Search Results - "Tytgat, Godelieve A"

Mutations in the SIX1/2 Pathway and the DROSHA/DGCR8 miRNA Microprocessor Complex Underlie High-Risk Blastemal Type Wilms Tumors by Wegert, Jenny, Ishaque, Naveed, Vardapour, Romina, Geörg, Christina, Gu, Zuguang, Bieg, Matthias, Ziegler, Barbara, Bausenwein, Sabrina, Nourkami, Nasenien, Ludwig, Nicole, Keller, Andreas, Grimm, Clemens, Kneitz, Susanne, Williams, Richard D., Chagtai, Tas, Pritchard-Jones, Kathy, van Sluis, Peter, Volckmann, Richard, Koster, Jan, Versteeg, Rogier, Acha, Tomas, O’Sullivan, Maureen J., Bode, Peter K., Niggli, Felix, Tytgat, Godelieve A., van Tinteren, Harm, van den Heuvel-Eibrink, Marry M., Meese, Eckart, Vokuhl, Christian, Leuschner, Ivo, Graf, Norbert, Eils, Roland, Pfister, Stefan M., Kool, Marcel, Gessler, Manfred

“…Blastemal histology in chemotherapy-treated pediatric Wilms tumors (nephroblastoma) is associated with adverse prognosis. To uncover the underlying tumor…”
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The immune landscape of neuroblastoma: Challenges and opportunities for novel therapeutic strategies in pediatric oncology by Wienke, Judith, Dierselhuis, Miranda P., Tytgat, Godelieve A.M., Künkele, Annette, Nierkens, Stefan, Molenaar, Jan J.

“…Immunotherapy holds great promise for the treatment of pediatric cancers. In neuroblastoma, the recent implementation of anti-GD2 antibody Dinutuximab into the…”
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Neuroblastoma plasticity during metastatic progression stems from the dynamics of an early sympathetic transcriptomic trajectory by Villalard, Benjamin, Boltjes, Arjan, Reynaud, Florie, Imbaud, Olivier, Thoinet, Karine, Timmerman, Ilse, Croze, Séverine, Theoulle, Emy, Atzeni, Gianluigi, Lachuer, Joël, Molenaar, Jan J., Tytgat, Godelieve A. M., Delloye-Bourgeois, Céline, Castellani, Valérie

“…Despite their indisputable importance in neuroblastoma (NB) pathology, knowledge of the bases of NB plasticity and heterogeneity remains incomplete. They may…”
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The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children: a review by Van Paemel, Ruben, Vlug, Roos, De Preter, Katleen, Van Roy, Nadine, Speleman, Frank, Willems, Leen, Lammens, Tim, Laureys, Geneviève, Schleiermacher, Gudrun, Tytgat, Godelieve A. M., Astrahantseff, Kathy, Deubzer, Hedwig, De Wilde, Bram

“…Cell-free DNA profiling using patient blood is emerging as a non-invasive complementary technique for cancer genomic characterization. Since these liquid…”
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[18F]mFBG PET-CT for detection and localisation of neuroblastoma: a prospective pilot study by Samim, Atia, Blom, Thomas, Poot, Alex J., Windhorst, Albert D., Fiocco, Marta, Tolboom, Nelleke, Braat, Arthur J. A. T., Viol, Sebastiaan L. Meyer, van Rooij, Rob, van Noesel, Max M., Lam, Marnix G. E. H., Tytgat, Godelieve A. M., de Keizer, Bart

“…  Purpose Meta -[ 18 F]fluorobenzylguanidine ([ 18 F]mFBG) is a positron emission tomography (PET) radiotracer that allows for fast and high-resolution imaging…”
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Recommendations for the standardization of bone marrow disease assessment and reporting in children with neuroblastoma on behalf of the International Neuroblastoma Response Criteria Bone Marrow Working Group by Burchill, Susan A., Beiske, Klaus, Shimada, Hiroyuki, Ambros, Peter F., Seeger, Robert, Tytgat, Godelieve A.M., Brock, Penelope R., Haber, Michelle, Park, Julie R., Berthold, Frank

