Search Results - "Uéno, T."

Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance by Yamazaki, Chisato M., Yamaguchi, Aiko, Anami, Yasuaki, Xiong, Wei, Otani, Yoshihiro, Lee, Jangsoon, Ueno, Naoto T., Zhang, Ningyan, An, Zhiqiang, Tsuchikama, Kyoji

“…Breast tumors generally consist of a diverse population of cells with varying gene expression profiles. Breast tumor heterogeneity is a major factor…”
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Role of epidermal growth factor receptor in breast cancer by Masuda, Hiroko, Zhang, Dongwei, Bartholomeusz, Chandra, Doihara, Hiroyoshi, Hortobagyi, Gabriel N., Ueno, Naoto T.

“…Decades of research in molecular oncology have brought about promising new therapies which are designed to target specific molecules which promote tumor growth…”
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Differential Response to Neoadjuvant Chemotherapy Among 7 Triple-Negative Breast Cancer Molecular Subtypes by MASUDA, Hiroko, BAGGERLY, Keith A, FRASER SYMMANS, W, UENO, Naoto T, YING WANG, YA ZHANG, GONZALEZ-ANGULO, Ana Maria, MERIC-BERNSTAM, Funda, VALERO, Vicente, LEHMANN, Brian D, PIETENPOL, Jennifer A, HORTOBAGYI, Gabriel N

“…The clinical relevancy of the 7-subtype classification of triple-negative breast cancer (TNBC) reported by Lehmann and colleagues is unknown. We investigated…”
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JNK Signaling in Stem Cell Self-Renewal and Differentiation by Semba, Takashi, Sammons, Rachel, Wang, Xiaoping, Xie, Xuemei, Dalby, Kevin N, Ueno, Naoto T

“…C-JUN N-terminal kinases (JNKs), which belong to the mitogen-activated protein kinase (MAPK) family, are evolutionarily conserved kinases that mediate cell…”
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ER stress (PERK eIF2 phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation by Kouroku, Y, Fujita, E, Tanida, I, Ueno, T, Isoai, A, Kumagai, H, Ogawa, S, Kaufman, R J, Kominami, E, Momoi, T

“…Expanded polyglutamine 72 repeat (polyQ72) aggregates induce endoplasmic reticulum (ER) stress-mediated cell death with caspase-12 activation and vesicular…”
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Precise control of hydrogen response of semicontinuous palladium film using piezoelectric resonance method by Nakamura, N., Ueno, T., Ogi, H.

“…During deposition of metallic material on a substrate, a semicontinuous film composed of isolated and connected clusters is formed transiently at a few…”
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ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK-AKT-mTOR Signaling Pathway by Nguyen, Khoa, Yan, Yuanqing, Yuan, Bin, Dasgupta, Abhishek, Sun, Jeffrey, Mu, Hong, Do, Kim-Anh, Ueno, Naoto T, Andreeff, Michael, Battula, V Lokesh

“…Breast cancer stem-like cells (BCSC) are implicated in cancer recurrence and metastasis of triple-negative breast cancer (TNBC). We have recently discovered…”
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Microfluidics separation reveals the stem-cell–like deformability of tumor-initiating cells by Zhang, Weijia, Kai, Kazuharu, Choi, Dong Soon, Iwamoto, Takayuki, Nguyen, Yen H, Wong, Helen, Landis, Melissa D, Ueno, Naoto T, Chang, Jenny, Qin, Lidong

“…Here we report a microfluidics method to enrich physically deformable cells by mechanical manipulation through artificial microbarriers. Driven by hydrodynamic…”
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Revisiting the definition of estrogen receptor positivity in HER2-negative primary breast cancer by Fujii, T., Kogawa, T., Dong, W., Sahin, A.A., Moulder, S., Litton, J.K., Tripathy, D., Iwamoto, T., Hunt, K.K., Pusztai, L., Lim, B., Shen, Y., Ueno, N.T.

