Search Results - "Tyrrell, Lynda"

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    Phosphorylation of Sodium Channel Nav1.8 by p38 Mitogen-Activated Protein Kinase Increases Current Density in Dorsal Root Ganglion Neurons by Hudmon, Andy, Choi, Jin-Sung, Tyrrell, Lynda, Black, Joel A, Rush, Anthony M, Waxman, Stephen G, Dib-Hajj, Sulayman D

    Published in The Journal of neuroscience (19-03-2008)
    “…The sensory neuron-specific sodium channel Na v 1.8 and p38 mitogen-activated protein kinase are potential therapeutic targets within nociceptive dorsal root…”
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    Transfection of rat or mouse neurons by biolistics or electroporation by Waxman, Stephen G, Dib-Hajj, Sulayman D, Choi, Jin Sung, Macala, Lawrence J, Tyrrell, Lynda, Black, Joel A, Cummins, Theodore R

    Published in Nature protocols (01-08-2009)
    “…Properties of ion channels are affected by the background of the cells in which they are expressed. Thus, it is important for investigators interested in…”
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    ERK1/2 Mitogen-Activated Protein Kinase Phosphorylates Sodium Channel Nav1.7 and Alters Its Gating Properties by Stamboulian, Severine, Choi, Jin-Sung, Ahn, Hye-Sook, Chang, Yu-Wen, Tyrrell, Lynda, Black, Joel A, Waxman, Stephen G, Dib-Hajj, Sulayman D

    Published in The Journal of neuroscience (03-02-2010)
    “…Na v 1.7 sodium channels can amplify weak stimuli in neurons and act as threshold channels for firing action potentials. Neurotrophic factors and…”
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    Nav1.7 Mutant A863P in Erythromelalgia: Effects of Altered Activation and Steady-State Inactivation on Excitability of Nociceptive Dorsal Root Ganglion Neurons by Harty, T. Patrick, Dib-Hajj, Sulayman D, Tyrrell, Lynda, Blackman, Rachael, Hisama, Fuki M, Rose, John B, Waxman, Stephen G

    Published in The Journal of neuroscience (29-11-2006)
    “…Inherited erythromelalgia/erythermalgia (IEM) is a neuropathy characterized by pain and redness of the extremities that is triggered by warmth. IEM has been…”
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    Nav1.7 is the Predominant Sodium Channel in Rodent Olfactory Sensory Neurons by Ahn, Hye-Sook, Black, Joel A, Zhao, Peng, Tyrrell, Lynda, Waxman, Stephen G, Dib-Hajj, Sulayman D

    Published in Molecular pain (10-05-2011)
    “…Background: Voltage-gated sodium channel Nav1.7 is preferentially expressed in dorsal root ganglion (DRG) and sympathetic neurons within the peripheral nervous…”
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  7. 7

    Size Matters: Erythromelalgia Mutation S241T in Nav1.7 Alters Channel Gating by Lampert, Angelika, Dib-Hajj, Sulayman D., Tyrrell, Lynda, Waxman, Stephen G.

    Published in The Journal of biological chemistry (24-11-2006)
    “…The Nav1.7 sodium channel is preferentially expressed in most nociceptive dorsal root ganglion neurons and in sympathetic neurons. Inherited erythromelalgia…”
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  8. 8

    Differential modulation of sodium channel Nav1.6 by two members of the fibroblast growth factor homologous factor 2 subfamily by Rush, Anthony M., Wittmack, Ellen K., Tyrrell, Lynda, Black, Joel A., Dib-Hajj, Sulayman D., Waxman, Stephen G.

    Published in The European journal of neuroscience (01-05-2006)
    “…FHF2A and FHF2B are two members of the fibroblast growth factor homologous factor 2 (FHF2) subfamily with distinct N termini. Using a generic antibody and…”
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    Activating and Dominant Inactivating c-KIT Catalytic Domain Mutations in Distinct Clinical Forms of Human Mastocytosis by Longley, B. Jack, Metcalfe, Dean D., Tharp, Michael, Wang, Xiaomei, Tyrrell, Lynda, Lu, Shu-zhuang, Heitjan, David, Ma, Yongsheng

    “…Human mastocytosis is characterized by increased mast cells. It usually occurs as a sporadic disease that is often transient and limited in children and…”
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    A Pore-blocking Hydrophobic Motif at the Cytoplasmic Aperture of the Closed-state Nav1.7 Channel Is Disrupted by the Erythromelalgia-associated F1449V Mutation by Lampert, Angelika, O'Reilly, Andrias O., Dib-Hajj, Sulayman D., Tyrrell, Lynda, Wallace, B.A., Waxman, Stephen G.

