Search Results - "Tysseling, Vicki"

The potential for understanding the synaptic organization of human motor commands via the firing patterns of motoneurons by Johnson, Michael D, Thompson, Christopher K, Tysseling, Vicki M, Powers, Randall K, Heckman, Charles J

“…Motoneurons are unique in being the only neurons in the CNS whose firing patterns can be easily recorded in human subjects. This is because of the one-to-one…”
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Self-Assembling Nanofibers Inhibit Glial Scar Formation and Promote Axon Elongation after Spinal Cord Injury by Tysseling-Mattiace, Vicki M, Sahni, Vibhu, Niece, Krista L, Birch, Derin, Czeisler, Catherine, Fehlings, Michael G, Stupp, Samuel I, Kessler, John A

“…Peptide amphiphile (PA) molecules that self-assemble in vivo into supramolecular nanofibers were used as a therapy in a mouse model of spinal cord injury…”
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Firing characteristics of deep dorsal horn neurons after acute spinal transection during administration of agonists for 5-HT1B/1D and NMDA receptors by Thaweerattanasinp, Theeradej, Heckman, Charles J, Tysseling, Vicki M

“…Spinal cord injury (SCI) results in a loss of serotonin (5-HT) to the spinal cord and a loss of inhibition to deep dorsal horn (DDH) neurons, which produces an…”
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Self-assembling peptide amphiphile promotes plasticity of serotonergic fibers following spinal cord injury by Tysseling, Vicki M., Sahni, Vibhu, Pashuck, Eugene T., Birch, Derin, Hebert, Amy, Czeisler, Catherine, Stupp, Samuel I., Kessler, John A.

“…Injection into the injured spinal cord of peptide amphiphile (PA) molecules that self‐assemble and display the laminin epitope IKVAV at high density improved…”
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Bursting interneurons in the deep dorsal horn develop increased excitability and sensitivity to serotonin after chronic spinal injury by Thaweerattanasinp, Theeradej, Birch, Derin, Jiang, Mingchen C, Tresch, Matthew C, Bennett, David J, Heckman, Charles J, Tysseling, Vicki M

“…The loss of descending serotonin (5-HT) to the spinal cord contributes to muscle spasms in chronic spinal cord injury (SCI). Hyperexcitable motoneurons receive…”
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The Involvement of CaV1.3 Channels in Prolonged Root Reflexes and Its Potential as a Therapeutic Target in Spinal Cord Injury by Jiang, Mingchen C., Birch, Derin V., Heckman, Charles J., Tysseling, Vicki M.

“…Spinal cord injury (SCI) results in not only the loss of voluntary muscle control, but also in the presence of involuntary movement or spasms. These spasms…”
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SDF1 in the dorsal corticospinal tract promotes CXCR4+ cell migration after spinal cord injury by Tysseling, Vicki M, Mithal, Divakar S, Sahni, Vibhu, Birch, Derin, Jung, Hosung, Belmadani, Abdelhak, Miller, Richard J, Kessler, John A

“…Stromal cell-derived factor-1 (SDF1) and its major signaling receptor, CXCR4, were initially described in the immune system; however, they are also expressed…”
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BMPR1a and BMPR1b Signaling Exert Opposing Effects on Gliosis after Spinal Cord Injury by Sahni, Vibhu, Mukhopadhyay, Abhishek, Tysseling, Vicki, Hebert, Amy, Birch, Derin, Mcguire, Tammy L, Stupp, Samuel I, Kessler, John A

“…Astrogliosis following spinal cord injury (SCI) involves an early hypertrophic response that is beneficial and a subsequent formation of a dense scar. We…”
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Characterization of motor units in behaving adult mice shows a wide primary range by Ritter, Laura K, Tresch, Matthew C, Heckman, C J, Manuel, Marin, Tysseling, Vicki M

“…The mouse is essential for genetic studies of motor function in both normal and pathological states. Thus it is important to consider whether the structure of…”
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Chronic electromyograms in treadmill running SOD1 mice reveal early changes in muscle activation by Quinlan, Katharina A., Kajtaz, Elma, Ciolino, Jody D., Imhoff‐Manuel, Rebecca D., Tresch, Matthew C., Heckman, Charles J., Tysseling, Vicki M.

