Search Results - "Tyree, Curtis"

A Novel Antiinflammatory Maintains Glucocorticoid Efficacy with Reduced Side Effects by Coghlan, Michael J, Jacobson, Peer B, Lane, Ben, Nakane, Masaki, Lin, Chun Wei, Elmore, Steven W, Kym, Philip R, Luly, Jay R, Carter, George W, Turner, Russell, Tyree, Curtis M, Hu, Junlian, Elgort, Marc, Rosen, Jon, Miner, Jeffrey N

“…Glucocorticoids (GCs) are commonly used to treat inflammatory disease; unfortunately, the long-term use of these steroids leads to a large number of…”
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Nonsteroidal Selective Glucocorticoid Modulators:  The Effect of C-10 Substitution on Receptor Selectivity and Functional Potency of 5-Allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines by Kym, Philip R, Kort, Michael E, Coghlan, Michael J, Moore, Jimmie L, Tang, Rui, Ratajczyk, James D, Larson, Daniel P, Elmore, Steven W, Pratt, John K, Stashko, Michael A, Falls, H. Douglass, Lin, Chun W, Nakane, Masake, Miller, Loan, Tyree, Curtis M, Miner, Jeffery N, Jacobson, Peer B, Wilcox, Denise M, Nguyen, Phong, Lane, Benjamin C

“…The preparation and characterization of a series of C-10 substituted 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines as a novel class of…”
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Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators by Elmore, Steven W, Pratt, John K, Coghlan, Michael J, Mao, Yue, Green, Brian E, Anderson, David D, Stashko, Michael A, Lin, Chun W, Falls, Douglas, Nakane, Masaki, Miller, Loan, Tyree, Curtis M, Miner, Jeffrey N, Lane, Ben

“…The SAR at C-5 of the 10-methoxy-2,2,4-trimethylbenzopyrano[3,4-f]quinoline core leading to identification of (−) anti 1-methylcyclohexen-3-yl as the optimum…”
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Nonsteroidal Selective Glucocorticoid Modulators:  the Effect of C-5 Alkyl Substitution on the Transcriptional Activation/Repression Profile of 2,5-Dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines by Elmore, Steven W, Coghlan, Michael J, Anderson, David D, Pratt, John K, Green, Brian E, Wang, Alan X, Stashko, Michael A, Lin, Chun W, Tyree, Curtis M, Miner, Jeffery N, Jacobson, Peer B, Wilcox, Denise M, Lane, Benjamin C

“…The preparation and characterization of a series of selective glucocorticoid receptor modulators are described. The preliminary structure−activity relationship…”
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Hydrazinonaphthalene and Azonaphthalene Thrombopoietin Mimics Are Nonpeptidyl Promoters of Megakaryocytopoiesis by Duffy, Kevin J, Darcy, Michael G, Delorme, Evelyne, Dillon, Susan B, Eppley, Daniel F, Erickson-Miller, Connie, Giampa, Leslie, Hopson, Christopher B, Huang, Yifang, Keenan, Richard M, Lamb, Peter, Leong, Lynnette, Liu, Nannan, Miller, Stephen G, Price, Alan T, Rosen, Jon, Shah, Rakhi, Shaw, Tony N, Smith, Heather, Stark, Kenneth C, Tian, Shin-Shay, Tyree, Curtis, Wiggall, Kenneth J, Zhang, Lily, Luengo, Juan I

“…High-throughput screening for the induction of a luciferase reporter gene in a thrombopoietin (TPO)-responsive cell line resulted in the identification of…”
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17β-Estradiol inhibits cytokine induction of the human E-selectin promoter by Tyree, Curtis M., Zou, Aihua, Allegretto, Elizabeth A.

“…Estradiol has been shown to decrease levels of the cell adhesion molecule E-selectin in cultured cells and in women on hormone replacement therapy. We set out…”
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trans-Activation and repression properties of the novel nonsteroid glucocorticoid receptor ligand 2,5-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5-(1-methylcyclohexen-3-y1)-1H-[1]benzopyrano[3,4-f]quinoline (A276575) and its four stereoisomers by Lin, Chun Wel, Nakane, Masaki, Stashko, Mike, Falls, Doug, Kuk, Jane, Miller, Loan, Huang, Ruth, Tyree, Curtis, Miner, Jeffrey N, Rosen, John, Kym, Philip R, Coghlan, Mike J, Carter, George, Lane, Ben C

“…Glucocorticoids are potent anti-inflammatory and immunosuppressant agents. However, they also produce serious side effects that limit their usage. It has been…”
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The mammalian two-hybrid assay for detection of coactivator-nuclear receptor interactions by Tyree, Curtis M, Klausing, Kay

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Manganese poisoning and the attack of trivalent manganese upon catecholamines by Archibald, F S, Tyree, C

“…Human manganese poisoning or manganism results in damage to the substantia nigra of the brain stem, a drop in the level of the inhibitory neurotransmitter…”
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Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease by Kounnas, Maria Z., Danks, Anne M., Cheng, Soan, Tyree, Curtis, Ackerman, Elizabeth, Zhang, Xulun, Ahn, Kwangwook, Nguyen, Phuong, Comer, Dan, Mao, Long, Yu, Chengzhi, Pleynet, David, Digregorio, Paul J., Velicelebi, Gonul, Stauderman, Kenneth A., Comer, William T., Mobley, William C., Li, Yue-Ming, Sisodia, Sangram S., Tanzi, Rudolph E., Wagner, Steven L.

