Bioactive Hydrogels with an Ordered Cellular Structure Combine Interconnected Macroporosity and Robust Mechanical Properties

Bioactive Hydrogels with an Ordered Cellular Structure Combine Interconnected Macroporosity and Robust Mechanical Properties

A method for preparing porous hydrogel scaffolds suitable for bioengineering applications based on colloidal‐crystal templating is demonstrated. Templated scaffolds are shown to have highly interconnected porosities at moderate void fractions due to their ordered arrangement of voids, and thus combi...

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Bibliographic Details
Published in:Advanced materials (Weinheim) Vol. 17; no. 4; pp. 399 - 403
Main Authors: Stachowiak, A. N., Bershteyn, A., Tzatzalos, E., Irvine, D. J.
Format: Journal Article
Language:English
Published: Weinheim WILEY-VCH Verlag 23-02-2005
WILEY‐VCH Verlag
Subjects:
Biomaterials
Hydrogels
Porous materials
Templates
Online Access:Get full text
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Summary:A method for preparing porous hydrogel scaffolds suitable for bioengineering applications based on colloidal‐crystal templating is demonstrated. Templated scaffolds are shown to have highly interconnected porosities at moderate void fractions due to their ordered arrangement of voids, and thus combine abundant pathways for cell migration (see Figure) and mass transport with compressive moduli comparable to soft tissues.
Bibliography:This work was supported by the Whitaker Foundation (grant number RG-02-0837). AS was supported by a National Defense Science and Engineering Graduate fellowship. We thank Lorna Gibson, Don Galler, Brendan Harley, and Nicki Watson (Keck Imaging Facility, Whitehead Institute) for helpful discussions. Supporting Information is available online from Wiley InterScience, or from the authors.
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ArticleID:ADMA200400507
This work was supported by the Whitaker Foundation (grant number RG‐02‐0837). AS was supported by a National Defense Science and Engineering Graduate fellowship. We thank Lorna Gibson, Don Galler, Brendan Harley, and Nicki Watson (Keck Imaging Facility, Whitehead Institute) for helpful discussions. Supporting Information is available online from Wiley InterScience, or from the authors.
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ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200400507