Search Results - "UGUREL, Selma"

Merkel cell carcinoma-derived exosome-shuttle miR-375 induces fibroblast polarization by inhibition of RBPJ and p53 by Fan, Kaiji, Spassova, Ivelina, Gravemeyer, Jan, Ritter, Cathrin, Horny, Kai, Lange, Anja, Gambichler, Thilo, Ødum, Niels, Schrama, David, Schadendorf, Dirk, Ugurel, Selma, Becker, Jürgen C.

“…Merkel cell carcinoma (MCC) is a highly invasive and metastatic skin cancer. While high expression of miR-375 is a characteristic of MCC, it seems not to…”
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Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy by Hofmann, Lars, Forschner, Andrea, Loquai, Carmen, Goldinger, Simone M, Zimmer, Lisa, Ugurel, Selma, Schmidgen, Maria I, Gutzmer, Ralf, Utikal, Jochen S, Göppner, Daniela, Hassel, Jessica C, Meier, Friedegund, Tietze, Julia K, Thomas, Ioannis, Weishaupt, Carsten, Leverkus, Martin, Wahl, Renate, Dietrich, Ursula, Garbe, Claus, Kirchberger, Michael C, Eigentler, Thomas, Berking, Carola, Gesierich, Anja, Krackhardt, Angela M, Schadendorf, Dirk, Schuler, Gerold, Dummer, Reinhard, Heinzerling, Lucie M

“…Abstract Background Anti-programmed cell death receptor-1 (PD-1) antibodies represent an effective treatment option for metastatic melanoma as well as for…”
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Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma by Ritter, Cathrin, Fan, Kaiji, Paschen, Annette, Reker Hardrup, Sine, Ferrone, Soldano, Nghiem, Paul, Ugurel, Selma, Schrama, David, Becker, Jürgen C.

“…Merkel cell carcinoma (MCC) is a rare and aggressive, yet highly immunogenic skin cancer. The latter is due to its viral or UV-associated carcinogenesis. For…”
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Activity of ipilimumab plus nivolumab in avelumab-refractory Merkel cell carcinoma by Glutsch, Valerie, Kneitz, Hermann, Gesierich, Anja, Goebeler, Matthias, Haferkamp, Sebastian, Becker, Jürgen C., Ugurel, Selma, Schilling, Bastian

“…Background Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine cutaneous malignancy with poor prognosis. In Europe, approved systemic therapies…”
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The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma by Van Allen, Eliezer M, Wagle, Nikhil, Sucker, Antje, Treacy, Daniel J, Johannessen, Cory M, Goetz, Eva M, Place, Chelsea S, Taylor-Weiner, Amaro, Whittaker, Steven, Kryukov, Gregory V, Hodis, Eran, Rosenberg, Mara, McKenna, Aaron, Cibulskis, Kristian, Farlow, Deborah, Zimmer, Lisa, Hillen, Uwe, Gutzmer, Ralf, Goldinger, Simone M, Ugurel, Selma, Gogas, Helen J, Egberts, Friederike, Berking, Carola, Trefzer, Uwe, Loquai, Carmen, Weide, Benjamin, Hassel, Jessica C, Gabriel, Stacey B, Carter, Scott L, Getz, Gad, Garraway, Levi A, Schadendorf, Dirk

“…Most patients with BRAF(V600)-mutant metastatic melanoma develop resistance to selective RAF kinase inhibitors. The spectrum of clinical genetic resistance…”
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Drug-induced sarcoidosis-like reaction in adjuvant immunotherapy: Increased rate and mimicker of metastasis by Chorti, Eleftheria, Kanaki, Theodora, Zimmer, Lisa, Hadaschik, Eva, Ugurel, Selma, Gratsias, Emmanouil, Roesch, Alexander, Bonella, Francesco, Wessendorf, Thomas E., Wälscher, Julia, Theegarten, Dirk, Schadendorf, Dirk, Livingstone, Elisabeth

“…Anti-[programmed cell death protein 1 (PD-1)] antibodies nivolumab and pembrolizumab were approved for adjuvant treatment of melanoma as they demonstrated…”
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Editorial: Women in skin cancer vol II: 2022 by Ugurel, Selma, Patel, Sapna P.