“…Alzheimer's disease (AD) is characterized pathologically by the abundance of senile plaques and neurofibrillary tangles in the brain. We synthesized over 1200…”
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Drug discovery and the intracellular receptor family by Miner, Jeffrey N, Tyree, Curtis M

“…Drug discovery using intracellular receptors (IRs) as targets presents its own set of unique complications and advantages. The natural ligands for these…”
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The plasmid replicon of EBV consists of multiple cis-acting elements that facilitate DNA synthesis by the cell and a viral maintenance element by Aiyar, Ashok, Tyree, Curtis, Sugden, Bill

“…Plasmids containing oriP, the plasmid origin of Epstein–Barr virus (EBV), are replicated stably in human cells that express a single viral trans‐acting factor,…”
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Structure and Function of the Small Subunit of TFIIF (RAP30) from Drosophilamelanogaster(∗) by Frank, Deborah J., Tyree, Curtis M., George, Catherine P., Kadonaga, James T.

“…To study the mechanism of basal transcription by RNA polymerase II, a cDNA encoding the Drosophila homologue of the small subunit of TFIIF (also referred to as…”
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Modulation of [gamma]-Secretase Reduces [beta]-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease by Kounnas, Maria Z, Danks, Anne M, Cheng, Soan, Tyree, Curtis, Ackerman, Elizabeth, Zhang, Xulun, Ahn, Kwangwook, Nguyen, Phuong, Comer, Dan, Mao, Long, Yu, Chengzhi, Pleynet, David, Digregorio, Paul J, Velicelebi, Gonul, Stauderman, Kenneth A, Comer, William T, Mobley, William C, Li, Yue-Ming, Sisodia, Sangram S, Tanzi, Rudolph E, Wagner, Steven L

“…Alzheimer's disease (AD) is characterized pathologically by the abundance of senile plaques and neurofibrillary tangles in the brain. We synthesized over 1200…”
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Synthesis and Characterization of Non-Steroidal Ligands for the Glucocorticoid Receptor:  Selective Quinoline Derivatives with Prednisolone-Equivalent Functional Activity by Coghlan, Michael J, Kym, Philip R, Elmore, Steven W, Wang, Alan X, Luly, Jay R, Wilcox, Denise, Stashko, Michael, Lin, Chun-Wei, Miner, Jeffrey, Tyree, Curtis, Nakane, Masaki, Jacobson, Peer, Lane, Benjamin C

“…A novel class of functional ligands for the human glucocorticoid receptor is described. Substituents in the C-10 position of the tetracyclic core are essential…”
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A Nonsteroidal Glucocorticoid Receptor Antagonist by Miner, Jeffrey N, Tyree, Curtis, Hu, Junlian, Berger, Elaine, Marschke, Keith, Nakane, Masaki, Coghlan, Michael J, Clemm, Dave, Lane, Ben, Rosen, Jon

“…Selective intracellular receptor antagonists are used clinically to ameliorate hormone-dependent disease states. Patients with Cushing’s syndrome have high…”
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17beta-Estradiol inhibits cytokine induction of the human E-selectin promoter by Tyree, Curtis M, Zou, Aihua, Allegretto, Elizabeth A

“…Estradiol has been shown to decrease levels of the cell adhesion molecule E-selectin in cultured cells and in women on hormone replacement therapy. We set out…”
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Identification of a minimal set of proteins that is sufficient for accurate initiation of transcription by RNA polymerase II by TYREE, C. M, GEORGE, C. P, LIRA-DE VITO, L. M, WAMPLER, S. L, DAHMUS, M. E, ZAWEL, L, KADONAGA, J. T

“…In eukaryotes, initiation of mRNA synthesis is a multistep process that is carried out by RNA polymerase II and auxiliary factors that are commonly referred to…”
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Accurate and efficient RNA polymerase II transcription with a soluble nuclear fraction derived from Drosophila embryos by Kamakaka, R.T. (University of California at San Diego, San Diego, CA), Tyree, C.M, Kadonaga, J.T

“…We describe the preparation and biochemical properties of a soluble nuclear fraction derived from Drosophila embryos. This extract, which can be easily…”
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In vitro transcription of a Drosophila U1 small nuclear RNA gene requires TATA box-binding protein and two proximal cis-acting elements with stringent spacing requirements by Zamrod, Z, Tyree, C M, Song, Y, Stumph, W E

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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