    Published in The Journal of biological chemistry (29-08-2008)
    “…Sodium channel Nav1.7 has recently elicited considerable interest as a key contributor to human pain. Gain-of-function mutations of Nav1.7 produce painful…”
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  11. 11

    Mutation I136V Alters Electrophysiological Properties of the NaV1.7 Channel in a Family with Onset of Erythromelalgia in the Second Decade by Cheng, Xiaoyang, Dib-Hajj, Sulayman D, Tyrrell, Lynda, Waxman, Stephen G

    Published in Molecular pain (02-01-2008)
    “…Background: Primary erythromelalgia is an autosomal dominant pain disorder characterized by burning pain and skin redness in the extremities, with onset of…”
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  12. 12

    Glycosylation Alters Steady-State Inactivation of Sodium Channel Nav1.9/NaN in Dorsal Root Ganglion Neurons and Is Developmentally Regulated by Tyrrell, Lynda, Renganathan, Muthukrishnan, Dib-Hajj, Sulayman D, Waxman, Stephen G

    Published in The Journal of neuroscience (15-12-2001)
    “…Na channel NaN (Na(v)1.9) produces a persistent TTX-resistant (TTX-R) current in small-diameter neurons of dorsal root ganglia (DRG) and trigeminal ganglia…”
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  13. 13

    Mutations at opposite Ends of the DIII/S4-S5 Linker of Sodium Channel NaV1.7 Produce Distinct Pain Disorders by Cheng, Xiaoyang, Dib-Hajj, Sulayman D, Tyrrell, Lynda, Wright, Dowain A, Fischer, Tanya Z, Waxman, Stephen G

    Published in Molecular pain (29-04-2010)
    “…Background: Two groups of gain-of-function mutations in sodium channel NaV1.7, which are expressed in dorsal root ganglion (DRG) neurons, produce two…”
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  14. 14

    Somatic c- KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm by Longley, B. Jack, Tyrrell, Lynda, Lu, Shu-Zhuang, Ma, Yong-Sheng, Langley, Keith, Ding, Tie-gang, Duffy, Thomas, Jacobs, Peter, Tang, Laura H, Modlin, Irvin

    Published in Nature genetics (01-03-1996)
    “…Mastocytosis is characterized by accumulations of mast cells in various organs (1). Most cases are indolent and confined to the skin, where discrete mast cell…”
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    Murine cutaneous mastocytosis and epidermal melanocytosis induced by keratinocyte expression of transgenic stem cell factor by Kunisada, T, Lu, S Z, Yoshida, H, Nishikawa, S, Mizoguchi, M, Hayashi, S, Tyrrell, L, Williams, D A, Wang, X, Longley, B J

    Published in The Journal of experimental medicine (18-05-1998)
    “…The growth and differentiation of mast cells and melanocytes require stem cell factor (SCF), the ligand for the kit receptor tyrosine kinase. SCF may exist as…”
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    Chymase Cleavage of Stem Cell Factor Yields a Bioactive, Soluble Product by Longley, B. Jack, Tyrrell, Lynda, Ma, Yongsheng, Williams, David A., Halaban, Ruth, Langley, Keith, Lu, Hsieng S., Schechter, Norman M.

    “…Stem cell factor (SCF) is produced by stromal cells as a membrane-bound molecule, which may be proteolytically cleaved at a site close to the membrane to…”
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    Early- and late-onset inherited erythromelalgia: genotype–phenotype correlation by Han, Chongyang, Dib-Hajj, Sulayman D., Lin, Zhimiao, Li, Yan, Eastman, Emmanuella M., Tyrrell, Lynda, Cao, Xianwei, Yang, Yong, Waxman, Stephen G.

    Published in Brain (London, England : 1878) (01-07-2009)
    “…Inherited erythromelalgia (IEM), an autosomal dominant disorder characterized by severe burning pain in response to mild warmth, has been shown to be caused by…”
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  18. 18

    Paroxysmal Extreme Pain Disorder M1627K Mutation in Human Nav1.7 Renders DRG Neurons Hyperexcitable by Dib-Hajj, Sulayman D, Estacion, Mark, Jarecki, Brian W, Tyrrell, Lynda, Fischer, Tanya Z, Lawden, Mark, Cummins, Theodore R, Waxman, Stephen G

    Published in Molecular pain (19-09-2008)
    “…Background: Paroxysmal extreme pain disorder (PEPD) is an autosomal dominant painful neuropathy with many, but not all, cases linked to gain-of-function…”
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  19. 19

    Altered Metabolism of Mast-Cell Growth Factor (c-kit Ligand) in Cutaneous Mastocytosis by Longley, B. Jack, Morganroth, Greg S, Tyrrell, Lynda, Ding, Tie Gang, Anderson, Dirk M, Williams, Douglas E, Halaban, Ruth

    Published in The New England journal of medicine (06-05-1993)
    “…Mastocytosis is a heterogeneous group of diseases characterized by increased numbers of mast cells in various organs 1 . In individual patients, mastocytosis…”
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  20. 20

    Gain-of-function mutations in sodium channel Na(v)1.9 in painful neuropathy by Huang, Jianying, Han, Chongyang, Estacion, Mark, Vasylyev, Dymtro, Hoeijmakers, Janneke G J, Gerrits, Monique M, Tyrrell, Lynda, Lauria, Giuseppe, Faber, Catharina G, Dib-Hajj, Sulayman D, Merkies, Ingemar S J, Waxman, Stephen G

    Published in Brain (London, England : 1878) (01-06-2014)
    “…Sodium channel Nav1.9 is expressed in peripheral nociceptive neurons, as well as visceral afferents, and has been shown to act as a threshold channel. Painful…”
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