Search Results - "Tyndyk, Margarita L."

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice by Anisimov, Vladimir N., Zabezhinski, Mark A., Popovich, Irina G., Piskunova, Tatiana S., Semenchenko, Anna V., Tyndyk, Margarita L., Yurova, Maria N., Rosenfeld, Svetlana V., Blagosklonny, Mikhail V

“…The nutrient-sensing TO R (target of rapamycin) pathway is involved in cellular and organismal aging. Rapamycin, an inhibitor of TO R, extends lifespan in…”
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Metformin slows down aging and extends life span of female SHR mice by Anisimov, Vladimir N., Berstein, Lev M., Egormin, Peter A., Piskunova, Tatiana S., Popovich, Irina G., Zabezhinski, Mark A., Tyndyk, Margarita L., Yurova, Maria V., Kovalenko, Irina G., Poroshina, Tatiana E., Semenchenko, Anna V.

“…Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. It…”
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If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice by Anisimov, Vladimir N, Berstein, Lev M, Popovich, Irina G, Zabezhinski, Mark A, Egormin, Peter A, Piskunova, Tatiana S, Semenchenko, Anna V, Tyndyk, Margarita L, Yurova, Maria N, Kovalenko, Irina G, Poroshina, Tatiana E

“…Hyperglycemia and hyperinsulinemia accelerate both aging and cancer. Antidiabetic biguanides such as metformin decrease glucose, insulin and IGF-1 level…”
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Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo by Anisimov, Vladimir N., Egormin, Peter A., Piskunova, Tatiana S., Popovich, Irina G., Tyndyk, Margarita L., Yurova, Maria N., Zabezhinski, Mark A., Anikin, Ivan V., Karkach, Arseniy S., Romanyukha, Alexey A.

“…Population studies have shown that treatment with the antidiabetic biguanide metformin significantly reduced cancer risk. In our animal studies, metformin…”
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Effects of Isoflavone-Rich NADES Extract of Pueraria lobata Roots and Astaxanthin-Rich Phaffia rhodozyma Extract on Prostate Carcinogenesis in Rats by Semenov, Alexander L, Tyndyk, Margarita L, Von, Julia D, Ermakova, Elena D, Dorofeeva, Anastasia A, Tumanyan, Irina A, Radetskaya, Ekaterina A, Yurova, Maria N, Zherebker, Alexander, Gorbunov, Alexander Yu, Fedoros, Elena I, Panchenko, Andrey V, Anisimov, Vladimir N

“…Prostate cancer (PCa) is one of the most common male malignancies worldwide. In the current study, we evaluated the effects of a natural deep eutectic solvent…”
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The Effect of Polyphenolic Composition BP-C3 on the Efficacy and Hematological Toxicity of Cyclophosphamide in the Chemotherapy of Mice Bearing Soft Tissue Sarcomas Induced by Benzo[a]pyrene by Panchenko, Andrey V., Fedoros, Elena I., Pigarev, Sergey E., Maydin, Mikhail A., Gubareva, Ekaterina A., Kireeva, Galina S., Tyndyk, Margarita L., Kuznetsova, Anastasia I., Nekhaeva, Tatyana L., Danilova, Anna B., Baldueva, Irina A., Anisimov, Vladimir N.

“…This study aimed to evaluate the effect of lignin-derived polyphenolic composition BP-C3 on the efficacy and hematological toxicity of cyclophosphamide (CPA)…”
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Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice by Anisimov, Vladimir N, Zabezhinski, Mark A, Popovich, Irina G, Piskunova, Tatiana S, Semenchenko, Anna V, Tyndyk, Margarita L, Yurova, Maria N, Antoch, Marina P, Blagosklonny, Mikhail V

“…Aging is associated with obesity and cancer. Calorie restriction both slows down aging and delays cancer. Evidence has emerged that the nutrient-sensing…”
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Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin by Popovich, Irina G, Anisimov, Vladimir N, Zabezhinski, Mark A, Semenchenko, Anna V, Tyndyk, Margarita L, Yurova, Maria N, Blagosklonny, Mikhail V

“…Target of Rapamycin (TOR) is involved in cellular and organismal aging. Rapamycin extends lifespan and delays cancer in mice. It is important to determine the…”
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Assessment of antitumor activity of BP-C1, a platinum-based anticancer agent with a lignin-derived polymeric ligand, in autochthonous induced and spontaneous carcinogenesis rodent models by Fedoros, Elena I., Tyndyk, Margarita L., Popovich, Irina G., Anikin, Ivan V., Yurova, Maria N., Gubareva, Ekaterina A., Pigarev, Sergey E., Panchenko, Andrey V., Solovyev, Nikolay D., Anisimov, Vladimir N.

“…A standard approach to study the anticancer activity of novel drugs is their testing in animals with inoculated tumors, which has some limitations. An…”
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Sex differences in aging, life span and spontaneous tumorigenesis in 129/Sv mice neonatally exposed to metformin by Anisimov, Vladimir N, Popovich, Irina G, Zabezhinski, Mark A, Egormin, Peter A, Yurova, Maria N, Semenchenko, Anna V, Tyndyk, Margarita L, Panchenko, Andrey V, Trashkov, Alexandr P, Vasiliev, Andrey G, Khaitsev, Nikolai V

“…The perinatal (prenatal and early neonatal) period is a critical stage for hypothalamic programming of sexual differentiation as well as for the development of…”
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Central and Peripheral Effects of Insulin/IGF-1 Signaling in Aging and Cancer: Antidiabetic Drugs as Geroprotectors and Anticarcinogens by ANISIMOV, VLADIMIR N., BERSTEIN, LEV M., POPOVICH, IRINA G., ZABEZHINSKI, MARK A., EGORMIN, PETER A., TYNDYK, MARGARITA L., ANIKIN, IVAN V., SEMENCHENKO, ANNA V., YASHIN, ANATOLI I.

