoma that harbors a nonmethylated O 6 -methylguanine–DNA methyltransferase promotor, standard temozolomide…”
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The course of tumor-related epilepsy in glioblastoma patients: A retrospective analysis by Stritzelberger, Jenny, Gesmann, Anna, Fuhrmann, Imke, Uhl, Martin, Brandner, Sebastian, Welte, Tamara-M., Schembs, Leah, Dörfler, Arnd, Coras, Roland, Adler, Werner, Schwab, Stefan, Putz, Florian, Fietkau, Rainer, Distel, Luitpold, Hamer, Hajo

“…•We conducted a retrospective analysis to analyze the course, characteristics and prognosis of tumor-related epilepsy.•Our results demonstrate a generally good…”
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Early postoperative tumor progression predicts clinical outcome in glioblastoma—implication for clinical trials by Merkel, Andreas, Soeldner, Dorothea, Wendl, Christina, Urkan, Dilek, Kuramatsu, Joji B., Seliger, Corinna, Proescholdt, Martin, Eyupoglu, Ilker Y., Hau, Peter, Uhl, Martin

“…Molecular markers define the diagnosis of glioblastoma in the new WHO classification of 2016, challenging neuro-oncology centers to provide timely treatment…”
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Status epilepticus in patients with glioblastoma: Clinical characteristics, risk factors, and epileptological outcome by Stritzelberger, Jenny, Gesmann, Anna, Fuhrmann, Imke, Balk, Stefanie, Reindl, Caroline, Madžar, Dominik, Uhl, Martin, Welte, Tamara M., Brandner, Sebastian, Eisenhut, Felix, Dörfler, Arnd, Coras, Roland, Adler, Werner, Schwab, Stefan, Putz, Florian, Fietkau, Rainer, Distel, Luitpold, Hamer, Hajo M.

“…•Nearly 10 % of patients with glioblastoma suffered from status epilepticus in this retrospective, single-centre analysis.•SE occurrence was linked to…”
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Clinical Reasoning: A 49-year-old man with fever and proximal weakness of his arms by Seliger, Corinna, Schulte-Mattler, Wilhelm, Bogdahn, Ulrich, Uhl, Martin

“…A 49-year-old man with no significant medical history was seen by a neurologic consultant in eastern Bavaria, Germany, after he developed weakness of both…”
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CTNI-07. LOMUSTINE/TEMOZOLOMIDE CHEMOTHERAPY FOR NEWLY DIAGNOSED MGMT-METHYLATED IDHWT GLIOBLASTOMA ACCORDING TO CETEG/NOA-09: REAL-WORLD EXPERIENCE IN A MULTICENTER COHORT by Weller, Johannes, Zeyen, Thomas, Schlegel, Uwe, Lazaridis, Lazaros, Werner, Jan-Michael, Onken, Julia, Zeiner, Pia, Drexler, Richard, Hau, Peter, Seidel, Clemens, Grosse, Lucia, Clusmann, Hans, Sabel, Michael, Ringel, Florian, Pichler, Josef, Grauer, Oliver, Hundsberger, Thomas, Schnell, Oliver, Mair, Maximilian J, Uhl, Martin, Schmidt-Graf, Friederike, Glas, Martin, Galldiks, Norbert, Unteroberdörster, Meike, Steinbach, Joachim, Ricklefs, Franz, Renovanz, Mirjam, Delev, Daniel Ivanov, Turgut, Merih O, Flesch, Oliver R, Cipriani, Debora, Preusser, Matthias, Kebir, Sied, Misch, Martin, Goldbrunner, Roland, Westphal, Manfred, Tabatabai, Ghazaleh, Schäfer, Niklas, Schneider, Matthias, Vatter, Hartmut, Giordano, Frank, Schaub, Christina, Herrlinger, Ulrich

“…Abstract INTRODUCTION The CeTeG/NOA-09 trial demonstrated superior median overall survival (mOS, 48.1 months) in MGMT-methylated glioblastoma treated with…”
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Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-β2 by Seliger, Corinna, Meyer, Anne-Louise, Renner, Kathrin, Leidgens, Verena, Moeckel, Sylvia, Jachnik, Birgit, Dettmer, Katja, Tischler, Ulrike, Gerthofer, Valeria, Rauer, Lisa, Uhl, Martin, Proescholdt, Martin, Bogdahn, Ulrich, Riemenschneider, Markus J, Oefner, Peter J, Kreutz, Marina, Vollmann-Zwerenz, Arabel, Hau, Peter

“…To this day, glioblastoma (GBM) remains an incurable brain tumor. Previous research has shown that metformin, an oral anti-diabetic drug, may decrease GBM cell…”
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SD-208, a novel transforming growth factor β receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo by UHL, Martin, AULWURM, Steffen, MURPHY, Alison, WONG, Darren H, WICK, Wolfgang, HIGGINS, Linda S, WELLER, Michael, WISCHHUSEN, Jörg, WEILER, Markus, JING YING MA, ALMIREZ, Ramona, MANGADU, Ruban, LIU, Yu-Wang, PLATTEN, Michael, HERRLINGER, Ulrich

“…The cytokine transforming growth factor (TGF)-beta, by virtue of its immunosuppressive and promigratory properties, has become a major target for the…”
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Adaptive Immune Response to and Survival Effect of Temozolomide- and Valproic Acid-induced Autophagy in Glioblastoma by Proske, Judith, Walter, Lisa, Bumes, Elisabeth, Hutterer, Markus, Vollmann-Zwerenz, Arabel, Eyüpoglu, Ilker Y, Savaskan, Nicolai E, Seliger, Corinna, Hau, Peter, Uhl, Martin

“…The combination of radiotherapy, temozolomide and valproic acid (VPA) has shown some promise in retrospective analyses of patients with glioblastoma, although…”
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