Search Results - "Tyrrell, Pippa"

Detection of Atrial Fibrillation After Ischemic Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis by KISHORE, Amit, VAIL, Andy, MAJID, Arshad, DAWSON, Jesse, LEES, Kennedy R, TYRRELL, Pippa J, SMITH, Craig J

“…Atrial fibrillation (AF) confers a high risk of recurrent stroke, although detection methods and definitions of paroxysmal AF during screening vary. We…”
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Weekly variation in health-care quality by day and time of admission: a nationwide, registry-based, prospective cohort study of acute stroke care by Bray, Benjamin D, Dr, Cloud, Geoffrey C, FRCP, James, Martin A, FRCP, Hemingway, Harry, Prof, Paley, Lizz, BA, Stewart, Kevin, FRCP, Tyrrell, Pippa J, Prof, Wolfe, Charles D A, Prof, Rudd, Anthony G, Prof

“…Summary Background Studies in many health systems have shown evidence of poorer quality health care for patients admitted on weekends or overnight than for…”
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Associations between stroke mortality and weekend working by stroke specialist physicians and registered nurses: prospective multicentre cohort study by Bray, Benjamin D, Ayis, Salma, Campbell, James, Cloud, Geoffrey C, James, Martin, Hoffman, Alex, Tyrrell, Pippa J, Wolfe, Charles D A, Rudd, Anthony G

“…Observational studies have reported higher mortality for patients admitted on weekends. It is not known whether this "weekend effect" is modified by clinical…”
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Diagnosis of Stroke-Associated Pneumonia: Recommendations From the Pneumonia in Stroke Consensus Group by Smith, Craig J, Kishore, Amit K, Vail, Andy, Chamorro, Angel, Garau, Javier, Hopkins, Stephen J, Di Napoli, Mario, Kalra, Lalit, Langhorne, Peter, Montaner, Joan, Roffe, Christine, Rudd, Anthony G, Tyrrell, Pippa J, van de Beek, Diederik, Woodhead, Mark, Meisel, Andreas

“…BACKGROUND AND PURPOSE—Lower respiratory tract infections frequently complicate stroke and adversely affect outcome. There is currently no agreed terminology…”
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SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke): A Randomized Controlled Phase 2 Trial by Smith, Craig J, Hulme, Sharon, Vail, Andy, Heal, Calvin, Parry-Jones, Adrian R, Scarth, Sylvia, Hopkins, Karen, Hoadley, Margaret, Allan, Stuart M, Rothwell, Nancy J, Hopkins, Stephen J, Tyrrell, Pippa J

“…BACKGROUND AND PURPOSE—The proinflammatory cytokine IL-1 (interleukin-1) has a deleterious role in cerebral ischemia, which is attenuated by IL-1 receptor…”
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Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2) by Muir, Keith W, Bulters, Diederik, Willmot, Mark, Sprigg, Nikola, Dixit, Anand, Ward, Nick, Tyrrell, Pippa, Majid, Arshad, Dunn, Laurence, Bath, Philip, Howell, Julian, Stroemer, Paul, Pollock, Kenneth, Sinden, John

“…BackgroundHuman neural stem cell implantation may offer improved recovery from stroke. We investigated the feasibility of intracerebral implantation of the…”
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Interleukin-1 in Stroke: From Bench to Bedside by Sobowale, Oluwaseun A, Parry-Jones, Adrian R, Smith, Craig J, Tyrrell, Pippa J, Rothwell, Nancy J, Allan, Stuart M

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The association between delays in screening for and assessing dysphagia after acute stroke, and the risk of stroke-associated pneumonia by Bray, Benjamin D, Smith, Craig J, Cloud, Geoffrey C, Enderby, Pam, James, Martin, Paley, Lizz, Tyrrell, Pippa J, Wolfe, Charles D A, Rudd, Anthony G

“…BackgroundThere is no robust evidence that screening patients with acute stroke for dysphagia reduces the risk of stroke-associated pneumonia (SAP), or of how…”
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How Is Pneumonia Diagnosed in Clinical Stroke Research?: A Systematic Review and Meta-Analysis by Kishore, Amit K, Vail, Andy, Chamorro, Angel, Garau, Javier, Hopkins, Stephen J, Di Napoli, Mario, Kalra, Lalit, Langhorne, Peter, Montaner, Joan, Roffe, Christine, Rudd, Anthony G, Tyrrell, Pippa J, van de Beek, Diederik, Woodhead, Mark, Meisel, Andreas, Smith, Craig J

“…BACKGROUND AND PURPOSE—Diagnosis of pneumonia complicating stroke is challenging, and there are currently no consensus diagnostic criteria. As a first step in…”
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Impact and sustainability of centralising acute stroke services in English metropolitan areas: retrospective analysis of hospital episode statistics and stroke national audit data by Morris, Stephen, Ramsay, Angus I G, Boaden, Ruth J, Hunter, Rachael M, McKevitt, Christopher, Paley, Lizz, Perry, Catherine, Rudd, Anthony G, Turner, Simon J, Tyrrell, Pippa J, Wolfe, Charles D A, Fulop, Naomi J