“…BACKGROUND The current study was conducted to expedite international standardized reporting of bone marrow disease in children with neuroblastoma and to…”
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123I-MIBG scintigraphy and 18F-FDG-PET imaging for diagnosing neuroblastoma by Bleeker, Gitta, Tytgat, Godelieve A M, Adam, Judit A, Caron, Huib N, Kremer, Leontien C M, Hooft, Lotty, van Dalen, Elvira C

“…Neuroblastoma is an embryonic tumour of childhood that originates in the neural crest. It is the second most common extracranial malignant solid tumour of…”
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Incidence and survival of paediatric renal tumours in the Netherlands between 1990 and 2014 by Schulpen, Maya, Roy, Prakriti, Wijnen, Marc H.W.A., Tytgat, Godelieve A.M., van den Heuvel-Eibrink, Marry M., van Tinteren, Harm, Karim-Kos, Henrike E.

“…This population-based study is the first to provide a detailed analysis of trends in incidence and survival of children and adolescents diagnosed with renal…”
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Cell-Free RNA from Plasma in Patients with Neuroblastoma: Exploring the Technical and Clinical Potential by Lak, Nathalie S M, Seijger, Anne, van Zogchel, Lieke M J, Gelineau, Nina U, Javadi, Ahmad, Zappeij-Kannegieter, Lily, Bongiovanni, Laura, Andriessen, Anneloes, Stutterheim, Janine, van der Schoot, C Ellen, de Bruin, Alain, Tytgat, Godelieve A M

“…Neuroblastoma affects mostly young children, bearing a high morbidity and mortality. Liquid biopsies, e.g., molecular analysis of circulating tumor-derived…”
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Correction to: The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children: as review by Van Paemel, Ruben, Vlug, Roos, De Preter, Katleen, Van Roy, Nadine, Speleman, Frank, Willems, Leen, Lammens, Tim, Laureys, Geneviève, Schleiermacher, Gudrun, Tytgat, Godelieve A. M., Astrahantseff, Kathy, Deubzer, Hedwig, De Wilde, Bram

“…In the original version of this article, a reader pointed out that there was a mistake in the phrasing in a paragraph. This could potentially be harmful to…”
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Thrombocytopenia after meta-iodobenzylguanidine (MIBG) therapy in neuroblastoma patients may be caused by selective MIBG uptake via the serotonin transporter located on megakaryocytes by Blom, Thomas, Meinsma, Rutger, di Summa, Franca, van den Akker, Emile, van Kuilenburg, André B. P., Hansen, Marten, Tytgat, Godelieve A. M.

“…Background The therapeutic use of [ 131 I]meta-iodobenzylguanidine ([ 131 I]MIBG) is often accompanied by hematological toxicity, primarily consisting of…”
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Fenretinide induces mitochondrial ROS and inhibits the mitochondrial respiratory chain in neuroblastoma by Cuperus, Roos, Leen, René, Tytgat, Godelieve A. M, Caron, Huib N, van Kuilenburg, André B. P

“…Fenretinide induces apoptosis in neuroblastoma by induction of reactive oxygen species (ROS). In this study, we investigated the role of mitochondria in…”
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Thyroid function after diagnostic 123I-metaiodobenzylguanidine in children with neuroblastic tumors by Clement, Sarah C., Tytgat, Godelieve A. M., van Trotsenburg, A. S. Paul, Kremer, Leontien C. M., van Santen, Hanneke M.

