Search Results - "UCHIMOTO, Hiroshi"

Spontaneous Neoplastic Lesions in Aged Sprague-Dawley Rats by NAKAZAWA, Motokuni, TAWARATANI, Takeharu, UCHIMOTO, Hiroshi, KAWAMINAMI, Akitaka, UEDA, Makoto, UEDA, Akiko, SHINODA, Yasuhiko, IWAKURA, Keiko, KURA, Kohei, SUMI, Nobuyoshi

“…Neoplastic lesions were observed in untreated aged Sprague Dawley (SD) rats throughout their lifespan starting at 5 weeks. Their mean survival times were 89 to…”
Get full text

Nonsuppurative Meningoencephalitis in a Laboratory Beagle Dog by Ueda, Akiko, Ueda, Makoto, Nakazawa, Motokuni, Uchimoto, Hiroshi, Kotera, Takashi, Nakai, Nobuko, Iwakura, Keiko

“…We encountered a case of nonsuppurative meningoencephalitis with neurologic signs of depression, tremor, and ataxic gait in a 15-month-old vaccinated male…”
Get full text

Testicular Yolk Sac Carcinoma in an Aged Sprague-Dawley Rat by Nakazawa, Motokuni, Tawaratani, Takeharu, Uchimoto, Hiroshi, Kawaminami, Akitaka, Ueda, Makoto, Ueda, Akiko, Iwakura, Keiko, Sumi, Nobuyoshi, Kura, Kohei

“…A spontaneous yolk sac carcinoma derived from the testis of an old male Sprague-Dawley rat was examined morphologically. The tumor was composed of cuboidal…”
Get full text

THE MECHANISM OF LACTITOL (NS-4) IN INDUCING ADRENOMEDULLARY PROLIFERATIVE LESION IN RATS by YOSHIDA, Masaru, ISHIBASHI, Seitaro, NAKAZAWA, Motokuni, TAMURA, Hironobu, UCHIMOTO, Hiroshi, KAWAGUCHI, Kazushiro, YOSHIKAWA, Kenichi, HAMASU, Yasuhisa, SUMI, Nobuyoshi

“…We used 13-week repeated oral administration of lactitol as part of a study to clarify the mechanism by which lactitol induces the proliferation of…”
Get full text

BILATERAL GRANULOSA/THECA CELL TUMOR IN AN AGED RAT by Nakazawa, Motokuni, Tawaratani, Takeharu, Yoshida, Masaru, Uchimoto, Hiroshi, Kawaminami, Akitaka, Ueda, Makoto, Iwakura, Keiko, Sumi, Nobuyoshi

“…A malignant granulosa cell tumor and a benign granulosa/theca cell tumor were found in a 124-week-old Sprague-Dawaley female rat. These ovarian tumors were…”
Get full text

新規頻尿・尿失禁治療剤 (±)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydtoxy-2-phenylacetate monohydrochloride monohydrate (NS-21) のラットにおける13週間反復経口投与毒性試験ならびに5週間回復試験 by 西口, 保幸, 安達, 孝浩, 中沢, 素邦, 俵谷, 武治, 内本, 啓史, 吉田, 勝, 石橋, 成太良, 北山, 英太, 岩倉, 啓子, 鷲見, 信好

“…NS-21を0, 6, 30, 150および750mg/kgの投与用量でラットに13週間反復経口投与し, さらに0, 30, 150および750mg/k9投与群については5週間の回復試験を実施して, 以下の成績を得た。1. 一般臨床検査では, 死亡が750mg/kg投与群の雄7例, 雌2例で認められ,…”
Get full text

PRULIFLOXACIN (NM441)のラットを用いた経口投与による13週間反復投与毒性試験および5週間回復試験 by 石橋, 成大良, 中沢, 素邦, 俵谷, 武治, 内本, 啓史, 吉田, 勝, 岩倉, 啓子, 鷲見, 信好, 神藤, 康弘

“…Prulifloxacinの反復投与毒性を検討するために,0,30,170および1000 mg/kgの投与量で,ラットを用いた13週間経口投与毒性試験および5週間回復試験を実施し,以下の結果を得た。1. 一般臨床検査では,1000…”
Get full text

PRULIFLOXACIN (NM441)のイヌを用いた経口投与による13週間反復投与毒性試験および5週間回復試験 by 吉田, 勝, 河南, 明孝, 俵谷, 武治, 内本, 啓史, 石橋, 成大良, 岩倉, 啓子, 鷲見, 信好, 神藤, 康弘

“…Prulifloxacinの反復投与毒性を検討するために,0,20,100および500 mg/kgの投与量で, イスを用いた13週間経口投与毒性試験および5週間回復試験を実施し,以下の結果を得た。1. 一般臨床検査では,嘔吐,流涎,体重の減少ないしは増加抑制が1OO…”
Get full text

