Search Results - "Tyrrell, Lynda"
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Gain-of-function mutations in sodium channel Nav1.9 in painful neuropathy
Published in Brain (London, England : 1878) (01-06-2014)Get full text
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Phosphorylation of Sodium Channel Nav1.8 by p38 Mitogen-Activated Protein Kinase Increases Current Density in Dorsal Root Ganglion Neurons
Published in The Journal of neuroscience (19-03-2008)“…The sensory neuron-specific sodium channel Na v 1.8 and p38 mitogen-activated protein kinase are potential therapeutic targets within nociceptive dorsal root…”
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3
Transfection of rat or mouse neurons by biolistics or electroporation
Published in Nature protocols (01-08-2009)“…Properties of ion channels are affected by the background of the cells in which they are expressed. Thus, it is important for investigators interested in…”
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ERK1/2 Mitogen-Activated Protein Kinase Phosphorylates Sodium Channel Nav1.7 and Alters Its Gating Properties
Published in The Journal of neuroscience (03-02-2010)“…Na v 1.7 sodium channels can amplify weak stimuli in neurons and act as threshold channels for firing action potentials. Neurotrophic factors and…”
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5
Nav1.7 Mutant A863P in Erythromelalgia: Effects of Altered Activation and Steady-State Inactivation on Excitability of Nociceptive Dorsal Root Ganglion Neurons
Published in The Journal of neuroscience (29-11-2006)“…Inherited erythromelalgia/erythermalgia (IEM) is a neuropathy characterized by pain and redness of the extremities that is triggered by warmth. IEM has been…”
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Nav1.7 is the Predominant Sodium Channel in Rodent Olfactory Sensory Neurons
Published in Molecular pain (10-05-2011)“…Background: Voltage-gated sodium channel Nav1.7 is preferentially expressed in dorsal root ganglion (DRG) and sympathetic neurons within the peripheral nervous…”
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Size Matters: Erythromelalgia Mutation S241T in Nav1.7 Alters Channel Gating
Published in The Journal of biological chemistry (24-11-2006)“…The Nav1.7 sodium channel is preferentially expressed in most nociceptive dorsal root ganglion neurons and in sympathetic neurons. Inherited erythromelalgia…”
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Differential modulation of sodium channel Nav1.6 by two members of the fibroblast growth factor homologous factor 2 subfamily
Published in The European journal of neuroscience (01-05-2006)“…FHF2A and FHF2B are two members of the fibroblast growth factor homologous factor 2 (FHF2) subfamily with distinct N termini. Using a generic antibody and…”
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Activating and Dominant Inactivating c-KIT Catalytic Domain Mutations in Distinct Clinical Forms of Human Mastocytosis
Published in Proceedings of the National Academy of Sciences - PNAS (16-02-1999)“…Human mastocytosis is characterized by increased mast cells. It usually occurs as a sporadic disease that is often transient and limited in children and…”
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A Pore-blocking Hydrophobic Motif at the Cytoplasmic Aperture of the Closed-state Nav1.7 Channel Is Disrupted by the Erythromelalgia-associated F1449V Mutation
Published in The Journal of biological chemistry (29-08-2008)“…Sodium channel Nav1.7 has recently elicited considerable interest as a key contributor to human pain. Gain-of-function mutations of Nav1.7 produce painful…”
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Mutation I136V Alters Electrophysiological Properties of the NaV1.7 Channel in a Family with Onset of Erythromelalgia in the Second Decade
Published in Molecular pain (02-01-2008)“…Background: Primary erythromelalgia is an autosomal dominant pain disorder characterized by burning pain and skin redness in the extremities, with onset of…”
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Glycosylation Alters Steady-State Inactivation of Sodium Channel Nav1.9/NaN in Dorsal Root Ganglion Neurons and Is Developmentally Regulated
Published in The Journal of neuroscience (15-12-2001)“…Na channel NaN (Na(v)1.9) produces a persistent TTX-resistant (TTX-R) current in small-diameter neurons of dorsal root ganglia (DRG) and trigeminal ganglia…”
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Mutations at opposite Ends of the DIII/S4-S5 Linker of Sodium Channel NaV1.7 Produce Distinct Pain Disorders
Published in Molecular pain (29-04-2010)“…Background: Two groups of gain-of-function mutations in sodium channel NaV1.7, which are expressed in dorsal root ganglion (DRG) neurons, produce two…”
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Somatic c- KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm
Published in Nature genetics (01-03-1996)“…Mastocytosis is characterized by accumulations of mast cells in various organs (1). Most cases are indolent and confined to the skin, where discrete mast cell…”
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Murine cutaneous mastocytosis and epidermal melanocytosis induced by keratinocyte expression of transgenic stem cell factor
Published in The Journal of experimental medicine (18-05-1998)“…The growth and differentiation of mast cells and melanocytes require stem cell factor (SCF), the ligand for the kit receptor tyrosine kinase. SCF may exist as…”
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Chymase Cleavage of Stem Cell Factor Yields a Bioactive, Soluble Product
Published in Proceedings of the National Academy of Sciences - PNAS (19-08-1997)“…Stem cell factor (SCF) is produced by stromal cells as a membrane-bound molecule, which may be proteolytically cleaved at a site close to the membrane to…”
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Early- and late-onset inherited erythromelalgia: genotype–phenotype correlation
Published in Brain (London, England : 1878) (01-07-2009)“…Inherited erythromelalgia (IEM), an autosomal dominant disorder characterized by severe burning pain in response to mild warmth, has been shown to be caused by…”
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Paroxysmal Extreme Pain Disorder M1627K Mutation in Human Nav1.7 Renders DRG Neurons Hyperexcitable
Published in Molecular pain (19-09-2008)“…Background: Paroxysmal extreme pain disorder (PEPD) is an autosomal dominant painful neuropathy with many, but not all, cases linked to gain-of-function…”
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Altered Metabolism of Mast-Cell Growth Factor (c-kit Ligand) in Cutaneous Mastocytosis
Published in The New England journal of medicine (06-05-1993)“…Mastocytosis is a heterogeneous group of diseases characterized by increased numbers of mast cells in various organs 1 . In individual patients, mastocytosis…”
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Gain-of-function mutations in sodium channel Na(v)1.9 in painful neuropathy
Published in Brain (London, England : 1878) (01-06-2014)“…Sodium channel Nav1.9 is expressed in peripheral nociceptive neurons, as well as visceral afferents, and has been shown to act as a threshold channel. Painful…”
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