Search Results - "UFER, Mike"

Comparative efficacy and safety of the novel oral anticoagulants dabigatran, rivaroxaban and apixaban in preclinical and clinical development by Ufer, Mike

“…Therapeutic oral anticoagulation is still commonly achieved by administration of warfarin or other vitamin K antagonists that are associated with an untoward…”
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Clinical Pharmacology of Clazosentan, a Selective Endothelin A Receptor Antagonist for the Prevention and Treatment of aSAH-Related Cerebral Vasospasm by Juif, Pierre-Eric, Dingemanse, Jasper, Ufer, Mike

“…Aneurysmal subarachnoid hemorrhage (aSAH) may lead to cerebral vasospasm and is associated with significant morbidity and mortality. It represents a major…”
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The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease by Neumann, Ulf, Ufer, Mike, Jacobson, Laura H, Rouzade‐Dominguez, Marie‐Laure, Huledal, Gunilla, Kolly, Carine, Lüönd, Rainer M, Machauer, Rainer, Veenstra, Siem J, Hurth, Konstanze, Rueeger, Heinrich, Tintelnot‐Blomley, Marina, Staufenbiel, Matthias, Shimshek, Derya R, Perrot, Ludovic, Frieauff, Wilfried, Dubost, Valerie, Schiller, Hilmar, Vogg, Barbara, Beltz, Karen, Avrameas, Alexandre, Kretz, Sandrine, Pezous, Nicole, Rondeau, Jean‐Michel, Beckmann, Nicolau, Hartmann, Andreas, Vormfelde, Stefan, David, Olivier J, Galli, Bruno, Ramos, Rita, Graf, Ana, Lopez Lopez, Cristina

“…The beta‐site amyloid precursor protein cleaving enzyme‐1 (BACE‐1) initiates the generation of amyloid‐β (Aβ), and the amyloid cascade leading to amyloid…”
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The challenges of clinical trials in fragile X syndrome by Jacquemont, Sébastien, Berry-Kravis, Elizabeth, Hagerman, Randi, von Raison, Florian, Gasparini, Fabrizio, Apostol, George, Ufer, Mike, Des Portes, Vincent, Gomez-Mancilla, Baltazar

“…Rationale Advances in understanding the underlying mechanisms of conditions such as fragile X syndrome (FXS) and autism spectrum disorders have revealed…”
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Cardiodynamic Interactions between Two S1P1 Receptor Modulators in an Experimental Clinical Setting: Different Pharmacokinetic Properties as an Opportunity to Mitigate First-Dose Heart Rate Effects by Juif, Pierre-Eric, Ufer, Mike, Dingemanse, Jasper

“…A decrease in heart rate (HR) is a well-established first-dose effect of sphingosine-1-phosphate subtype 1 receptor (S1P1R) modulators. For compounds with a…”
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Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients by Binder, Andreas, May, Denisa, Baron, Ralf, Maier, Christoph, Tölle, Thomas R, Treede, Rolf-Detlef, Berthele, Achim, Faltraco, Frank, Flor, Herta, Gierthmühlen, Janne, Haenisch, Sierk, Huge, Volker, Magerl, Walter, Maihöfner, Christian, Richter, Helmut, Rolke, Roman, Scherens, Andrea, Uçeyler, Nurcan, Ufer, Mike, Wasner, Gunnar, Zhu, Jihong, Cascorbi, Ingolf

“…Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The…”
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Pharmacokinetics and Pharmacodynamics of Cenerimod, A Selective S1P1R Modulator, Are Not Affected by Ethnicity in Healthy Asian and White Subjects by Juif, Pierre‐Eric, Dingemanse, Jasper, Winkle, Peter, Ufer, Mike

“…Cenerimod is a sphingosine‐1‐phosphate 1 receptor (S1P1R) modulator in phase II development for treatment of systemic lupus erythematosus. Its pharmacokinetics…”
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Effect of Rifampin‐Mediated OATP1B1 and OATP1B3 Transporter Inhibition on the Pharmacokinetics of the P2Y12 Receptor Antagonist Selatogrel by Schilling, Uta, Dingemanse, Jasper, Voors‐Pette, Christine, Romeijn, Christel, Dogterom, Peter, Ufer, Mike

“…In vitro studies have indicated that the P2Y12 receptor antagonist selatogrel is a substrate of organic anion‐transporting‐polypeptide (OATP)1B1 and OATP1B3…”
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Impact of siponimod on vaccination response in a randomized, placebo-controlled study by Ufer, Mike, Shakeri-Nejad, Kasra, Gardin, Anne, Su, Zhenzhong, Paule, Ines, Marbury, Thomas C, Legangneux, Eric

“…OBJECTIVE:To evaluate effects of siponimod on response to T-cell–dependent (influenza) and T-cell–independent (pneumococcal polysaccharide vaccine [PPV-23])…”
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Quantification of cortisol and 6 beta-hydroxycortisol in human urine by LC-MS/MS, and gender-specific evaluation of the metabolic ratio as biomarker of CYP3A activity by Lutz, Ursula, Bittner, Nataly, Ufer, Mike, Lutz, Werner K.

