Search Results - "Tyrakis, Petros A."

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  1. 1

    Constitutive Glycolytic Metabolism Supports CD8+ T Cell Effector Memory Differentiation during Viral Infection by Phan, Anthony T., Doedens, Andrew L., Palazon, Asis, Tyrakis, Petros A., Cheung, Kitty P., Johnson, Randall S., Goldrath, Ananda W.

    Published in Immunity (Cambridge, Mass.) (15-11-2016)
    “…Extensive metabolic changes accompany T cell activation, including a switch to glycolytic energy production and increased biosynthesis. Recent studies suggest…”
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    A Late-Stage Intermediate in Salinomycin Biosynthesis Is Revealed by Specific Mutation in the Biosynthetic Gene Cluster by Yurkovich, Marie E., Tyrakis, Petros A., Hong, Hui, Sun, Yuhui, Samborskyy, Markiyan, Kamiya , Kohei, Leadlay, Peter F.

    “…Say “when”: Analysis of the biosynthetic gene cluster for the polyether antibiotic and anticancer agent salinomycin (1) shows that its core structure is…”
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    Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects by Tyrakis, Petros A., Yurkovich, Marie E., Sciacovelli, Marco, Papachristou, Evangelia K., Bridges, Hannah R., Gaude, Edoardo, Schreiner, Alexander, D’Santos, Clive, Hirst, Judy, Hernandez-Fernaud, Juan, Springett, Roger, Griffiths, John R., Frezza, Christian

    Published in Cell reports (Cambridge) (24-10-2017)
    “…Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid (TCA) cycle mutated in hereditary and sporadic cancers. Despite recent advances in understanding…”
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    An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression by Palazon, Asis, Tyrakis, Petros A., Macias, David, Veliça, Pedro, Rundqvist, Helene, Fitzpatrick, Susan, Vojnovic, Nikola, Phan, Anthony T., Loman, Niklas, Hedenfalk, Ingrid, Hatschek, Thomas, Lövrot, John, Foukakis, Theodoros, Goldrath, Ananda W., Bergh, Jonas, Johnson, Randall S.

    Published in Cancer cell (13-11-2017)
    “…Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion…”
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  6. 6

    S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate by Tyrakis, Petros A., Palazon, Asis, Macias, David, Lee, Kian. L., Phan, Anthony. T., Veliça, Pedro, You, Jia, Chia, Grace S., Sim, Jingwei, Doedens, Andrew, Abelanet, Alice, Evans, Colin E., Griffiths, John R., Poellinger, Lorenz, Goldrath, Ananda W., Johnson, Randall S.

    Published in Nature (London) (08-12-2016)
    “…R -2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of R…”
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    Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis by Evans, Colin E, Palazon, Asis, Sim, Jingwei, Tyrakis, Petros A, Prodger, Alice, Lu, Xiao, Chan, Saria, Bendahl, Pär-Ola, Belting, Mattias, Von Euler, Love, Rundqvist, Helene, Johnson, Randall S, Branco, Cristina

    Published in Biology open (15-05-2017)
    “…Thrombosis can cause localized ischemia and tissue hypoxia, and both of these are linked to cancer metastasis. Vascular micro-occlusion can occur as a result…”
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    Abstract A19: Pulmonary microthrombosis enhances tumorigenesis via myeloid hypoxia-inducible factors by Evans, Colin E., Palazon, Asis, Sim, Jingwei, Tyrakis, Petros A., Bendahl, Par-Ola, Belting, Mattias, Rundqvist, Helene, Branco, Cristina, Johnson, Randall S.

    Published in Cancer research (Chicago, Ill.) (01-04-2016)
    “…Abstract Thrombosis causes local blood flow restriction and tissue hypoxia, and both of these are associated with tumor cell metastasis. To better understand…”
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    S-2-hydroxyglutarate regulates CD8^sup +^ T-lymphocyte fate by Tyrakis, Petros A, Palazon, Asis, Macias, David, Lee, Kian L, Phan, Anthony T, Veliça, Pedro, You, Jia, Chia, Grace S, Sim, Jingwei, Doedens, Andrew, Abelanet, Alice, Evans, Colin E, Griffiths, John R, Poellinger, Lorenz, Goldrath, Ananda W, Johnson, Randall S

    Published in Nature (London) (08-12-2016)
    “…R-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of…”
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    Journal Article
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