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MHC class-I downregulation in PD-1/PD-L1 inhibitor refractory Merkel cell carcinoma and its potential reversal by histone deacetylase inhibition: a case series by Ugurel, Selma, Spassova, Ivelina, Wohlfarth, Jonas, Drusio, Christina, Cherouny, Angela, Melior, Anita, Sucker, Antje, Zimmer, Lisa, Ritter, Cathrin, Schadendorf, Dirk, Becker, Jürgen C.

“…Background Merkel cell carcinoma (MCC) is an aggressive skin cancer in which PD-1/PD-L1 blockade has shown remarkable response rates. However, a significant…”
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BRAF and MEK inhibition in melanoma patients enables reprogramming of tumor infiltrating lymphocytes by Peiffer, Lukas, Farahpour, Farnoush, Sriram, Ashwin, Spassova, Ivelina, Hoffmann, Daniel, Kubat, Linda, Stoitzner, Patrizia, Gambichler, Thilo, Sucker, Antje, Ugurel, Selma, Schadendorf, Dirk, Becker, Jürgen C.

“…Background Combined inhibition of BRAF/MEK is an established therapy for melanoma. In addition to its canonical mode of action, effects of BRAF/MEK inhibitors…”
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Efficacy of PD-1–based immunotherapy after radiologic progression on targeted therapy in stage IV melanoma by Kreft, Sophia, Gesierich, Anja, Eigentler, Thomas, Franklin, Cindy, Valpione, Sara, Ugurel, Selma, Utikal, Jochen, Haferkamp, Sebastian, Blank, Christian, Larkin, James, Garbe, Claus, Schadendorf, Dirk, Lorigan, Paul, Schilling, Bastian

“…Targeted therapy (TT) is an effective treatment for advanced BRAFV600-mutated melanoma, but most patients eventually acquire resistance and progress. Here, we…”
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Final Results of Phase III SYMMETRY Study: Randomized, Double-Blind Trial of Elesclomol Plus Paclitaxel Versus Paclitaxel Alone As Treatment for Chemotherapy-Naive Patients With Advanced Melanoma by O'DAY, Steven J, EGGERMONT, Alexander M. M, FRIEDLANDER, Philip, GARBE, Claus, UGUREL, Selma, COLLICHIO, Frances, WEI GUO, LUFKIN, Joelle, BAHCALL, Safi, VUKOVIC, Vojo, HAUSCHILD, Axel, CHIARION-SILENI, Vanna, KEFFORD, Richard, GROB, Jean Jacques, MORTIER, Laurent, ROBERT, Caroline, SCHACHTER, Jacob, TESTORI, Alessandro, MACKIEWICZ, Jacek

“…Elesclomol, an investigational first-in-class compound, induces oxidative stress, triggers mitochondrial-induced apoptosis in cancer cells, and shows synergy…”
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Epidemiology, biology and therapy of Merkel cell carcinoma: conclusions from the EU project IMMOMEC by Becker, Jürgen C., Stang, Andreas, Hausen, Axel zur, Fischer, Nicole, DeCaprio, James A., Tothill, Richard W., Lyngaa, Rikke, Hansen, Ulla Kring, Ritter, Cathrin, Nghiem, Paul, Bichakjian, Christopher K., Ugurel, Selma, Schrama, David

“…Merkel cell carcinoma (MCC) is a highly aggressive, often lethal neuroendocrine cancer. Its carcinogenesis may be either caused by the clonal integration of…”
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Circulating Cell-Free miR-375 as Surrogate Marker of Tumor Burden in Merkel Cell Carcinoma by Fan, Kaiji, Ritter, Cathrin, Nghiem, Paul, Blom, Astrid, Verhaegen, Monique E, Dlugosz, Andrzej, Ødum, Niels, Woetmann, Anders, Tothill, Richard W, Hicks, Rodney J, Sand, Michael, Schrama, David, Schadendorf, Dirk, Ugurel, Selma, Becker, Jürgen C

