Antineoplastic Activity of 9″-Lithospermic Acid Methyl Ester in Glioblastoma Cells

To date, many potent compounds have been found which are derived from plants and herbs and possess anticancer properties due to their antioxidant effects. 9″-Lithospermic acid methyl ester is an effective natural compound derived from the Velen. It has been proven that this compound has substantial...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 25; no. 4; p. 2094
Main Authors:	Tzitiridou, Panagiota, Zoi, Vasiliki, Papagrigoriou, Theodora, Lazari, Diamanto, Sioka, Chrissa, Alexiou, Georgios A, Kyritsis, Athanassios P
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-02-2024
Subjects:	9″-lithospermic acid methyl ester Acids Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antioxidants Apoptosis Benzofurans - pharmacology Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - pathology Brain research Cancer Cancer therapies Cell cycle Cell death Cell Line, Tumor Cell Proliferation Chemotherapy Cytotoxicity Depsides Diabetes Diabetic retinopathy Drug dosages glioblastoma Glioblastoma - metabolism Glioblastoma multiforme Glioma gliomas Health aspects Herbs Motility natural products Pharmaceutical industry Radiation therapy temozolomide Temozolomide - pharmacology Greece United States temozolomide 9″-lithospermic acid methyl ester natural products cancer glioblastoma gliomas
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Summary:	To date, many potent compounds have been found which are derived from plants and herbs and possess anticancer properties due to their antioxidant effects. 9″-Lithospermic acid methyl ester is an effective natural compound derived from the Velen. It has been proven that this compound has substantial properties in different diseases, but its effects in cancer have not been thoroughly evaluated. The aim of this work was to study the effects of 9″-Lithospermic acid methyl ester (9″-methyl lithospermate) in U87 and T98 glioblastoma cell lines. Its effects on cellular viability were assessed via Trypan Blue and Crystal Violet stains, the cell cycle analysis through flow cytometry, and cell migration by employing the scratch wound healing assay. The results demonstrated that 9″-methyl lithospermate was able to inhibit cellular proliferation, induce cellular death, and inhibit cell migration. Furthermore, these results were intensified by the addition of temozolomide, the most prominent chemotherapeutic drug in glioblastoma tumors. Further studies are needed to reproduce these findings in animal models and investigate if 9″-lithospermic acid methyl ester represents a potential new therapeutic addition for gliomas.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms25042094