Search Results - "Tzioras, Makis"

Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration by Henstridge, Christopher M, Tzioras, Makis, Paolicelli, Rosa C

“…Synapse loss is an early feature shared by many neurodegenerative diseases, and it represents the major correlate of cognitive impairment. Recent studies…”
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Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease by Pickett, Eleanor K., Herrmann, Abigail G., McQueen, Jamie, Abt, Kimberly, Dando, Owen, Tulloch, Jane, Jain, Pooja, Dunnett, Sophie, Sohrabi, Sadaf, Fjeldstad, Maria P., Calkin, Will, Murison, Leo, Jackson, Rosemary J., Tzioras, Makis, Stevenson, Anna, d’Orange, Marie, Hooley, Monique, Davies, Caitlin, Colom-Cadena, Marti, Anton-Fernandez, Alejandro, King, Declan, Oren, Iris, Rose, Jamie, McKenzie, Chris-Anne, Allison, Elizabeth, Smith, Colin, Hardt, Oliver, Henstridge, Christopher M., Hardingham, Giles E., Spires-Jones, Tara L.

“…A key knowledge gap blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) peptide…”
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Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis by Henstridge, Christopher M., Sideris, Dimitrios I., Carroll, Emily, Rotariu, Sanziana, Salomonsson, Sally, Tzioras, Makis, McKenzie, Chris-Anne, Smith, Colin, von Arnim, Christine A. F., Ludolph, Albert C., Lulé, Dorothée, Leighton, Danielle, Warner, Jon, Cleary, Elaine, Newton, Judith, Swingler, Robert, Chandran, Siddharthan, Gillingwater, Thomas H., Abrahams, Sharon, Spires-Jones, Tara L.

“…In addition to motor neurone degeneration, up to 50% of amyotrophic lateral sclerosis (ALS) patients present with cognitive decline. Understanding the…”
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Inhibitory synapse loss and accumulation of amyloid beta in inhibitory presynaptic terminals in Alzheimer's disease by Kurucu, Hatice, Colom‐Cadena, Martí, Davies, Caitlin, Wilkins, Lewis, King, Declan, Rose, Jamie, Tzioras, Makis, Tulloch, Jane H., Smith, Colin, Spires‐Jones, Tara L.

“…Background and purpose Synapse degeneration in Alzheimer's disease (AD) correlates strongly with cognitive decline. There is well‐established excitatory…”
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Cystatin F ( Cst7 ) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer's disease by Daniels, Michael J D, Lefevre, Lucas, Szymkowiak, Stefan, Drake, Alice, McCulloch, Laura, Tzioras, Makis, Barrington, Jack, Dando, Owen R, He, Xin, Mohammad, Mehreen, Sasaguri, Hiroki, Saito, Takashi, Saido, Takaomi C, Spires-Jones, Tara L, McColl, Barry W

“…Microglial endolysosomal (dys)function is strongly implicated in neurodegenerative disease. Transcriptomic studies show that a microglial state characterised…”
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A comparison of blood and brain‐derived ageing and inflammation‐related DNA methylation signatures and their association with microglial burdens by Stevenson, Anna J., McCartney, Daniel L., Gadd, Danni A., Shireby, Gemma, Hillary, Robert F., King, Declan, Tzioras, Makis, Wrobel, Nicola, McCafferty, Sarah, Murphy, Lee, McColl, Barry W., Redmond, Paul, Taylor, Adele M., Harris, Sarah E., Russ, Tom C., McIntosh, Andrew M., Mill, Jonathan, Smith, Colin, Deary, Ian J., Cox, Simon R., Marioni, Riccardo E., Spires‐Jones, Tara L.

“…Inflammation and ageing‐related DNA methylation patterns in the blood have been linked to a variety of morbidities, including cognitive decline and…”
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Comparative profiling of the synaptic proteome from Alzheimer's disease patients with focus on the APOE genotype by Hesse, Raphael, Hurtado, Maica Llavero, Jackson, Rosemary J, Eaton, Samantha L, Herrmann, Abigail G, Colom-Cadena, Marti, Tzioras, Makis, King, Declan, Rose, Jamie, Tulloch, Jane, McKenzie, Chris-Anne, Smith, Colin, Henstridge, Christopher M, Lamont, Douglas, Wishart, Thomas M, Spires-Jones, Tara L

“…Degeneration of synapses in Alzheimer's disease (AD) strongly correlates with cognitive decline, and synaptic pathology contributes to disease pathophysiology…”
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Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features by Lorenzini, Ileana, Alsop, Eric, Levy, Jennifer, Gittings, Lauren M, Lall, Deepti, Rabichow, Benjamin E, Moore, Stephen, Pevey, Ryan, Bustos, Lynette M, Burciu, Camelia, Bhatia, Divya, Singer, Mo, Saul, Justin, McQuade, Amanda, Tzioras, Makis, Mota, Thomas A, Logemann, Amber, Rose, Jamie, Almeida, Sandra, Gao, Fen-Biao, Marks, Michael, Donnelly, Christopher J, Hutchins, Elizabeth, Hung, Shu-Ting, Ichida, Justin, Bowser, Robert, Spires-Jones, Tara, Blurton-Jones, Mathew, Gendron, Tania F, Baloh, Robert H, Van Keuren-Jensen, Kendall, Sattler, Rita