“…Drug–drug and food–drug interactions are often due to an inhibition or induction of drug-metabolizing cytochrome P450 (CYP) enzymes and may result in…”
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Development of mavoglurant and its potential for the treatment of fragile X syndrome by Gomez-Mancilla, Baltazar, Berry-Kravis, Elizabeth, Hagerman, Randi, von Raison, Florian, Apostol, George, Ufer, Mike, Gasparini, Fabrizio, Jacquemont, Sébastien

“…Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. With no curative treatment available, current therapeutic approaches…”
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Influence of Rifampin‐Mediated Organic Anion‐Transporting Polypeptide 1B1/1B3 Inhibition on the Pharmacokinetics of Clazosentan by Juif, Pierre‐Eric, Voors‐Pette, Christine, Ufer, Mike, Dogterom, Peter, Dingemanse, Jasper

“…Clazosentan is a selective endothelin A receptor antagonist in development for the prevention and treatment of vasospasm postsubarachnoid hemorrhage. It is a…”
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Intravenous Dosing as an Alternate Approach to Safely Achieve Supratherapeutic Exposure for Assessments of Cardiac Repolarization: A Randomized Clinical Trial with Mavoglurant (AFQ056) by Ufer, Mike, MD, PhD, Sagkriotis, Alexandros, PhD, Salunke, Atish, MPharm, Ganesan, Subramanian, PhD, Tisserant, Anne, PhD, Dodman, Angela, PhD, Voltz, Emilie, PhD, Woessner, Ralph, PhD, Jordaan, Pierre, MD, Legangneux, Eric, MD

“…Abstract Purpose The conduct of thorough QTc (TQT) studies is often challenging with compounds that are characterized by limited tolerability in healthy…”
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Genotype Frequencies of Selected Drug Metabolizing Enzymes and ABC Drug Transporters among Breast Cancer Patients on FAC Chemotherapy by Afsar, Nasir Ali, Haenisch, Sierk, Mateen, Ahmed, Usman, Ahmed, Ufer, Mike, Ahmed, Khwaja Zafar, Ahmad, Hakimuddin Razi, Cascorbi, Ingolf

“…:  Polymorphic genes of drug metabolizing enzymes and transporters may influence drug response. With some exemptions, single nucleotide polymorphisms in such…”
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Pharmacokinetics and Pharmacodynamics of Approved and Investigational P2Y12 Receptor Antagonists by Schilling, Uta, Dingemanse, Jasper, Ufer, Mike

“…Coronary artery disease remains the major cause of mortality worldwide. Antiplatelet drugs such as acetylsalicylic acid and P2Y12 receptor antagonists are…”
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Comparative pharmacokinetics of vitamin K antagonists : Warfarin, phenprocoumon and acenocoumarol by UFER, Mike

“…Vitamin K antagonists belong to the group of most frequently used drugs worldwide. They are used for long-term anticoagulation therapy, and exhibit their…”
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Identification of cytochromes P 450 2C9 and 3A4 as the major catalysts of phenprocoumon hydroxylation in vitro by Ufer, Mike, Svensson, Jan O., Krausz, Kristopher W., Gelboin, Harry V., Rane, Anders, Tybring, Gunnel

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Effects of folic acid supplementation on the pharmacokinetics and anticoagulant effect of warfarin: An open-label, prospective study of long-term administration in adults by Muszkat, Mordechai, MD, Bialer, Omer, MD, Blotnick, Simcha, PhD, Adar, Liat, PhD, Xie, Hong-Guang, MD, PhD, Ufer, Mike, MD, PhD, Cascorbi, Ingolf, MD, PhD, Caraco, Yoseph, MD

“…Abstract Background: Folic acid supplementation in patients with folic acid deficiency has been associated with increased clearance of phenytoin to its…”
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Determination of phenprocoumon, warfarin and their monohydroxylated metabolites in human plasma and urine by liquid chromatography–mass spectrometry after solid-phase extraction by Ufer, Mike, Kammerer, Bernd, Kirchheiner, Julia, Rane, Anders, Svensson, Jan-Olof

“…A high-performance liquid chromatography–mass spectrometry (HPLC–MS) method for the quantification of phenprocoumon, warfarin, and their known monohydroxylated…”
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Abuse potential assessment of the new dual orexin receptor antagonist daridorexant in recreational sedative drug users as compared to suvorexant and zolpidem by Ufer, Mike, Kelsh, Debra, Schoedel, Kerri A, Dingemanse, Jasper

“…Abstract Study Objectives Abuse potential properties have been reported for the dual orexin receptor antagonists (DORAs) suvorexant and lemborexant…”
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