Search Results - "Tzika, Aria A"
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Pseudomonas aeruginosa Quorum Sensing Molecule Alters Skeletal Muscle Protein Homeostasis by Perturbing the Antioxidant Defense System
Published in mBio (01-10-2019)“…Skeletal muscle function is compromised in many illnesses, including chronic infections. The quorum sensing (QS) signal, 2-amino acetophenone (2-AA), is…”
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The bacterial quorum sensing signal 2'-aminoacetophenone rewires immune cell bioenergetics through the Ppargc1a/Esrra axis to mediate tolerance to infection
Published in eLife (13-09-2024)“…How bacterial pathogens exploit host metabolism to promote immune tolerance and persist in infected hosts remains elusive. To achieve this, we show that ( ) a…”
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Skeletal muscle mitochondrial dysfunction mediated by Pseudomonas aeruginosa quorum-sensing transcription factor MvfR: reversing effects with anti-MvfR and mitochondrial-targeted compounds
Published in mBio (17-07-2024)“…Sepsis and chronic infections with , a leading "ESKAPE" bacterial pathogen, are associated with increased morbidity and mortality and skeletal muscle atrophy…”
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The role of ventral tegmental area in chronic stroke rehabilitation: an exploratory study
Published in Frontiers in neurology (05-12-2023)“…The acknowledged role of external rewards in chronic stroke rehabilitation, offering positive reinforcement and motivation, has significantly contributed to…”
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The Severity of Sensorimotor Tracts Degeneration May Predict Motor Performance in Chronic Stroke Patients, While Brain Structural Network Dysfunction May Not
Published in Frontiers in neurology (31-03-2022)“…Although the relationship between corticospinal tract (CST) fiber degeneration and motor outcome after stroke has been established, the relationship of…”
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Skeletal muscle mitochondrial uncoupling in a murine cancer cachexia model
Published in International journal of oncology (01-09-2013)“…Approximately half of all cancer patients present with cachexia, a condition in which disease-associated metabolic changes lead to a severe loss of skeletal…”
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Effects of a small, volatile bacterial molecule on Pseudomonas aeruginosa bacteria using whole cell high-resolution magic angle spinning nuclear magnetic resonance spectroscopy and genomics
Published in International journal of molecular medicine (01-10-2018)“…In the present study, high-resolution magic-angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy was applied to live Pseudomonas aeruginosa…”
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Inhibitors of pathogen intercellular signals as selective anti-infective compounds
Published in PLoS pathogens (01-09-2007)“…Long-term antibiotic use generates pan-resistant super pathogens. Anti-infective compounds that selectively disrupt virulence pathways without affecting cell…”
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Connectivity alterations assessed by combining fMRI and MR-compatible hand robots in chronic stroke
Published in NeuroImage (Orlando, Fla.) (01-08-2009)“…The aim of this study was to investigate functional reorganization of motor systems by probing connectivity between motor related areas in chronic stroke…”
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A small volatile bacterial molecule triggers mitochondrial dysfunction in murine skeletal muscle
Published in PloS one (30-09-2013)“…Mitochondria integrate distinct signals that reflect specific threats to the host, including infection, tissue damage, and metabolic dysfunction; and play a…”
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High-resolution magic angle spinning magnetic resonance spectroscopy detects glycine as a biomarker in brain tumors
Published in International journal of oncology (01-02-2010)“…The non-essential amino acid neurotransmitter glycine (Gly) may serve as a biomarker for brain tumors. Using 36 biopsies from patients with brain tumors [12…”
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In vivo high-resolution magic angle spinning proton NMR spectroscopy of Drosophila melanogaster flies as a model system to investigate mitochondrial dysfunction in Drosophila GST2 mutants
Published in International journal of molecular medicine (01-07-2014)“…In vivo nuclear magnetic resonance spectroscopy (NMR), a non-destructive biochemical tool used for investigating live organisms, has recently been performed in…”
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In vivo high-resolution magic angle spinning magnetic and electron paramagnetic resonance spectroscopic analysis of mitochondria-targeted peptide in Drosophila melanogaster with trauma-induced thoracic injury
Published in International journal of molecular medicine (01-02-2016)“…Trauma is the most common cause of mortality among individuals aged between 1 and 44 years and the third leading cause of mortality overall in the US. In this…”
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Burn Injury Causes Mitochondrial Dysfunction in Skeletal Muscle
Published in Proceedings of the National Academy of Sciences - PNAS (12-04-2005)“…Severe burn trauma is generally followed by a catabolic response that leads to muscle wasting and weakness affecting skeletal musculature. Here, we perform…”
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Noninvasive Magnetic Resonance Spectroscopic Imaging Biomarkers to Predict the Clinical Grade of Pediatric Brain Tumors
Published in Clinical cancer research (15-12-2004)“…The diagnosis and therapy of childhood brain tumors, most of which are low grade, can be complicated because of their frequent adjacent location to crucial…”
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Proton magnetic resonance spectroscopic imaging as a cancer biomarker for pediatric brain tumors (Review)
Published in International journal of oncology (01-03-2008)“…Magnetic resonance (MR) techniques offer a non-invasive, non-irradiating yet sensitive approach to diagnose and monitor cancer, which encompasses diverse…”
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Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy
Published in Science translational medicine (11-01-2012)“…Mutations in the gene isocitrate dehydrogenase 1 (IDH1) are present in up to 86% of grade II and III gliomas and secondary glioblastoma. Arginine 132 (R132)…”
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Combining magnetic resonance spectroscopy and molecular genomics offers better accuracy in brain tumor typing and prediction of survival than either methodology alone
Published in International journal of oncology (01-04-2011)“…Recent advents in magnetic resonance spectroscopy (MRS) techniques permit subsequent microarray analysis over the entire human transcriptome in the same tissue…”
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Proton MRS imaging in pediatric brain tumors
Published in Pediatric radiology (01-06-2016)“…Magnetic resonance (MR) techniques offer a noninvasive, non-irradiating yet sensitive approach to diagnosing and monitoring pediatric brain tumors. Proton MR…”
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