“…While motor and cortical neurons are affected in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), it remains largely unknown if and how…”
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Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model by Davies, Caitlin, Tulloch, Jane, Yip, Ellie, Currie, Lydia, Colom-Cadena, Marti, Wegmann, Susanne, Hyman, Bradley T, Wilkins, Lewis, Hooley, Monique, Tzioras, Makis, Spires-Jones, Tara L

“…A key hallmark of Alzheimer’s disease (AD) is the accumulation of hyperphosphorylated tau in neurofibrillary tangles. This occurs alongside neuroinflammation…”
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Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer's Disease by Brown, Rosalind, Lam, Alice D, Gonzalez-Sulser, Alfredo, Ying, Andrew, Jones, Mary, Chou, Robert Chang-Chih, Tzioras, Makis, Jordan, Crispin Y, Jedrasiak-Cape, Izabela, Hemonnot, Anne-Laure, Abou Jaoude, Maurice, Cole, Andrew J, Cash, Sydney S, Saito, Takashi, Saido, Takaomi, Ribchester, Richard R, Hashemi, Kevan, Oren, Iris

“…Network hyperexcitability is a feature of Alzheimer' disease (AD) as well as numerous transgenic mouse models of AD. While hyperexcitability in AD patients and…”
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Synaptic degeneration in Alzheimer disease by Tzioras, Makis, McGeachan, Robert I., Durrant, Claire S., Spires-Jones, Tara L.

“…Alzheimer disease (AD) is characterized by progressive cognitive decline in older individuals accompanied by the presence of two pathological protein…”
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Synaptic oligomeric tau in Alzheimer’s disease — A potential culprit in the spread of tau pathology through the brain by Colom-Cadena, Martí, Davies, Caitlin, Sirisi, Sònia, Lee, Ji-Eun, Simzer, Elizabeth M., Tzioras, Makis, Querol-Vilaseca, Marta, Sánchez-Aced, Érika, Chang, Ya Yin, Holt, Kristjan, McGeachan, Robert I., Rose, Jamie, Tulloch, Jane, Wilkins, Lewis, Smith, Colin, Andrian, Teodora, Belbin, Olivia, Pujals, Sílvia, Horrocks, Mathew H., Lleó, Alberto, Spires-Jones, Tara L.

“…In Alzheimer’s disease, fibrillar tau pathology accumulates and spreads through the brain and synapses are lost. Evidence from mouse models indicates that tau…”
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A role for astrocytes and microglia in synapse loss in Alzheimer’s disease by Tzioras, Makis, Daniels, Michael, Davies, Caitlin, Hooley, Monique, He, Xin, Dando, Owen R., Hardingham, Giles, McColl, Barry, Spires‐Jones, Tara L.

“…Background Neuropathologically, synapse loss correlates most strongly with the progressive cognitive decline observed in Alzheimer’s disease (AD). Despite…”
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Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease by Colom-Cadena, Martí, Toombs, Jamie, Simzer, Elizabeth, Holt, Kristjan, McGeachan, Robert, Tulloch, Jane, Jackson, Rosemary J., Catterson, James H., Spires-Jones, Maxwell P., Rose, Jamie, Waybright, Lora, Caggiano, Anthony O., King, Declan, Gobbo, Francesco, Davies, Caitlin, Hooley, Monique, Dunnett, Sophie, Tempelaar, Robert, Meftah, Soraya, Tzioras, Makis, Hamby, Mary E., Izzo, Nicholas J., Catalano, Susan M., Durrant, Claire S., Smith, Colin, Dando, Owen, Spires-Jones, Tara L.

“…Synapse loss correlates with cognitive decline in Alzheimer’s disease, and soluble oligomeric amyloid beta (Aβ) is implicated in synaptic dysfunction and loss…”
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Synaptic resilience is associated with maintained cognition during ageing by King, Declan, Holt, Kris, Toombs, Jamie, HE, Xin, Dando, Owen, Okely, Judith A, Tzioras, Makis, Rose, Jamie, Gunn, Ciaran, Correia, Adele, Montero, Carmen, McAlister, Hannah, Tulloch, Jane, Lamont, Douglas, Taylor, Adele M, Harris, Sarah E, Redmond, Paul, Cox, Simon R, Henstridge, Christopher M, Deary, Ian J, Smith, Colin, Spires‐Jones, Tara L

“…Introduction It remains unclear why age increases risk of Alzheimer's disease and why some people experience age‐related cognitive decline in the absence of…”
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Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8 by Tzioras, Makis, Daniels, Michael J D, Davies, Caitlin, Baxter, Paul, King, Declan, McKay, Sean, Varga, Balazs, Popovic, Karla, Hernandez, Madison, Stevenson, Anna J, Barrington, Jack, Drinkwater, Elizabeth, Borella, Julia, Holloway, Rebecca K, Tulloch, Jane, Moss, Jonathan, Latta, Clare, Kandasamy, Jothy, Sokol, Drahoslav, Smith, Colin, Miron, Veronique E, Káradóttir, Ragnhildur Thóra, Hardingham, Giles E, Henstridge, Christopher M, Brennan, Paul M, McColl, Barry W, Spires-Jones, Tara L

“…Synapse loss correlates with cognitive decline in Alzheimer's disease (AD). Data from mouse models suggests microglia are important for synapse degeneration,…”
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