Search Results - "Uğur Şahin"

Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine-elicited human sera by Muik, Alexander, Lui, Bonny Gaby, Wallisch, Ann-Kathrin, Bacher, Maren, Mühl, Julia, Reinholz, Jonas, Ozhelvaci, Orkun, Beckmann, Nina, Güimil Garcia, Ramón de la Caridad, Poran, Asaf, Shpyro, Svetlana, Finlayson, Andrew, Cai, Hui, Yang, Qi, Swanson, Kena A, Türeci, Özlem, Şahin, Uğur

“…The globally circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern Omicron (B.1.1.529) has a large number of mutations,…”
Get full text

Neutralization of SARS-CoV-2 lineage B.1.1.7 pseudovirus by BNT162b2 vaccine-elicited human sera by Muik, Alexander, Wallisch, Ann-Kathrin, Sänger, Bianca, Swanson, Kena A, Mühl, Julia, Chen, Wei, Cai, Hui, Maurus, Daniel, Sarkar, Ritu, Türeci, Özlem, Dormitzer, Philip R, Şahin, Uğur

“…Recently, a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage called B.1.1.7 (variant of concern: VOC 202012/01), which is reported to…”
Get full text

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine by Polack, Fernando P, Thomas, Stephen J, Kitchin, Nicholas, Absalon, Judith, Gurtman, Alejandra, Lockhart, Stephen, Perez, John L, Pérez Marc, Gonzalo, Moreira, Edson D, Zerbini, Cristiano, Bailey, Ruth, Swanson, Kena A, Roychoudhury, Satrajit, Koury, Kenneth, Li, Ping, Kalina, Warren V, Cooper, David, Frenck, Robert W, Hammitt, Laura L, Türeci, Özlem, Nell, Haylene, Schaefer, Axel, Ünal, Serhat, Tresnan, Dina B, Mather, Susan, Dormitzer, Philip R, Şahin, Uğur, Jansen, Kathrin U, Gruber, William C

“…A vaccine containing an RNA molecule encoding the SARS-CoV-2 spike protein was tested in a trial in which two injections were given 3 weeks apart. After the…”
Get full text

Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults by Mulligan, Mark J., Lyke, Kirsten E., Kitchin, Nicholas, Absalon, Judith, Gurtman, Alejandra, Lockhart, Stephen, Neuzil, Kathleen, Raabe, Vanessa, Bailey, Ruth, Swanson, Kena A., Li, Ping, Koury, Kenneth, Kalina, Warren, Cooper, David, Fontes-Garfias, Camila, Shi, Pei-Yong, Türeci, Özlem, Tompkins, Kristin R., Walsh, Edward E., Frenck, Robert, Falsey, Ann R., Dormitzer, Philip R., Gruber, William C., Şahin, Uğur, Jansen, Kathrin U.

“…In March 2020, the World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome…”
Get full text

Safety and immunogenicity of the SARS-CoV-2 BNT162b1 mRNA vaccine in younger and older Chinese adults: a randomized, placebo-controlled, double-blind phase 1 study by Li, Jingxin, Hui, Aimin, Zhang, Xiang, Yang, Yumei, Tang, Rong, Ye, Huayue, Ji, Ruiru, Lin, Mei, Zhu, Zhongkui, Türeci, Özlem, Lagkadinou, Eleni, Jia, Siyue, Pan, Hongxing, Peng, Fuzhong, Ma, Zhilong, Wu, Zhenggang, Guo, Xiling, Shi, Yunfeng, Muik, Alexander, Şahin, Uğur, Zhu, Li, Zhu, Fengcai

“…An effective vaccine is needed to end the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Here, we assess the preliminary safety,…”
Get full text

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates by Walsh, Edward E, Frenck, Robert W, Falsey, Ann R, Kitchin, Nicholas, Absalon, Judith, Gurtman, Alejandra, Lockhart, Stephen, Neuzil, Kathleen, Mulligan, Mark J, Bailey, Ruth, Swanson, Kena A, Li, Ping, Koury, Kenneth, Kalina, Warren, Cooper, David, Fontes-Garfias, Camila, Shi, Pei-Yong, Türeci, Özlem, Tompkins, Kristin R, Lyke, Kirsten E, Raabe, Vanessa, Dormitzer, Philip R, Jansen, Kathrin U, Şahin, Uğur, Gruber, William C

“…Two doses 3 weeks apart of a lipid nanoparticle, nucleoside-modified RNA vaccine encoding a trimerized SARS-CoV-2 receptor–binding domain elicited high levels…”
Get full text

Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents by Frenck, Robert W, Klein, Nicola P, Kitchin, Nicholas, Gurtman, Alejandra, Absalon, Judith, Lockhart, Stephen, Perez, John L, Walter, Emmanuel B, Senders, Shelly, Bailey, Ruth, Swanson, Kena A, Ma, Hua, Xu, Xia, Koury, Kenneth, Kalina, Warren V, Cooper, David, Jennings, Timothy, Brandon, Donald M, Thomas, Stephen J, Türeci, Özlem, Tresnan, Dina B, Mather, Susan, Dormitzer, Philip R, Şahin, Uğur, Jansen, Kathrin U, Gruber, William C

“…This randomized trial of the BNT162b2 vaccine involved 2260 adolescents 12 to 15 years of age. Similar levels of antibody to SARS-CoV-2 were elicited in the…”
Get full text

D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization by Weissman, Drew, Alameh, Mohamad-Gabriel, de Silva, Thushan, Collini, Paul, Hornsby, Hailey, Brown, Rebecca, LaBranche, Celia C., Edwards, Robert J., Sutherland, Laura, Santra, Sampa, Mansouri, Katayoun, Gobeil, Sophie, McDanal, Charlene, Pardi, Norbert, Hengartner, Nick, Lin, Paulo J.C., Tam, Ying, Shaw, Pamela A., Lewis, Mark G., Boesler, Carsten, Şahin, Uğur, Acharya, Priyamvada, Haynes, Barton F., Korber, Bette, Montefiori, David C.

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein acquired a D614G mutation early in the pandemic that confers greater infectivity…”
Get full text

A randomized study to evaluate safety and immunogenicity of the BNT162b2 COVID-19 vaccine in healthy Japanese adults by Haranaka, Miwa, Baber, James, Ogama, Yoichiro, Yamaji, Masako, Aizawa, Masakazu, Kogawara, Osamu, Scully, Ingrid, Lagkadinou, Eleni, Türeci, Ӧzlem, Şahin, Uğur, Dormitzer, Philip R., Gruber, William C., Lockhart, Stephen

“…We report interim safety and immunogenicity findings from an ongoing phase 1/2 study of BNT162b2 in healthy Japanese adults. Participants were randomized 3:1…”
Get full text

Development of a new on-line system for the sequential speciation and determination of chromium species in various samples using a combination of chelating and ion exchange resins by Sahan, Serkan, Sacmaci, Serife, Kartal, Senol, Sacmaci, Mustafa, Sahin, Ugur, Uelgen, Ahmet

“…A new on-line flow injection (FI) procedure for the sequential separation, preconcentration and speciation of Cr(III)/Cr(VI) species in different matrices is…”
Get full text

Bivalent Omicron BA.1–Adapted BNT162b2 Booster in Adults Older than 55 Years by Winokur, Patricia, Gayed, Juleen, Fitz-Patrick, David, Thomas, Stephen J., Diya, Oyeniyi, Lockhart, Stephen, Xu, Xia, Zhang, Ying, Bangad, Vishva, Schwartz, Howard I., Denham, Douglas, Cardona, Jose F., Usdan, Lisa, Ginis, John, Mensa, Federico J., Zou, Jing, Xie, Xuping, Shi, Pei-Yong, Lu, Claire, Buitrago, Sandra, Scully, Ingrid L., Cooper, David, Koury, Kenneth, Jansen, Kathrin U., Türeci, Özlem, Şahin, Uğur, Swanson, Kena A., Gruber, William C., Kitchin, Nicholas

“…The immunogenicity of a bivalent mRNA vaccine with both ancestral and omicron BA.1 sequences elicited higher neutralization titers against BA.1 than did the…”
Get full text

The tight junction protein claudin 6 is a potential target for patient-individualized treatment in esophageal and gastric adenocarcinoma and is associated with poor prognosis by Simon, Adrian Georg, Lyu, Su Ir, Laible, Mark, Wöll, Stefan, Türeci, üzlem, Åahin, UÄur, Alakus, Hakan, Fahrig, Luca, Zander, Thomas, Buettner, Reinhard, Bruns, Christiane Josephine, Schroeder, Wolfgang, Gebauer, Florian, Quaas, Alexander

“…Abstract Background The prognosis of esophageal adenocarcinoma (EAC) and gastric adenocarcinoma (GAC) remains poor, and new therapeutic approaches are urgently…”
Get full text

Prediction of response to neoadjuvant chemotherapy by MammaTyper® across breast cancer subtypes: A retrospective cross-sectional study by Schettini, Francesco, Saracchini, Silvana, Bassini, Anna, Marus, Wally, Corsetti, Serena, Specogna, Ilaria, Bertola, Manuela, Micheli, Elvia, Wirtz, Ralph M., Laible, Mark, Şahin, Uğur, Strina, Carla, Milani, Manuela, Aguggini, Sergio, Tancredi, Richard, Fiorio, Elena, Sulfaro, Sandro, Generali, Daniele

“…Neoadjuvant chemotherapy (NACT) is widely used in the treatment of triple-negative and HER2-positive breast cancer (BC), but its use in estrogen receptor (ER)…”
Get full text

