Search Results - "Tzafriri, Abraham R."

Cardiovascular Tissue Engineering Models for Atherosclerosis Treatment Development by Tscheuschner, Linnea, Tzafriri, Abraham R

“…In the early years of tissue engineering, scientists focused on the generation of healthy-like tissues and organs to replace diseased tissue areas with the aim…”
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Innervation Patterns May Limit Response to Endovascular Renal Denervation by Tzafriri, Abraham R., PhD, Mahfoud, Felix, MD, Keating, John H., DVM, DACVP, Markham, Peter M., MS, Spognardi, Anna, BA, Wong, Gee, BS, HT, Fuimaono, Kristine, BS, Böhm, Michael, MD, Edelman, Elazer R., MD, PhD

“…Abstract Background Renal denervation is a new interventional approach to treat hypertension with variable results. Objectives The purpose of this study was to…”
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Defining drug and target protein distributions after stent-based drug release: Durable versus deployable coatings by Tzafriri, Abraham R., Garcia-Polite, Fernando, Li, Xiaojian, Keating, John, Balaguer, Josep-Maria, Zani, Brett, Bailey, Lynn, Markham, Peter, Kiorpes, Timothy C., Carlyle, Wenda, Edelman, Elazer R.

“…Innovations in drug eluting stent designs make it increasingly important to develop models for differentiating performance through spatial definition of drug,…”
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Ototoxicity: a high risk to auditory function that needs to be monitored in drug development by Pasdelou, Marie-Pierre, Byelyayeva, Lise, Malmström, Susanna, Pucheu, Sylvie, Peytavy, Marie, Laullier, Hugo, Hodges, Jr, Donald B, Tzafriri, Abraham R, Naert, Gaëlle

“…Hearing loss constitutes a major global health concern impacting approximately 1.5 billion people worldwide. Its incidence is undergoing a substantial surge…”
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Stat5 signaling specifies basal versus stress erythropoietic responses through distinct binary and graded dynamic modalities by Porpiglia, Ermelinda, Hidalgo, Daniel, Koulnis, Miroslav, Tzafriri, Abraham R, Socolovsky, Merav

“…Erythropoietin (Epo)-induced Stat5 phosphorylation (p-Stat5) is essential for both basal erythropoiesis and for its acceleration during hypoxic stress. A key…”
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Sustained Efficacy and Arterial Drug Retention by a Fast Drug Eluting Cross-Linked Fatty Acid Coronary Stent Coating by Artzi, Natalie, Tzafriri, Abraham R., Faucher, Keith M., Moodie, Geoffrey, Albergo, Theresa, Conroy, Suzanne, Corbeil, Scott, Martakos, Paul, Virmani, Renu, Edelman, Elazer R.

“…The long held assumption that sustained drug elution from stent coatings over weeks to months is imperative for clinical efficacy has limited the choice for…”
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Taking paclitaxel coated balloons to a higher level: Predicting coating dissolution kinetics, tissue retention and dosing dynamics by Tzafriri, Abraham R., Parikh, Sahil A., Edelman, Elazer R.

“…Paclitaxel coated balloons (PCBs) are a promising non-implantable alternative to drug-eluting stents, whereby drug is delivered to the arterial wall in solid…”
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Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis by Tzafriri, Abraham R., Garcia-Polite, Fernando, Zani, Brett, Stanley, James, Muraj, Benny, Knutson, Jennifer, Kohler, Robert, Markham, Peter, Nikanorov, Alexander, Edelman, Elazer R.

“…Calcific atherosclerosis is a major challenge to intraluminal drug delivery in peripheral artery disease (PAD). We evaluated the effects of orbital atherectomy…”
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Mortality and Paclitaxel-Coated Devices: An Individual Patient Data Meta-Analysis by Rocha-Singh, Krishna J., Duval, Sue, Jaff, Michael R., Schneider, Peter A., Ansel, Gary M., Lyden, Sean P., Mullin, Christopher M., Ioannidis, John P.A., Misra, Sanjay, Tzafriri, Abraham R., Edelman, Elazer R., Granada, Juan F., White, Christopher J., Beckman, Joshua A.