“…To investigate whether further centralisation of acute stroke services in Greater Manchester in 2015 was associated with changes in outcomes and whether the…”
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Reduction of inflammation after administration of interleukin-1 receptor antagonist following aneurysmal subarachnoid hemorrhage: results of the Subcutaneous Interleukin-1Ra in SAH (SCIL-SAH) study by Galea, James, Ogungbenro, Kayode, Hulme, Sharon, Patel, Hiren, Scarth, Sylvia, Hoadley, Margaret, Illingworth, Karen, McMahon, Catherine J, Tzerakis, Nikolaos, King, Andrew T, Vail, Andy, Hopkins, Stephen J, Rothwell, Nancy, Tyrrell, Pippa

“…OBJECTIVE Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating cerebrovascular event with long-term morbidity and mortality. Patients who survive the…”
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Interleukin-1 and neuronal injury by Allan, Stuart M, Tyrrell, Pippa J, Rothwell, Nancy J

“…Interleukin-1 is a pro-inflammatory cytokine that has numerous biological effects, including activation of many inflammatory processes (through activation of T…”
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Regulation of interleukin-1 in acute brain injury by Brough, David, Tyrrell, Pippa J, Allan, Stuart M

“…Inflammation is a complex vascular response that has evolved to eliminate infection and to repair injured tissue. It is subject to tight regulatory control of…”
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Lessons for major system change: centralization of stroke services in two metropolitan areas of England by Turner, Simon, Ramsay, Angus, Perry, Catherine, Boaden, Ruth, McKevitt, Christopher, Morris, Stephen, Pursani, Nanik, Rudd, Anthony, Tyrrell, Pippa, Wolfe, Charles, Fulop, Naomi

“…Our aim was to identify the factors influencing the selection of a model of acute stroke service centralization to create fewer high-volume specialist units in…”
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The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial by Singh, Navneet, Hopkins, Stephen J, Hulme, Sharon, Galea, James P, Hoadley, Margaret, Vail, Andy, Hutchinson, Peter J, Grainger, Samantha, Rothwell, Nancy J, King, Andrew T, Tyrrell, Pippa J

“…Interleukin-1 (IL-1) is a key mediator of ischaemic brain injury induced by stroke and subarachnoid haemorrhage (SAH). IL-1 receptor antagonist (IL-1Ra) limits…”
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Why do stroke survivors not receive recommended amounts of active therapy? Findings from the ReAcT study, a mixed-methods case-study evaluation in eight stroke units by Clarke, David J, Burton, Louisa-Jane, Tyson, Sarah F, Rodgers, Helen, Drummond, Avril, Palmer, Rebecca, Hoffman, Alex, Prescott, Matthew, Tyrrell, Pippa, Brkic, Lianne, Grenfell, Katie, Forster, Anne

“…Objective: To identify why the National Clinical Guideline recommendation of 45 minutes of each appropriate therapy daily is not met in many English stroke…”
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Characterizing the Mechanisms of Central and Peripheral Forms of Neurostimulation in Chronic Dysphagic Stroke Patients by Michou, Emilia, Mistry, Satish, Jefferson, Samantha, Tyrrell, Pippa, Hamdy, Shaheen

“…Abstract Background Swallowing problems following stroke may result in increased risk of aspiration pneumonia, malnutrition, and dehydration…”
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Can a novel clinical risk score improve pneumonia prediction in acute stroke care? A UK multicenter cohort study by Smith, Craig J, Bray, Benjamin D, Hoffman, Alex, Meisel, Andreas, Heuschmann, Peter U, Wolfe, Charles D A, Tyrrell, Pippa J, Rudd, Anthony G

“…Pneumonia frequently complicates stroke and has a major impact on outcome. We derived and internally validated a simple clinical risk score for predicting…”
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Brain inflammation is induced by co-morbidities and risk factors for stroke by Drake, Caroline, Boutin, Hervé, Jones, Matthew S, Denes, Adam, McColl, Barry W, Selvarajah, Johann R, Hulme, Sharon, Georgiou, Rachel F, Hinz, Rainer, Gerhard, Alexander, Vail, Andy, Prenant, Christian, Julyan, Peter, Maroy, Renaud, Brown, Gavin, Smigova, Alison, Herholz, Karl, Kassiou, Michael, Crossman, David, Francis, Sheila, Proctor, Spencer D, Russell, James C, Hopkins, Stephen J, Tyrrell, Pippa J, Rothwell, Nancy J, Allan, Stuart M

“…Highlights ► Risk factors for stroke include atherosclerosis, obesity, diabetes and hypertension. ► Stroke risk factors are associated with peripheral…”
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Phase II anti-inflammatory and immune-modulating drugs for acute ischaemic stroke by Smith, Craig J, Denes, Adam, Tyrrell, Pippa J, Di Napoli, Mario

“…Stroke is the second leading cause of death worldwide and the leading cause of adult neurological disability. Despite advances in stroke unit care, and…”
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