“…Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer…”
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Melatonin Administered before or after a Cytotoxic Drug Increases Mammary Cancer Stabilization Rates in HER2/Neu Mice by Panchenko, Andrey V, Tyndyk, Margarita L, Maydin, Mikhail A, Baldueva, Irina A, Artemyeva, Anna S, Kruglov, Stepan S, Kireeva, Galina S, Golubev, Alexey G, Belyaev, Alexey M, Anisimov, Vladimir N

“…The effects of chemotherapy are known to depend on the time of administration. Circadian rhythms are disturbed in tumors and in tumor bearers. Agents involved…”
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Novel water-soluble lignin derivative BP-Cx-1: identification of components and screening of potential targets in silico and in vitro by Fedoros, Elena I, Orlov, Alexey A, Zherebker, Alexander, Gubareva, Ekaterina A, Maydin, Mikhail A, Konstantinov, Andrey I, Krasnov, Konstantin A, Karapetian, Ruben N, Izotova, Ekaterina I, Pigarev, Sergey E, Panchenko, Andrey V, Tyndyk, Margarita L, Osolodkin, Dmitry I, Nikolaev, Evgeny N, Perminova, Irina V, Anisimov, Vladimir N

“…Identification of molecular targets and mechanism of action is always a challenge, in particular - for natural compounds due to inherent chemical complexity…”
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Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice by Anisimov, Vladimir N, Piskunova, Tatiana S, Popovich, Irina G, Zabezhinski, Mark A, Tyndyk, Margarita L, Egormin, Peter A, Yurova, Maria V, Rosenfeld, Svetlana V, Semenchenko, Anna V, Kovalenko, Irina G, Poroshina, Tatiana E, Berstein, Lev M

“…Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. It…”
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In mice transgenic for IGF1 under keratin-14 promoter, lifespan is decreased and the rates of aging and thymus involution are accelerated by Anisimov, Vladimir N, Labunets, Irina F, Popovich, Irina G, Tyndyk, Margarita L, Yurova, Maria N, Golubev, Alexey G

“…IGF1 signaling is supposedly a key lifespan determinant in metazoans. However, controversial lifespan data were obtained with different means used to modify…”
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Enchancement of Toremifene Anti-Tumor Action by Metformin and Unusual Side Effect of Toremifene in Male Transgenic Mice with HER2-Positive Breast Tumor by Stukov, Alexander N, Osipov, Mikhail A, Semiglazova, Tatjana Y, Filatova, Larisa V, Alexandrov, Valerij A, Bespalov, Vladimir G, Semenov, Alexander L, Tyndyk, Margarita L, Yurova, Maria N, Panchenko, Andrey V, Baranenko, Denis A

“…HER2-positive breast tumors are found in 25-30% of patients with breast cancer and are characterized by aggressive course and reduced sensitivity to both…”
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Anticancer activity and tissue distribution of platinum (II) complex with lignin-derived polymer of benzene-poly-carboxylic acids by Solovyev, Nikolay D., Fedoros, Elena I., Drobyshev, Evgenii J., Ivanenko, Natalya B., Pigarev, Sergey E., Tyndyk, Margarita L., Anisimov, Vladimir N., Vilpan, Yury A., Panchenko, Andrey V.

“…[Display omitted] •Inoculated Ehrlich ascitic carcinoma was used as mammary cancer model.•Performance of cisplatin, carboplatin and Pt complex with…”
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Polyphenolic drug composition based on benzenepolycarboxylic acids (BP-C3) increases life span and inhibits spontaneous tumorigenesis in female SHR mice by Anisimov, Vladimir N, Popovich, Irina G, Zabezhinski, Mark A, Yurova, Maria N, Tyndyk, Margarita L, Anikin, Ivan V, Egormin, Peter A, Baldueva, Irina A, Fedoros, Elena I, Pigarev, Sergey E, Panchenko, Andrey V

“…Effects of long-term application of novel polyphenolic composition BP-C3, containing polyphenolic benzenepolycarboxylic acids, vitamins and minerals on some…”
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Biomarkers of aging, life span and spontaneous carcinogenesis in the wild type and HER-2 transgenic FVB/N female mice by Panchenko, Andrey V., Popovich, Irina G., Trashkov, Alexandr P., Egormin, Peter A., Yurova, Maria N., Tyndyk, Margarita L., Gubareva, Ekaterina A., Artyukin, Ilia N., Vasiliev, Andrey G., Khaitsev, Nikolai V., Zabezhinski, Mark A., Anisimov, Vladimir N.

“…FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death…”
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Effect of the polyphenol composition BP-C3 on haematological and intestinal indicators of 5-fluorouracil toxicity in mice by Panchenko, Andrey V, Fedoros, Elena I, Pigarev, Sergey E, Maydin, Mikhail A, Gubareva, Ekaterina A, Yurova, Maria N, Kireeva, Galina S, Lanskikh, Galina P, Tyndyk, Margarita L, Anisimov, Vladimir N

“…BP-C3 is a formulation, which comprises lignin-derived polyphenolic composition of benzenepolycarboxylic acids (BP-Cx-1) with iron complex, selenium, ascorbic…”
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