Search Results - "Tyrakis, Petros A."
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Constitutive Glycolytic Metabolism Supports CD8+ T Cell Effector Memory Differentiation during Viral Infection
Published in Immunity (Cambridge, Mass.) (15-11-2016)“…Extensive metabolic changes accompany T cell activation, including a switch to glycolytic energy production and increased biosynthesis. Recent studies suggest…”
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The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function
Published in Cell reports (Cambridge) (26-09-2023)“…2-Hydroxyglutarate (2HG) is a byproduct of the tricarboxylic acid (TCA) cycle and is readily detected in the tissues of healthy individuals. 2HG is found in…”
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A Late-Stage Intermediate in Salinomycin Biosynthesis Is Revealed by Specific Mutation in the Biosynthetic Gene Cluster
Published in Chembiochem : a European journal of chemical biology (02-01-2012)“…Say “when”: Analysis of the biosynthetic gene cluster for the polyether antibiotic and anticancer agent salinomycin (1) shows that its core structure is…”
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Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects
Published in Cell reports (Cambridge) (24-10-2017)“…Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid (TCA) cycle mutated in hereditary and sporadic cancers. Despite recent advances in understanding…”
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An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression
Published in Cancer cell (13-11-2017)“…Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion…”
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S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
Published in Nature (London) (08-12-2016)“…R -2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of R…”
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Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis
Published in Biology open (15-05-2017)“…Thrombosis can cause localized ischemia and tissue hypoxia, and both of these are linked to cancer metastasis. Vascular micro-occlusion can occur as a result…”
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The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia
Published in Cell metabolism (03-04-2018)“…Animals require an immediate response to oxygen availability to allow rapid shifts between oxidative and glycolytic metabolism. These metabolic shifts are…”
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Abstract A19: Pulmonary microthrombosis enhances tumorigenesis via myeloid hypoxia-inducible factors
Published in Cancer research (Chicago, Ill.) (01-04-2016)“…Abstract Thrombosis causes local blood flow restriction and tissue hypoxia, and both of these are associated with tumor cell metastasis. To better understand…”
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S-2-hydroxyglutarate regulates CD8^sup +^ T-lymphocyte fate
Published in Nature (London) (08-12-2016)“…R-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of…”
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The immunometabolite S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
Published in Nature (London) (26-10-2016)“…R-2-hydroxyglutarate accumulates to millimolar levels in cancers with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of…”
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