Search Results - "UEDA, Masahiro"

Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells by Matsuoka, Satomi, Ueda, Masahiro

“…Phosphatidylinositol 3,4,5-trisphosphate (PIP3) and PIP3 phosphatase (PTEN) are enriched mutually exclusively on the anterior and posterior membranes of…”
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Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias by Kawakami, Kouki, Yanagawa, Masataka, Hiratsuka, Suzune, Yoshida, Misaki, Ono, Yuki, Hiroshima, Michio, Ueda, Masahiro, Aoki, Junken, Sako, Yasushi, Inoue, Asuka

“…Signaling-biased ligands acting on G-protein-coupled receptors (GPCRs) differentially activate heterotrimeric G proteins and β-arrestins. Although a wealth of…”
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Excitable dynamics of Ras triggers spontaneous symmetry breaking of PIP3 signaling in motile cells by Fukushima, Seiya, Matsuoka, Satomi, Ueda, Masahiro

“…Spontaneous cell movement is underpinned by an asymmetric distribution of signaling molecules including small G proteins and phosphoinositides on the cell…”
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Single molecule tracking based drug screening by Watanabe, Daisuke, Hiroshima, Michio, Yasui, Masato, Ueda, Masahiro

“…The single-molecule tracking of transmembrane receptors in living cells has provided significant insights into signaling mechanisms, such as mobility and…”
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Structures and functions of the gut microbial lipidome by Morozumi, Satoshi, Ueda, Masahiro, Okahashi, Nobuyuki, Arita, Makoto

“…Microbial lipids provide signals that are responsible for maintaining host health and controlling disease. The differences in the structures of microbial…”
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Automated single-molecule imaging in living cells by Yasui, Masato, Hiroshima, Michio, Kozuka, Jun, Sako, Yasushi, Ueda, Masahiro

“…An automated single-molecule imaging system developed for live-cell analyses based on artificial intelligence-assisted microscopy is presented. All significant…”
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Development of Low Molecular Weight Ligands for Integrin αvβ3 by Makino, Akira, Ueda, Masahiro, Uematsu, Yoshitaka, Ohora, Takuya, Ohtani, Takayuki, Miyagawa, Shinobu, Fujibayashi, Yasuhisa, Okazawa, Hidehiko, Tokunaga, Yuji, Kiyono, Yasushi

“…We designed and synthesized non-peptide organic molecular ligands for integrin αvβ3. Candidate ligands featured amidino analog and carboxy groups as binding…”
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Stochastic Signal Processing and Transduction in Chemotactic Response of Eukaryotic Cells by Ueda, Masahiro, Shibata, Tatsuo

“…Single-molecule imaging analysis of chemotactic response in eukaryotic cells has revealed a stochastic nature in the input signals and the signal transduction…”
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Parallel signaling pathways regulate excitable dynamics differently to mediate pseudopod formation during eukaryotic chemotaxis by Tanabe, Yuki, Kamimura, Yoichiro, Ueda, Masahiro

“…In eukaryotic chemotaxis, parallel signaling pathways regulate the spatiotemporal pseudopod dynamics at the leading edge of a motile cell through the…”
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Large-scale single-molecule imaging aided by artificial intelligence by Hiroshima, Michio, Yasui, Masato, Ueda, Masahiro

“…Abstract Single-molecule imaging analysis has been applied to study the dynamics and kinetics of molecular behaviors and interactions in living cells. In spite…”
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Excitable Signal Transduction Induces Both Spontaneous and Directional Cell Asymmetries in the Phosphatidylinositol Lipid Signaling System for Eukaryotic Chemotaxis by Nishikawa, Masatoshi, Hörning, Marcel, Ueda, Masahiro, Shibata, Tatsuo

“…Intracellular asymmetry in the signaling network works as a compass to navigate eukaryotic chemotaxis in response to guidance cues. Although the compass…”
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Calcium responses to external mechanical stimuli in the multicellular stage of Dictyostelium discoideum by Hashimura, Hidenori, Morimoto, Yusuke V., Hirayama, Yusei, Ueda, Masahiro

“…Calcium acts as a second messenger to regulate many cellular functions, including cell motility. In Dictyostelium discoideum , the cytosolic calcium level…”
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A sub-population of Dictyostelium discoideum cells shows extremely high sensitivity to cAMP for directional migration by Ohtsuka, Daisuke, Ota, Nobutoshi, Amaya, Satoshi, Matsuoka, Satomi, Tanaka, Yo, Ueda, Masahiro

“…The chemotaxis of Dictysotelium discoideum cells in response to a chemical gradient of cyclic adenosine 3′,5′-monophosphate (cAMP) was studied using a newly…”
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Heterotrimeric G-protein shuttling via Gip1 extends the dynamic range of eukaryotic chemotaxis by Kamimura, Yoichiro, Miyanaga, Yukihiro, Ueda, Masahiro

“…Chemotactic eukaryote cells can sense chemical gradients over a wide range of concentrations via heterotrimeric G-protein signaling; however, the underlying…”
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Self-organization of the phosphatidylinositol lipids signaling system for random cell migration by Arai, Yoshiyuki, Shibata, Tatsuo, Matsuoka, Satomi, Sato, Masayuki J., Yanagida, Toshio, Ueda, Masahiro, Cantley, Lewis Clayton

“…Phosphatidylinositol (Ptdlns) lipids have been identified as key signaling mediators for random cell migration as well as chemo-attractant-induced directional…”
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Transient Acceleration of Epidermal Growth Factor Receptor Dynamics Produces Higher-Order Signaling Clusters by Hiroshima, Michio, Pack, Chan-gi, Kaizu, Kazunari, Takahashi, Koichi, Ueda, Masahiro, Sako, Yasushi

“…Cell signaling depends on spatiotemporally regulated molecular interactions. Although the movements of signaling proteins have been analyzed with various…”
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SRC kinase activator CDCP1 promotes hepatocyte growth factor–induced cell migration/invasion of a subset of breast cancer cells by Kawase, Naoyuki, Sugihara, Atsuya, Kajiwara, Kentaro, Hiroshima, Michio, Akamatsu, Kanako, Nada, Shigeyuki, Matsumoto, Kunio, Ueda, Masahiro, Okada, Masato

“…Cancer invasion and metastasis are the major causes of cancer patient mortality. Various growth factors, including hepatocyte growth factor (HGF), are known to…”
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A dynamic partitioning mechanism polarizes membrane protein distribution by Banerjee, Tatsat, Matsuoka, Satomi, Biswas, Debojyoti, Miao, Yuchuan, Pal, Dhiman Sankar, Kamimura, Yoichiro, Ueda, Masahiro, Devreotes, Peter N., Iglesias, Pablo A.

“…The plasma membrane is widely regarded as the hub of the numerous signal transduction activities. Yet, the fundamental biophysical mechanisms that…”
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Application of single-molecule analysis to singularity phenomenon of cells by Hiroshima, Michio, Bannai, Hiroko, Matsumoto, Gen, Ueda, Masahiro

“…Single-molecule imaging in living cells is an effective tool for elucidating the mechanisms of cellular phenomena at the molecular level. However, the analysis…”
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Different Heterotrimeric G Protein Dynamics for Wide-Range Chemotaxis in Eukaryotic Cells by Kamimura, Yoichiro, Ueda, Masahiro

“…Chemotaxis describes directional motility along ambient chemical gradients and has important roles in human physiology and pathology. Typical chemotactic…”
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