“…Key points The present study demonstrates that electromyograms (EMGs) obtained during locomotor activity in mice were effective for identification of early…”
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Design and evaluation of a chronic EMG multichannel detection system for long-term recordings of hindlimb muscles in behaving mice by Tysseling, Vicki M, Janes, Lindsay, Imhoff, Rebecca, Quinlan, Katharina A, Lookabaugh, Brad, Ramalingam, Shyma, Heckman, C.J, Tresch, Matthew C

“…Abstract Mouse models are commonly used for identifying the behavioral consequences of genetic modifications, progression or recovery from disease or trauma…”
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Erratum to: SDF1 in the dorsal corticospinal tract promotes CXCR4+ cell migration after spinal cord injury by Tysseling, Vicki M, Mithal, Divakar S, Sahni, Vibhu, Birch, Derin, Jung, Hosung, Miller, Richard J, Kessler, John A

“…During production of the original article [1], Divakar Singh Mithal's middle initial was omitted, and listed as 'Mithal D'. The correct attribution is 'Mithal…”
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SDF1 in the dorsal corticospinal tract promotes CXCR4+ cell migration after spinal cord injury by Tysseling, Vicki M, Mithal, Divakar, Sahni, Vibhu, Birch, Derin, Jung, Hosung, Belmadani, Abdelhak, Miller, Richard J, Kessler, John A

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Modification of gelation kinetics in bioactive peptide amphiphiles by Niece, Krista L, Czeisler, Catherine, Sahni, Vibhu, Tysseling-Mattiace, Vicki, Pashuck, Eugene T, Kessler, John A, Stupp, Samuel I

“…Abstract Peptide amphiphiles (PAs) previously designed in our laboratory are known to self-assemble into nanofibers that exhibit bioactivity both in vitro and…”
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Soma size and Cav1.3 channel expression in vulnerable and resistant motoneuron populations of the SOD1G93A mouse model of ALS by Shoenfeld, Liza, Westenbroek, Ruth E., Fisher, Erika, Quinlan, Katharina A., Tysseling, Vicki M., Powers, Randall K., Heckman, Charles J., Binder, Marc D.

“…Although the loss of motoneurons is an undisputed feature of amyotrophic lateral sclerosis (ALS) in man and in its animal models (SOD1 mutant mice), how the…”
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Muscle Spasms after Spinal Cord Injury Stem from Changes in Motoneuron Excitability and Synaptic Inhibition, Not Synaptic Excitation by Mahrous, Amr, Birch, Derin, Heckman, C J, Tysseling, Vicki

“…Muscle spasms are common in chronic spinal cord injury (SCI), posing challenges to rehabilitation and daily activities. Pharmacological management of spasms…”
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Scaling of Motor Output, From Mouse to Humans by Manuel, Marin, Chardon, Matthieu, Tysseling, Vicki, Heckman, C J

“…Appropriate scaling of motor output from mouse to humans is essential. The motoneurons that generate all motor output are, however, very different in rodents…”
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Firing characteristics of deep dorsal horn neurons after acute spinal transection during administration of agonists for 5-HT 1B/1D and NMDA receptors by Thaweerattanasinp, Theeradej, Heckman, Charles J., Tysseling, Vicki M.

“…Spinal cord injury (SCI) results in a loss of serotonin (5-HT) to the spinal cord and a loss of inhibition to deep dorsal horn (DDH) neurons, which produces an…”
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The Involvement of Ca V 1.3 Channels in Prolonged Root Reflexes and Its Potential as a Therapeutic Target in Spinal Cord Injury by Jiang, Mingchen C, Birch, Derin V, Heckman, Charles J, Tysseling, Vicki M

“…Spinal cord injury (SCI) results in not only the loss of voluntary muscle control, but also in the presence of involuntary movement or spasms. These spasms…”
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Ambulatory function in motor incomplete spinal cord injury: a magnetic resonance imaging study of spinal cord edema and lower extremity muscle morphometry by Smith, A C, Weber, K A, Parrish, T B, Hornby, T G, Tysseling, V M, McPherson, J G, Wasielewski, M, Elliott, J M

“…Study design: This research utilized a cross-sectional design. Objectives: Spinal cord edema length has been measured with T2-weighted sagittal MRI to predict…”
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