“…Although 1% has been used as cut-off for estrogen receptor (ER) positivity, several studies have reported that tumors with ER < 1% have characteristics similar…”
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Targeting EGFR in Triple Negative Breast Cancer by Ueno, Naoto T, Zhang, Dongwei

“…Our preliminary data show that erlotinib inhibits Triple-negative breast cancer (TNBC) in a xenograft model. However, inhibition of metastasis by erlotinib is…”
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Age-dependent Degradation of the Protein Adsorption Capacity of Titanium by Hori, N., Att, W., Ueno, T., Sato, N., Yamada, M., Saruwatari, L., Suzuki, T., Ogawa, T.

“…Reported bone-implant contact percentages are far below the ideal 100%. We tested a hypothesis that the protein adsorption capability of titanium, which is…”
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Significant Differences in Drug Lag in Clinical Development Among Various Strategies Used for Regulatory Submissions in Japan by Ueno, T, Asahina, Y, Tanaka, A, Yamada, H, Nakamura, M, Uyama, Y

“…Although the number of global clinical trials (GCTs) conducted in multiple countries including Japan has increased recently, it is not clear how much these…”
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Hydrocarbon Deposition Attenuates Osteoblast Activity on Titanium by Hayashi, R., Ueno, T., Migita, S., Tsutsumi, Y., Doi, H., Ogawa, T., Hanawa, T., Wakabayashi, N.

“…Although the reported percentage of bone-implant contact is far lower than 100%, the cause of such low levels of bone formation has rarely been investigated…”
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Use of pHlurorin-mKate2-human LC3 to Monitor Autophagic Responses by Tanida, I, Ueno, T, Uchiyama, Y

“…In this chapter, we introduce the usage of pHluorin-mKate2-human LC3 for monitoring autophagy. Using EGFP and RFP, tandem fluorescent protein-tagged LC3 has…”
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Identification of triple-negative breast cancer cell lines classified under the same molecular subtype using different molecular characterization techniques: Implications for translational research by Espinosa Fernandez, Jose Rodrigo, Eckhardt, Bedrich L, Lee, Jangsoon, Lim, Bora, Pearson, Troy, Seitz, Rob S, Hout, David R, Schweitzer, Brock L, Nielsen, Tyler J, Lawrence, O Rayne, Wang, Ying, Rao, Arvind, Ueno, Naoto T

“…The original algorithm that classified triple-negative breast cancer (TNBC) into six subtypes has recently been revised. The revised algorithm (TNBCtype-IM)…”
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Estrogen Receptor (ER) mRNA and ER-Related Gene Expression in Breast Cancers That Are 1% to 10% ER-Positive by Immunohistochemistry by IWAMOTO, Takayuki, BOOSER, Daniel, MATSUOKA, Junji, YANG, Elliana J, HORTOBAGYI, Gabriel N, HATZIS, Christos, FRASER SYMMANS, W, PUSZTAI, Lajos, VALERO, Vicente, MURRAY, James L, KOENIG, Kimberly, ESTEVA, Francisco J, UENO, Naoto T, JIE ZHANG, WEIWEI SHI, YUAN QI

“…We examined borderline estrogen receptor (ER) -positive cancers, defined as having 1% to 10% positivity by immunohistochemistry (IHC), to determine whether…”
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Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer by Allensworth, Jennifer L., Evans, Myron K., Bertucci, François, Aldrich, Amy J., Festa, Richard A., Finetti, Pascal, Ueno, Naoto T., Safi, Rachid, McDonnell, Donald P., Thiele, Dennis J., Van Laere, Steven, Devi, Gayathri R.

“…Cancer cells often have increased levels of reactive oxygen species (ROS); however, acquisition of redox adaptive mechanisms allows for evasion of ROS-mediated…”
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Comparison of molecular profile in triple-negative inflammatory and non-inflammatory breast cancer not of mesenchymal stem-like subtype by Funakoshi, Yohei, Wang, Ying, Semba, Takashi, Masuda, Hiroko, Hout, David, Ueno, Naoto T, Wang, Xiaoping

“…Inflammatory breast cancer (IBC) is an aggressive form of breast cancer. The triple-negative subtype of IBC (TN-IBC) is particularly aggressive. Identification…”
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The Emerging Impact of Social Media on Cancer Patient Education in Japan by Sasaki, Yuya, Ueno, Naoto T.

“…This letter to the editor focuses on the potential of social media to improve cancer awareness in Japan…”
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