“…Background Metaiodobenzylguanidine (MIBG) labeled with radioisotopes can be used for diagnostics 123 I − ) and treatment ( 131 I − ) in patients with…”
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Catecholamines profiles at diagnosis: Increased diagnostic sensitivity and correlation with biological and clinical features in neuroblastoma patients by Verly, Iedan R.N, van Kuilenburg, André B.P, Abeling, Nico G.G.M, Goorden, Susan M.I, Fiocco, Marta, Vaz, Frédéric M, van Noesel, Max M, Zwaan, C. Michel, Kaspers, GertJan L, Merks, Johannes H.M, Caron, Huib N, Tytgat, Godelieve A.M

“…Abstract Introduction Neuroblastoma (NBL) accounts for 10% of the paediatric malignancies and is responsible for 15% of the paediatric cancer-related deaths…”
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A comprehensive overview of liquid biopsy applications in pediatric solid tumors by Janssen, Ferdinand W., Lak, Nathalie S. M., Janda, Claudia Y., Kester, Lennart A., Meister, Michael T., Merks, Johannes H. M., van den Heuvel-Eibrink, Marry M., van Noesel, Max M., Zsiros, Jozsef, Tytgat, Godelieve A. M., Looijenga, Leendert H. J.

“…Liquid biopsies are emerging as an alternative source for pediatric cancer biomarkers with potential applications during all stages of patient care, from…”
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Author Correction: A comprehensive overview of liquid biopsy applications in pediatric solid tumors by Janssen, Ferdinand W., Lak, Nathalie S. M., Janda, Claudia Y., Kester, Lennart A., Meister, Michael T., Merks, Johannes H. M., van den Heuvel-Eibrink, Marry M., van Noesel, Max M., Zsiros, Jozsef, Tytgat, Godelieve A. M., Looijenga, Leendert H. J.

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Methylated RASSF1a Is the First Specific DNA Marker for Minimal Residual Disease Testing in Neuroblastoma by STUTTERHEIM, Janine, AIT ICHOU, Fatima, DEN OUDEN, Emmy, VERSTEEG, Rogier, CARON, Huib N, TYTGAT, Godelieve A. M, DER SCHOOL, C. Ellen Van

“…PCR-based detection of minimal residual disease (MRD) in neuroblastoma (NB) is presently based on NB-specific transcripts. However, the expression of these…”
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Detecting Minimal Residual Disease in Neuroblastoma: The Superiority of a Panel of Real-Time Quantitative PCR Markers by Stutterheim, Janine, Gerritsen, Annemieke, Zappeij-Kannegieter, Lily, Yalcin, Bilgehan, Dee, Rob, van Noesel, Max M, Berthold, Frank, Versteeg, Rogier, Caron, Huib N, van der Schoot, C. Ellen, Tytgat, Godelieve A.M

“…PCR-based detection of minimal residual disease (MRD) in neuroblastoma (NB) patients can be used for initial staging and monitoring therapy response in bone…”
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Selective serotonin reuptake inhibitors (SSRIs) prevent meta-iodobenzylguanidine (MIBG) uptake in platelets without affecting neuroblastoma tumor uptake by Blom, Thomas, Meinsma, Rutger, Rutgers, Marja, Buitenhuis, Corine, Dekken-Van den Burg, Marieke, van Kuilenburg, André B. P., Tytgat, Godelieve A. M.

“…Background The therapeutic use of [ 131 I]meta-iodobenzylguanidine ([ 131 I]MIBG) is often accompanied by hematological toxicity, mainly consisting of…”
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Humanized MISTRG as a preclinical in vivo model to study human neutrophil-mediated immune processes by Martinez-Sanz, Paula, Laurent, Adrien R G, Slot, Edith, Hoogenboezem, Mark, Bąbała, Nikolina, van Bruggen, Robin, Rongvaux, Anthony, Flavell, Richard A, Tytgat, Godelieve A M, Franke, Katka, Matlung, Hanke L, Kuijpers, Taco W, Amsen, Derk, Karrich, Julien J

“…MISTRG mice have been genetically modified to allow development of a human myeloid compartment from engrafted human CD34+ haemopoietic stem cells, making them…”
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