Search Results - "Tzakos, A. G."

Molecular requirements involving the human platelet protease-activated receptor-4 mechanism of activation by peptide analogues of its tethered-ligand by Moschonas, I. C., Kellici, T. F., Mavromoustakos, T., Stathopoulos, P., Tsikaris, V., Magafa, V., Tzakos, A. G., Tselepis, A. D.

“…Thrombin is the most potent agonist of human platelets and its effects are primarily mediated through the protease-activated receptors (PARs)-1 and -4…”
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Structure–function discrimination of the N‐ and C‐ catalytic domains of human angiotensin‐converting enzyme: implications for Cl– activation and peptide hydrolysis mechanisms by Tzakos, Andreas G., Galanis, Athanassios S., Spyroulias, Georgios A., Cordopatis, Paul, Manessi‐Zoupa, Evy, Gerothanassis, Ioannis P.

“…Human somatic angiotensin I‐converting enzyme (sACE) has two active sites present in two sequence homologous protein domains (ACE_N and ACE_C) possessing…”
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Structure and function of the myelin proteins: current status and perspectives in relation to multiple sclerosis by Tzakos, Andreas G, Troganis, Anastassios, Theodorou, Vassiliki, Tselios, Theodore, Svarnas, Christos, Matsoukas, John, Apostolopoulos, Vasso, Gerothanassis, Ioannis P

“…Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination and loss of neurological function,…”
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Development of a novel apigenin prodrug programmed for alkaline-phosphatase instructed self-inhibition to combat cancer by Diamantis, Dimitrios, Tsiailanis, Antonios D., Papaemmanouil, Christina, Nika, Maria-Christina, Kanaki, Zoi, Golic Grdadolnik, Simona, Babic, Andrej, Tzakos, Eleftherios Paraskevas, Fournier, Isabelle, Salzet, Michel, Kushwaha, Prem Prakash, Thomaidis, Nikolaos S., Rampias, Theodoros, Shankar, Eswar, Karakurt, Serdar, Gupta, Sanjay, Tzakos, Andreas G.

“…Elevated levels of alkaline phosphatase (ALP) in the tumor microenvironment (TME) are a hallmark of cancer progression and thus inhibition of ALP could serve…”
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Cyanobacterial cyclopeptides as lead compounds to novel targeted cancer drugs by Sainis, Ioannis, Fokas, Demosthenes, Vareli, Katerina, Tzakos, Andreas G, Kounnis, Valentinos, Briasoulis, Evangelos

“…Cyanobacterial cyclopeptides, including microcystins and nodularins, are considered a health hazard to humans due to the possible toxic effects of high…”
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Complementary Segmental Labeling of Large RNAs:  Economic Preparation and Simplified NMR Spectra for Measurement of More RDCs by Tzakos, Andreas G, Easton, Laura E, Lukavsky, Peter J

“…NMR structure determination of large RNAs is often restricted by limited RDC information caused by chemical shift degeneracy. We established a general, time-…”
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Domain-Selective Ligand-Binding Modes and Atomic Level Pharmacophore Refinement in Angiotensin I Converting Enzyme (ACE) Inhibitors by Tzakos, Andreas G, Gerothanassis, Ioannis P

“…Somatic ACE (EC 3.4.15.1), a ZnII metalloproteinase, is composed of functionally active N and C domains resulting from tandem gene duplication. Despite the…”
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On the structural basis of the hypertensive properties of angiotensin II: a solved mystery or a controversial issue? by Tzakos, Andreas G, Gerothanassis, Ioannis P, Troganis, Anastassios N

“…Angiotensin II (AII), Asp1-Arg2-Val3-Tyr4-Ile5-His6-Pro7-Phe8, the primary active hormone of the Renin-Angiotensin-System (RAS), is a major vasoconstrictor…”
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NMR techniques for very large proteins and rnas in solution by Tzakos, Andreas G, Grace, Christy R R, Lukavsky, Peter J, Riek, Roland

“…Three-dimensional structure determination of small proteins and oligonucleotides by solution NMR is established. With the development of novel NMR and labeling…”
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NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist by Tzakos, Andreas G., Fuchs, Patrick, van Nuland, Nico A. J., Troganis, Anastasios, Tselios, Theodore, Deraos, Spyros, Matsoukas, John, Gerothanassis, Ioannis P., Bonvin, Alexandre M. J. J.

“…Experimental autoimmune encephalomyelitis can be induced in susceptible animals by immunodominant determinants of myelin basic protein (MBP). To characterize…”
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On the molecular basis of the recognition of angiotensin II (AII). NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131 by Tzakos, Andreas G, Bonvin, Alexandre M J J, Troganis, Anasstasios, Cordopatis, Paul, Amzel, Mario L, Gerothanassis, Ioannis P, van Nuland, Nico A J

“…The high-resolution 3D structure of the octapeptide hormone angiotensin II (AII) in aqueous solution has been obtained by simulated annealing calculations,…”
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NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist: structural implications for the MHC II (I-Au)-peptide complex from docking calculations by Tzakos, Andreas G, Fuchs, Patrick, van Nuland, Nico A J, Troganis, Anastasios, Tselios, Theodore, Deraos, Spyros, Matsoukas, John, Gerothanassis, Ioannis P, Bonvin, Alexandre M J J

“…Experimental autoimmune encephalomyelitis can be induced in susceptible animals by immunodominant determinants of myelin basic protein (MBP). To characterize…”
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