Ribozyme Assays to Quantify the Capping Efficiency of In Vitro-Transcribed mRNA by Vlatkovic, Irena, Ludwig, János, Boros, Gábor, Szabó, Gábor Tamás, Reichert, Julia, Buff, Maximilian, Baiersdörfer, Markus, Reinholz, Jonas, Mahiny, Azita Josefine, Şahin, Uğur, Karikó, Katalin

“…The presence of the cap structure on the 5'-end of in vitro-transcribed (IVT) mRNA determines its translation and stability, underpinning its use in…”
Get full text

Preclinical characterization of an mRNA-encoded anti-Claudin 18.2 antibody by Bähr-Mahmud, Hayat, Ellinghaus, Ursula, Stadler, Christiane R., Fischer, Leyla, Lindemann, Claudia, Chaturvedi, Anuhar, Diekmann, Jan, Wöll, Stefan, Biermann, Imke, Hebich, Bernhard, Scharf, Caroline, Siefke, Manuela, Roth, Alexandra S., Rao, Martin, Brettschneider, Kerstin, Ewen, Eva-Maria, Şahin, Uğur, Türeci, Özlem

“…IMAB362/Zolbetuximab, a first-in-class IgG1 antibody directed against the cancer-associated gastric-lineage marker CLDN18.2, has recently been reported to have…”
Get full text

Safety and Immunogenicity of the BNT162b2 Vaccine Coadministered with Seasonal Inactivated Influenza Vaccine in Adults by Murdoch, Louise, Quan, Karen, Baber, James A., Ho, Agnes W. Y., Zhang, Ying, Xu, Xia, Lu, Claire, Cooper, David, Koury, Kenneth, Lockhart, Stephen P., Anderson, Annaliesa S., Türeci, Özlem, Şahin, Uğur, Swanson, Kena A., Gruber, William C., Kitchin, Nicholas

“…Introduction Vaccination is a critical tool for preventing coronavirus disease 2019 (COVID-19) and influenza illnesses. Coadministration of the COVID-19…”
Get full text

Immunogenicity and safety of BNT162b2 mRNA vaccine in Chinese adults: A phase 2 randomised clinical trial by Hui, Ai-Min, Li, Jingxin, Zhu, Li, Tang, Rong, Ye, Huayue, Lin, Mei, Ge, Lei, Wang, Xiyuan, Peng, Fuzhong, Wu, Zhenggang, Guo, Xiling, Shi, Yunfeng, Pan, Hongxing, Zhu, Jiahong, Song, Zhizhou, Qiu, Jingjun, Wang, Wei, Zheng, Jianfei, Ozhelvaci, Orkun, Shpyro, Svetlana, Bushway, Meghan, Derhovanessian, Evelyna, Kühnle, Marie-Cristine, Luxemburger, Ulrich, Muik, Alexander, Shishkova, Yoana, Khondker, Zakaria, Hu, Simin, Lagkadinou, Eleni, Şahin, Uğur, Türeci, Özlem, Zhu, Fengcai

“…BNT162b2, an mRNA vaccine against COVID-19, is being utilised worldwide, but immunogenicity and safety data in Chinese individuals are limited. This phase 2,…”
Get full text

Lipoprotein apheresis efficacy and challenges: single center experience by Özdemir, Zehra Narlı, Şahin, Uğur, Yıldırım, Yasin, Kaya, Cansın Tulunay, İlhan, Osman

“…Lipoprotein apheresis (LA) is an extracorporeal therapy which removes apolipoprotein B-containing particles from the circulation. We evaluated techniques and…”
Get full text

Highlighting the Prognostic Importance of Measurable Residual Disease Among Acute Myeloid Leukemia Risk Factors by Narlı Özdemir, Zehra, Şahin, Uğur, Dalva, Klara, Baltacı, Mehmet Akif, Uslu, Atilla, Öztürk, Cemaleddin, Cengiz Seval, Güldane, Toprak, Selami Koçak, Kurt Yüksel, Meltem, Topçuoğlu, Pervin, Arslan, Önder, Özcan, Muhit, Beksaç, Meral, İlhan, Osman, Gürman, Günhan, Civriz Bozdağ, Sinem

“…Objective: The optimal timing of measurable residual disease (MRD) evaluation in acute myeloid leukemia (AML) patients has not been well defined yet. We aimed…”
Get full text

A Case of Superwarfarin Poisoning Due to Repetitive Occupational Dermal Rodenticide Exposure in a Worker by Narlı Özdemir, Zehra, Şahin, Uğur, Merter, Mustafa, Gündüz, Mehmet, Ateşağaoğlu, Berna, Beksaç, Meral

“…Superwarfarin poisoning is usually due to chronic occult small-dose exposures and can easily be misdiagnosed and may lead to serious complications. The…”
Get full text