LACTITOL(NS-4)のラットにおける13週間反復経口投与毒性試験ならびに5週間回復試験 by 西口, 保幸, 石橋, 成太良, 垂井, 睦, 藤本, 正次, 俵谷, 武治, 吉田, 勝, 内本, 啓史, 安達, 孝浩, 浜洲, 泰久, 鷲見, 信好

“…Lactitolの安全性を検討するために, 0, 0.625, 2.5および10 g/kgの投与用量で, ラットを用いた強制経口投与による13週間反復投与毒性試験を実施し, さらに5週間回復試験を行い, 以下の結果を得た。1. 一般臨床検査では, 軟便および摂餌量の減少が2.5 g/kg投与群に,…”
Get full text

Testicular Yolk Sac Carcinoma in an Aged Sprague-Dawley Rat by Motokuni Nakazawa, Takeharu Tawaratani, Hiroshi Uchimoto, Akitaka Kawaminami, Makoto Ueda, Akiko Ueda, Keiko Iwakura, Nobuyoshi Sumi, Kohei Kura

“…A spontaneous yolk sac carcinoma derived from the testis of an old male Sprague-Dawley rat was examined morphologically. The tumor was composed of cuboidal…”
Get full text

A 13-WEEK ORAL TOXICITY STUDY OF PRULIFLOXACIN (NM441) IN RATS FOLLOWED BY A 5-WEEK RECOVERY TEST by ISHIBASHI, Seitaro, NAKAZAWA, Motokuni, TAWARATANI, Takeharu, UCHIMOTO, Hiroshi, YOSHIDA, Masaru, IWAKURA, Keiko, SUMI, Nobuyoshi, SHINDO, Yasuhiro

“…A repeated dose toxicity study of prulifloxacin, a new antibacterial agent, was conducted in Sprague-Dawley rats. Male and female rats were given the test…”
Get full text

A 13-WEEK ORAL TOXICITY STUDY OF PRULIFLOXACIN (NM441) IN DOGS FOLLOWED BY A 5-WEEK RECOVERY TEST by YOSHIDA, Masaru, KAWAMINAMI, Akitaka, TAWARATANI, Takeharu, UCHIMOTO, Hiroshi, ISHIBASHI, Seitaro, IWAKURA, Keiko, SUMI, Nobuyoshi, SHINDO, Yasuhiro

“…A repeated dose toxicity study of prulifloxacin, a new antibacterial agent, was conducted in beagle dogs. Male and female dogs were given the test material…”
Get full text

A 13-WEEK ORAL REPEATED DOSE TOXICITY STUDY OF (±)-4-DIETHYLAMINO-1, 1-DIMETHYLBUT-2-YN-1-YL 2-CYCLOHEXYL-2-HYDROXY-2-PHENYLACETATE MONOHYDROCHLORIDE MONOHYDRATE (NS-21), A NOVEL DRUG FOR URINARY FREQUENCY AND INCONTINENCE, IN RATS FOLLOWED BY A 5-WEEK RECOVERY TEST by NISHIGUCHI, Yasuyuki, ADACHI, Takahiro, NAKAZAWA, Motokuni, TAWARATNI, Takeharu, UCHIMOTO, Hiroshi, YOSHIDA, Masaru, ISHIBASHI, Seitaro, KITAYAMA, Eita, WAKURA, Keiko, SUMI, Nobuyoshi

“…A 13-week oral repeated dose toxicity study of (±)-4-diethylamino-1, 1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride…”
Get full text

13-WEEK ORAL TOXICITY STUDY OF LACTITOL (NS-4) IN RATS FOLLOWED BY 5-WEEK RECOVERY TEST by NISHIGUCHI, Yasuyuki, ISHIBASHI, Seitaro, TARUI, Mutsumi, FUJIMOTO, Shoji, TAWARATANI, Takeharu, YOSHIDA, Masaru, UCHIMOTO, Hiroshi, ADACHI, Takahiro, HAMASU, Yasuhisa, SUMI, Nobuyoshi

“…Twenty male and 20 female Slc: SD rats were orally given lactitol, a hepatic encephalopathy drug, for 13 weeks at doses of 0, 0.625, 2.5 or 10 g/kg/day. A 5…”
Get full text

BILATERAL GRANULOSA/THECA CELL TUMOR IN AN AGED RAT by Motokuni Nakazawa, Takeharu Tawaratani, Masaru Yoshida, Hiroshi Uchimoto, Akitaka Kawaminami, Makoto Ueda, Keiko Iwakuta, Nobuyoshi Sumi

“…A malignant granulosa cell tumor and a benign granulosa/theca cell tumor were found in a 124-week-old Sprague-Dawaley female rat. These ovarian tumors were…”
Get full text