“…Merkel cell carcinoma (MCC) is an aggressive skin cancer with neuroendocrine differentiation. There is an unmet need for MCC-specific blood-based surrogate…”
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Case report: Durable complete response of a mucosal melanoma of the rectum after neoadjuvant immunotherapy with ipilimumab plus nivolumab by Krueger, Oskar, Eisenburger, Robin, Tasdogan, Alpaslan, Zimmer, Lisa, Livingstone, Elisabeth, Hadaschik, Eva, Theurer, Sarah, Brodin, Berthold, Schadendorf, Dirk, Ugurel, Selma

“…Melanoma causes the majority of skin cancer-related deaths. Despite novel therapy options, metastatic melanoma still has a poor prognosis. Immune checkpoint…”
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Comparison of visual diagnostic accuracy of dermatologists practicing in Germany in patients with light skin and skin of color by Krefting, Frederik, Moelleken, Maurice, Hölsken, Stefanie, Placke, Jan-Malte, Eisenburger, Robin Tamara, Albrecht, Lea Jessica, Tasdogan, Alpaslan, Schadendorf, Dirk, Ugurel, Selma, Dissemond, Joachim, Sondermann, Wiebke

“…Visual clinical diagnosis of dermatoses in people of color (PoC) is a considerable challenge in daily clinical practice and a potential cause of misdiagnosis…”
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Targeted next generation sequencing of mucosal melanomas identifies frequent NF1 and RAS mutations by Cosgarea, Ioana, Ugurel, Selma, Sucker, Antje, Livingstone, Elisabeth, Zimmer, Lisa, Ziemer, Mirjana, Utikal, Jochen, Mohr, Peter, Pfeiffer, Christiane, Pföhler, Claudia, Hillen, Uwe, Horn, Susanne, Schadendorf, Dirk, Griewank, Klaus G, Roesch, Alexander

“…Mucosal melanoma represents ~1% of all melanomas, frequently having a poor prognosis due to diagnosis at a late stage of disease. Mucosal melanoma differs from…”
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Retraction Note: TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT by Hill, Richard, Madureira, Patricia A., Ferreira, Bibiana, Baptista, Inês, Machado, Susana, Colaҫo, Laura, dos Santos, Marta, Liu, Ningshu, Dopazo, Ana, Ugurel, Selma, Adrienn, Angyal, Kiss-Toth, Endre, Isbilen, Murat, Gure, Ali O., Link, Wolfgang

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Clinical and genetic analysis of melanomas arising in acral sites by Zaremba, Anne, Murali, Rajmohan, Jansen, Philipp, Möller, Inga, Sucker, Antje, Paschen, Annette, Zimmer, Lisa, Livingstone, Elisabeth, Brinker, Titus J., Hadaschik, Eva, Franklin, Cindy, Roesch, Alexander, Ugurel, Selma, Schadendorf, Dirk, Griewank, Klaus G., Cosgarea, Ioana

“…Melanomas arising in acral sites are associated with a poorer prognosis than other melanoma subtypes. The aim of this study was to evaluate…”
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Serum Amyloid A As a Prognostic Marker in Melanoma Identified by Proteomic Profiling by FINDEISEN, Peter, ZAPATKA, Marc, PECCERELLA, Teresa, MATZK, Heike, NEUMAIER, Michael, SCHADENDORF, Dirk, UGUREL, Selma

“…Currently known prognostic serum biomarkers of melanoma are powerful in metastatic disease, but weak in early-stage patients. This study was aimed to identify…”
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Clinical determinants of long-term survival in metastatic uveal melanoma by Koch, Elias A. T., Petzold, Anne, Wessely, Anja, Dippel, Edgar, Erdmann, Michael, Heinzerling, Lucie, Hohberger, Bettina, Knorr, Harald, Leiter, Ulrike, Meier, Friedegund, Mohr, Peter, Rahimi, Farnaz, Schell, Beatrice, Schlaak, Max, Terheyden, Patrick, Schuler-Thurner, Beatrice, Ugurel, Selma, Utikal, Jochen, Vera, Julio, Weichenthal, Michael, Ziller, Fabian, Berking, Carola, Heppt, Markus V.

“…This study aimed to identify prognostic factors in patients with metastatic uveal melanoma (UM) that were associated with long-term survival in a real-world…”
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