“…BACKGROUND:Paclitaxel-containing devices (PTXDs) significantly reduce reintervention in patients with symptomatic femoropopliteal peripheral artery disease. A…”
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Investigating Balloon-Vessel Contact Pressure Patterns in Angioplasty: In Silico Insights for Drug-Coated Balloons by Stratakos, Efstathios, Antonini, Luca, Poletti, Gianluca, Berti, Francesca, Tzafriri, Abraham R., Petrini, Lorenza, Pennati, Giancarlo

“…Drug-Coated Balloons have shown promising results as a minimally invasive approach to treat stenotic arteries, but recent animal studies have revealed limited,…”
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Stent elution rate determines drug deposition and receptor-mediated effects by Tzafriri, Abraham R., Groothuis, Adam, Price, G. Sylvester, Edelman, Elazer R.

“…Drug eluting stent designs abound and yet the dependence of efficacy on drug dose and elution duration remains unclear. We examined these issues within a…”
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Balloon-based drug coating delivery to the artery wall is dictated by coating micro-morphology and angioplasty pressure gradients by Tzafriri, Abraham R., Muraj, Benny, Garcia-Polite, Fernando, Salazar-Martín, Antonio G., Markham, Peter, Zani, Brett, Spognardi, Anna, Albaghdadi, Mazen, Alston, Steve, Edelman, Elazer R.

“…Paclitaxel coated balloon catheters (PCB) were developed as a polymer-free non-implantable alternative to drug eluting stents, delivering similar drug payloads…”
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Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy: Insights From Preclinical Models by Tzafriri, Abraham R, Mahfoud, Felix, Keating, John H, Spognardi, Anna-Maria, Markham, Peter M, Wong, Gee, Highsmith, Debby, O’Fallon, Patrick, Fuimaono, Kristine, Edelman, Elazer R

“…Radiofrequency renal denervation is under investigation for treatment of hypertension with variable success. We developed preclinical models to examine the…”
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Lost in translational filters between peers by Kolandaivelu, Kumaran, Tzafriri, Abraham R

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Arterial microanatomy determines the success of energy-based renal denervation in controlling hypertension by Tzafriri, Abraham R, Keating, John H, Markham, Peter M, Spognardi, Anna-Maria, Stanley, James R L, Wong, Gee, Zani, Brett G, Highsmith, Debby, O'Fallon, Patrick, Fuimaono, Kristine, Mahfoud, Felix, Edelman, Elazer R

“…Renal denervation (RDN) is a treatment option for patients with hypertension resistant to conventional therapy. Clinical trials have demonstrated variable…”
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A tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma by Indolfi, Laura, Ligorio, Matteo, Ting, David T, Xega, Kristina, Tzafriri, Abraham R, Bersani, Francesca, Aceto, Nicola, Thapar, Vishal, Fuchs, Bryan C, Deshpande, Vikram, Baker, Aaron B, Ferrone, Cristina R, Haber, Daniel A, Langer, Robert, Clark, Jeffrey W, Edelman, Elazer R

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most devastating and painful cancers. It is often highly resistant to therapy owing to inherent…”
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Luminal flow patterns dictate arterial drug deposition in stent-based delivery by Kolachalama, Vijaya B., Tzafriri, Abraham R., Arifin, Davis Y., Edelman, Elazer R.

“…Endovascular stents reside in a dynamic flow environment and yet the impact of flow on arterial drug deposition after stent-based delivery is only now…”
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Lesion complexity determines arterial drug distribution after local drug delivery by Tzafriri, Abraham R., Vukmirovic, Neda, Kolachalama, Vijaya B., Astafieva, Irina, Edelman, Elazer R.

“…Though stents are deployed in diseased arteries drug distribution has only been quantified in intact, non-diseased vessels. We correlated steady-state arterial…”
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Mechanisms of Tissue Uptake and Retention in Zotarolimus-Coated Balloon Therapy by Kolachalama, Vijaya B, Pacetti, Stephen D, Franses, Joseph W, Stankus, John J, Zhao, Hugh Q, Shazly, Tarek, Nikanorov, Alexander, Schwartz, Lewis B, Tzafriri, Abraham R, Edelman, Elazer R

“…BACKGROUND—Drug-coated balloons are increasingly used for peripheral vascular disease, and, yet, mechanisms of tissue uptake and retention remain poorly…”
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Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug by Carlyle, Wenda C., McClain, James B., Tzafriri, Abraham R., Bailey, Lynn, Zani, Brett G., Markham, Peter M., Stanley, James R.L., Edelman, Elazer R.

“…Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating…”
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