Highly stable multi-anchored magnetic nanoparticles for optical imaging within biofilms

[Display omitted] Magnetic nanoparticles are the next tool in medical diagnoses and treatment in many different biomedical applications, including magnetic hyperthermia as alternative treatment for cancer and bacterial infections, as well as the disruption of biofilms. The colloidal stability of the...

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Bibliographic Details
Published in:	Journal of colloid and interface science Vol. 459; pp. 175 - 182
Main Authors:	Stone, R.C., Fellows, B.D., Qi, B., Trebatoski, D., Jenkins, B., Raval, Y., Tzeng, T.R., Bruce, T.F., McNealy, T., Austin, M.J., Monson, T.C., Huber, D.L., Mefford, O.T.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-12-2015 Elsevier
Subjects:	Animals Biofilms Cattle Click chemistry Dihydroxyphenylalanine - chemistry Fluorescence Fluorescent Dyes - chemistry Heterobifunctional Imaging Legionella pneumophila - cytology Legionella pneumophila - physiology Magnetic nanoparticles MATERIALS SCIENCE Mice Microscopy, Fluorescence Multi-anchored Nanoparticles - chemistry NitroDOPA Polyethylene Glycols - chemistry Polyethylene oxide Biofilms Multi-anchored Imaging Magnetic nanoparticles Fluorescence Click chemistry Heterobifunctional Polyethylene oxide NitroDOPA
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Summary:	[Display omitted] Magnetic nanoparticles are the next tool in medical diagnoses and treatment in many different biomedical applications, including magnetic hyperthermia as alternative treatment for cancer and bacterial infections, as well as the disruption of biofilms. The colloidal stability of the magnetic nanoparticles in a biological environment is crucial for efficient delivery. A surface that can be easily modifiable can also improve the delivery and imaging properties of the magnetic nanoparticle by adding targeting and imaging moieties, providing a platform for additional modification. The strategy presented in this work includes multiple nitroDOPA anchors for robust binding to the surface tied to the same polymer backbone as multiple poly(ethylene oxide) chains for steric stability. This approach provides biocompatibility and enhanced stability in fetal bovine serum (FBS) and phosphate buffer saline (PBS). As a proof of concept, these polymer-particles complexes were then modified with a near infrared dye and utilized in characterizing the integration of magnetic nanoparticles in biofilms. The work presented in this manuscript describes the synthesis and characterization of a nontoxic platform for the labeling of near IR-dyes for bioimaging.
Bibliography:	USDOE Office of Science (SC) National Science Foundation (NSF) AC04-94AL85000; ECC1062873; CMMI-1057633; CMMI-1130819 SAND2016-12686J
ISSN:	0021-9797 1095-7103
DOI:	10.1016/j.jcis.2015.08.012